CN115397502B - Liquid injection device, system and cartridge unit thereof - Google Patents
Liquid injection device, system and cartridge unit thereof Download PDFInfo
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- CN115397502B CN115397502B CN202180028185.5A CN202180028185A CN115397502B CN 115397502 B CN115397502 B CN 115397502B CN 202180028185 A CN202180028185 A CN 202180028185A CN 115397502 B CN115397502 B CN 115397502B
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- liquid injection
- injection device
- liquid
- cartridge unit
- discharge
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
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- 108090001061 Insulin Proteins 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
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- 238000012377 drug delivery Methods 0.000 description 1
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- 201000005884 exanthem Diseases 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A liquid injection device (1) for injecting a liquid into the skin through a microneedle (10) is provided, comprising a cartridge unit (20) having a microneedle, a discharge hole (11) for discharging the liquid, a syringe portion (21) for containing the liquid, and a washer portion (23) for extruding the liquid from the syringe portion toward the discharge hole, and a main body (30) having at least a cartridge mounting portion for detachably mounting the cartridge unit and sliding portions (37, 38) for axially moving the washer portion of the mounted cartridge unit, and being used in a replaceable cartridge unit.
Description
Technical Field
The present invention relates to a liquid injection device for injecting a liquid such as a cosmetic liquid or a medicinal liquid into the skin through a microneedle, and a system and cartridge unit thereof.
Background
Microneedles are used as percutaneous absorption devices in the medical and cosmetic fields.
The skin is composed of epidermis and dermis. The epidermis is a rigid protein composed of the stratum corneum, basal layer, acantha layer, etc. The stratum corneum forms a barrier against the ingress of bacteria and dust, and prevents the evaporation of moisture from the body; the basal layer produces keratinocytes and protects the skin from ultraviolet rays with melanin.
On the other hand, dermis is composed of fibrous collagen, gel-like hyaluronic acid, or the like, and is formed by spreading nerves, blood vessels, lymphatic vessels, or the like, and is a highly elastic protein layer.
The amount of fluid that can be injected into the skin is extremely small compared with the amount that enters the subcutaneous tissue, and is 0.2 ml or less in the highly elastic dermis and about 1/100 in the epidermis as a scleroprotein. Further, since the thickness of the skin is about 1.5 to 2mm in total between the epidermis and the dermis, the microneedle is an effective device that can control the percutaneous absorption amount and depth.
In particular in the cosmetic field, the aim is to inject a cosmetic liquid into the epidermis of low permeability. For this purpose, in the cosmetic field, sealed microneedles are used, and collagen or hyaluronic acid hardened into a needle shape is laid in a needle shape, and fixed to the site of the skin to be repaired such as eyes and french marks for a long time with an adhesive to allow penetration.
As related prior art, patent document 1 discloses a structure including a housing, a microneedle array holder holding a microneedle array, and a shuttle (Shuttle) holding a cartridge, wherein the microneedle array holder is movable between a retracted position and an extended position. In this structure, only the cartridge containing the drug solution can be replaced, and the microneedle array disposed separately from the cartridge and its microneedle array holder are moved from the retracted position to the extended position by the energy storage means. The energy storage means is in particular a helical spring which contacts the skin at a certain impact velocity.
Further, patent document 2 discloses an operation tool capable of easily and reliably injecting a desired amount of fluid into skin tissue in a short time when intradermal injection is performed by a fluid injector using a multi-microneedle device. The device is characterized by being simple and low-cost, and comprising a mechanism for sequentially moving the needle in the device body between an initial position in which the needle is retracted into the opening, a first position projecting outward from the opening to a first distance, and a second position projecting outward to a second distance shorter than the first distance. After the fluid exits at the second position, the injector is pushed to the initial position by magnetic force.
Since the injection is not repeated a predetermined amount each time it is returned to the original position, a structure is disclosed as a structure for injecting all of the fluid of the required amount in the fluid injector into the skin tissue of the required position.
Patent document 3 discloses a drug delivery assembly having a delivery assembly including a plurality of microneedles configured to transdermally deliver a drug to a patient, and including a sensing unit configured to measure at least one physical parameter determined from a volume of a drug within the device. The device discloses a structure that forms a capacitor with two electrodes between which the drug flows and the volume is measured by measuring the capacitance of the capacitor. In addition, a structure for measuring by a photodetector is also disclosed. In this case, these measurement devices are required between the microneedle and the container of the drug, and there is a problem in that the structure and control of the device become complicated, in addition to the inability to easily replace the container and the microneedle.
Prior art literature
Patent literature
Patent document 1: japanese patent application laid-open No. 2016-523115
Patent document 2: international publication No. 2014/017561
Patent document 3: japanese patent application laid-open No. 2020-504650.
Disclosure of Invention
Technical problem to be solved by the invention
As a problem with the above prior art, the adhesive may cause rash, swelling, and the like due to the long-term contact of the sealed microneedles with the skin. In addition, many seals are required to penetrate the cosmetic liquid over a large area, which is inefficient.
On the other hand, when the microneedle is mounted to the front end of the syringe and injected from the needle, most of the liquid may leak out without entering the skin due to the low skin penetration. In particular, when the liquid is injected into the epidermis, the injection amount must be controlled in several μl, and the operation itself is difficult due to the minute amount. In addition, the injected cosmetic liquid is expensive and if overflowed from the skin, the cost performance is much worse.
The present invention has been made in view of the above-described problems of the prior art, and provides a technique for accurately and simply injecting a minute amount of liquid by a liquid injection device for injecting the liquid from a microneedle into skin having low permeability. Meanwhile, the object is to provide a technique which can inject liquid into epidermis in a short time without waste and can inject beauty liquid in a large area by cooperating with the operation of the user when the skin is in contact with the device.
Technical means for solving the problems
In order to solve the above-described problems, the present invention provides the following liquid injection device.
According to a first aspect of the present invention, there is provided a liquid injection device for injecting a liquid into skin through a microneedle, the liquid injection device comprising a cartridge unit and a body, wherein the cartridge unit includes the microneedle, a discharge hole for discharging the liquid, and a container portion for containing the liquid. The main body further includes a cartridge mounting portion for detachably mounting the cartridge unit and a force generating mechanism for generating a liquid discharge action with respect to the mounted cartridge unit. Thereby, a liquid injection device can be provided which can be used with a cartridge unit replaced.
According to a second aspect of the present invention, in the cartridge unit, the tip portion includes a microneedle and a discharge hole, and the tip portion can be attached to the container portion for use.
According to a third embodiment of the present invention, the liquid injection device may further include a discharge amount setting device for setting a discharge amount when the liquid is discharged from the cartridge unit.
According to a fourth embodiment of the present invention, the discharge amount setting device may be configured to set the discharge amount per unit time by changing the state of the discharge hole according to the characteristics of the liquid.
According to a fifth aspect of the present invention, the container portion of the cartridge unit includes at least a syringe portion and a gasket portion for extruding liquid from the syringe portion to the discharge hole, and the force generating mechanism may include a slide portion for axially moving the gasket portion of the mounted cartridge unit.
According to a sixth aspect of the present invention, the liquid injection device may further include a discharge number setting device for setting the number of times liquid is discharged from the cartridge unit.
According to a seventh aspect of the present invention, the liquid injection device may further include a driving device that drives the sliding portion of the liquid injection device in the axial direction.
According to an eighth embodiment of the present invention, the discharge amount setting device may include a first control unit that sets the discharge amount per unit time by controlling the driving speed of the driving device.
According to a ninth embodiment of the present invention, the discharge amount setting device may include a second control unit that adjusts the amount of extrusion of the washer portion by the driving device.
According to a tenth aspect of the present invention, the driving device may be a motor including a drive shaft for axially driving the sliding portion.
According to an eleventh aspect of the present invention, the liquid injection device may further include an operation unit that manually operates the sliding unit.
According to a twelfth embodiment of the present invention, there may be provided a liquid injection device wherein the force generating mechanism includes a vibrating portion that vibrates the cartridge unit in the axial direction.
According to a thirteenth aspect of the present invention, the device may further include a third control unit that sets a vibration frequency of the vibration unit in the force generation mechanism.
According to a fourteenth aspect of the present invention, the liquid injection device may further include a fourth control unit that controls a force applied from the force generating mechanism to the cartridge unit.
According to a fifteenth aspect of the present invention, there is provided a liquid injection device in which a body of the liquid injection device is composed of a grip portion for a user to grip and an action portion including at least a cartridge mounting portion, and the grip portion and the action portion each have an angle of 50 degrees to 80 degrees in a longitudinal direction.
According to a sixteenth embodiment of the present invention, in the liquid injection device, a fifth control unit may be provided that detects the inclination angle of the main body and controls to be activatable or notified to the user when the inclination angle is within a predetermined angle range.
According to a seventeenth embodiment of the present invention, the fifth control unit may set the discharge amount per unit time based on the detected inclination angle of the main body.
According to an eighteenth embodiment of the present invention, the device may include: and a sixth control unit for controlling the force generating mechanism based on the detection result.
According to a nineteenth aspect of the present invention, in the configuration in which the force generating mechanism includes the vibration portion, the cartridge unit may have a plurality of discharge holes, and the discharge holes may be arranged at intervals ranging from 2mm to 20 mm.
According to a twentieth embodiment of the present invention, there is provided a system, using the above-described liquid injection device, composed of a plurality of cartridge units each containing two or more liquids having different effects and a main body, which can provide various effects by replacing and using the cartridge units.
According to a twenty-first embodiment of the present invention, there is provided a system composed of a plurality of cartridge units and a body each having at least one different microneedle of a length, a disposition density and a distribution area, which can provide various effects by replacing and using the cartridge units.
According to a twenty-second embodiment of the present invention, in the above system, the tip portion is provided with the microneedle and the discharge hole, and in the structure in which the tip portion is attached to the container portion, the cartridge unit is replaced by replacement of the tip portion and used, thereby providing various effects.
Effects of the invention
The present invention achieves the following effects by the above-described structure.
By providing the cartridge unit with the micro-needle and the syringe portion for containing the cosmetic liquid, the medical liquid, etc., the micro-needle for the optimal state of the liquid can be selected and provided, and the user can perform various required operations at the time of replacing the cartridge unit without being annoyed by advanced knowledge or selection.
In the liquid injection device of the present invention, the components include the cartridge unit and the sliding part driven by the motor, and the like, and the liquid injection device has the advantages of small number of components, simple structure, high cost performance and stable quality.
In addition, in the configuration having the distal end portion, since the microneedle and the syringe portion can be provided separately, even if they differ depending on the authentication system or the like, the cartridge unit that can be associated with the liquid injection device of the present invention can be easily provided. In addition, the syringe portion as a general-purpose component contributes to mass production.
In the structure provided with the motor of the present invention, the discharge of the liquid can be controlled. That is, the discharge speed of the liquid may be adjusted by the discharge speed adjusting device, or the extrusion amount of the gasket portion may be adjusted by using the home sensor.
Further, by controlling the motor by the skin sensor that detects contact with the skin or the like in the vicinity of the microneedles, the liquid can be discharged at an appropriate timing according to the distance from the skin.
By providing the elastic support member that elastically supports the predetermined portion of the syringe portion toward the gasket portion side, the cartridge unit can be supported with appropriate elasticity and pressure while contributing to waterproofing of the main body side.
In the structure provided with the vibration part of the present invention, simple discharge of liquid can be realized. In particular, by controlling the vibration frequency and intensity, the discharge amount can be adjusted to an appropriate level.
Further, by controlling the motor by the skin sensor that detects contact with the skin or the like in the vicinity of the microneedles, the liquid can be discharged at an appropriate timing according to the distance from the skin.
By providing the elastic support member that elastically supports the predetermined portion of the syringe portion toward the gasket portion side, the cartridge unit can be supported with appropriate elasticity and pressure while contributing to waterproofing of the main body side.
The present invention helps to provide various effects by providing the cartridge unit and its front end as a replaceable system, enabling the random selection of various types of combinations of liquids and microneedles.
Drawings
Fig. 1 is a sectional view for explaining an internal mechanism of a liquid injection apparatus according to a first embodiment of the present invention.
Fig. 2 is an oblique view thereof.
Fig. 3 is an enlarged view of the head.
Fig. 4 is a diagram showing a state in which the cartridge unit is assembled.
Fig. 5 is a diagram showing a state in which the cartridge unit is separated.
Fig. 6 is an explanatory diagram of a control circuit according to the first embodiment of the present invention.
Fig. 7 is an explanatory diagram showing an implementation state of the counter unit of the linear motor.
Fig. 8 is a view showing an external appearance of a liquid injection device according to a first embodiment of the present invention.
Fig. 9 is an oblique view of a liquid injection device according to a second embodiment of the present invention.
Fig. 10 is a sectional view illustrating an internal mechanism thereof.
Fig. 11 is an explanatory view of the vibration mechanism thereof.
Fig. 12 is an oblique view of the front end portion.
Fig. 13 is an explanatory diagram showing the shape of the microneedle.
Fig. 14 is a view showing another state of the front end portion.
Fig. 15 is an explanatory diagram of a control circuit according to the second embodiment of the present invention.
Fig. 16 is an explanatory diagram showing a swinging state of the head.
Fig. 17 is a view showing the angle between the grip portion and the action portion.
Detailed Description
Hereinafter, embodiments of the present invention will be described based on examples shown in the drawings. Further, the embodiments are not limited to the following.
(First embodiment)
Fig. 1 is a sectional view for explaining an internal mechanism of a liquid injection device according to a first embodiment of the present invention, and fig. 2 is an oblique view thereof in a state where a circuit board is detached.
The present invention is a liquid injection device 1 for injecting liquid into skin through a microneedle 10, which is composed of a cartridge unit 20 and a main body 30.
The microneedle 10 having the discharge hole 11 is disposed at the front end, and includes a syringe portion 21 for containing a liquid and a gasket portion 22 for pushing out the liquid from the syringe portion 21 to the discharge hole 11 at the rear end thereof, and these constitute the cartridge unit 20.
In the present invention, the cartridge unit is particularly characterized in that the cartridge unit is used, and the cartridge mounting portion is provided on the body of the liquid injection device, so that the cartridge unit can be mounted and dismounted. Further, as the force generating mechanism according to the present invention, a slide portion for moving the gasket portion of the cartridge unit in the axial direction is provided so that the liquid in the cartridge is discharged from the discharge hole.
The sliding portion may perform a sliding operation manually or may perform a sliding operation automatically. For example, in the case of manual operation, an operation portion such as a slide bar or a button may be provided in the main body, and the liquid may be discharged from the discharge hole by an axial operation of the gasket portion following an operation of the operation portion.
In the present embodiment, a structure in which the sliding portion is operated by the driving device is disclosed. As the driving device, a well-known driving device that operates in the axial direction, such as a hydraulic cylinder or an air cylinder, may be used in addition to a linear motor or the like described later. These driving means may be controlled by the control means described below.
The main body 30 is composed of a head 31 having a distal end covering the periphery of the microneedle 10, a housing portion 32 housing the cartridge unit 20 and other internal components, a linear motor 33 driving a drive shaft in the housing portion 32, a battery 34 supplying electric power, a control board 35 having a control circuit, an operation switch 36 for operation, and the like.
In use, in a state in which the head 31 is removed, the cartridge unit 20 is inserted into the cylindrical cartridge mounting portion 320 at the front end of the housing portion 32, and the head 31 is then fitted over the head receiving portion 321 at the front end of the housing portion 32.
Fig. 3 shows a state of the inside of the head 31. As shown in fig. 2, two cams 3210 are provided on the outer peripheral surface of the head receiving portion 321, and cam grooves 311 that engage with the cams 3210 are provided on the inner peripheral surface of the head 31, so that the head 31 can be easily attached and detached by pressing and rotating the head receiving portion 321.
At this time, the cartridge unit 20 is stably supported by an elastic support member provided inside the head portion 31, that is, a cartridge pressing rubber 310 made of rubber and elastically supported toward the gasket portion 22 in the present embodiment.
The cartridge pressing rubber 310 suppresses shaking of the cartridge unit 20, and also has a waterproof effect of preventing liquid or the like from entering the inside from the periphery of the cartridge unit.
Fig. 4 is a view showing an assembled state of the cartridge unit 20, and fig. 5 is a view showing a separated state of the cartridge unit.
In the present embodiment, the cartridge unit 20 is constituted by a tip portion 23 provided with the microneedles 10 and the discharge holes 11, a cylindrical syringe portion 21 accommodating a liquid, and a gasket portion 22. The liquid in the syringe portion 21 is discharged from the discharge hole 11 through a flow hole, not shown, in the distal end portion 23.
More specifically, the gasket portion 22 is constituted by a sealing member 220 that seals the liquid in the syringe portion 21 and a rear end member 221 that receives the driving force from the linear motor 33.
The rear end member 221 may have a structure in which the rear end member 221 is pushed and slid, as in the other driving device.
As is well known, a large number of very fine needles, having a diameter and a length of less than 1mm, are provided on the microneedle at the tip 23, and penetrate the stratum corneum, which is impermeable to substances, more shallowly than the dermis, which has many pain points. In addition to medical applications such as injection of drugs such as insulin and vaccines, cosmetic applications such as injection of cosmetic solutions are also contemplated.
In addition to PLA (polylactic acid), collagen, hyaluronic acid, or the like is preferably used as a material of the microneedle. For cosmetic use, a solid needle is generally used, and the cosmetic liquid is discharged through the discharge holes 11 of the flat portion around the needle, and can permeate through the skin micropores opened by the microneedles.
In the present invention, a discharge amount setting device is provided for setting a discharge amount when the liquid is discharged from the cartridge unit 20. As the discharge amount setting means, the discharge amount per unit time can be set by changing the frictional resistance of the fluid by adjusting the diameter of the discharge hole, the length of the passing portion, the state of the discharge hole of the material or the like. According to this structure, even if the driving device is manual, if operated with a certain strength, an appropriate discharge amount suitable for the liquid to be used can be maintained.
By thus changing the states of the microneedles and the discharge orifices appropriate for the cartridge unit 20, the size of the discharge orifices can be changed and adjusted according to the amount, momentum, viscosity, etc. of the liquid. If the force is too large or the amount is too large, the liquid may drop or not be properly applied, resulting in a large loss of the cosmetic liquid, so it is important to properly adjust the discharge speed.
In addition, a pressurizing chamber, not shown, may be provided in the cartridge unit 20 without changing the state of the discharge hole, and the discharge amount may be set by adjusting the speed of the liquid flowing out from the pressurizing chamber to the discharge hole.
In the present embodiment, the liquid in the syringe portion 21 is pushed out by the linear motor 33, but even in this case, the discharge amount can be set by changing the aperture of the discharge hole 11.
The state of the discharge hole 11 is preferably selected according to the liquid in the interior, and for example, when the viscosity of the liquid is 30pa·s, the pore diameter is preferably about 0.2 to 1mm, and when the viscosity is 30000pa·s, it is preferably 1 to 2mm. In this way, depending on the viscosity of the liquid, varying the discharge orifice can achieve more effective application and help prevent clogging.
The diameter of the circular portion of the microneedle 10 is 5 to 25mm, for example, preferably about 12 mm. The structure in which the liquid is pushed out by the gasket portion 22 can be applied to a cosmetic liquid having a high viscosity, for example, 5000pa·s or more, and the aperture of the discharge hole can be selected from a wide range of 30 μm to 2 mm.
In addition, in the structure having the plurality of discharge holes 11, the discharge holes for the liquid are preferably arranged at intervals of at least 100 μm to 500 μm. By ensuring such a spacing, the microneedles and the discharge orifices can be alternately and efficiently distributed.
The present invention is not limited to solid microneedles, and hollow needles may be used. In this case, the discharge hole 11 is configured to be discharged from the hole of the microneedle. In particular, in medical applications, the use of hollow microneedles is common, but solid microneedles for cosmetic use are not excluded.
One end of the syringe portion 21 may be screw-coupled with the front end portion 23 or a cap, not shown, and the other end may be sealed with a gasket portion 22 to provide the cartridge unit 20 for various liquids. The syringe portion 21 may be made of a transparent member so that the amount of liquid inside can be easily confirmed.
Since the microneedles 10 act on the human body, manufacturers may be limited by licensing regulations and laws and regulations, but such separability of the front end portion 23 facilitates the application of the licensed microneedles 10 to the cartridge unit 20 of the present invention.
In addition, in the practice of the present invention, the microneedle 10 and the syringe portion 21 of the cartridge unit 20 may be integrally formed.
As the liquid contained in the syringe portion 21, cosmetic liquids such as collagen, hyaluronic acid, placenta, hydroquinone, tranexamic acid, and vitamin derivatives can be used. In addition, minoxidil, finasteride, swertia extract, vitamin derivatives, and the like can be used as the liquid for hair growth.
In the present invention, the use of the liquid as a subject is not limited to cosmetic use, medical use, and the like, so that the liquid having various effects can be freely used by changing the cartridge unit 20, which is of great advantage.
It is also preferable to have the structure as follows: the washer portion 22 of the cartridge unit 20 can move only forward and cannot return backward. If the gasket portion 22 is returned, foreign matter may be mixed in the internal liquid or the optimal combination with the microneedle may be destroyed, so that the gasket portion 22 may have a ratchet-like and irreversible action, for example.
The rear end of the washer 22 is in contact with a plunger 37 that slides back and forth in the housing 32, and the plunger 37 is connected to a drive shaft 38 to form a sliding portion.
In the present invention, when the driving device, particularly the linear motor 33 is used, the following control can be performed. That is, the linear motor 33 is controlled by the control circuit 40 provided on the control board 35 to slide forward by a predetermined amount of movement, and extrusion of the gasket portion 23 of the cartridge unit 20 is controlled, whereby optimal liquid discharge can be achieved.
Fig. 6 is an explanatory diagram of the control circuit 40. In the present embodiment, the linear motor 33 and the operation switch 36 are connected to a control board 35 such as an IC having a motor driver, and a home point sensor 44 and a skin sensor 45 are provided.
In the present invention, the linear motor 33 is preferably controlled as follows.
First, the control circuit 40 includes a discharge speed adjusting unit 41 as a first control unit.
In the liquid injection device, when the optimum discharge amount per unit time is determined by the viscosity and the characteristics of the liquid, the discharge speed adjustment section 41 may adjust the discharge speed by adjusting only the operation speed of the linear motor 33.
According to the discharge speed adjusting portion 41, the liquid can be prevented from dripping by decelerating or increasing the momentum by the application portion and the liquid, and necessary and sufficient application can be performed.
Next, the control circuit 40 includes an extrusion amount control unit 42 as a second control unit. By controlling the extrusion amount of the plunger 37, the liquid discharge amount can be accurately adjusted. If the plunger 37 is moved only by an amount equivalent to a distance of several microliters without dropping liquid from the skin, an appropriate amount of liquid is discharged from the discharge hole 11 of the cartridge unit 20.
In order to more accurately detect the movement amount of the drive shaft 38, a home sensor 44 may be provided. The origin sensor 44 is constituted by, for example, a sensor stopper 440 and a sensor 441 attached to the housing 32, and detects the origin position of the drive shaft 38. Then, as shown in fig. 7, a C-shaped light shielding plate 380 is provided at the connection position of the drive shaft 38 and the plunger 37, and the number of times the light shielding plate 380 is shielded by the counter part 46 is counted, whereby the extrusion amount based on the number of revolutions can be detected.
The cartridge unit 20 receives a sliding resistance from the washer section 22 at the time of operation, and the head section 31 matches the movement amount of the drive shaft 38 and the movement amount of the washer section 22 by engagement of the cam 3210 with the cam groove 311 and a sufficient strength against the sliding resistance of the cartridge pressing rubber 310.
Even if the power is turned off, the number of revolutions of the counter portion 46 is stored, and therefore, the extrusion amount control portion 42 can continuously control the extrusion amount since the number of revolutions is added from the stored number of revolutions at the next use.
The method of controlling the extrusion amount is not limited to the above-described configuration, and the position of the gasket portion 22 may be detected by a known position sensor and controlled based on the detected position.
The liquid injection device of the present invention is not a general disposable type, but can reuse the liquid of the cartridge unit 20 several tens times, and therefore, it is important to detect the origin position of the plunger 37 at the start of use and the position after use by the position sensor 44. As a result, the extrusion amount of the predetermined amount from the current position can be controlled again at the next start of use.
Further, the end of use of the cartridge unit 20 may be detected using the counter part 46. When the liquid in the inside becomes empty, even if the linear motor 33 is operated, the washer section 22 hits the front end surface of the syringe section 22 and cannot be further operated, so the detected revolution number of the counter section 46 becomes 0, and error detection 47 is performed. Upon error detection 47, it is detected that the injector portion 22 is empty.
If the injector unit 22 becomes empty, a new one is replaced.
When error detection 47 occurs, linear motor 33 is rotated, causing plunger 37 to retract to the home position and stop, and the user may be prompted to replace the cartridge.
If a position sensor is provided, the remaining amount of liquid may be detected based on the current position of the gasket portion 22, without such erroneous detection.
As shown in the drawings, the linear motor includes a type in which a driving shaft protrudes from one side and a type in which a driving shaft protrudes from the rear to extend a stroke. In the latter case, the shutter 380 may be provided at the rear end position of the drive shaft instead of the connection position between the drive shaft 38 and the plunger 37 as described above. Furthermore, the drive shaft itself may be detected by a sensor.
In the present invention, the cartridge unit may further include a discharge number setting device for setting the number of times the liquid is discharged from the cartridge unit. Conventionally, the injection amount by which the injection is performed twice and the percutaneous absorption amount by which the skin is smeared may be more efficient because the penetration rate of the epidermis is low when the injection is performed once using the microneedle discharge.
Therefore, the control circuit 40 may further include a discharge control unit 43 for performing a plurality of times of discharge. In this case, the linear motor 33 may perform the drive control only a predetermined number of times.
In this configuration, the discharge control unit 43 can also control the discharge time. The discharge time may be arbitrarily set by a user's switch operation, or may be set by the skin sensor 45, and the discharge may be performed based on the input information.
A skin sensor 45 is provided on the head 31. As shown in fig. 3, a terminal 312 of a skin sensor for detecting approaching or contacting the skin is provided, and the terminal 312 is configured to detect approaching or contacting the skin by a known electrostatic sensor by flowing a minute current through the circuit board 36 when the terminal is contacted by a connection shaft 39 provided on the upper surface of the housing 32.
By activating the linear motor 33 in response to contact with the skin or the like, the liquid is continuously discharged from the discharge hole 11 every time the user contacts the skin with the injection device, and even if the injection is performed in a large area, the injection can be completed in a short time.
At this time, the time when the skin sensor 45 leaves the skin is detected, and by using this as a trigger to control the discharge of the liquid, the discharged liquid stays in the head 31 due to the surface tension with the microneedle, and when the microneedle is brought into contact with the skin again, the amount absorbed by the skin is the sum of the amount injected from the needle and the amount left in the head, so that more liquid can be absorbed transdermally. The present structure is particularly suitable when solid microneedles are used.
The above-described structure controls the number of ejections, but the number of injections of the microneedle other than the number of ejections may be changed. In the present embodiment, the microneedles are injected by pressing the body against the skin, but the microneedles may be connected to a vibration motor, and the injection may be performed a predetermined number of times by vibration of the vibration motor. In this case, the control may be performed in combination with the discharge in the discharge control unit 43.
Fig. 8 shows an external appearance of a liquid injection apparatus 1 according to a first embodiment of the present invention. The user can hold the rod-shaped housing 2 and perform operations such as turning on/off of the power supply, mode selection, and discharge by operating the switch 36 or the like.
The housing 2 has a diameter of 3 cm to 5 cm and an overall length of 20 cm to 30 cm, and is of a thickness and length suitable for gripping by the palm of a user's hand to stabilize the support body 30.
As described above, by removing the head 31, the cartridge unit 20 can be easily attached and detached. By the combination of the body and the plurality of cartridges, a system is achieved which can be used to provide multiple efficiencies by replacing the cartridge unit.
By making the plurality of cartridge units different in at least one of the length, arrangement density, and distribution area of the microneedle 10, for example, according to the difference in the parts of the face and scalp, the type of liquid, the difference between cosmetic and medical uses, and the like, various functions can be achieved.
In the case of the structure having the front end portion 23, the cartridge unit may be replaced by replacing the front end portion 23 and used, thereby providing various effects.
Furthermore, the present invention may also provide only cartridge unit 20 monomers.
(Second embodiment)
Next, a second embodiment having a different force generating mechanism will be shown. In this embodiment, the shape of the main body is also different from that of the first embodiment, and the operational effects thereof will be described.
Fig. 9 is an oblique view of a liquid injection device according to a second embodiment of the present invention, and fig. 10 is a sectional view for explaining an internal mechanism thereof.
The liquid injection device 100 of the present embodiment is composed of a cartridge unit 120 and a main body 130. The cartridge unit 120 in this embodiment does not have a syringe portion or a gasket portion, but has a container portion 121 and a needle cap 122 screwed into the container portion as a front end portion, and a protective cap for protecting the microneedle 10 when not in use.
The needle cap 122 has a number of microneedles 10 and three discharge apertures 124 (shown in fig. 12).
In the present embodiment, by applying vibration to the cartridge unit 120, the liquid in the container part 121 is discharged from the discharge hole, and permeates the skin through the microneedle 10.
The main body 130 is composed of a grip 140 to be gripped by a user and an action portion 150 having a mounting portion 151 of the cartridge unit 120 inside, and as shown in the figure, the grip 140 and the action portion 150 each have a curved shape having an angle of 55 degrees in the longitudinal direction.
The housing 141 of the grip 140 is integrally formed with the housing 152 of the action part, and in this embodiment, the vibration part is accommodated in the housing 152 of the action part in the same manner as the mounting part 151. The vibration part is composed of a solenoid 160, a joint 161 connected to the shaft of the solenoid 160, a slider 162 vibrating back and forth through the joint 161, and an outer cylinder holding the vibrating slider 162 at the outer circumference.
The solenoid 160 is fixed to the housing 152 by elastic members 164, 165 so that vibration of the solenoid 160 is not directly transmitted to the housing 152. Thereby, the feeling of use is improved and noise is reduced.
In the present embodiment, as the force generation mechanism, there is provided a vibration portion that vibrates the cartridge unit 120 in the axial direction, that is, in the same direction as the protruding direction of the microneedles. Fig. 11 illustrates this structure in detail. As shown in fig. 11 (a), the solenoid 160 includes a spring 1602 on the outer periphery of the electromagnet 1601, and vibrates in the axial direction by the switching of the electromagnet and the action of the spring. Vibration is transmitted to the slider 162 through the joint 161 connected to the shaft 1603 of the solenoid 160.
The slider 162 is provided with a plurality of slits 1621 in the axial direction and has elasticity in the radial direction, and, as shown in fig. 11 (B), an engagement convex portion 1622 is provided on the inner periphery thereof, and engages with an engagement concave portion 1211 on the outer periphery of the container portion 121.
Therefore, when the cartridge unit 120 is inserted into the mounting portion 151 formed in the slider 162, it can be detachably mounted by the engagement of the engagement protrusion 1622 and the engagement recess 1211.
The bent portions of the grip 140 and the acting portion 150 have operation switches 131 for operation. In addition, the housing 141 of the grip 140 accommodates a battery 142 for supplying power and a control board 143 having a control circuit.
The components respectively accommodated in the grip portion 140 and the action portion 150 are preferable because of the good weight balance of the structure of the present embodiment, but the present invention is not limited thereto.
By controlling and vibrating the solenoid 160 as described above while the needle cap 122 is directed downward, the cosmetic liquid or the like is discharged from the discharge hole 124 by the self weight of the liquid in the container portion 121.
At this time, as the cosmetic liquid permeates to the skin surface by vibration, a tapping effect of tapping the skin gently can be obtained.
However, in order to achieve smooth discharge and optimal application amount, it is necessary to adjust the viscosity of the liquid, the aperture of the discharge hole, the vibration frequency, the stroke, and the like. Accordingly, the structure of the needle cap 122 and the control method of the solenoid 160 will be described in detail below.
Fig. 12 shows an oblique view of the needle cap 122 as a front end portion, and fig. 13 shows the shape of the microneedle.
As shown, the needle cap 122 has a rounded front end abutting the skin surface and is provided with discharge holes 124 at three points on the circumference, and a large number of microneedles 10 are uniformly implanted in the circle.
The diameter of the circular portion is around 12mm, suitably in the range of 5 to 25mm. The pore diameter of the drain hole is preferably in the range of 0.8mm to 1.6mm at a preferable viscosity (200-1000 mPa.S) of the cosmetic liquid. Although one discharge hole may be provided at the center, by providing a plurality of discharge holes, the cosmetic liquid can be appropriately distributed into the microneedles 10 in the circle.
In the present embodiment using the vibration portion as the force generation mechanism, the aperture of the discharge hole needs to be made relatively large as compared with the first embodiment. For this purpose, large-diameter discharge holes are arranged at appropriate intervals, and the centers of the discharge holes are arranged at the respective vertex positions of a virtual regular triangle having a side length of 6.6 mm. When the aperture of the discharge hole is in the above range, the spacing distance is preferably 4mm to 12mm.
In the present invention, another preferred state of the front end portion is shown in fig. 14. In addition to fig. 14 (a) having the discharge holes 124 at three points in the above-described embodiment, fig. 14 (b) has the discharge holes 124' at the vertex positions of the virtual square of the rounded front end, and a large number of microneedles 10 are implanted around it.
Fig. 14 (c) also includes discharge holes 124' at two points opposed to each other on the circumference of the circular tip.
Further, fig. 14 (d) has a discharge hole 124' at one point on the circumference of the circular front end.
In addition, fig. 14 (e) has a discharge hole 124' at the center of the rounded front end.
The diameter of the circular portion in the present invention is preferably in the range of about 5mm to 25mm, particularly in the case of a large diameter of approximately 25mm, as shown in fig. 14 (b), four or more discharge holes are suitable, on the other hand, in the case of a small diameter of approximately 5mm, as shown in fig. 14 (d) and (e), one point is sufficient.
In the present embodiment, it is preferable that the discharge holes of the front end portion are arranged at intervals in the range of 2mm to 20 mm. That is, these are determined according to the size of the distal end portion, and for example, when the diameter of the distal end portion is 5mm, the interval is about 2mm when 4 points are arranged as shown in fig. 14 (b). When the diameter is 25mm, the interval is about 20mm when two points are arranged as shown in fig. 14 (c).
According to the findings of the inventors, it was confirmed that when the discharge hole is vibrated to discharge an appropriate amount of liquid, even if the cap (122) is downward, the liquid does not leak immediately, and the use effect is particularly good.
The microneedle in this example has a substantially rectangular pyramid shape having a planar portion on the upper surface, and as shown in fig. 13, the height (H) is about 200 μm, the bottom side length (L1) is about 100 μm, and the top side length (L2) is about 40 μm. Compared with a general microneedle with a sharp front end, the flat top surface can ensure good penetration effect of the cosmetic liquid and is difficult to feel pain. The ratio of L1 to L2 to H is preferably about 1:2 to 3:5 to 7 in terms of the permeation effect and the strength of the microneedle.
In the first embodiment, various structures are disclosed for adjusting the discharge amount when the liquid is discharged from the cartridge unit 20 by the discharge amount setting means. The same discharge amount setting device may be provided in this embodiment.
Meanwhile, in the present embodiment provided with the vibration portion, the following control is particularly preferable.
Fig. 15 is an explanatory diagram of the control circuit 400. In the present embodiment, the control board 143 including an IC or the like has a notification portion 410 for notifying a user by emitting light, displaying, or sounding, the tilt sensor 411, and the skin sensor 412, in addition to the solenoid 160 and the operation switch 131.
The solenoid 160 is preferably controlled as follows.
First, the control circuit 40 has a vibration frequency control section 401 as a third control section. The vibration frequency control section 401 can adjust the discharge amount by adjusting the on/off and polarity inversion frequency of the current to the solenoid 160. In general, the lower the frequency, the smaller the discharge amount, and the higher the frequency, the larger the discharge amount.
In the present invention, the preferred range of the vibration frequency is 5 to 30Hz, and if it is lower than 5Hz, stable discharge cannot be obtained, and if it is higher than 30Hz, continuous discharge like a general cosmetic liquid is performed, and the discharge amount is too large.
The vibration frequency control section 401 can also change the vibration frequency within an appropriate range by operating the operation switch 131.
As another structure for adjusting the discharge amount, the stroke (amplitude) and the intensity of the pushing of the solenoid 160 may be adjusted by the intensity control unit 402 as the fourth control unit. When the voltage applied to the solenoid 160 increases, the stroke of the solenoid 160 increases within the maximum stroke range, and the pushing force (pushing force) also increases. Therefore, the intensity control section 402 can adjust the stroke and intensity by adjusting the voltage.
For example, the stroke is preferably in the range of 1mm to 3mm, and not only the discharge amount of the cosmetic liquid but also the feeling of touch to the skin surface of the user can be adjusted. If a strong tap feeling is desired, the stroke is set to be large or the thrust is set to be strong, and if it is desired to be applied to a sensitive part such as an eye, the stroke is set to be weak. Preferably, the thrust range is adjustable within a range of 30% to 100% when the thrust range is at most 100%.
In the structure of the present embodiment having the vibration portion, the angle of the needle cap 122 is also important. As described above, if it is oriented downward, the discharge amount becomes excessive due to gravity, and the liquid is not discharged when it is oriented upward with respect to the horizontal. Therefore, the depression angle of the axial direction (protruding direction of the microneedle) with respect to the horizontal is preferably in the range of 0 to 25 degrees.
Since this angle is important for the liquid injection apparatus 100, the following structure is adopted.
That is, the grip portion 140 and the action portion 150 are each bent in the longitudinal direction at an angle of 55 degrees, and the tip portion is formed to be slightly downward when the grip portion 140 is gripped. As an angle which tends to be the depression angle described above, it is preferable to set the angle between the grip portion 140 and the action portion 150 to 50 degrees to 80 degrees.
Further, the liquid injection device 100 may be provided with an inclination angle sensor 411 to obtain the angle of the device. The control circuit 400 includes a tilt linkage control unit 403 as a5 th control unit, and controls the operation of the solenoid 160 when the tilt angle of the tilt angle sensor 411 is good or bad.
For example, the control may be performed only when the inclination angle is good, or may be stopped when the inclination angle is not suitable. Further, if the inclination angle is good, the notification part 410 may emit blue light, and if the inclination angle is not suitable, may emit red light to notify the user of the suitable angle. Further, when the inclination angle is not appropriate, the notification portion 410 may issue a warning sound for notification.
Whether or not the control according to the inclination angle sensor 411 is performed can be switched from the operation switch 131. Depending on the angle of the skin surface to be applied, an action may be desired even if the inclination is not appropriate, and thus the action of the solenoid 160 may be set so as not to stop.
Further, the tilt linkage control unit 403 may set the discharge amount per unit time according to the tilt angle. That is, the discharge amount can be set in the same manner as the discharge amount setting device in the first embodiment, and the discharge amount can be set by instructing the vibration frequency control unit 401 or the intensity control unit 402 to control or adjusting the vibration frequency, stroke, intensity, and the like by the tilt linkage control unit 403.
The working portion 150 has a head 153 at its front end. The head 153 is connected to the housing 152 by a plunger 154. The plunger portion 154 sandwiches an O-ring made of rubber, and even if there is a drop of liquid at the needle cap 122, it is sealed so that the liquid does not flow into the inside of the housing 152 due to vibration.
The head 153 is provided with a skin sensor 412, as in the head 31 of the first embodiment, and the discharge control unit 404 may control the discharge time. That is, by triggering the solenoid 160 by contact with the skin or the like, the liquid can be discharged from the discharge hole 243 every time the user brings the injection device into contact with the skin.
The control time and the like according to the discharge control unit 404 are arbitrary as in embodiment 1.
The head 153 has a skin surface electrode 155 made of a conductive material, and the grip 140 has a hand electrode 144, so that various electric cosmetic effects can be achieved. For example, a weak current may be applied from the skin surface side electrode 155 to the skin surface to function as so-called iontophoresis for improving the permeability of the cosmetic liquid. At this time, by matching with the tapping of the vibrating portion, the penetration effect can be further enhanced.
Further, an electric muscle stimulus called EMS (Electrical Muscle Stimulation) in which a current having a frequency of several Hz to several kHz is applied from the skin surface side electrode and a high frequency of about 1Mhz, for example, of an RF current may be applied.
If a high hardness material such as metal is used as the conductive material of the head 153, pain may be felt when the skin is lightly tapped. Thus, the head 153 may also be made to swing to alleviate the impact.
As shown in fig. 16, the skin-side electrode 155 is configured such that a portion thereof can swing within a range of about + -10 degrees on the head 153, thereby avoiding excessive interference with the skin.
In the present embodiment, a structure using a solenoid is disclosed to realize the vibration portion, but a mechanism for generating vibration is arbitrary. For example, a vibration motor, ultrasonic vibration, a vibration speaker, a pneumatic vibrator, or the like may be used as appropriate.
Further, the shapes of the force generating mechanism and the main body are not necessarily limited to the above combination. In the structure using the vibrating portion, the case may be rod-shaped, and in the structure having the sliding portion, a curved body may be used.
Further, as shown in fig. 17, a body having a substantially T-shape may be used. Also in these embodiments, when the vibrating portion is used, it is preferable that the angle between the acting portion 170 and the holding portion 171 is formed to be 70 degrees, as shown in fig. 17 (a). However, the structure is not limited to the structure using the sliding portion, and in the structure using the vibrating portion or other force generating mechanism, as shown in fig. 17 (B) and (C), any angle such as 90 degrees or 110 degrees may be used.
Description of the reference numerals
1 Liquid injection device
10 Microneedle
11 Discharge holes
20 Cartridge unit
21 Injector part
22 Gasket portion
23 Front end part
30 Body
31 Head part
32 Housing part
33 Motor
34 Cell
35 Control substrate
36 Operation switch
37 Plunger
38 Drive shaft
39 Connecting shaft
40 Control circuit
41 Discharge speed adjusting section
42 Extrusion amount control part
43 Discharge control section
44 Original point sensor
45 Skin sensor
100 Liquid injection device
120 Cartridge unit
121 Container part
122 Needle cap
124 Discharge hole
130 Body
131 Operation switch
140 Grip portion
141 Casing
142 Battery
143 Control substrate
144 Electrode
150 Action part
151 Mounting portion
152 Shell
153 Head
154 Plunger portion
155 Skin surface side electrode
160 Solenoid
161 Joint
162 Slide block
163 Outer cylinder
400 Control circuit
401 Vibration frequency control unit
402 Intensity control unit
403 Inclination linkage control part
404 Discharge control unit
410 Notification unit
411 Inclination angle sensor
412 Skin sensor
Claims (21)
1. A liquid injection device for injecting a liquid into skin through a microneedle, comprising a cartridge unit and a main body,
The cartridge unit includes the microneedle, a discharge hole for discharging the liquid, and a container portion for accommodating the liquid;
The main body is provided with:
a cartridge mounting portion for detachably mounting the cartridge unit,
A force generating mechanism for generating a discharge action of the liquid with respect to the cartridge unit mounted;
the cartridge unit can be replaced and used;
The main body of the liquid injection device is composed of a holding part for holding by a user and an action part at least provided with the cartridge mounting part, and the included angle between the holding part and the action part in the length direction is 50-80 degrees respectively.
2. The liquid injection device of claim 1, wherein the liquid injection device comprises,
In the cartridge unit, the tip portion includes the microneedles and the discharge holes, and the tip portion is attached to the container portion for use.
3. The liquid injection device according to claim 1 or 2, wherein,
The liquid injection device includes a discharge amount setting device for setting a discharge amount when the liquid is discharged from the cartridge unit.
4. A liquid injection apparatus according to claim 3, wherein,
The discharge amount setting means sets the discharge amount per unit time by changing the state of the discharge hole according to the characteristic of the liquid.
5. The liquid injection device according to any one of claims 1-2, wherein,
The container portion of the cartridge unit is provided with at least a syringe portion and a gasket portion for extruding the liquid from the syringe portion to the discharge hole,
The force generating mechanism is configured to include a sliding portion for axially moving the washer portion of the mounted cartridge unit.
6. The liquid injection apparatus according to claim 5, wherein,
The liquid injection device includes a discharge number setting device for setting the number of times of discharging the liquid from the cartridge unit.
7. The liquid injection apparatus according to claim 5, wherein,
The liquid injection device includes a driving device that drives the sliding portion of the liquid injection device in an axial direction.
8. The liquid injection apparatus of claim 7, wherein the liquid injection apparatus comprises,
The discharge amount setting device includes a first control unit that sets a discharge amount per unit time by controlling a driving speed of the driving device.
9. The liquid injection apparatus of claim 7, wherein the liquid injection apparatus comprises,
The discharge amount setting device includes a second control unit that adjusts the amount of extrusion of the washer portion according to the driving device.
10. The liquid injection device according to claim 7, wherein,
The driving device is a motor provided with a driving shaft for axially driving the sliding part.
11. The liquid injection device according to claim 5, wherein,
The liquid injection device includes an operation unit for manually operating the sliding unit.
12. The liquid injection device according to any one of claims 1-2, wherein,
The force generating mechanism is configured to include a vibration portion that vibrates the cartridge unit in an axial direction.
13. The liquid injection device of claim 12, wherein the liquid injection device comprises,
The device is provided with a third control unit that sets the vibration frequency of the vibration unit in the force generation mechanism.
14. The liquid injection device according to any one of claims 1-2, wherein,
The liquid injection device includes a fourth control unit that controls the force applied from the force generating mechanism to the cartridge unit.
15. The liquid injection device according to any one of claims 1-2, wherein,
The liquid injection device includes a fifth control unit that detects an inclination angle of the main body and controls to be activatable or notified to a user when the inclination angle is within a predetermined angle range.
16. The liquid injection device of claim 15 wherein the liquid injection device comprises,
The fifth control section sets the discharge amount per unit time based on the detected inclination angle of the main body.
17. The liquid injection device according to any one of claims 1 to 2, comprising:
a skin sensor for detecting the proximity or contact of the microneedle with the skin,
And a sixth control unit for controlling the force generation mechanism based on the detection result.
18. The liquid injection device of claim 12, wherein the liquid injection device comprises,
In the cartridge unit, there are a plurality of the discharge holes, the discharge holes being arranged at intervals ranging from 2mm to 20 mm.
19. A system employing the liquid injection device according to any one of claims 1 to 18, characterized in that,
Is composed of a plurality of cartridge units respectively containing more than two liquids with different effects and a main body,
Multiple functions are provided by replacing and using the cartridge unit.
20. A system employing the liquid injection device according to any one of claims 1 to 18, characterized in that,
Comprises a plurality of cartridge units each having microneedles differing in at least one of length, arrangement density, and distribution area, and a main body,
Multiple functions are provided by replacing and using the cartridge unit.
21. The system of claim 19 or 20, wherein the system comprises a plurality of sensors,
In the system, the tip portion is provided with the microneedle and the discharge hole, and in a structure in which the tip portion is attached to the container portion, instead of replacing the cartridge unit, a plurality of effects are provided by replacing the tip portion and using it.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-114884 | 2020-07-02 | ||
| JP2020114884 | 2020-07-02 | ||
| PCT/JP2021/025124 WO2022004876A1 (en) | 2020-07-02 | 2021-07-02 | Liquid injection device, and system and cartridge unit therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115397502A CN115397502A (en) | 2022-11-25 |
| CN115397502B true CN115397502B (en) | 2024-10-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180028185.5A Active CN115397502B (en) | 2020-07-02 | 2021-07-02 | Liquid injection device, system and cartridge unit thereof |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPWO2022004876A1 (en) |
| CN (1) | CN115397502B (en) |
| WO (1) | WO2022004876A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1571685A (en) * | 2001-09-12 | 2005-01-26 | 贝克顿迪肯森公司 | Microneedle-based pen device for drug delivery and method for using same |
| KR20160007337A (en) * | 2014-07-11 | 2016-01-20 | 주식회사 현대메디텍 | Sylinge connecting type autometic drug injection apparatus |
| KR20200019399A (en) * | 2018-08-14 | 2020-02-24 | 주식회사 브리텍 | Skin Beauty Applicator in use with Micro Needle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156245A0 (en) * | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
| DK2699293T3 (en) * | 2011-04-20 | 2019-04-29 | Amgen Inc | AUTO INJECTION DEVICE |
| DE202012008911U1 (en) * | 2012-09-15 | 2012-10-16 | Alexandre Raznatovski | Portable Handdosiergerät for the delivery of predetermined Dosiermenge the flowable medium of a conventional plastic syringe or a cartridge |
| JP2015217176A (en) * | 2014-05-19 | 2015-12-07 | 株式会社根本杏林堂 | Chemical feeder |
| EP3185934B1 (en) * | 2014-08-28 | 2018-06-20 | UNL Holdings LLC | Skin sensors for drug delivery devices |
| EP3284492A4 (en) * | 2015-04-16 | 2019-01-16 | Nemoto Kyorindo Co., Ltd. | Liquid medicine injection device, method for controlling liquid medicine injection device, and computer program |
| CN206896423U (en) * | 2016-11-07 | 2018-01-19 | 奥美康康健制品有限公司 | single dose syringe |
-
2021
- 2021-07-02 CN CN202180028185.5A patent/CN115397502B/en active Active
- 2021-07-02 WO PCT/JP2021/025124 patent/WO2022004876A1/en active Application Filing
- 2021-07-02 JP JP2022534125A patent/JPWO2022004876A1/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1571685A (en) * | 2001-09-12 | 2005-01-26 | 贝克顿迪肯森公司 | Microneedle-based pen device for drug delivery and method for using same |
| KR20160007337A (en) * | 2014-07-11 | 2016-01-20 | 주식회사 현대메디텍 | Sylinge connecting type autometic drug injection apparatus |
| KR20200019399A (en) * | 2018-08-14 | 2020-02-24 | 주식회사 브리텍 | Skin Beauty Applicator in use with Micro Needle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115397502A (en) | 2022-11-25 |
| JPWO2022004876A1 (en) | 2022-01-06 |
| WO2022004876A1 (en) | 2022-01-06 |
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