CN103371187B - Bactericidal composition containing antibiotic in pyrimidine nucleoside class - Google Patents
Bactericidal composition containing antibiotic in pyrimidine nucleoside class Download PDFInfo
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- CN103371187B CN103371187B CN201210108918.9A CN201210108918A CN103371187B CN 103371187 B CN103371187 B CN 103371187B CN 201210108918 A CN201210108918 A CN 201210108918A CN 103371187 B CN103371187 B CN 103371187B
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- pyrimidine nucleoside
- nucleoside class
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- 239000002718 pyrimidine nucleoside Substances 0.000 title claims abstract description 61
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 26
- -1 cycloheximide triazole Chemical class 0.000 claims abstract description 35
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 32
- YPHMISFOHDHNIV-FSZOTQKASA-N Cycloheximide Natural products C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 claims abstract description 29
- 239000005761 Dimethomorph Substances 0.000 claims abstract description 29
- QNBTYORWCCMPQP-JXAWBTAJSA-N (Z)-dimethomorph Chemical compound C1=C(OC)C(OC)=CC=C1C(\C=1C=CC(Cl)=CC=1)=C/C(=O)N1CCOCC1 QNBTYORWCCMPQP-JXAWBTAJSA-N 0.000 claims abstract description 28
- OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000004563 wettable powder Substances 0.000 claims description 25
- 241000233679 Peronosporaceae Species 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 235000007164 Oryza sativa Nutrition 0.000 claims description 14
- 235000009566 rice Nutrition 0.000 claims description 14
- 239000000375 suspending agent Substances 0.000 claims description 14
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- 239000000839 emulsion Substances 0.000 claims description 8
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 8
- 239000003094 microcapsule Substances 0.000 claims description 8
- 241001530056 Athelia rolfsii Species 0.000 claims description 7
- 241000193738 Bacillus anthracis Species 0.000 claims description 7
- 206010008570 Chloasma Diseases 0.000 claims description 7
- 208000003351 Melanosis Diseases 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 claims description 7
- 229940088710 antibiotic agent Drugs 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 241000582441 Peronospora tabacina Species 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 239000002777 nucleoside Substances 0.000 claims description 4
- 125000003835 nucleoside group Chemical group 0.000 claims 3
- 240000007594 Oryza sativa Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
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- 239000000575 pesticide Substances 0.000 description 37
- 239000003814 drug Substances 0.000 description 34
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- 239000013530 defoamer Substances 0.000 description 10
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 7
- 240000003768 Solanum lycopersicum Species 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 6
- 206010067482 No adverse event Diseases 0.000 description 6
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- 239000003995 emulsifying agent Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000219109 Citrullus Species 0.000 description 4
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 4
- 240000008067 Cucumis sativus Species 0.000 description 4
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 4
- 241000209140 Triticum Species 0.000 description 4
- 235000021307 Triticum Nutrition 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
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- 238000002156 mixing Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 206010011732 Cyst Diseases 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
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- 230000001965 increasing effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
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- 239000002245 particle Substances 0.000 description 2
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- 239000000243 solution Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- RXJKFRMDXUJTEX-UHFFFAOYSA-N triethylphosphine Chemical compound CCP(CC)CC RXJKFRMDXUJTEX-UHFFFAOYSA-N 0.000 description 2
- PCCSBWNGDMYFCW-UHFFFAOYSA-N 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione Chemical compound O=C1C(C)(C=2C=CC(OC=3C=CC=CC=3)=CC=2)OC(=O)N1NC1=CC=CC=C1 PCCSBWNGDMYFCW-UHFFFAOYSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical class NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 239000005772 Famoxadone Substances 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
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- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
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- 235000013339 cereals Nutrition 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
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- 239000000417 fungicide Substances 0.000 description 1
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- 150000002576 ketones Chemical class 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
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- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
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- ABDKAPXRBAPSQN-UHFFFAOYSA-N veratrole Chemical class COC1=CC=CC=C1OC ABDKAPXRBAPSQN-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing antibiotic in pyrimidine nucleoside class, the bactericidal composition containing active components A and active component B, active components A is selected from antibiotic in pyrimidine nucleoside class, and active component B is selected from any one compound following：Dimethomorph, phosethyl-Al, cycloheximide triazole, and the weight of active components A and active component B is than for 1: 80～60: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious potentiation, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of potentiation.
Description
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of bactericidal composition containing antibiotic in pyrimidine nucleoside class in crop
Application in disease.
Technical background
Antibiotic in pyrimidine nucleoside class (agricultural antiobiotic 120) is called：Pesticide corrosion 120；Antimycoin
120；120 agricultural antibiotics.Antibiotic in pyrimidine nucleoside class be a kind of efficiently, broad spectrum biological disinfection agent, there is prevention ＆ protection and interior
Inhale treatment double effects, have strong inhibitory action to many phytopathogens, to cucurbits powdery mildew, flowers powdery mildew and Semen Tritici aestivi
Rust preventive effect is preferable.
Dimethomorph (Dimethomorph) chemical name：(E, Z) -4- [3- (4- chlorphenyl) 3- (3,4- dimethoxy benzenes
Base) acryloyl] morpholine, molecular formula：C21H22ClNO4.Dimethomorph be single-minded kill Oomycete fungal antibacterial, its action character is
Destroy the formation of cell envelope, have effect to each stage of oomycetes life cycle, in the formation rank of sporangiophore and oospore
Section is particularly sensitive, and (＜ 0.25 μ g/ml) is suppressed at much lower concentrations.With phenylamide medicament no interactions resistance.
Phosethyl-Al (Fosetyl-aluminium) chemical name：Three-(ethylphosphonic acid) aluminum, molecular formula：
C6H18AlO9P3.Phosethyl-Al is systemic fungicide, can conduct up and down in plant, has protection and therapeutical effect.
Cycloheximide triazole (Famoxadone) chemical name：3- anilino- -5- methyl -5- (4- Phenoxyphenyl) -1,3- azoles
Quinoline -2,4- diketone, molecular formula：C22H18N2O4.It is inhibitor of energy is Mitochondrial electron transmission inhibitor, to complex III
Middle cytochrome c oxidoreductase has inhibitory action.Other acts on mechanism in studying further.It has protection, treatment, shovel
Remove, permeate, systemic activity, no hand over resistance with phenyl amide series bactericidal agent.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the generation of disease drug resistance.No
Compounded with kind composition, be to prevent and treat the very common method of resistance disease.Heterogeneity is compounded, and is imitated according to practical application
Really, to judge certain compounding be potentiation, plus and or antagonism.In most cases, the compounding effect of pesticide is all to add
And effect, really have potentiation compounding seldom, especially potentiation clearly, synergy ratio very high compounding just more
Few.Through inventor's research, finding will be mutual with dimethomorph, phosethyl-Al, cycloheximide triazole for antibiotic in pyrimidine nucleoside class
Compounding, there is good potentiation within the specific limits, and about antibiotic in pyrimidine nucleoside class and dimethomorph, triethylphosphine acid
Aluminum, the correlation of cycloheximide triazole compound, at present at home and abroad there is not yet relevant report.
Content of the invention
The purpose of the present invention is to propose to a kind of have that synergistic function, use cost be low, preventive effect is good containing pyrimidine nucleoside
The bactericidal composition of antibiotics.
A kind of bactericidal composition containing antibiotic in pyrimidine nucleoside class is it is characterised in that comprise active components A and active component
B, active components A and active component B weight are than for 1: 80～60: 1, described active components A is selected from antibiotic in pyrimidine nucleoside class,
Active component B is selected from one of dimethomorph, phosethyl-Al, cycloheximide triazole and plants.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class it is characterised in that：Active components A and active component B
Weight than for 1: 40～30: 1.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class it is characterised in that：Antibiotic in pyrimidine nucleoside class and alkene
The weight of morpholide is than for 1: 15～10: 1.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class it is characterised in that：Antibiotic in pyrimidine nucleoside class and three
The weight of fosetyl-aluminium is than for 1: 20～2: 1.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class it is characterised in that：Antibiotic in pyrimidine nucleoside class with
The weight of cycloheximide triazole is than for 1: 10～10: 1.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class it is characterised in that：Compositionss make wettable powder,
Water dispersible granules, suspending agent, water preparation, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
The described bactericidal composition containing antibiotic in pyrimidine nucleoside class is used for preventing and treating the disease of crop, and described crop includes
Vegetable, fruit tree, cereal crops, ornamental plant.
Described disease includes melasma, powdery mildew, anthrax, banded sclerotial blight, droop, rust, downy mildew, epidemic disease, frost
Phytophthora root rot, balck shank, rice blast, glume blight, net blotch.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on a kind of chemical combination
The mixed ratio of thing and another kind of compound and potentiation degree, simultaneously also relevant with target disease.Generally in compositionss
The weight percentage of active component is the 2%～90% of gross weight, preferably 5%～80%.According to different preparation classes
Type, active component content scope is different.Generally, liquid preparation contains by weight 1%～60% active substance, preferably
Ground is 5%～50%；Solid preparation contains by weight 5%～80% active substance, and preferably 10%～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, be beneficial to during administration active component in water
Dispersion.Surface-active contents are the 2%～30% of total formulation weight, balance of solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art：Can be selected from
One or more of dispersant, wetting agent, thickening agent or defoamer.According to different dosage form, this area in preparation, can also be contained
Stabilizer well known to technical staff, antifreeze etc..
The bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be by ability
Processing method preparation well known to field technique personnel, will add after active component mixed with liquid flux or solid carrier
Surfactant such as one or more of dispersant, stabilizer, wetting agent, binding agent, defoamer etc..
The bactericidal composition of the present invention, can be processed into acceptable dosage form on any pesticide on demand.Wherein preferably agent
Type is wettable powder, water dispersible granules, suspending agent, water preparation, microemulsion, aqueous emulsion, microcapsule suspending agent.
Compositionss are made and are comprised following component and content during wettable powder：Active components A 1%～60%, active component
B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
Compositionss are made and are included following component and content during water dispersible granules：Active components A 1%～60%, active component
More than B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0～8%, filler
Amount.
Compositionss are made and are included following component and content during suspending agent：Active components A 1%～50%, active component B1%
～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickening agent 0.05%～2%, anti-
Freeze agent 0～8%, deionized water adds to 100%.
Compositionss are made and are included following component and content during water preparation：Active components A 0.5%～40%, active component B
0.5%～40%, dispersant 2%～15%, wetting agent 1%-10%, antifreeze 0～8%, deionized water add to 100%.
Compositionss are made and are included following component and content during microemulsion：Active components A 0.5%～50%, active component
B0.5%～50%, emulsifying agent 1%～15%, solvent 1%～10%, antifreeze 0～8%, stabilizer 0～3%, defoamer
0.01%～2%, deionized water adds to 100%.
Compositionss are made and are included following component and content during aqueous emulsion：Active components A 0.5%～50%, active component
B0.5%～50%, solvent 1%～20%, emulsifying agent 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, increasing
Thick dose 0.05%～2%, deionized water add to 100%.
Compositionss are made and are included following component and content during microcapsule suspending agent：Active components A 0.5%～50%, activity become
Divide B0.5%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifying agent
1%～7%, pH adjusting agent 0.1%～5%, defoamer 0.01%～2%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The water preparation the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
It is an advantage of the current invention that：
(1) present composition has good potentiation and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) agriculture
Medicinal dose reduces, and reduces residual quantity on crop for the pesticide, mitigates environmental pollution；(3) expand fungicidal spectrum, to multiple diseases
As melasma, powdery mildew, anthrax, banded sclerotial blight, droop, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast,
Glume blight, net blotch have greater activity.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage ratio in embodiment is all weight percentage, but
The invention is not limited in this.
Application Example one
Example 1～8 wettable powder
By antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, filler mixing, mix all in mixed cylinder
Even, remix uniformly after pulverizing through jet mill, you can make wettable powder product of the present invention.Specifically be shown in Table 1,
2.
The each component of table 1 example 1～4 and content
The each component of table 2 example 5～8 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 9～16 water dispersible granules
By antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, disintegrating agent, filler together through comminution by gas stream
Obtain the particle diameter of needs, obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer after granulation and drying,
Of the present invention water dispersible granules product is obtained.Specifically it is shown in Table 3,4.
The each component of table 3 example 9～12 and content
The each component of table 4 example 13～16 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 17～22 suspending agent
By dispersant, wetting agent, defoamer, thickening agent, antifreeze through high speed shear mix homogeneously, add pyrimidine nucleoside
Antibiotics, active component B, surplus deionized water is supplied, ball milling 2～3 hours in ball mill, so that diameter of particle is all existed
Less than 5 μm, of the present invention suspending agent product is obtained.Specifically it is shown in Table 5.
The each component of table 5 example 17～22 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 23～27 water preparation
By antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, antifreeze through high speed shear mixing all
Even, deionized water supplies surplus, and of the present invention aqua product is obtained.Specifically it is shown in Table 6.
The each component of table 6 example 23～27 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 28～30 microemulsion
Antibiotic in pyrimidine nucleoside class, active component B are dissolved in equipped with the homogenizer of solvent, by emulsifying agent, antifreeze,
Defoamer is added in the homogenizer equipped with above-mentioned solution, and surplus deionized water strongly mixes after supplying and homogenizes,
Obtain the transparent microemulsion product of the present invention of clear appearance afterwards.Specifically it is shown in Table 7.
The each component of table 7 example 28～30 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 31～33 aqueous emulsion
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；Will
Deionized water, antifreeze, thickening agent, defoamer mix, and become homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil
Phase, is obtained aqueous emulsion product of the present invention.Specifically it is shown in Table 8.
The each component of table 8 example 31～33 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
Example 34～36 microcapsule suspending agent
By antibiotic in pyrimidine nucleoside class, active component B, macromolecule cyst material, solvent mixing, make dissolving uniformly oily
Phase, in a shear condition, oil phase is added to containing in emulsifying agent, pH adjusting agent, dispersant, the aqueous phase solution of defoamer, remaining
Amount deionized water is supplied, and bi-material reacts in oil-water interfaces, forms high score ascus wall, makes the present composition and divide
Dissipate good microcapsule suspending agent product.Specifically it is shown in Table 9.
The each component of table 9 example 32～34 and content
Dimethomorph, phosethyl-Al, cycloheximide triazole in table are exchanged, novel formulation can be obtained.
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.First pass through indoor virulence to survey
Fixed, after clear and definite two kinds of medicaments are compounding by a certain percentage synergy ratio (SR), SR ＜ 0.5 is antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 is potentiation, on this basis, then carries out field test.
Test method：Determine that after each medicament effective inhibition concentration scope, medicament sets 5 respectively by active constituent content through prerun
Individual dosage is processed, if clear water comparison.Reference《Farm-chemical indoor determination test rule antibacterial》Carry out, using mycelial growth speed
Rate method measures the virulence to crop pathogenic bacteria for the medicament.Measure colony diameter with crossing method after 72h, calculate each process and only grow
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley method
Calculate two medicaments different ratio synergy ratio (SR), SR ＜ 0.5 is antagonism, 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 is potentiation.Computing formula is as follows：
Wherein：A, b are respectively active components A and the ratio shared in combination of active component B；
A is antibiotic in pyrimidine nucleoside class；
B selects and plants to one of dimethomorph, phosethyl-Al, cycloheximide triazole.
Application Example two：
For trying disease：Tomato blight.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine having of pesticide corrosion 120 and dimethomorph active compound and the two different ratio mixture through pilot study
Effect inhibition concentration scope.
Toxicity test result
Table 10 pesticide corrosion 120 compounds the toxicity test analysis of results table to tomato blight with dimethomorph
As shown in Table 10, pesticide corrosion 120 is equal to tomato blight synergy ratio SR when 1: 80～60: 1 with dimethomorph proportioning
More than 1.5, illustrate that both all show potentiation at mixture in the range of 1: 80～60: 1, when pesticide corrosion 120 and dimethomorph
, when 1: 15～10: 1, potentiation is more prominent for proportioning, and synergy ratio is all more than 2.20.Wherein when pesticide corrosion 120 and alkene acyl
Morpholine weight is more maximum than for synergy ratio when 2: 3, and potentiation is the most obvious.Test through applicant and find pesticide corrosion 120 and alkene acyl
The proportioning of morpholine be 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,2: 3,1: 2,1: 3,1: 4,1: 5,1: 6,
When 1: 7,1: 8,1: 9,1: 10,1: 15, pesticide corrosion 120 and dimethomorph compound to melasma, powdery mildew, anthrax, banded sclerotial blight, withered
Wither disease, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, the preventing and treating of net blotch has obvious increasing
Effect acts on, and synergy ratio is all more than 1.50.
Application Example three：
For trying disease：Rice sheath blight disease.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine pesticide corrosion 120 and technical-grade fosetyl-aluminum and the two different ratio mixture through pilot study
Effectively inhibition concentration scope.
Toxicity test result
Table 11 pesticide corrosion 120 compounds the toxicity test analysis of results table to rice sheath blight disease with phosethyl-Al
As shown in Table 11, pesticide corrosion 120 and phosethyl-Al to the proportioning of rice sheath blight disease when 1: 80～60: 1, synergic ratio
Value SR is all higher than 1.5, illustrates that both all show potentiation, when pesticide corrosion 120 and three second at mixture in the range of 1: 80～60: 1
, when 1: 20～2: 1, potentiation is more prominent for the proportioning of phosphonic acids aluminum, and synergy ratio is all more than 2.30.Wherein work as pesticide corrosion 120
More maximum than for synergy ratio when 1: 10 with phosethyl-Al weight, potentiation is the most obvious.Through applicant's test, find that agriculture resists
120 is 2: 1,1: 1,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 11,1: 12,1: 13,1: 14,1 with the proportioning of phosethyl-Al
: 15,1: 20 when, pesticide corrosion 120 and phosethyl-Al compound to melasma, powdery mildew, anthrax, banded sclerotial blight, droop, rust,
Downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, the preventing and treating of net blotch have obvious potentiation, potentiation
Ratio is all more than 1.50.
Application Example four：
For trying disease：Downy mildew of garpe.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine having of pesticide corrosion 120 and cycloheximide triazole active compound and the two different ratio mixture through pilot study
Effect inhibition concentration scope.
Toxicity test result
Table 12 pesticide corrosion 120 compounds the toxicity test analysis of results table to downy mildew of garpe with cycloheximide triazole
As shown in Table 12, pesticide corrosion 120 and cycloheximide triazole to the proportioning of downy mildew of garpe when 1: 80～60: 1, synergy ratio
SR is all higher than 1.5, illustrates that both all show potentiation at mixture in the range of 1: 80～60: 1, when pesticide corrosion 120 and azoles bacterium
, when 1: 10～10: 1, potentiation is more prominent for the proportioning of ketone, and synergy ratio is all more than 2.20.Wherein when pesticide corrosion 120 with
Cycloheximide triazole weight is more maximum than for synergy ratio when 1: 1, and potentiation is the most obvious.Through applicant test find pesticide corrosion 120 with
The proportioning of cycloheximide triazole be 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,
When 1: 7,1: 8,1: 9,1: 10, pesticide corrosion 120 and cycloheximide triazole compound to melasma, powdery mildew, anthrax, banded sclerotial blight, droop,
Rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, the preventing and treating of net blotch have obvious potentiation to make
With synergy ratio is all more than 1.50.
Application Example five antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating wheat powdery mildew test of pesticide effectiveness
This test arrangement is ground by Shaanxi Welch Crop Protection Co., Ltd. in Zaozhuang City of the Shandong Province Tai Er village, test medicine
Send out, provide, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial),
40% phosethyl-Al wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The wheat powdery mildew state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 13 antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating wheat powdery mildew test of pesticide effectiveness
As can be seen from Table 13, antibiotic in pyrimidine nucleoside class effectively can prevent and treat wheat powdery mildew after compounding with active component B,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example Elmidone nucleoside antibiotics and active component B and its compounding prevent and treat the downy mildew of garpe test of pesticide effectiveness
This test arrangement is ground by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province Weinan suburban area, test medicine
Send out, provide, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial),
40% phosethyl-Al wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The downy mildew of garpe state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 14 antibiotic in pyrimidine nucleoside class and active component B and its compounding prevent and treat the downy mildew of garpe test of pesticide effectiveness
As can be seen from Table 14, antibiotic in pyrimidine nucleoside class effectively can prevent and treat downy mildew of garpe after compounding with active component B,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
This test arrangement is ground by Shaanxi Welch Crop Protection Co., Ltd. in Xian District, Shanxi Province suburban area, test medicine
Send out, provide, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial),
40% phosethyl-Al wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The tomato blight state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.The
7 days after secondary dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 15 antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
As can be seen from Table 15, antibiotic in pyrimidine nucleoside class effectively can prevent and treat tomato blight after compounding with active component B, prevents
Control the preventive effect that effect is superior to single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province's Hanzhong City, test medicine
For, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial), 40% 3
Fosetyl-aluminium wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The rice blast state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 16 antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
As can be seen from Table 16, antibiotic in pyrimidine nucleoside class effectively can prevent and treat rice blast after compounding with active component B,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province Jingyang County, test medicine
For, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial), 40% 3
Fosetyl-aluminium wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The cucumber downy mildew state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 17 antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 17, antibiotic in pyrimidine nucleoside class effectively can prevent and treat cucumber downy mildew after compounding with active component B,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating watermelon blight test of pesticide effectiveness
This test arrangement is researched and developed, is carried by Shaanxi Welch Crop Protection Co., Ltd. in Heze city of Shandong province, test medicine
For, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 50% dimethomorph wettable powder (commercial), 40% 3
Fosetyl-aluminium wettable powder (commercial), 30% cycloheximide triazole wettable powder (autogamy).
The watermelon blight state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 18 antibiotic in pyrimidine nucleoside class and active component B and its compounding preventing and treating watermelon blight test of pesticide effectiveness
As can be seen from Table 18, antibiotic in pyrimidine nucleoside class effectively can prevent and treat watermelon blight after compounding with active component B,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Test through different places throughout the country draws afterwards, antibiotic in pyrimidine nucleoside class and dimethomorph, triethylphosphine
To the melasma in various crop, powdery mildew, anthrax, banded sclerotial blight, droop, rust, downy mildew after sour aluminum, cycloheximide triazole are compounding
The preventive effect of the Common Diseases such as disease, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch, all more than 95%, is better than
Single dose preventive effect, potentiation is obvious.
Claims (8)
1. a kind of bactericidal composition containing antibiotic in pyrimidine nucleoside class is it is characterised in that containing active components A and active component B,
For 1 80 ~ 60 1, described active components A is selected from antibiotic in pyrimidine nucleoside class to active components A and active component B weight ratio, lives
Property composition B be selected from one of dimethomorph, phosethyl-Al, cycloheximide triazole plant.
2. the bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 1 it is characterised in that：Active components A
With the weight of active component B than for 1 40 ~ 30 1.
3. the bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 2 it is characterised in that：Pyridimine nucleosides
The weight of antibiotics and dimethomorph is than for 1 15 ~ 10 1.
4. the bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 2 it is characterised in that：Pyridimine nucleosides
The weight of antibiotics and phosethyl-Al is than for 1 20 ~ 21.
5. the bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 2 it is characterised in that：Pyridimine nucleosides
The weight of antibiotics and cycloheximide triazole is than for 1 10 ~ 10 1.
6. any one according to claim 3 to 5 contain antibiotic in pyrimidine nucleoside class bactericidal composition it is characterised in that：
Compositionss make wettable powder, water dispersible granules, suspending agent, water preparation, microemulsion, aqueous emulsion, microcapsule suspending agent.
7. the bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 6 is used for preventing and treating answering of crop pest
With.
8. according to claim 7 application it is characterised in that：Described disease include melasma, powdery mildew, anthrax,
Banded sclerotial blight, droop, rust, downy mildew, epidemic disease, peronospora tabacina, balck shank, rice blast, glume blight, net blotch.
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| CN108178698A (en) * | 2018-03-19 | 2018-06-19 | 联保作物科技有限公司 | Complex composition, agricultural bacteriocide and its application containing antibiotic in pyrimidine nucleoside class and dipotassium hydrogen phosphate |
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