CN114145452B - 特殊医学用途全营养配方食品 - Google Patents
特殊医学用途全营养配方食品 Download PDFInfo
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- CN114145452B CN114145452B CN202111508872.5A CN202111508872A CN114145452B CN 114145452 B CN114145452 B CN 114145452B CN 202111508872 A CN202111508872 A CN 202111508872A CN 114145452 B CN114145452 B CN 114145452B
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- Prior art keywords
- sodium
- compound
- powder
- maltodextrin
- whey protein
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- 235000013305 food Nutrition 0.000 title claims abstract description 18
- 229940088594 vitamin Drugs 0.000 claims abstract description 26
- 229930003231 vitamin Natural products 0.000 claims abstract description 26
- 235000013343 vitamin Nutrition 0.000 claims abstract description 26
- 239000011782 vitamin Substances 0.000 claims abstract description 26
- 239000000843 powder Substances 0.000 claims abstract description 25
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 14
- 235000010755 mineral Nutrition 0.000 claims abstract description 14
- 239000011707 mineral Substances 0.000 claims abstract description 14
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 12
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 12
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 12
- -1 compound vitamin Chemical class 0.000 claims abstract description 12
- 150000001875 compounds Chemical class 0.000 claims abstract description 12
- 239000007787 solid Substances 0.000 claims abstract description 12
- 235000019698 starch Nutrition 0.000 claims abstract description 12
- 239000008107 starch Substances 0.000 claims abstract description 12
- 235000021119 whey protein Nutrition 0.000 claims abstract description 12
- 235000019871 vegetable fat Nutrition 0.000 claims abstract description 11
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 8
- 229920001525 carrageenan Polymers 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000000679 carrageenan Substances 0.000 claims abstract description 7
- 229940113118 carrageenan Drugs 0.000 claims abstract description 7
- 238000005469 granulation Methods 0.000 claims abstract description 7
- 230000003179 granulation Effects 0.000 claims abstract description 7
- 239000007921 spray Substances 0.000 claims abstract description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000011575 calcium Substances 0.000 claims abstract description 6
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 6
- 239000001103 potassium chloride Substances 0.000 claims abstract description 6
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 6
- 239000001508 potassium citrate Substances 0.000 claims abstract description 6
- 229960002635 potassium citrate Drugs 0.000 claims abstract description 6
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims abstract description 6
- 235000011082 potassium citrates Nutrition 0.000 claims abstract description 6
- 239000011780 sodium chloride Substances 0.000 claims abstract description 6
- 239000001509 sodium citrate Substances 0.000 claims abstract description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 10
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 10
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 7
- 229960005055 sodium ascorbate Drugs 0.000 claims description 7
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 6
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 150000003904 phospholipids Chemical class 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000011732 tocopherol Substances 0.000 claims description 6
- 229960001295 tocopherol Drugs 0.000 claims description 6
- 235000010384 tocopherol Nutrition 0.000 claims description 6
- 229930003799 tocopherol Natural products 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 5
- 239000011665 D-biotin Substances 0.000 claims description 5
- 235000000638 D-biotin Nutrition 0.000 claims description 5
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 5
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 5
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
- 229960002104 cyanocobalamin Drugs 0.000 claims description 5
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 5
- 239000011666 cyanocobalamin Substances 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 5
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 5
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 5
- 229960000342 retinol acetate Drugs 0.000 claims description 5
- 235000019173 retinyl acetate Nutrition 0.000 claims description 5
- 239000011770 retinyl acetate Substances 0.000 claims description 5
- 229960002477 riboflavin Drugs 0.000 claims description 5
- 235000019192 riboflavin Nutrition 0.000 claims description 5
- 239000002151 riboflavin Substances 0.000 claims description 5
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 5
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 5
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 5
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 5
- 235000005282 vitamin D3 Nutrition 0.000 claims description 5
- 239000011647 vitamin D3 Substances 0.000 claims description 5
- 229940021056 vitamin d3 Drugs 0.000 claims description 5
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 4
- 239000011755 sodium-L-ascorbate Substances 0.000 claims description 4
- 235000019187 sodium-L-ascorbate Nutrition 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 3
- 229960000355 copper sulfate Drugs 0.000 claims description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 3
- 229960001781 ferrous sulfate Drugs 0.000 claims description 3
- 239000011790 ferrous sulphate Substances 0.000 claims description 3
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
- 229960003390 magnesium sulfate Drugs 0.000 claims description 3
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 3
- 229940099596 manganese sulfate Drugs 0.000 claims description 3
- 239000011702 manganese sulphate Substances 0.000 claims description 3
- 235000007079 manganese sulphate Nutrition 0.000 claims description 3
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 3
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 3
- 239000001230 potassium iodate Substances 0.000 claims description 3
- 235000006666 potassium iodate Nutrition 0.000 claims description 3
- 229940093930 potassium iodate Drugs 0.000 claims description 3
- 239000011781 sodium selenite Substances 0.000 claims description 3
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- 238000003756 stirring Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- 229940117373 dl-alpha tocopheryl acetate Drugs 0.000 claims description 2
- 235000012711 vitamin K3 Nutrition 0.000 claims description 2
- 239000011652 vitamin K3 Substances 0.000 claims description 2
- 229940041603 vitamin k 3 Drugs 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 10
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 3
- 235000019175 phylloquinone Nutrition 0.000 description 3
- 239000011772 phylloquinone Substances 0.000 description 3
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 3
- 229960001898 phytomenadione Drugs 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本申请提供了一种性质均一、稳定的特殊医学用途全营养配方食品，其中包含植物脂肪粉、固体淀粉糖、分离乳清蛋白粉、柠檬酸钾、柠檬酸钠、复配矿物质、磷酸氢钙、氯化钾、复配维生素、氯化钠等成分。本申请的特殊医学用途全营养配方食品中复配维生素使用喷雾制粒方法，以麦芽糊精和卡拉胶作为赋形剂制备；该制备方法有效提高了产品的均一性。
Description
发明领域：
本申请属于食品领域，具体地，本申请提供了一种性质均一、稳定的特殊医学用途全营养配方食品。
背景技术：
老人、术后病人、肿瘤患者以及某些慢性病患者经常受到进食困难，消化吸收障碍或者代谢紊乱问题的困扰，造成营养状况不佳，进而影响身体状态和疾病治疗。
针对这类人群对于膳食和营养的特殊要求，临床上经常推荐其食用特殊医学用途全营养配方食品。特殊医学用途全营养配方食品中蛋白、脂肪、糖类、维生素和矿物质种类全面配比科学，可以有效补充此类人群的营养缺陷，甚至可以此类人群的单一营养源。
特殊医学用途全营养配方食品中成分多达仅百种，各种成分含量和颗粒尺寸差异巨大(经过有数个数量级的差异)，而且还存在大量的吸附、包裹等情况。如何将这些成分，特别是含量少而作用显著的维生素成分，快速、充分混合为均一而稳定的产品，是特殊医学用途全营养配方食品制备、质量控制中的难题之一。目前采用的预混料、超微粉碎、喷雾制粒等方法均有改进的空间。
发明内容
针对以上问题，申请人改进了预混维生素混合方法和复配矿物质处理方法，有效提高了维生素和矿物质的混合均匀度。
一方面，本申请提供了一种特殊医学用途全营养配方食品，其包含植物脂肪粉、固体淀粉糖、分离乳清蛋白粉、柠檬酸钾、柠檬酸钠、复配矿物质、磷酸氢钙、氯化钾、复配维生素、氯化钠；所述植物脂肪粉包括麦芽糊精、植物油、固体淀粉糖、分离乳清蛋白粉、单，双甘油脂肪酸酯、L-抗坏血酸钠、抗坏血酸棕榈酸酯、生育酚、磷脂。
进一步地，所述特殊医学用途全营养配方食品包含包含植物脂肪粉40-70％、固体淀粉糖10-20％、分离乳清蛋白粉5-10％、柠檬酸钾4-12％、柠檬酸钠2-8％、复配矿物质0.2-3％、磷酸氢钙0.5-3％、氯化钾0.2-2％、复配维生素0.2-1％、氯化钠0.1-1％；
优选地，植物脂肪粉59％、固体淀粉糖14.4％、分离乳清蛋白粉10％、柠檬酸钾7％、柠檬酸钠5％、复配矿物质1.5％、磷酸氢钙1.2％、氯化钾0.8％、复配维生素0.6％、氯化钠0.5％。
所述植物脂肪粉包括麦芽糊精35-50％、植物油15-35％、固体淀粉糖10-25％、分离乳清蛋白粉10-20％、单，双甘油脂肪酸酯0.1-1％、L-抗坏血酸钠0.1-2％、抗坏血酸棕榈酸酯0.01-0.1％、生育酚0.01-0.1％、磷脂0.005-0.03％；
优选地，麦芽糊精41.7％、植物油24％、固体淀粉糖17.4％、分离乳清蛋白粉15.8％、单，双甘油脂肪酸酯0.69％、L-抗坏血酸钠0.332％、抗坏血酸棕榈酸酯0.03％、生育酚0.03％、磷脂0.018％。
进一步地，所述复配维生素包含麦芽糊精70-90％、卡拉胶1-8％以及醋酸视黄酯0.05-0.2％、胆钙化醇0.0005-0.002％、dl-α-醋酸生育酚2-2.5％、植物甲萘醌0.01-0.03％、盐酸硫胺素0.1-0.4％、核黄素0.1-0.3％、盐酸吡哆醇0.1-0.3％、氰钴胺0.0001-0.001％、烟酰胺1-3％、叶酸0.01-0.05％、D-泛酸钙0.1-0.8％、L-抗坏血酸钠2-6％、D-生物素0.001-0.007％；
优选地，麦芽糊精85％、卡拉胶5％以及醋酸视黄酯0.1054％、胆钙化醇0.0011％、dl-α-醋酸生育酚2.2333％、植物甲萘醌0.0167％、盐酸硫胺素0.2％、核黄素0.1667％、盐酸吡哆醇0.2％、氰钴胺0.0005％、烟酰胺2％、叶酸0.0333％、D-泛酸钙0.6333％、L-抗坏血酸钠4.4047％、D-生物素0.005％。
进一步地，所述复配维生素的制备过程包括喷雾制粒步骤。
进一步地，所述喷雾制粒步骤为：将原料溶于2倍质量的50摄氏度水中，搅拌均匀；进料温度40摄氏度，进风口温度120摄氏度，泵速25％；喷雾干燥制备粉体。
进一步地，所述复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
具体实施方式
实施例1主要试剂和实验方法
麦芽糊精：常规国产原料，符合食品用相关标准；
卡拉胶：河南中辰生物科技有限公司。
包括维生素、矿物质在内其他原料为常规国产或进口食品级原料。
混合均匀度检测方法：
对同一批次产品，进行10次取样，检测其中的目标成分含量；计算平均值X和标准差S，通过公式CV＝S/X×100％来计算变异系数CV；每批次产品计算3次CV，取CV的平均值。
喷雾制粒：
使用浙江钱江伟岸干燥设备有限公司的PGL-B喷雾干燥制粒机；将原料溶于2倍质量的50摄氏度水中，搅拌均匀；进料温度40摄氏度，进风口温度120摄氏度，泵速25％；喷雾干燥制备粉体。
实施例2复配维生素的制备
申请人验证了大量赋形剂种类和组合(以下仅展示部分代表性配方)，发现适量使用卡拉胶可有有效提高维生素，特别是脂溶性维生素的分散效果。
以下复配维生素配方中的维生素相同，包含：醋酸视黄酯0.1054％、胆钙化醇0.0011％、dl-α-醋酸生育酚2.2333％、植物甲萘醌0.0167％、盐酸硫胺素0.2％、核黄素0.1667％、盐酸吡哆醇0.2％、氰钴胺0.0005％、烟酰胺2％、叶酸0.0333％、D-泛酸钙0.6333％、L-抗坏血酸钠4.4047％、D-生物素0.005％；约90％的赋形剂有区别。
不同赋形剂配方下各种维生素的CV的平均CV％值
结果表明，适当的增稠赋形剂可以有效的提高维生素，特别是脂溶性维生素A、E的分散效果；可能是由于溶液中胶体状态的变化非常敏感，改变增稠赋形剂的种类或者用量时，分散效果很容易发生变化。
实施例3特殊医学用途全营养配方食品实际制备
制备过程中复配维生素使用实施例2中优化的制备方法(85％麦芽糊精+5％卡拉胶赋形剂)制备。
按照以下配方配制特殊医学用途全营养配方食品：
植物脂肪粉59％、固体淀粉糖14.4％、分离乳清蛋白粉10％、柠檬酸钾7％、柠檬酸钠5％、复配矿物质1.5％、磷酸氢钙1.2％、氯化钾0.8％、复配维生素0.6％、氯化钠0.5％。
植物脂肪粉包括麦芽糊精41.7％、植物油24％、固体淀粉糖17.4％、分离乳清蛋白粉15.8％、单，双甘油脂肪酸酯0.69％、L-抗坏血酸钠0.332％、抗坏血酸棕榈酸酯0.03％、生育酚0.03％、磷脂0.018％。
所述复配维生素包含麦芽糊精70-90％、卡拉胶1-8％以及醋酸视黄酯0.05-0.2％、胆钙化醇0.0005-0.002％、dl-α-醋酸生育酚2-2.5％、植物甲萘醌0.01-0.03％、盐酸硫胺素0.1-0.4％、核黄素0.1-0.3％、盐酸吡哆醇0.1-0.3％、氰钴胺0.0001-0.001％、烟酰胺1-3％、叶酸0.01-0.05％、D-泛酸钙0.1-0.8％、L-抗坏血酸钠2-6％、D-生物素0.001-0.007％。复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
经检验，产品中矿物质和维生素分布均一，产品性质符合要求：
Claims (3)
1.一种特殊医学用途全营养配方食品，其特征在于，所述食品包括植物脂肪粉59％、固体淀粉糖14.4％、分离乳清蛋白粉10％、柠檬酸钾7％、柠檬酸钠5％、复配矿物质1.5％、磷酸氢钙1.2％、氯化钾0.8％、复配维生素0.6％、氯化钠0.5％；
所述植物脂肪粉包括麦芽糊精35-50％、植物油15-35％、固体淀粉糖10-25％、分离乳清蛋白粉10-20％、单，双甘油脂肪酸酯0.1-1％、L-抗坏血酸钠0.1-2％、抗坏血酸棕榈酸酯0.01-0.1％、生育酚0.01-0.1％、磷脂0.005-0.03％；
所述复配维生素包含麦芽糊精85％、卡拉胶5％以及醋酸视黄酯0.1054％、胆钙化醇0.0011％、dl-α-醋酸生育酚2.2333％、植物甲萘醌0.0167％、盐酸硫胺素0.2％、核黄素0.1667％、盐酸吡哆醇0.2％、氰钴胺0.0005％、烟酰胺2％、叶酸0.0333％、D-泛酸钙0.6333％、L-抗坏血酸钠4.4047％、D-生物素0.005％；
所述复配维生素的制备过程包括喷雾制粒步骤；所述喷雾制粒步骤为：将原料溶于2倍质量的50摄氏度水中，搅拌均匀；进料温度40摄氏度，进风口温度120摄氏度，泵速25％；喷雾干燥制备粉体。
2.根据权利要求1所述的食品，其中所述植物脂肪粉包括麦芽糊精41.7％、植物油24％、固体淀粉糖17.4％、分离乳清蛋白粉15.8％、单，双甘油脂肪酸酯0.69％、L-抗坏血酸钠0.332％、抗坏血酸棕榈酸酯0.03％、生育酚0.03％、磷脂0.018％。
3.根据权利要求1所述的食品，其中所述复配矿物质包括硫酸铜、硫酸镁、硫酸亚铁、硫酸锌、硫酸锰、碘酸钾、亚硒酸钠。
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