CN117398326A - Skin moisturizing and repairing composition and application thereof - Google Patents
Skin moisturizing and repairing composition and application thereof Download PDFInfo
- Publication number
- CN117398326A CN117398326A CN202311431590.9A CN202311431590A CN117398326A CN 117398326 A CN117398326 A CN 117398326A CN 202311431590 A CN202311431590 A CN 202311431590A CN 117398326 A CN117398326 A CN 117398326A
- Authority
- CN
- China
- Prior art keywords
- extract
- inonotus obliquus
- weight
- skin moisturizing
- culture filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 239000000284 extract Substances 0.000 claims abstract description 47
- 241000414067 Inonotus obliquus Species 0.000 claims abstract description 44
- 229940107657 flaxseed extract Drugs 0.000 claims abstract description 36
- 235000020704 flaxseed extract Nutrition 0.000 claims abstract description 36
- 206010020649 Hyperkeratosis Diseases 0.000 claims abstract description 30
- 239000000706 filtrate Substances 0.000 claims abstract description 30
- 244000211187 Lepidium sativum Species 0.000 claims abstract description 18
- 235000007849 Lepidium sativum Nutrition 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 14
- 238000003809 water extraction Methods 0.000 claims abstract description 9
- 230000008439 repair process Effects 0.000 claims description 17
- 239000002562 thickening agent Substances 0.000 claims description 11
- 239000002738 chelating agent Substances 0.000 claims description 10
- 239000003906 humectant Substances 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 229940113120 dipropylene glycol Drugs 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 229940100573 methylpropanediol Drugs 0.000 claims description 2
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229940070721 polyacrylate Drugs 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 240000009164 Petroselinum crispum Species 0.000 claims 1
- 229960003993 chlorphenesin Drugs 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 235000011197 perejil Nutrition 0.000 claims 1
- 229960003885 sodium benzoate Drugs 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 34
- 230000000694 effects Effects 0.000 abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 239000000944 linseed oil Substances 0.000 abstract description 12
- 235000021388 linseed oil Nutrition 0.000 abstract description 11
- 210000000434 stratum corneum Anatomy 0.000 abstract description 11
- 240000007087 Apium graveolens Species 0.000 abstract description 9
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 abstract description 9
- 235000010591 Appio Nutrition 0.000 abstract description 9
- 239000002537 cosmetic Substances 0.000 abstract description 8
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 abstract description 7
- 229920002498 Beta-glucan Polymers 0.000 abstract description 7
- 238000000605 extraction Methods 0.000 abstract description 7
- 238000000194 supercritical-fluid extraction Methods 0.000 abstract description 5
- 229920001542 oligosaccharide Polymers 0.000 abstract description 4
- 150000002482 oligosaccharides Chemical class 0.000 abstract description 4
- 239000012528 membrane Substances 0.000 abstract description 3
- 239000012466 permeate Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 240000006240 Linum usitatissimum Species 0.000 abstract description 2
- 235000004431 Linum usitatissimum Nutrition 0.000 abstract description 2
- 235000004426 flaxseed Nutrition 0.000 abstract description 2
- 239000000686 essence Substances 0.000 description 27
- 230000000052 comparative effect Effects 0.000 description 18
- 238000012360 testing method Methods 0.000 description 14
- 230000008859 change Effects 0.000 description 13
- 230000006870 function Effects 0.000 description 7
- 210000002615 epidermis Anatomy 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000011160 research Methods 0.000 description 5
- 210000004207 dermis Anatomy 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 240000005980 Eryngium maritimum Species 0.000 description 1
- 235000003933 Eryngium maritimum Nutrition 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- -1 chlorophenylglycol Chemical compound 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a skin moisturizing and repairing composition and application thereof, and belongs to the technical field of cosmetics. The composition of the invention comprises the following components: inonotus obliquus extract, hydrolyzed flaxseed extract and littoral celery callus culture filtrate. The combination of the three components of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate has a synergistic effect, and can synergistically promote skin moisturizing and repairing. Compared with high molecular beta-glucan or linseed oil which is difficult to permeate into a basal layer, the hydrolyzed linseed extract selected by the invention is rich in oligosaccharide, has good water solubility, can enter the basal layer through the stratum corneum better, and achieves the effect of repairing the basal membrane. In addition, compared with the inonotus obliquus extract obtained by an organic supercritical extraction process or a traditional water-alcohol extraction process, the inonotus obliquus extract obtained by the subcritical water extraction process has a stronger moisturizing and repairing effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a skin moisturizing and repairing composition and application thereof.
Background
Whether the skin is tender, plump and healthy or not is critical to the fullness of the outermost layer of the epidermis of the skin, i.e. the moisture content of the stratum corneum. The basal layer is a connecting layer between epidermis and dermis, and has the function of a semipermeable membrane; the nutrients and moisture required for the survival and growth of cells in the epidermis are both efficiently transported from the dermis to the epidermis by the basal layer. The integrity of the function of the substrate layer is therefore critical to maintaining the health and youthfulness of the skin, maintaining the moisture content of the epidermis. However, as the age increases, the compactness and function of the basal layer gradually deteriorate, and nutrients and moisture in the dermis layer cannot be effectively transported to the epidermis layer, so that various skin problems such as skin water shortage, aging, etc. occur.
At present, the traditional moisturizing and skin care strategies in the market mainly focus on moisturizing and repairing the outer stratum corneum, have single mechanism, and often neglect the importance of the functional integrity of the inner stratum basale; the repairing of the outer stratum corneum can improve the water content of the skin and reduce the percutaneous water loss rate of the skin in a short time, but the external stratum corneum can not treat the root cause, and the moisturizing and repairing effects are not long. If the function of the basal layer is defective, the moisture and nutrition of the dermis layer cannot be effectively and timely transported upwards, and once the exogenous moisturizing repair components are deactivated or cleaned, the problems of dry, rough and aging skin and the like are re-exposed after a period of time.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a skin moisturizing repair composition and application thereof, wherein the skin moisturizing repair composition can realize double repair effects of a basal layer and a stratum corneum and has more excellent and lasting moisturizing repair effects.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
in a first aspect, the present invention provides a skin moisturising treatment composition comprising the following components: inonotus obliquus extract, hydrolyzed flaxseed extract and littoral celery callus culture filtrate.
Inonotus obliquus extract can effectively strengthen the cohesive force of keratinocytes and enhance the skin barrier function; the hydrolyzed flaxseed extract is rich in oligosaccharide, has good water solubility, can effectively enter a basal layer through a stratum corneum, promotes the synthesis of collagen IV, and promotes the repair of an epithelial basement membrane of the basal layer; in addition, the coastal cress callus culture filtrate can significantly promote the expression of the basal layer laminin and the collagen IV.
The inventor of the invention researches and discovers that the three components of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate have a synergistic effect, and can synergistically improve the moisture content of the skin horny layer and synergistically promote the recovery of the skin barrier function. The absence of any one, any two or three of these three components can significantly deteriorate the moisturizing and repairing functions of the composition.
In addition, the inventor of the present invention found that the moisturizing and repairing effects of the composition are remarkably deteriorated after the hydrolyzed flaxseed extract is replaced with high molecular beta-glucan or flaxseed oil. The hydrolyzed flaxseed extract selected by the invention is rich in oligosaccharide, has good water solubility, can better enter the basal layer through the stratum corneum compared with high molecular beta-glucan, and has better effect of repairing the basal membrane. The lipophilic linseed oil is used as a sebum bionic vegetable oil, a closed oil film is generally formed on the outermost layer of skin, the effect of preventing water loss is achieved, the lipophilic linseed oil is difficult to permeate into a basal layer, and the effect of repairing the basal layer is difficult to achieve. Thus, the hydrolyzed flaxseed extract in the composition of the invention is not replaced by high molecular beta-glucan or flaxseed oil.
As a preferred embodiment of the composition of the present invention, the Inonotus obliquus extract is extracted by a subcritical water extraction process.
The invention compares the moisturizing and repairing functions of the inonotus obliquus extract obtained by 3 different extraction processes (subcritical water extraction process, organic supercritical extraction process and traditional water-alcohol extraction process). As a result, it was found that the composition containing the inonotus obliquus extract obtained by the subcritical water extraction process has a better moisturizing and repairing effect than the composition containing the inonotus obliquus extract obtained by the organic supercritical extraction process or the conventional hydroalcoholic extraction process.
In the skin moisturizing repair composition, the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate are respectively 0.4-1.5 parts by weight, 0.4-1.5 parts by weight and 0.04-1.1 parts by weight.
As a preferred embodiment of the composition of the invention, the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate are 0.8-1 parts by weight, 0.8-1 parts by weight and 0.08-0.1 parts by weight, respectively.
The inventor researches and discovers that the composition has better moisturizing and repairing effects when the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate are in the weight part range.
As a preferred embodiment of the composition of the invention, the weight part ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral cress callus culture filtrate is (0.33-3): 1: (0.06-2.2).
As a preferred embodiment of the composition of the invention, the weight ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral celery callus culture filtrate is 1:1: (0.08-0.1).
The inventor researches and discovers that the composition has better moisturizing and repairing effects when the weight ratio of the inonotus obliquus extract to the hydrolyzed flaxseed extract to the coastal cress callus culture filtrate is in the range.
As a preferred embodiment of the composition of the invention, the weight ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral celery callus culture filtrate is 1:1:0.1.
the inventor researches find that the weight ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral celery callus culture filtrate is 1:1: at 0.1, the composition has optimal moisturizing and repairing efficacy.
Moreover, the composition comprising Inonotus obliquus extract, hydrolyzed flaxseed extract and littoral callus culture filtrate can be applied in skin care products and cosmetics.
In the invention, the inventor applies a composition consisting of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate to the essence, wherein the composition consisting of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate accounts for 1-5% of the total weight of the essence.
The essence comprises the composition, as well as a humectant, a chelating agent, a thickening agent and a preservative.
As a preferred embodiment of the essence, the essence comprises, by weight, 3-7% of a humectant, 0.02-0.05% of a chelating agent, 0.1-0.2% of a thickening agent and 0.3-0.8% of a preservative.
As a preferred embodiment of the essence of the present invention, the humectant is at least one selected from the group consisting of glycerin, polyglycerol, diglycerol, butanediol, 1, 3-propanediol, methylpropanediol, dipropylene glycol, 1, 2-hexanediol, betaine, trehalose, xylitol and sodium hyaluronate. As a preferred embodiment of the essence of the present invention, the chelating agent is selected from at least one of disodium EDTA and tetrasodium EDTA. As a preferred embodiment of the essence of the present invention, the thickener is selected from at least one of carbomer, xanthan gum, polyacrylate crosslinked polymer-6 and acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer. As a preferred embodiment of the essence of the present invention, the preservative is at least one selected from the group consisting of methylparaben, sodium benzoate, chlorophenylglycol, phenoxyethanol, potassium sorbate, p-hydroxyacetophenone and octanoyl hydroxamic acid.
As a preferred embodiment of the essence of the present invention, the humectant consists of glycerin, sodium hyaluronate, butylene glycol and 1, 2-hexanediol; the chelating agent is disodium EDTA; the thickener is xanthan gum; the preservative is p-hydroxyacetophenone.
The inventor of the invention researches and discovers that the moisture retention and repair effects of the essence can be better by adopting the humectant, the chelating agent, the thickening agent and the preservative as auxiliary agents and combining with the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral celery callus culture filtrate.
In a second aspect, the invention also provides a preparation method of the essence, which comprises the following steps:
s1, adding water, a humectant, a chelating agent and a thickening agent into a main pot, stirring and heating to 80-85 ℃, and stirring for 30 minutes until the mixture is completely uniform to obtain a material A;
s2, cooling the material A to 45-50 ℃, adding the inonotus obliquus extract, the hydrolyzed flaxseed extract, the coastal cress callus culture filtrate and the preservative, and stirring uniformly to obtain the essence.
Compared with the prior art, the invention has the beneficial effects that:
(1) According to the invention, the main functional components of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal celery callus culture filtrate are combined, so that the double repairing effect of the basal layer and the stratum corneum can be achieved from inside to outside, and the cosmetic has more excellent and lasting moisturizing and repairing effects. And the three components complement each other in mechanism, and have synergistic effect.
(2) The inonotus obliquus extract selected by the invention is obtained by adopting a subcritical water extraction process. Compared with the inonotus obliquus extract obtained by an organic supercritical extraction process and a traditional water-alcohol extraction process, the inonotus obliquus extract obtained by a subcritical water extraction process has better moisturizing and repairing effects.
(3) Compared with high molecular beta-glucan, the hydrolyzed flaxseed extract selected by the invention is rich in oligosaccharide, has good water solubility, can enter the basal layer through the stratum corneum better, and achieves the effect of repairing the basal layer. In addition, the hydrolyzed flaxseed extract selected by the invention can not be replaced by the flaxseed oil, and the flaxseed oil is vegetable oil, so that the flaxseed oil is difficult to permeate into the basal layer and the effect of repairing the basal layer is difficult to achieve.
Drawings
FIG. 1 shows the skin moisture content change rate (%) at 4 hours, the skin moisture content change rate (%) at 8 hours, the skin moisture loss change rate (%) at 7 days (D7) and the skin moisture loss change rate (%) at 14 days (D14) of subjects using the essence of examples 1 to 17 and comparative examples 1 to 20 of the present invention.
Detailed Description
The technical scheme of the invention is further described below by referring to examples. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. The methods or operations used in the examples, unless specifically indicated, are conventional methods or conventional operations in the art.
The essential oils of examples 1 to 17 and comparative examples 1 to 13 contained the components other than water and the parts by weight thereof were as shown in Table 1, and the units were: parts by weight. The total parts by weight of the essences in examples 1 to 17 and comparative examples 1 to 13 were 100 parts, and the balance was water, except for the components in Table 1. Inonotus obliquus extract in examples 1-17 and comparative examples 1-13 was extracted by subcritical water extraction process. Inonotus obliquus extract is purchased from BASF of Germany under the trade name Inolixir TM . The hydrolyzed Linseed extract was purchased from BASF, germany under the trademark Oligolin TM The method comprises the steps of carrying out a first treatment on the surface of the Coastal celery callus culture filtrate was purchased from Biotec Marine, france, a subsidiary of Seppic, under the trade name Celtosome TM Eryngium Maritimum。
TABLE 1
The essential liquids of comparative examples 14 to 20 contain the other components except for the water and parts by weight thereof as shown in Table 2, and the units are: parts by weight. The total weight parts of the essences in comparative examples 14 to 20 were 100 parts, and the balance was water except for the components in Table 2. The thickener in the extracts of comparative examples 19 and 20 was SOLUBILISANT LRI, available from Senxin essence pigment technology (China). Beta-glucan was purchased from De Xinxiang essence fragrance (Nantong) Inc. under the trade nameLinseed OIL is purchased from biocosethic under the trade name REFINED LINSEED OIL.
TABLE 2
The preparation method of the essence in the embodiments 1-17 and the comparative examples 1-20 comprises the following steps:
s1, adding water, a humectant, a chelating agent and a thickening agent into a main pot, stirring and heating to 80-85 ℃, and stirring for 30 minutes until the mixture is completely uniform to obtain a material A;
s2, cooling the material A to 45-50 ℃, adding the inonotus obliquus extract, the hydrolyzed flaxseed extract, the coastal cress callus culture filtrate and the preservative, and stirring uniformly to obtain the essence.
Performance testing
The essences of examples 1 to 17 and comparative examples 1 to 20 were subjected to a skin horny layer moisture content and a rate of change of a percutaneous moisture loss value.
Test object: age range: 30 healthy subjects were selected for each group of samples, 20-50 years old. (healthy men and women are defined as those who do not have chronic disease or major disease or allergic constitution, and who do not take any drugs at present).
Preparation before testing: the tested part is the inner side of the two arms, any product (cosmetics or external medicines) cannot be used 2-3 days before testing, and water cannot be contacted for 1-3 hours. Before the test, the subjects need to uniformly clean the inner sides of the arms and wipe the inner sides with a chipless water-absorbing dry paper towel.
Test environment: temperature: 20-22 ℃, humidity: 40-60%, and the test is carried out in a closed space without being directly irradiated by sunlight and an air conditioner air outlet on the test site.
The testing method comprises the following steps: before the experiment starts, the subject sits still for 30min in a constant temperature and humidity environment (the temperature is 20-22 ℃ and the humidity is 40-60%), and then the samples in each example and the comparative example are quantitatively (5 drops, about 0.2 g) smeared on the positions of the two-arm circles by referring to QB/T4256-2011 cosmetic moisturizing efficacy evaluation guidelines. The same arm can mark multiple areas, 1 cm apart. The test products are randomly distributed on the left and right arms. The moisture content of the skin horny layer at 0h (initial value of the unused sample), 4h, 8h after the sample was used, respectively, was measured three times with an instrument MOISTUREMETERSC MSC1212 (DELFIN), and the change rate of the moisture content of the skin horny layer at 4h, 8h was calculated (remark: no other cosmetics or external medicines were used during the use of the product).
The moisture content change rate (%) of the skin horny layer was calculated according to the following formula:
the skin horny layer moisture content change rate (%) = (skin horny layer moisture content after use-skin horny layer moisture content before use)/skin horny layer moisture content before use×100%.
Further, on the 0 th day, the 7 th day (D7) and the 14 th day (D14) after the continuous use of the test sample (twice a day, once a day, 5 drops each time, about 0.2g each time the test sample was used), the percutaneous moisture loss value (TWEL) of the test area was measured by using the percutaneous moisture loss measuring instrument VapoMeter, and the rate of change in the percutaneous moisture loss value was analyzed. Remarks: no other cosmetics or external medicines are used during the use of the product. The percutaneous moisture loss value TWEL is a measure of the moisture loss by measuring the water vapor pressure gradient at the skin surface, and reflects the water permeability barrier of the skin. When barrier function is impaired, TEWL values increase; conversely, TEWL decreases, suggesting that the barrier tends to repair. The greater the decrease in the rate of change of the transdermal moisture loss value before use compared to the control, the better the recovery of skin barrier function. Skin percutaneous moisture loss change rate= (percutaneous moisture loss rate after use-initial percutaneous moisture loss rate)/initial percutaneous moisture loss rate×100%.
The test results are shown in table 3 below.
TABLE 3 Table 3
From Table 3, it is clear that the moisture-keeping and repairing functions of the essence are greatly affected by the changes of the weight parts and the proportions of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the littoral celery callus culture filtrate and the extraction process of the inonotus obliquus extract.
Comparing the data of example 3 with the data of comparative examples 1-13, it is evident that the absence of one, two or three of Inonotus obliquus extract, hydrolyzed flaxseed extract and littoral callus culture filtrate in the formulation of the concentrate reduced the moisturizing and repairing effects of the concentrate to varying degrees, as evidenced by the higher skin stratum corneum moisture content change rate of example 3 relative to comparative examples 1-13 at 4 hours and 8 hours, and the higher absolute value of skin transdermal moisture loss change rate of example 3 at days 7 and 14 of use than comparative examples 1-13. In addition, as can be seen from the data of comparative examples 3 and comparative examples 1-13, the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate synergistically improved the moisturizing and repairing effects of the essence.
Analysis of the data of examples 3-17 shows that the concentrate has good moisturizing and repairing effects when the weight parts and the weight part ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate are within a certain range.
Comparing the data of example 3 with the data of comparative examples 14-17, it is understood that the essence containing the Inonotus obliquus extract obtained by the subcritical water extraction process has a better moisturizing and repairing effect than the essence containing the Inonotus obliquus extract obtained by the organic supercritical extraction process or the conventional hydroalcoholic extraction process.
Comparing the data of example 3 with comparative example 18, it is clear that the moisturizing and repairing effects of the essence are significantly deteriorated after the hydrolyzed flaxseed extract is replaced with the high molecular beta-glucan.
As is clear from the data of comparative examples 3 and 19 to 20, the moisturizing and repairing effects of the essence are remarkably deteriorated after the hydrolyzed flaxseed extract is replaced with flaxseed oil (the amount of the dissolved flaxseed oil is increased by using the solubilizing agent).
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. A skin moisturizing repair composition comprising the following components: inonotus obliquus extract, hydrolyzed flaxseed extract and coastal parsley callus culture filtrate; the inonotus obliquus extract is extracted by adopting a subcritical water extraction process.
2. The skin moisturizing repair composition of claim 1, wherein the inonotus obliquus extract is 0.4-1.5 parts by weight, the hydrolyzed flaxseed extract is 0.4-1.5 parts by weight, and the coastal cress callus culture filtrate is 0.04-1.1 parts by weight.
3. The skin moisturizing repair composition of claim 2, wherein the inonotus obliquus extract is 0.8-1 parts by weight, the hydrolyzed flaxseed extract is 0.8-1 parts by weight, and the coastal cress callus culture filtrate is 0.08-0.1 parts by weight.
4. The skin moisturizing repair composition of claim 2, wherein the weight ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate is (0.33-3): 1: (0.06-2.2).
5. The skin moisturizing repair composition of claim 4, wherein the weight ratio of the inonotus obliquus extract, the hydrolyzed flaxseed extract and the coastal cress callus culture filtrate is 1:1: (0.08-0.1).
6. Use of a skin moisturizing repair composition according to any one of claims 1-5 in the preparation of a skin product.
7. A concentrate comprising the skin moisturizing repair composition of any one of claims 1-5, wherein the skin moisturizing repair composition comprises 1-5% by weight of the total concentrate.
8. The concentrate of claim 7, further comprising the following components: humectants, chelating agents, thickeners, and preservatives.
9. The concentrate of claim 8, wherein the humectant comprises 3 to 7% by weight of the total concentrate, the chelating agent comprises 0.02 to 0.05%, the thickener comprises 0.1 to 0.2%, and the preservative comprises 0.3 to 0.8%.
10. The concentrate of claim 8, wherein the humectant is selected from at least one of glycerin, polyglycerol, diglycerol, butylene glycol, 1, 3-propanediol, methylpropanediol, dipropylene glycol, 1, 2-hexanediol, betaine, trehalose, xylitol, dextran, and sodium hyaluronate;
and/or the chelating agent is selected from at least one of disodium EDTA and tetrasodium EDTA;
and/or the thickener is selected from at least one of carbomer, xanthan gum, polyacrylate crosslinked polymer-6 and acrylic acid (ester) type/C10-30 alkanol acrylate crosslinked polymer;
and/or the preservative is selected from at least one of methylparaben, sodium benzoate, chlorphenesin, phenoxyethanol, potassium sorbate, p-hydroxyacetophenone, and octanoyl hydroxamic acid.
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| CN111297760A (en) * | 2020-03-27 | 2020-06-19 | 广东梵蜜琳生物科技有限公司 | Composition with repairing effect and application thereof |
| CN114344211A (en) * | 2021-12-28 | 2022-04-15 | 广州戊戌科技有限公司 | Moisturizing and stabilizing composition and preparation method thereof |
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