CN102573769B

CN102573769B - Dentifrice composition

Info

Publication number: CN102573769B
Application number: CN2010800429267A
Authority: CN
Inventors: 山本幸司; 平山隆; 天野步
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2009-11-06
Filing date: 2010-11-01
Publication date: 2013-12-04
Anticipated expiration: 2030-11-01
Also published as: JP2011098918A; HK1172251A1; WO2011055707A1; JP5597969B2; CN102573769A

Abstract

Disclosed is a dentifrice composition which exhibits high local retention properties for a preparation in the oral cavity, while having an excellent bactericidal effect on oral biofilms. The dentifrice composition has a flavor that is almost free from unpleasant taste and excellent feeling of use, while being suppressed in stickiness. Specifically disclosed is a dentifrice composition which is characterized by containing (A) isopropyl methyl phenol, (B) at least one fragrance material selected from among 3-octanol, 3-octyl acetate, 3-octanone and fenchone, (C) sorbit, (D) glycerin and (E) a polyethylene glycol that has an average molecular weight of 280-9,300. The dentifrice composition additionally contains (F) anisaldehyde.

Description

Dentrifice composition

Technical field

The present invention relates to that preparation anelasticity in oral cavity is high, oral biological film sterilizing power excellence, and abnormal flavour is few, the viscous sense is few, use the excellent Dentrifice composition of sense.

Background technology

It is generally acknowledged, dental caries, this two large oral disease of periodontal disease are various bacterial due in biomembrane in oral cavity.Especially, dental caries is that streptococcus, the periodontal disease of Streptococcus mutans (S.mutans) etc. is to be main bacterial infection disease by obligate anaerobic gram negative bacilli such as porphyromonas gingivalis (P.gingivalis), in addition, the reason of halitosis is relevant with oral cavity bacteriums such as Fusobacterium nucleatums (F.nucleatum).Therefore, it is said as the prevention of illness in oral cavity, improve effective means, pathogenic bacteria number in biomembrane in oral cavity is remained on low-level comparatively useful.

On the other hand, in order to reduce intraoral pathogenic bacteria number, use slightly water-soluble antibacterial or cationic antibacterial, anionic antibacterial effective, especially, for biomembranous antibacterial, suitable use isopropyl methyl phenol (patent documentation 1; Japanese Patent Laid-Open 2005-179266 communique, patent documentation 2; Japanese Patent Laid-Open 2006-182662 communique).

The known isopropyl methyl phenol that is applicable to kill the inner pathogenic bacteria of biomembrane, its to the impregnability in biomembrane than other sterilization component excellences.But, because the compositions that contains isopropyl methyl phenol has distinctive abnormal flavour, produce the shortcoming that sense is used in significantly infringement, need to improve this point.

For above-mentioned problem, for example proposed, by phenyl phenol, with specific ratio, mixing specific acyl sarcosinates, reduce the technology (patent documentation 3 of the abnormal flavour of antimicrobial component; Japanese Patent Laid-Open 2007-161613 communique), by isopropyl methyl phenol with specific mass ratio mixings Menthol and sodium chloride, the technology (patent documentation 4 of reduction foreign odor, abnormal flavour; Japanese Patent Laid-Open 2008-143825 communique).But, while mixing more acyl sarcosinates, producing sometimes the oral mucosa be considered to from acyl sarcosinates stimulates, in addition, during mixed chlorinated sodium, produce due to saline taste, the type of fragrance such as is limited at the new problem, uses sense also to be far from being satisfactory.

In addition, although the method for covering and reduce abnormal flavour by sweeting agents such as glucide is also arranged, now, the taste of sweeting agent too strongly may not be talked and can suppress abnormal flavour.Therefore, seek to reduce the new technique from the abnormal flavour of isopropyl methyl phenol.

And then, in order effectively to kill the pathogenic bacteria of biomembrane inside, when making isopropyl methyl phenol with the high concentration topical effect, be necessary to improve the impregnability to biomembrane inside.But, Dentrifice composition in the past, preparation, is difficult to keep satisfactorily medicament here with high concentration at the oral cavity internal diffusion due to dispersibility.

As improving the technology of isopropyl methyl phenol mix preparation in intraoral anelasticity, someone proposes to mix the method (patent documentation 5 of specific polyoxyethylene (POE) hardened castor oil and tackifying silicon dioxide; Japanese Patent Laid-Open 2009-96747 communique).But this technology only limits to not mix the dentifrice of the pickling agent with abrasiveness, in addition, produce sometimes the distinctive abnormal flavour of anionic surfactant, also left over problem aspect usability.

As method that can the effective supply sterilization component, someone proposes to contain the collagen film of sterilization component or the adhesive preparation (patent documentation 6 that collagen tablet is attached to tooth surface; Japanese Patent Laid-Open 2006-182705 communique, patent documentation 7; Japanese Patent Laid-Open 2007-182705 communique).But, used the method for this attaching dosage form composition to be difficult to improve the bactericidal effect that is present in the biomembrane inside between teeth space and tooth and gingiva.

On the other hand, Sorbitol, glycerol, Polyethylene Glycol usually all as wetting agent to prevent dry purpose and to keep the good purpose of outward appearance etc. to be blended in (patent documentation 8 in Dentrifice composition; No. 3959636 communique of Japan Patent).But, because its viscosity coca increases, produces the viscous sense according to the stringiness of the different preparations of combined amount, therefore, also there is the problem of feeling variation of using in these wetting agents.

Like this, isopropyl methyl phenol is due to the biomembranous impregnability excellence in oral cavity, sterilization component as Dentrifice composition is useful, but mix isopropyl methyl phenol in Dentrifice composition, do not use sense, make it be trapped in satisfactorily in oral cavity, bring into play high biological film sterilizing effect and do not damage, these for prior art be all difficult, be difficult to practical.Therefore, expectation develop not only preparation excellent in intraoral anelasticity, bring into play high oral biological film bactericidal effect, and abnormal flavour and the viscous sense is few, use the excellent Dentrifice composition of sense.

The prior art document

Patent documentation

[patent documentation 1] Japanese Patent Laid-Open 2005-179266 communique

[patent documentation 2] Japanese Patent Laid-Open 2006-182662 communique

[patent documentation 3] Japanese Patent Laid-Open 2007-161613 communique

[patent documentation 4] Japanese Patent Laid-Open 2008-143825 communique

[patent documentation 5] Japanese Patent Laid-Open 2009-96747 communique

[patent documentation 6] Japanese Patent Laid-Open 2006-182705 communique

[patent documentation 7] Japanese Patent Laid-Open 2007-182705 communique

No. 3959636 communique of [patent documentation 8] Japan Patent

Summary of the invention

The present invention In view of the foregoing forms, and purpose is to provide that a kind of not only preparation is excellent in intraoral anelasticity, oral biological film sterilizing power excellence, and abnormal flavour and the viscous sense is few, use the excellent Dentrifice composition of sense.

The people is for achieving the above object in invention, repeatedly make great efforts research, found that: having mixed the fragrance component more than a kind, (C) Sorbitol, (D) glycerol, (E) mean molecule quantity that (A) isopropyl methyl phenol, (B) be selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone is 280～9, the Dentrifice composition of 300 Polyethylene Glycol, against expectation, the sterilizing power excellence that preparation is high in intraoral anelasticity, biomembrane is inner, and abnormal flavour is few, the viscous sense also less, use sense excellent, and completed the present invention.

In the present invention, at mean molecule quantity, be 280～9, under the existence of 300 Polyethylene Glycol, the bactericidal action that isopropyl methyl phenol has is effectively brought into play in biomembrane inside, simultaneously, and then owing to also using Sorbitol and glycerol, not only preparation improves in intraoral anelasticity, can effectively bring into play bactericidal action, the viscous sense of inhibitory preparation, and, by isopropyl methyl phenol and with mixing specific fragrance component, inhibition, from the generation of the distinctive abnormal flavour of the composition that cleans the teeth, makes it have good fragrance.

Therefore, according to the present invention, by mixing the specific spice of (B) composition in the Dentrifice composition containing (A) isopropyl methyl phenol, and and with (C)～(E) composition, the various problems in the past that can achieve a solution, suppressed viscous sense from the abnormal flavour of isopropyl methyl phenol and preparation, use sense and make preparation be detained satisfactorily, bring into play high biological film sterilizing effect in oral cavity, have excellent bactericidal effect concurrently and use the prevention to oral diseases such as periodontal disease of sense or improve effective Dentrifice composition not damaging.

The fragrance component of above-mentioned (B) composition all has unique fragrance, although sometimes in cheese flavor spice etc. is in harmonious proportion spice trace use, due to undesirable fragrance being arranged itself, so be restricted as the use of the spice of Dentrifice composition.The inventor finds, by the specific spice of so above-mentioned (B) composition with isopropyl methyl phenol also with being mixed in Dentrifice composition, unexpectedly, can fully suppress the abnormal flavour from isopropyl methyl phenol.

And then, in the present invention, by (D) composition/(C) composition is 0.6～1.8 by quality ratio, can more improve in the oral cavity of preparation anelasticity and without the viscous sense.

In addition, in the present invention, by further mixing (F) anisaldehyde in the Dentrifice composition having mixed above-mentioned (A)～(E) composition, can more reduce distinctive abnormal flavour, further improve and use sense.

Therefore, the invention provides following Dentrifice composition.

(1) a kind of Dentrifice composition, is characterized in that, contains:

(A) isopropyl methyl phenol,

(B) be selected from least one fragrance component in 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone,

(C) Sorbitol,

(D) glycerol and

(E) Polyethylene Glycol that mean molecule quantity is 280～9,300.

(2) as the Dentrifice composition of (1) record, (D)/(C) mass ratio of composition is 0.6～1.8.

(3) Dentrifice composition of putting down in writing as (1) or (2), contain (A) composition 0.01～0.2 quality %, (B) composition 0.0001～0.1 quality %, (C) composition 5～30 quality %, (D) composition 5～30 quality %, and (E) composition 0.1～5 quality %.

(4) as the Dentrifice composition of (1), (2) or (3) record, also contain (F) anisaldehyde.

(5) as the Dentrifice composition of (4) record, contain (F) composition 0.0001～0.1 quality %.

(6) a kind of toothpaste, in (1)～(5) in the Dentrifice composition of any one record further mixed-abrasive 0～50 quality %, propylene glycol 0～10 quality %, binding agent 0.1～5 quality %, 0.1～10 quality % is formulated for surfactant.

[invention effect]

Dentrifice composition of the present invention, preparation is high in intraoral local anelasticity, oral biological film sterilizing power excellence, and almost do not have abnormal flavour, viscous sense little yet, use sense also excellent.

The specific embodiment

Below, the present invention is described in detail in detail.Dentrifice composition of the present invention, it is characterized in that, contain (A) isopropyl methyl phenol, (B) is selected from one kind or two or more fragrance component, (C) Sorbitol, (D) glycerol in 3-capryl alcohol, 3-octyl acetate, fenchone, and the Polyethylene Glycol that (E) mean molecule quantity is 280～9,300.

(A) isopropyl methyl phenol used in the present invention is 4-isopropyl-3-methylphenol, can use Osaka to change into the commercially available product that is called as isopropyl methyl phenol that (strain) produces.

(A) combined amount of isopropyl methyl phenol is 0.01～0.2% all (quality %, lower same) of compositions, and especially suitable is 0.02～0.1%, less than 0.01%, can not bring into play sufficient bactericidal effect sometimes, surpasses 0.2% words, sometimes produce abnormal flavour, taste deterioration.

(B) composition is to covering from the effective fragrance component of the abnormal flavour of isopropyl methyl phenol, is the one kind or two or more fragrance component be selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone.

While combining two or more above-mentioned fragrance component, the combination of 3-capryl alcohol and 3-octyl acetate and/or fenchone is suitable.

Even if in capryl alcohol, the 1-capryl alcohol of the spice as Dentrifice composition commonly used does not have to cover the effect from the abnormal flavour of isopropyl methyl phenol, is not suitable for as fragrance component of the present invention.

Above-mentioned (B) composition can be used commercially available product, for example the 3-capryl alcohol can be used the product of the wild spice of salt (strain), 3-octyl acetate and 3-octanone can use respectively (strain) aboveground spice manufacture product, fenchone can be used the product of fragrant Rong Xingye (strain) etc.

(B) total combined amount of composition is not particularly limited, with respect to total composition, and preferably 0.0001～0.1%, particularly preferably 0.0005～0.05%, especially preferably 0.001～0.02%.Combined amount less than 0.0001%, can not cover the abnormal flavour from isopropyl methyl phenol sometimes, uses the sense variation, surpasses 0.1%, and the fragrance of fragrance component itself is excessively strong, produces sometimes abnormal flavour.

(C) Sorbitol, as wetting agent, is also to improve preparation at a main cause of intraoral anelasticity and the composition that suppresses the one of the main reasons of abnormal flavour simultaneously.Sorbitol, so long as can be used in getting final product of common Dentrifice composition, be not particularly limited, and specifically can use east and change into the commercially available products such as D-D-sorbitol solution (70% D-sorbitol solution) that industry (strain) is produced.

The combined amount preferred composition of Sorbitol all 5～30%, embody the viewpoint of property at intraoral anelasticity, fragrance from improving preparation, more preferably 10～25%, further preferably 12～25%.Combined amount is less than 5%, and preparation is poor in intraoral anelasticity sometimes, and abnormal flavour can not be suppressed satisfactorily, and fragrance is poor, surpasses 30%, and viscous sense is sometimes increased, and uses sense poor.

(D) glycerol, as wetting agent, is also to improve preparation at a main cause of intraoral anelasticity and the composition that suppresses the one of the main reasons of viscosity simultaneously.Glycerol so long as can be used in getting final product of common Dentrifice composition, is not particularly limited, particularly, and the commercially available products such as glycerol (85% glycerol) that can use ライオ Application ケミカ Le (strain) to produce.

The combined amount preferred composition of glycerol all 5～30%, from improving the viewpoint of preparation in intraoral anelasticity, more preferably 10～25%, further preferably 12～25%.Combined amount is less than 5%, and preparation is poor in intraoral anelasticity sometimes, can not suppress the viscous sense, uses sense poor, surpasses 30%, and the viscous sense is increased, and uses sense poor, sometimes produces abnormal flavour.

In the present invention, from preparation in intraoral anelasticity, and the little viewpoint of viscous sense, (D) glycerol and (C) mass ratio of Sorbitol ((D)/(C)) preferably 0.5～2.0, particularly preferably 0.6～1.8.

(E) composition is the Polyethylene Glycol that mean molecule quantity is 280～9,300, is the composition that improves the one of the main reasons of anelasticity in oral cavity and biological film sterilizing effect.

The mean molecule quantity of Polyethylene Glycol is 280～9,300, preferably 380～3,800, and from the viewpoint that can obtain from the high biological film sterilizing effect of isopropyl methyl phenol, be important.During mean molecule quantity not sufficient 280, taste is poor sometimes, produces abnormal flavour, surpasses 9,300, to the effect of soaking into of biomembrane inside, reduces, and bactericidal effect is poor sometimes, and the viscous sense is high, uses sense poor.

In addition, above-mentioned mean molecule quantity is the value of mean molecule quantity of the Polyethylene Glycol of 2006 the 2nd editions records of accurate medicine material specification (medicine part outer article raw material Regulations lattice),, make its in pyridine with phthalic anhydride, change phthalic acid ester into, by the mean molecule quantity (lower same) recorded with the sodium hydroxide titration.

Particularly, can illustration Liquid Macrogol (mean molecule quantity 280～320), PEG400 (mean molecule quantity 380～420), Macrogol 600 (mean molecule quantity 570～630), cetomacrogol 1000 (mean molecule quantity 950～1,050), Macrogol 1540 (mean molecule quantity 1,290～1,650), Macrogol 2000 (mean molecule quantity 1,850～2,150), Macrogol 4000 (mean molecule quantity 2,600～3,800), polyethylene glycol 6000 (mean molecule quantity 7,300～9,300) etc.According to the commodity difference, sometimes as such as Polyethylene Glycol #200 etc. between Polyethylene Glycol and numerical value labelling #.

(E) Polyethylene Glycol can be used commercially available product, can use the first industrial pharmacy (strain), day oil (strain), Sanyo to change into the product of sales such as (strains).

The combined amount of above-mentioned Polyethylene Glycol, the bactericidal effect this point from isopropyl methyl phenol in biomembrane inside, preferred composition all 0.1～5%, particularly preferably 0.2～3%.Combined amount less than 0.1%, isopropyl methyl phenol descends to the impregnability of biomembrane inside sometimes, and the bactericidal effect of biomembrane inside is poor, surpasses 5%, and viscous sense is sometimes increased, and uses sense poor.

And then, in the present invention, preferably mix anisaldehyde as (F) composition, by also adding anisaldehyde the fragrance component except (B) composition, can more improve the coverage effect to the abnormal flavour from isopropyl methyl phenol, fragrance is better.

Anisaldehyde can be used the commercially available products such as product of ocean spice (strain).Its combined amount, with respect to the compositions full dose, preferably 0.0001～0.1%, particularly preferably 0.001～0.02%.Combined amount less than 0.0001%, can not fully improve the coverage effect from the abnormal flavour of isopropyl methyl phenol sometimes, surpasses 0.1%, and the same with (B) composition, the fragrance of anisaldehyde itself is excessively strong sometimes, produces abnormal flavour.

While mixing (F) anisaldehyde, from more improving the coverage effect this point from the abnormal flavour of isopropyl methyl phenol, (B) composition and (F) the total combined amount preferably 0.0002～0.15% of composition, particularly preferably 0.002～0.03%.Add up to combined amount less than 0.0002%, sometimes can not fully improve the coverage effect of abnormal flavour, surpass 0.15%, sometimes (B) and (F) fragrance of composition itself is excessively strong, the generation abnormal flavour.

In addition, (B) composition and (F) the particularly preferably combination of 3-capryl alcohol and anisaldehyde of combination of composition, thus, for the abnormal flavour from isopropyl methyl phenol, can bring into play especially excellent coverage effect.

Dentrifice composition of the present invention can be mixed with dentifrice, the especially toothpaste of toothpaste, liquid dentifrice, aqueous dentifrice, moistening dentifrice etc.Now, according to dosage form, in the scope of not damaging effect of the present invention, can also mix other known additives as any composition except above-mentioned neccessary composition.For example can mixed-abrasive, thickening agent, binding agent, surfactant, further mixing sweetener, antiseptic, effective ingredient, spice, coloring agent etc., mix these compositions manufacture with water as required.

Grinding agent can exemplify silica gel, aluminosilicate, the silicon based abrasive of zircoaluminate etc., calcium monohydrogenphosphate 2 hydrates, calcium monohydrogenphosphate is without hydrate, calcium phosphate, tetracalcium phosphate, OCP, the series of calcium phosphate grinding agent of calcium pyrophosphate etc., aluminium hydroxide, aluminium oxide, titanium dioxide, crystallinity silicic acid zirconium, polymethyl methacrylate, insoluble calcium metaphosphate, precipitated calcium carbonate, ground calcium carbonate, magnesium carbonate, magnesium phosphate, zeolite, Zirconium orthosilicate., hydroxyapatite, fluoro apatite, calcium deficiency apatite, synthetic resin based abrasive etc., can use one kind or two or more.Combined amount is generally 0～50% with respect to total composition, and particularly 5～40%.

As thickening agent, except (C)～(E) composition, can also mix other known thickening agents, one kind or two or more in sugar alcohol, polyhydric alcohol such as propylene glycol, ethylene glycol, 1,3 butylene glycol, reduction starch sugar compound.Can not mix above-mentioned thickening agent, combined amount be compositions all 0～10%, during mixing, be compositions all 2～10%, and (C), (D) and (E) the total combined amount of composition preferably in 10～60% scope.

Binding agent can exemplify cellulose-based binding agent, xanthan gum, carrageenan, guar gum, sodium alginate, Poise C-80M, montorillonite clay, gelatin, sodium polyacrylate of sodium carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxymethyl ethyl cellulose, methylcellulose etc. etc., can mix one kind or two or more in them.Combined amount is generally 0.1～5% with respect to total composition.

As surfactant, can mix the anionic surfactant that is generally used in Dentrifice composition, non-ionic surface active agent, amphoteric surfactant etc.

Anionic surfactant can exemplify N-acyl glutamate, N-methyl-N acyl methyltaurin sodium, N-methyl-N-acyl group Sodium L-alaninate, alpha-olefin sodium sulfonate of acyl sarcosinates, dodecylbenzene sodium sulfonate, hydrogenated coconut glycerine monofatty ester sulfate mono sodium, lauryl sulfoethanoic acid. sodium, N-palmityl sodium glutamate of Wan base Liu Suan salt, sodium N-lauroyl sarcosinate, tetradecanoyl sodium sarcosinate of sodium lauryl sulfate, sodium tetradecyl sulfate etc. etc. etc. etc.; wherein; alkyl sulfate, especially sodium lauryl sulfate is suitable.

As nonionic surfactant, use such as polyoxyethylene hardened castor oil, sucrose fatty acid ester, alkanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl polyglucoside, lauric acid ten polyglycerin ester etc.Wherein, from the foaming this point, suitable is polyoxyethylene alkyl ether, alkyl polyglucoside etc.

Amphoteric surfactant can be used lauryl dimethyl aminoacetic acid betanin, N-fatty acid distribution of coconut oil acyl group-N-carboxyl methyl-N-hydroxyethyl imidazoles betanin, fatty acid distribution of coconut oil amido propyl dimethylamino acetic acid betanin, fatty acid distribution of coconut oil amido propyl betaine etc., but be not limited to above-mentioned these.

The combined amount of surfactant normally 0.1～10%.

Sweeting agent can exemplify saccharin sodium, aspartame, stevioside, Flos Chrysanthemi extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine etc., and antiseptic can exemplify the p-Hydroxybenzoates such as butyl p-hydroxybenzoate, ethylparaben, sodium benzoate etc.

As various effective ingredient, except isopropyl methyl phenol, can also mix other effective ingredient, for example sodium fluoride, sodium monofluorophosphate, the fluorine compounds such as stannic fluoride, glucanase, become the enzymes such as dextranase, the potassium salt of phosphoric acid, the water-soluble phosphorus acid compounds such as sodium salt, tranexamic acid, episilon amino caproic acid, allantoin chloro hydroxy Al, hinokitol, sodium N-lauroyl sarcosinate, ascorbic acid, acetic acid dl-tocopherol, beta-cholestanol, α-bisabolol, the chlorhexidine salt, azulene, enoxolone, glycyrrhizic acid, sodium copper chlorophyllin, chlorophyll, the chelating phosphate cpds such as glycerophosphate, the copper compounds such as copper gluconate, aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivant thereof, sodium tripolyphosphate, zeolite, methoxy-ethylene, copolymer-maleic anhydride, polyvinyl pyrrolidone, epidihydrocholesterol, cetylpyridinium chloride, benzethonium chloride, beta-cholestanol, neko, zinc citrate, the Radix Angelicae Sinensis pilular extract, Cortex Phellodendri extractum, Flos Matricariae chamomillae, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Scutellariae, the extract of Flos Carthami etc. etc.The combined amount of these effective ingredient, in the scope that does not hinder effect of the present invention, can be used effective dose.

Except (B) composition and (F) composition, as other spice, for example can use, Eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, basil oil, Cardamom oil, Fructus Coriandri oil, Fructus Piperis peppermint oil, Oleum Menthae Rotundifoliae, Herba Menthae (Ha Star カ) oil, orange oil, Fructus Citri Limoniae oil, citrus seed oil, lime oil, oil of grapefruit, grape-fruit seed oil, platinum Fructus Citri grandis oil, Oleum lavandula angustifolia, oil of rosemary, bay oil, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, Celery oil, the bay tree leaf oil, Herba Origani oil, pinke needle oil, orange blossom oil, lemongrass oil, attar of roses, Jasmin oil, patchouli oil, flag flower extractum, rose absolute, orange flower absolute, the Rhizoma et radix valerianae absolute oil, the Fructus Mangifera Indicae absolute oil, the Herba Pogostemonis absolute oil, gingerin, the pepper tree fatty oil, green pepper (Capsicum) resinon, the natural perfume materials such as Fructus Capsici extract, and these spice processed are crossed and (heated up in a steamer section before going, heat up in a steamer section after going, fractional distillation, liquid-liquid extraction, purification, powder perfume) spice, and limonene, sobrerone, butanols, isoamyl alcohol, n-hexylene alcohol, cis-3-hexenol, cis-6-nonenol, linalool, alpha-terpineol, menthol, benzyl alcohol, phenethanol, anethole, thymol, estragole (Methyl chavicol), eugenol, carvone, menthone, pulegone, 1,8-eucalyptol, ionone, watermelon ketone, n-hexyl aldehyde, trans-2-hexenoic aldehyde, citral, cinnamic aldehyde, benzaldehyde, ethyl acetate, ethyl n-butyrate., isoamyl acetate, Exceed 600, ethyl 2-methylbutyrate, allyl bexanoate, the cyclohexane extraction allyl propionate, linalyl acetate, menthyl acetate, menthyl lactate, carvacryl acetate, phenoxyethyl isobutanoate, (-)-methyl cis-2-pent-2'-enyl-3-oxocyclopentylacetate, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl 2-aminobenzoate, the phenylethyl glycidic ester, ethyl lactate, vanilione, maltol, the γ of carbon number 4～12 and δ lactone, ambrettolide, dimethylsulphide, trimethylpyrazine, the Beta-methyl ethyl thio, furanone, ethylcyclopentenolone, 3-methyl cyclopentane-1,2-diketone (Cyclotene), 2-Methyl Butyric Acid, propanoic acid, p-met hoxycinnamic aldehyde, 3-1-menthoxypropane-1, the 2-glycol, menthone glycerol acetal, spilanthol, monomethyl succinate, the linalool oxide, the vanillyl butyl ether, single product spice such as isopulegol, and then, can also be used in combination strawberry essence, apple essence, melon essence, flavoring banana essence, flavoring peach essence, rasp berry essence, flavoring pineapple essence, grape essence, tropical fruit (tree) essence, Fructus Mangifera Indicae essence, prunus mume (sieb.) sieb.et zucc. essence, orange essence, Fructus Citri Limoniae essence, grapefruit essence, tea essence, butter essence, the mediation spice of milk flavour etc., and ethanol, propylene glycol, glyceryl triacetate, the known perfume base that the perfume solvent of fatty acid glyceride etc. etc. is used in Dentrifice composition.The combined amount of these perfume bases is not particularly limited, and preferably uses 0.000001～1% in compositions.In addition, as the tax of using above-mentioned perfume base is fragrant, use spice, preferably use 0.1～2.0% in compositions.

Coloring agent can exemplify blue No. 1, yellow No. 4 (FD& C, Yellow No.5 (19140)), green No. 3 etc.In addition, the combined amount of these compositions, in the scope of not damaging effect of the present invention, can be used common amount.

The material of taking in the container of Dentrifice composition of the present invention is not particularly limited, and can use the normally used container of Dentrifice composition.Particularly, can use the plastic containers etc. of polyethylene, polypropylene, polyethylene terephthalate, nylon etc.

[embodiment]

Below, enumerate embodiment and comparative example the present invention is described in detail in detail, but the present invention is not limited by following examples.In addition, in following example, %, as long as no special record, refers to quality %.

(embodiment, comparative example)

According to the Dentrifice composition (toothpaste) formed shown in following manufacture method preparation table 3～5.

(manufacture method)

(1) under room temperature in pure water mixed dissolution water soluble ingredient (except binding agent, propylene glycol) preparation A phase.

(2) preparation makes binding agent be dispersed in the B phase in propylene glycol at normal temperatures.

(3) stir in by B add to mutually A mutually in, mix preparation C phase.

(4) use 1.5L kneader (tor work is produced) by the composition beyond the water soluble ingredients such as spice, grinding agent be mixed at normal temperatures C mutually in, reduce pressure (4kPa) carries out deaeration, obtains Dentrifice composition 1.2kg.

In addition, isopropyl methyl phenol (Osaka changes into (strain) and produces), Sorbitol (east and change into that industry (strain) is produced, D-D-sorbitol solution (70% aqueous solution)), glycerol (ライオ Application ケミカ Le (strain) is produced, 85% glycerol), Macrogol 4000 (the first industrial pharmacy (strain) is produced, mean molecule quantity 3,500) are used in the preparation of Dentrifice composition.

Again, for form, be the composition of aqueous solution, comprise that all meaning in table is converted into the combined amount of pure minute.

As (B) fragrance component, the 3-capryl alcohol is used the wild spice of salt (strain) production, 3-octyl acetate and 3-octanone to use the product that (strain) aboveground spice making is produced, fenchone is used fragrant Rong Xingye (strain) production, anisaldehyde is used ocean spice (strain) production, the 1-capryl alcohol is used STOL perfume industry (strain) production.

In addition, about spice, the flavor compositions A～I shown in preparation table 1, and mix.Do not contain 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone, anisaldehyde in flavor compositions shown in table 1 again.

[table 1]

[table 2-1]

<essence 1 forms>
		Orange oil	1 mass parts
Lime oil	1
		Oil of grapefruit	1
Platinum Fructus Citri grandis oil	1
		Grape-fruit seed oil	1
Citral	1
		Ethanol	1
Add up to	7 mass parts

[table 2-2]

<essence 2 forms>
		Eucalyptus oil	1 mass parts
Oleum Cinnamomi	1
		Oleum Caryophylli	1
Sage oil	1
		Cardamom oil	1
Fructus Coriandri oil	1
		Bay oil	1
Flos Matricariae chamomillae oil	1
		Caraway oil	1
Ethanol	1
		Add up to	10 mass parts

[table 2-3]

<essence 3 forms>
		Wintergreen oil	1 mass parts
Olibanum oil	1
		Orange blossom oil	1
Indian oil of verbena	1
		Oleum Rosae Rugosae	1
Rose absolute	1
		The Fructus Mangifera Indicae absolute oil	1
Flag flower extractum	1
		Orange flower absolute	1
Ethanol	1
		Add up to	10 mass parts

[table 2-4]

<essence 4 forms>
		Menthyl lactate	1 mass parts
3-1-menthoxypropane-1, the 2-glycol	1
		The menthone glycerin ether	1
Spilanthol	1
		Monomethyl succinate	1
The linalool oxide	1
		The vanillyl butyl ether	1
Isopulegol	1
		Fructus Capsici extract	1
Gingerin	1
		The pepper tree fatty oil	1
The green pepper resinon	1
		Ethanol	1
Add up to	13 mass parts

[table 2-5]

<essence 5 forms>
		Furanone	1 mass parts
Ethylcyclopentenolone	1
		3-methyl cyclopentane-1, the 2-diketone	1
2-Methyl Butyric Acid	1
		Propanoic acid	1
P-met hoxycinnamic aldehyde	1
		Ethanol	1
Add up to	7 mass parts

[table 2-6]

<essence 6 forms>
		Cis-3-hexenol	1 mass parts
Trans-2-hexenoic aldehyde	1
		Ethyl n-butyrate.	1
γ-hendecane lactone	1
		δ-hendecane lactone	1
γ-decalactone	1
		δ-decalactone	1
Nonyl lactone	1
		δ-nonalactone	1
γ-hexalactone	1
		δ-caprolactone	1
Isoamyl acetate	1
		Benzaldehyde	1
Exceed 600	1
		The 2-Methyl Butyric Acid ethyl ester	1
Benzyl alcohol	1
		α-terpene alcohol	1
Linalyl acetate	1
		The glycidic acid phenethyl ester	1
Phenethanol	1
		Allyl hexanoate	1
Methyl cinnamate	1
		Ionone	1
The Beta-methyl ethyl thio	1
		Cis-6-nonenyl aldehyde	1
Watermelon ketone	1
		(-)-methyl cis-2-pent-2'-enyl-3-oxocyclopentylacetate	1
Ethanol	1
		Add up to	28 mass parts

The Dentrifice composition 50g of preparation is filled in the laminated tube (the white LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30 of LDPE55/PET12/LDPE20/, thick 257 μ m (Dai Nippon Printing's (strain) production)) of the diameter 26mm that innermost layer consists of straight chain shape Low Density Polyethylene.

Abbreviation and title in the layer structure of the laminated tube used are as follows, the thickness of each layer of numeral after abbreviation (μ m).

LDPE: Low Density Polyethylene

White LDPE: white low density polyethylene

LLDPE: straight chain shape Low Density Polyethylene

AL: aluminum

PET: polyethylene terephthalate

EMAA: ethylene methacrylic acid copolymer resin

For the Dentrifice composition obtained, estimate in accordance with the following methods the viscous sense of preparation when intraoral anelasticity, bactericidal effect, use the number, the having or not of abnormal flavour.Result is recorded in table 3～5 in the lump.

(1) evaluation methodology of the retention effect of preparation (anelasticity in oral cavity)

Add 20mL water in the tool plug test tube that the Dentrifice composition that about 1.0g prepares is housed, upper and lower vigorous stirring is after 10 seconds, and the dissolving of measuring Dentrifice composition now is residual, and the hold-up using it as preparation, according to the intraoral anelasticity of following standard evaluation.The measured value of the initial stage quality before stirring of take is 100%, after the residual component of the Dentrifice composition after stirring is filtered, calculates the percent of the measured value of the initial stage quality of the quality of residual component before with respect to above-mentioned stirring, using it as retention rate.

◎: retention rate is more than 60%

Zero: retention rate is more than 30%, less than 60%

△: retention rate is more than 10%, less than 30%

*: retention rate less than 10%

(2) assessment method of model biological film sterilizing effect

Process hydroxyapatite (HA) plate of diameter 7mm with the non-stimulated saliva of the people after the membrane filtration through 0.45 μ m, process 4 hours, in having added the pancreas peptone soybean broth culture medium of chlorhematin and menadione, 2 weeks Streptococcus mutans (Streptococcus mutans) of continuous culture, actinomyces naeslundii (Actinomyces naeslundii), veillonella parvula (Veillonella parvula), 5 strain mixed stockers of Fusobacterium nucleatum (Fusobacterium nucleatum) and porphyromonas gingivalis (Porphyromonas gingivalis), formation model biomembrane on the HA plate.Cultivate 2 Zhou Houqi, 1 time on the 1st, add 2 times of quality Artificial saliva (50mmol/L KCl+1mmol/LKH in the dentifrice formulation shown in following table 3～5 ₂PO ₄+ 1mmol/L CaCl ₂+ 0.1mmol/L MgCl ₂(pH7.0)), the centrifuged supernatant after dispersion, as test medicine liquid, impregnated in the model biomembrane wherein, impregnation process 3 minutes, then cultivate 3.When Pei Raising finishes, take out the model biomembrane, after dispersion, cultivate on agar plate, obtain thus the viable count of each strain in the model biomembrane.Viable count, because condition of culture more or less changes, makes Artificial saliva replace test medicine to do the used time, and about 8.5log cfu (colony-forming units/HA plate), be judged as biological film sterilizing power during not enough 6.0log cfu/HA plate high.

Model biological film sterilizing effect assessment benchmark

◎: not enough 5.0log cfu/HA plate

Zero: more than 5.0log cfu/HA plate～not enough 6.0log cfu/HA plate

△: more than 6.0log cfu/HA plate～not enough 7.0log cfu/HA plate

*: more than 7.0log cfu/HA plate

(3) the how many evaluation methodology of viscous sense in the use

Adopt 10 people's jury of experts to be estimated by sensory test.The about 1g of Dentrifice composition is placed on the commercially available product toothbrush and brushes teeth 3 minutes, for viscous sense in using the number, by the comparison with reference substance (comparative example 2), according to following 4 grades, estimated.According to following standard, by the average marks of 10 with ◎, zero, △, * mean.

How many (reference substances: comparative example 2) of intraoral viscous sense after using

4: compare the viscous sense with reference substance considerably less

3: compare the viscous sense with reference substance quite few

2: compare the viscous sense with reference substance less slightly

More than 1: with reference substance, compare equal or the viscous sense

Use the sense evaluation criterion

◎: more than 3.0 minutes～below 4.0 minutes

More than zero: 2.0 minute～less than 3.0 minutes

△: more than 1.5 minutes～less than 2.0 minutes

*: less than 1.5 minutes

(4) evaluation methodology of free from extraneous odour is arranged

Adopt 10 people's jury of experts to test and estimated by sense.The about 1g of Dentrifice composition is placed on the commercially available product toothbrush and brushes teeth 3 minutes, for whether feeling abnormal flavour in using, estimated according to following scoring.Obtain the meansigma methods of 10 people's evaluation result, according to following standard, the Dentrifice composition that can guarantee to be evaluated as ◎ and zero evaluation is judged as the Dentrifice composition that there is no abnormal flavour.

Having or not of abnormal flavour

4 minutes: there is no abnormal flavour fully

3 minutes: almost there is no abnormal flavour

2 minutes: abnormal flavour slightly

1 minute: abnormal flavour is arranged

The evaluation criterion that abnormal flavour has or not

◎: more than 3.7 minutes～below 4.0 minutes

◎～more than zero: 3.3 minute～less than 3.7 minutes

More than zero: 3.0 minute～less than 3.3 minutes

△: more than 2.0 minutes～less than 3.0 minutes

*: less than 2.0 minutes

[table 3-1]

[table 3-2]

[table 3-3]

[table 3-4]

In above-described embodiment 1～40, any one that flavor compositions A is changed in flavor compositions B～I can obtain same result.

[table 4]

[table 5-1]

[table 5-2]

[table 5-3]

[table 5-4]

[table 5-5]

Claims

1. a Dentrifice composition, is characterized in that, contains:

(A) isopropyl methyl phenol 0.01～0.2 quality %,

(B) be selected from least one fragrance component 0.0001～0.1 quality % in 3-capryl alcohol, 3-octyl acetate, 3-octanone and fenchone,

(C) Sorbitol 5～30 quality %,

(D) glycerol 5～30 quality %, and

(E) Polyethylene Glycol 0.1～5 quality % that mean molecule quantity is 280～9,300.

2. as the Dentrifice composition of claim 1 record, (D)/(C) mass ratio of composition is 0.6～1.8.

3. as the Dentrifice composition of claim 1 or 2 records, also contain (F) anisaldehyde 0.0001～0.1 quality %.

4. a toothpaste, in the Dentrifice compositions of claim 1 or 2 records, further mixed-abrasive 0～50 quality %, propylene glycol 0～10 quality %, binding agent 0.1～5 quality % and surfactant 0.1～10 quality % are formulated.