CN103705973B - Photic can be hyperchromic yellow ocular lens device and preparation method thereof - Google Patents
Photic can be hyperchromic yellow ocular lens device and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical instruments field, be specifically related to a kind of photic can be hyperchromic yellow ocular lens device, its optical body is made up of the polyacrylate polymers being cross-linked, and the polymerization single polymerization monomer of this polymer comprises: (a) at least one acrylate or methacrylate monomer; (b) have without or more than one styrene derivative monomer; (c) at least one cross-linking agent; (d) at least one ultraviolet absorber; (e) at least one blue-light absorbers; The photic toner of (f) at least one.Present invention also offers a kind of photic can be hyperchromic the preparation method of ocular lens device, the method comprises the steps: that a provides not containing the intraocular lens of photic toner; B. the finished product intraocular lens deriving from step a is immersed in the photic toner solution of heat, to make photic hyperchromic molecule infiltrate whole described polymer network; And the intraocular lens through dipping prepared by c. drying steps b is except desolventizing.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of photic can be hyperchromic yellow ocular lens device and preparation method thereof.
Background technology
Ocular lens device, have another name called intraocular lens, be widely used in the intraocular lens that the ophthalmic cataract geode replacing cataract patient removes rear implantation, about 20,000,000 people are worldwide had to carry out cataract implant surgery every year, wherein, the U.S.'s about 3,000,000 routine cataract implant surgeries every year.India about has 6,500,000 people to do cataract transplant operation every year.China also has now does cataract transplant operation more than 1,000,000 people, and this numeral is with in the annual speed of about 20 five to three ten percent increase, and after estimating 5-10, the annual cataract transplant operation of China will more than 7,000,000 person-times.Ultraviolet is very large to humans and animals eye injury, and therefore people, when preparing ocular lens device, can add ultraviolet absorber, usually to absorb major part or whole ultraviolet usually.We know, ultraviolet wave band is 200 to 400nm, and the light-wave band of shortwave blue light is 400-470nm, and shortwave blue light has very large injury to human and animal's class eyes equally, and just this injury is for ultraviolet, slightly smaller.Therefore, from 2000, ophthalmology worker starts to consider that shortwave blue light is to the amphiblestroid injury of ophthalmic, and AlconLaboratoriesInc. has pushed the ACRYSOFNatural crystalline lens of buff to world intraocular lens market after 2003, and obtains the extensive accreditation of ophthalmology worker.Then AMO is also proposed its crystalline lens.This crystalline lens is by the large portion of 400 to 410nm blue light short-wave band or all absorb, and stops its shortwave blue light to arrive the amphiblestroid probability of its ophthalmic like this, reduces the degeneration of ophthalmic retinal pigment epithelium, and causes making its maculopathy relevant to the age.
Summary of the invention
The object of this invention is to provide a kind of photic can be hyperchromic yellow ocular lens device, under the outdoor strong sunlight environment of this intraocular lens, hyperchromic to buff, effectively reduce its daylight to injury amphiblestroid in human eye; Once get back to its indoor weak light environment, its lens devices is light yellow by being automatically adjusted to, and does not affect the driveability of people, also effectively can sponge some blue light simultaneously, reduce its blue light to the amphiblestroid impact of ophthalmic.
For achieving the above object, the invention provides a kind of photic can be hyperchromic yellow ocular lens device, its optical body is made up of the polyacrylate polymers being cross-linked, and the polymerization single polymerization monomer of this polymer comprises:
(a), at least one acrylate or methacrylate monomer;
(b), have or without or more than one styrene derivative monomer;
(c), at least one cross-linking agent;
(d), at least one ultraviolet absorber;
(e), at least one blue-light absorbers;
The photic toner of (f), at least one;
The glass transition temperature of described ocular lens device is room temperature or lower, and the transmitance of hyperchromic front shortwave blue light when 400-470nm be not higher than 85%, and at the visible ray of more than 550nm, the transmitance of light is higher than 90%; After hyperchromic, when 400-470nm wave band, transmitance must not be greater than 90% higher than its transmitance of light wave of 65%, more than 550nm.
Preferably, described acrylate or methacrylate monomer are:
(1) alkyl acrylate, alkyl methacrylate, wherein alkyl is C
1-the straight or branched alkyl of 8; Or
(2) phenylethyl Arrcostab or methacrylic acid phenylalkyl ester, described phenylalkyl is Ph (CH
2)
n-, n=1-8; Or
(3) acrylic acid phenoxyalkyl ester or methacrylic acid phenoxyalkyl ester, described phenoxyalkyl is PhO (CH
2)
n-, n=1-8; Or
(4) acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl.
The concept of acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate is known, can see the associated description of description in CN102471225A, and its concrete representation example is 3-acryloxy-2-HPMA, also referred to as GAMA.
Preferably, described styrene derivative monomer is selected from styrene, 4-methyl styrene, 3-methyl styrene, 3,4-dimethyl styrene, 3-alkoxystyrene, 4-alkoxystyrene, one or more in the styrene that 3,4-dialkoxy styrene and 4-dimethylamino replace.
Preferably, described cross-linking agent is selected from ethylene glycol diacrylate, Ethylene glycol dimethacrylate, diacrylate propylene glycol ester, dimethyl allene acid propylene glycol ester, butanediol diacrylate, tetramethylene dimethacrylate, 1,4-divinylbenzene and 2-methyl isophthalic acid, one or more in 4-divinylbenzene.
Preferably, described photic toner is photicly strengthen the dye composition absorbing blue ray intensity, is selected from diarylethene, spiro-pyrans class, naphthopyrans class, azobenzene He one or more in spirooxazine compounds.The example of spiro-pyrans comprises 1 ', 3 '-dihydro-1 ', 3 ', 3 '-trimethyl-6-nitro spiral shell [2H-1-.alpha.-5:6-benzopyran-2,2 '-(2H)-indole] example of Luo oxazine comprises 1,3-dihydro-1,3,3-trimethyl-spiral shell [2H-indole-2,3 '-[3H] luxuriant and rich with fragrance [9,10-b] (Isosorbide-5-Nitrae) oxazine].
Preferably, described blue-light absorbers is polymerizable azo-compound, and the azo-compound said here is the substituted-phenyl azobenzene compound (I) that can absorb blue ray: 1-aryl-3-alkyl-4-vinyl benzene azo group-5-hydroxypyrazoles.The polymerizable functional group of substituted-phenyl azobenzene compound (I) is acryloyl group, methacryl group, acrylamide group, methacrylamide group, Ethenylbenzene group, propylene phenyl group or methyl vinyl phenyl group.
Preferably, described ultraviolet absorber is polymerizable type benzotriazole compound or polymerizable type Benzophenones compound, also can be the kind described in patent CN200580016948.5.
preferably, of the present invention photic can be hyperchromic yellow ocular lens device, be intraocular lens, or implantable glasses for the myopia intraocular lens.
Preferably, the consumption of described ultraviolet absorber is the 0.1-5.0% of described optical body quality.
Present invention also offers a kind of photic can be hyperchromic
yellowthe preparation method of ocular lens device, the method comprises the following step:
A. various monomer, cross-linking agent, ultraviolet absorber, blue-light absorbers and radical initiator are made uniform mixed liquor;
B. remove the air in mixed liquor, under an inert atmosphere, mixed liquor is transferred in preprepared lamellar mould; In a heated condition, be made into 5.0-11.0 inch long, 5.0-11.0 inch is wide, thick
degreefor the flaky material of 1.5-3.0 millimeters thick;
C. described flaky material is cut into circular coarse-grain sheet;
D. the extractable matter in extraction removing coarse-grain sheet, the then dry coarse-grain sheet extracted;
E. machine cuts is prepared into the butterfly-shaped wafer with optical surface;
F. after polishing, butterfly-shaped wafer engraving is prepared into various types of yellow ocular lens device.
Present invention also offers
a kind of photic can be hyperchromic the preparation method of yellow ocular lens device, the method comprises the steps:
A. provide not containing the yellow intraocular lens of photochromic agent;
B. yellow for the finished product deriving from step a intraocular lens is immersed in the photochromic agent solution of heat, thus makes described yellow intraocular lens slightly swelling, infiltrate in whole described polymer network to make photochromic molecules; And
C. the yellow intraocular lens through dipping prepared of drying steps b, thus removes all solvents.
Beneficial effect of the present invention is as follows:
The invention provides a kind of photic can be hyperchromic yellow ocular lens device, this yellow ocular lens device is when the low light level or indoor environment, its lens devices is light yellow, and do not affect the driveability of people, also effectively can sponge some blue light simultaneously, reduce its blue light to the amphiblestroid impact of ophthalmic; Then automatically hyperchromic to buff under strong light environment, effectively reduce its high light to injury amphiblestroid in human eye.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: not containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into ultraviolet absorber the 2-(2 '-hydroxyl-3 of 0.015mol ', 5 '-two tertiary phenyl)-5-chlorination benzotriazole, the azodiisobutyronitrile of 0.18mol, 1-phenyl-3-methyl-4-vinyl benzene azo group-5-the hydroxypyrazoles of 0.0007mol, 2.16mol 4-ethoxystyrene, the octadecyl methacrylate of 2.5mol, the acrylic acid 2-phenylethylester of 8.0mol, the diacrylate ethylene glycol diester of 0.65mol, and the Hydroxypropyl methacrylate of 0.27mol.Along with stirring, after the air in removing solution, transfer under a nitrogen in mould.Then at 120 DEG C, make block roughage, be then cut into the circular coarse-grain sheet of size required for us.With the circular coarse-grain sheet of methanol extraction at least 48 hours, then 85 DEG C of dryings except desolventizing, make the good coarse-grain sheet material of extraction.25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 393nm, 450nm when having 10% transmitance is greater than 70%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
Embodiment 2: not containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber ESCALOL 567 of 0.02mol, the azodiisobutyronitrile of 0.013mol, 1-phenyl-3-ethyl-4-vinyl benzene azo group-5-the hydroxypyrazoles of 0.0015mol, the 4-ethoxystyrene of 1.85mol, the lauryl methacrylate of 2.1mol, the acrylic acid 2-phenylethylester of 8.6mol, the diacrylate propylene glycol ester of 0.46mol.Along with stirring, after removing air, forward under a nitrogen in mould and make block roughage at 50 DEG C, then cut into the circular coarse-grain sheet of our required size.Circular coarse-grain sheet at least 48 hours are extracted with methanol or ethanol kind solvent, then dry except desolventizing at suitable temperature DEG C, make the good coarse-grain sheet material of extraction.25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.550,0.8mm when being 395nm, 450nm when having 10% transmitance is greater than 65%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
Embodiment 3: not containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber Octabenzone of 0.01mol, the azodiisobutyronitrile of 0.020mol, the 1-(4-aminomethyl phenyl of 0.0003mol)-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles, the 4-ethoxystyrene of 1.45mol, the octadecyl acrylate of 2.0mol, the acrylic acid 2-phenoxyethyl acrylate of 7.5mol, the tetramethylene dimethacrylate of 0.60mol.Along with stirring, after removing air, forward under a nitrogen in mould and at high temperature make block roughage, then cut into the circular coarse-grain sheet of my required size.With the circular coarse-grain sheet of alcohol extraction at least 48 hours, then dry except desolventizing at 30 DEG C, make the good coarse-grain sheet material of extraction.25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 390nm, 450nm when having 10% transmitance is greater than 75%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
Example 4: photic can hyperchromic light yellow lenticular preparation
In a wide mouthed bottle, in the aphthopyrans adding appropriate amount and appropriate methanol, stir until azo-compound blue light toner is all dissolved in methanol, the good coarse-grain sheet material putting into appropriate extraction carries out permeating more than at least 72 hours in solution, and then drying is prepared into photic light yellow coarse crystalline body that can be hyperchromic.
Before the lens material that embodiment 1 obtains is hyperchromic, 25 DEG C time, index of refraction is 1.545, coarse-grain sheet transmitance when 402nm of thick DEG C of 0.8mm is 10%, transmitance when transmitance when transmitance during 450nm is greater than 45%, 500nm is greater than 88%, 550nm is greater than 95%, after hyperchromic, 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.545,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm be greater than 30%, transmitance when transmitance during 500nm is greater than 80%, 550nm is greater than 95%.
Before the lens material that embodiment 2 obtains is hyperchromic 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.545,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm transmitance when being greater than 40%, 500nm transmitance when being greater than 75%, 550nm be greater than 95%.After hyperchromic, 25 DEG C time, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick DEG C of 1.545,0.8mm transmitance when transmitance is 10%, 450nm when 402nm when being greater than 25%, 500nm when being greater than 65%, 550nm is greater than 95%.
Before the lens material that embodiment 3 obtains is hyperchromic 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.545,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm transmitance when being greater than 50%, 500nm transmitance when being greater than 90%, 550nm be greater than 95%.After hyperchromic, 25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 402nm, 450nm when having 10% transmitance is greater than 40%, 500nm is greater than 85%, 550nm is greater than 95%.
Embodiment 5: containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into ultraviolet absorber the 2-(2 '-hydroxyl-3 of 0.015mol ', 5 '-two tertiary phenyl)-5-chlorination benzotriazole, the azodiisobutyronitrile of 0.017mol, 1-phenyl-3-methyl-4-vinyl benzene azo group-5-the hydroxypyrazoles of 0.0007mol, the polymerisable aphthopyrans of 0.0025mol, the 4-ethoxystyrene of 2.16mol, the octadecyl methacrylate of 2.5mol, the acrylic acid 2-phenylethylester of 8.0mol, the diacrylate ethylene glycol diester of 0.65mol, and the Hydroxypropyl methacrylate of 0.27mol.Along with stirring, after removing air, forward under a nitrogen in mould and at high temperature make block roughage, then chromium plating becomes the circular coarse-grain sheet of my required size.Circular coarse-grain sheet at least 48 hours are extracted with alcohols solvent, then dry except desolventizing at 65 DEG C, make the good coarse-grain sheet material of extraction.Before hyperchromic, 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.545,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm transmitance when being greater than 45%, 500nm transmitance when being greater than 88%, 550nm be greater than 95%; After hyperchromic, 25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 405nm, 450nm when having 10% transmitance is greater than 30%, 500nm is greater than 80%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
Example 6: containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber ESCALOL 567 of 0.01mol, the azodiisobutyronitrile of 0.013mol, 1-phenyl-3-ethyl-4-vinyl benzene azo group-5-the hydroxypyrazoles of 0.0015mol, the polymerisable methacrylic acid aphthopyrans ester of 0.004mol, the 4-ethoxystyrene of 1.85mol, the lauryl methacrylate of 2.1mol, the acrylic acid 2-phenylethylester of 8.6mol, the dimethyl allene acid propylene glycol ester of 0.46mol.Along with stirring, after removing air, forward under a nitrogen in mould and make block roughage at 80 DEG C, then cut into the circular coarse-grain sheet of my required size.Extract circular coarse-grain sheet at least 48 hours with alcohols solvent, then remove desolventizing 30-85 DEG C of drying, make the good coarse-grain sheet material of extraction.Before hyperchromic 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.550,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm transmitance when being greater than 35%, 500nm transmitance when being greater than 75%, 550nm be greater than 95%; After hyperchromic, 25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 407nm, 450nm when having 10% transmitance is greater than 25%, 500nm is greater than 65%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
Example 7: containing the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber Octabenzone of 0.02mol, the azodiisobutyronitrile of 0.020mol, the 1-(4-chlorphenyl of 0.0003mol)-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles, the polymerisable even methacrylic acid aphthopyrans ester of 0.002mol, the 4-ethoxystyrene of 1.45mol, the octadecyl acrylate of 2.0mol, the acrylic acid 2-phenoxyethyl acrylate of 7.5mol, the tetramethylene dimethacrylate of 0.60mol.Along with stirring, after removing air, forward under a nitrogen in mould and make block roughage at 120 DEG C, then cut into the circular coarse-grain sheet of required size.With the circular coarse-grain sheet of alcohol extraction at least 48 hours, then dry except desolventizing at 75 DEG C, make the good coarse-grain sheet material of extraction.Before hyperchromic 25 DEG C time index of refraction be the coarse-grain sheet of thick DEG C of 1.545,0.8mm at 402nm time the transmitance of transmitance when being 10%, 450nm transmitance when being greater than 50%, 500nm transmitance when being greater than 90%, 550nm be greater than 95%.After hyperchromic, 25 DEG C time, the transmitance when transmitance when transmitance that index of refraction is the coarse-grain sheet of thick DEG C of 1.545,0.8mm when being 402nm, 450nm when having 10% transmitance is greater than 40%, 500nm is greater than 85%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then inserts in a polishing medium prepared in advance by this butterfly-shaped coarse-grain sheet, at low temperatures, carries out polishing, then carves the product be prepared into required for us.
All documents that the present invention mentions are quoted as a reference all in this application, are just quoted separately as a reference as each section of document.
Should be appreciated that and above describe for the present invention to be as set forth in the claims only example and illustrative, not to be limited it.Content of the present invention disclosed by this paper, other embodiment of the present invention is apparent for a person skilled in the art.It should be noted that this description and embodiment only should be seen as example, actual range of the present invention is determined by claim.
Claims (7)
1. photic can be hyperchromic yellow ocular lens device, its optical body is made up of the polyacrylate polymers being cross-linked, and the polymerization single polymerization monomer of this polymer comprises:
(a), at least one acrylate or methacrylate monomer;
(b), have or without or more than one styrene derivative monomer;
(c), at least one cross-linking agent;
(d), at least one ultraviolet absorber;
(e), at least one blue-light absorbers;
The photic toner of (f), at least one;
Described photic toner is photicly strengthen the dye composition absorbing blue ray intensity, is selected from diarylethene, spiro-pyrans class, naphthopyrans class, azobenzene He one or more in spirooxazine compounds;
The glassy transition temperature of described ocular lens device is room temperature or lower, and the transmitance of hyperchromic front shortwave blue light when 400-450nm be not higher than 85%, and at the visible ray of more than 550nm, the transmitance of light is higher than 90%; After hyperchromic, when 400-450nm wave band, transmitance must not be greater than 90% higher than its transmitance of light wave of 65%, more than 550nm.
2. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, it is characterized in that described acrylate or methacrylate monomer are
(1) alkyl acrylate, alkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl; Or
(2) phenylethyl Arrcostab or methacrylic acid phenylalkyl ester, described phenylalkyl is Ph (CH
2)
n-, n=1-8; Or
(3) acrylic acid phenoxyalkyl ester or methacrylic acid phenoxyalkyl ester, described phenoxyalkyl is PhO (CH
2)
n-, n=1-8; Or
(4) acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl.
3. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, it is characterized in that described styrene derivative monomer is selected from styrene, 4-methyl styrene, 3-methyl styrene, 3,4-dimethyl styrene, 3-alkoxystyrene, 4-alkoxystyrene, one or more in the styrene that 3,4-dialkoxy styrene and 4-dimethylamino replace.
4. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, it is characterized in that described cross-linking agent is selected from ethylene glycol diacrylate, Ethylene glycol dimethacrylate, diacrylate propylene glycol ester, dimethyl allene acid propylene glycol ester, butanediol diacrylate, tetramethylene dimethacrylate, divinylbenzene and 2-methyl isophthalic acid, one or more in 4-divinylbenzene.
5. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, it is characterized in that described blue-light absorbers is polymerizable azo-compound, the azo-compound said here is the azo-compound that can absorb blue ray; The polymerizable functional group of azo-compound is acryloyl group, methacryl group, acrylamide group, methacrylamide group, Ethenylbenzene group, propylene phenyl group or methyl vinyl phenyl group.
6. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, it is characterized in that described ultraviolet absorber is polymerizable type benzotriazole compound or polymerizable type Benzophenones compound.
7. as claimed in claim 1 photic can be hyperchromic yellow ocular lens device, be intraocular lens, or implantable glasses for the myopia intraocular lens.
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| CN103340703A (en) * | 2013-06-17 | 2013-10-09 | 无锡蕾明视康科技有限公司 | Implantable myopia lens and preparation method thereof |
| CN104693646B (en) * | 2015-03-16 | 2017-05-31 | 南京工业大学 | Transparent plasticized PVC functional film and preparation method thereof |
| SG11201804325XA (en) * | 2015-11-25 | 2018-06-28 | Jins Inc | Optical element |
| CN106800376A (en) * | 2016-12-29 | 2017-06-06 | 武汉华星光电技术有限公司 | One kind filter blue light resists dizzy hand-set lid and preparation method thereof |
| JP6784720B2 (en) * | 2018-06-01 | 2020-11-11 | 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． | Polymer material and intraocular lens |
| CN109503758B (en) * | 2018-11-20 | 2019-11-15 | 华东师范大学 | A kind of photochromic polyacrylamide supramolecular hydrogel and preparation method |
| CN113545886B (en) * | 2021-04-06 | 2024-09-24 | 富螺(上海)医疗器械有限公司 | Method for manufacturing artificial lens |
| CN113527567B (en) * | 2021-07-26 | 2023-01-24 | 康小林 | Hydrophobic non-glare high refractive index ophthalmic polymeric materials |
| CN118440240A (en) * | 2024-04-30 | 2024-08-06 | 无锡蕾明视康科技有限公司 | Blue light filtering intraocular lens device for resisting protein deposition and calcification deposition and preparation method thereof |
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