CN101564458A - Application of Chinese medicinal composition in preparing medicament for treating bronchitis - Google Patents
Application of Chinese medicinal composition in preparing medicament for treating bronchitis Download PDFInfo
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Abstract
The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating bronchitis. The medicament mainly comprises fructus forsythiae, honeysuckle, isatidis root, rhubarb, patchouli, thick wood-fern rhizome, integripetal rhodiola herb and the like, exerts the integrated adjusting advantage of the composite Chinese medicament and realizes multi-target treatment through organic combination of pathogen dispelling, symptoms releasing and immunity adjustment; the Chinese medicinal composition can effectively resist bacteria and inflammation, relieve a cough, dissipate phlegm and adjust immunity; and clinical experiments prove that the Chinese medicinal composition has remarkable curative effect on acute and chronic bronchitis.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment bronchitis medicine, belong to field of Chinese herbal.
Background technology
Bronchitis is the inflammation by infection, physical chemistry stimulation or irritated trachea, bronchial mucosa and the surrounding tissue thereof that causes.Doctor trained in Western medicine thinks that acute/chronic bronchitis reduces because of respiratory tract local defense and immunologic function mostly and breathes the parasympathetic nervous reaction and increase, thereby causes bronchial mucosa to shrink spasm, secretions increase.In tcm clinical practice, belong to " cough ", " phlegm retention " category.
Acute bronchitis is a cardinal symptom with rhinorrhea, heating, cough, expectoration, and rubs bitterly after hoarseness, laryngalgia, slight breastbone are arranged.Initial stage expectorant is few, is viscosity, becomes purulence later on.Stimulation such as flue dust and cold air can both make cough increase the weight of.Acute bronchitis is many because of upper respiratory tract infection virus or antibacterial, or due to the stimulation of physics and chemistry allergic.In the patient more than 10 years old, the infection of influenza virus, respiratory syncytial virus, adenovirus is the most common, and it is again a kind of modal non-disease of being in hospital, and is ten one of the diseases of seeking medical advice greatly.Patient be mostly have influence on normal work incessantly because of coughing, life goes to hospital to treat.Primary disease paathogenic factor complexity can be by virus, antibacterial direct infection, or the virus of acute upper respiratory tract infection or antibacterial spread; Also may cause trachea-bronchia mucosa acute irritation by the suction of supercooled air, dust, irritative gas or smog; Or cause the irritated inflammatory reaction of trachea-bronchia by sensitinogen.Western medical treatment is mainly symptomatic treatment and control infection at present.
Chronic bronchitis (chronic bronchitis) is meant the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof, clinically with cough, expectoration or with panting and the chronic process of outbreak repeatedly is a feature.If the state of an illness is slow progress, Chang Bingfa obstructive emphysema, even pulmonary hypertension, pulmonary heart disease.According to China's national part reconnaissance information statistics in 1973, the chronic bronchitis prevalence is about 3.82%, increases with age growth, and the person can be up to about 15% more than 50 years old.Domestic generaI investigation part statistics prompting in 1992, prevalence is 3.2%.The cause of disease of chronic bronchitis is very complicated, and except that factors such as environment factor, weather, heredity, smoking, virus, bacterial infection are important factors.Except that the above-mentioned cause of disease, the body intrinsic factor participate in the generation of chronic bronchitis, lack of proper care as autonomic nervous function, can make parasympathetic functions hyperfunction, the air flue reaction to the inoperative faint stimulation of normal person, can cause the bronchoconstriction spasm than normal person height, secretions increase, symptom such as produce cough, expectoration, pant.At present, western medical treatment is based on control infection and eliminate the phlegm, antitussive, and show not enough for adjusting the intrinsic factor functional disorder.
The present invention is the improvement invention of carrying out on the basis of ZL03143211 patent, quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in preparation treatment bronchitis medicine.
Summary of the invention
The invention provides the application in a kind of Chinese medicine composition preparation treatment bronchitis medicine, this Chinese medicine composition is made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention is preferably:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
Chinese medicine composition of the present invention mainly is made up of Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Et Rhizoma Rhei, Herba Pogostemonis, Rhizoma Dryopteris Crassirhizomatis, Radix Rhodiolae etc., the integrally-regulated advantage of performance herbal mixture, the combination of dispeling disease and evil, relief of symptoms, adjusting immunity, realize many target treatments, this Chinese medicine composition can be effectively antibiotic, antiinflammatory, cough-relieving, reduce phlegm, regulate immunity, and clinical experiment confirms that acute/chronic bronchitis is all had significant curative effect.
Chinese medicine of the present invention can be had the Chinese medicine of same or similar effect fruit to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
The active component of Chinese medicine composition of the present invention is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times of water gaging decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, the powder that gets dry extract, standby;
Step (4) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
The dosage form of medicine of the present invention is capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
Wherein capsule is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times of water gaging decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder being added suitable acceptable accessories granulates;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing incapsulates, promptly.
Be preferably:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder is added appropriate amount of starch, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing incapsulates, promptly.
The preparation method of the tablet of medicine of the present invention, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection is: weighting raw materials in proportion, adopt conventional preparation method preparation, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record makes the acceptable regular dosage form of pharmaceutics.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Preferably, tracheitis was chronic bronchitis or acute bronchitis described in the present invention used.
The specific embodiment
Following embodiment is used to illustrate the preparation of medicine of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1
Prescription:
Fructus Forsythiae 200 gram Flos Loniceraes 300 gram Radix Isatidis 200 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 60 gram Rhizoma Dryopteris Crassirhizomatiss 300 gram Radix Rhodiolaes 60 gram Mentholums 9 grams
Herba Ephedrae 60 gram Semen Armeniacae Amarums 100 gram Herba Houttuyniae 200 gram Radix Glycyrrhizaes 100 grams
Gypsum Fibrosum 200 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder is added starch 142 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing, 1000 capsules of packing into, promptly.
Embodiment 2
Prescription:
Fructus Forsythiae 255 gram Flos Loniceraes 255 gram Radix Isatidis 255 gram Radix Et Rhizoma Rhei 51 grams
Herba Pogostemonis 85 gram Rhizoma Dryopteris Crassirhizomatiss 255 gram Radix Rhodiolaes 85 gram Mentholums 7.5 grams
Herba Ephedrae 85 gram Semen Armeniacae Amarum (parched) 85 gram Herba Houttuyniae 255 gram Radix Glycyrrhizaes 85 grams
Gypsum Fibrosum 255 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 5 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 6 times of amount ethanol extractions of 50% 2 times, 1 hour for the first time, 2.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7 times of water gagings decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder is added starch 151 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing, compacting gets 935 in flakes.
Embodiment 3
Prescription:
Fructus Forsythiae 300 gram Flos Loniceraes 200 gram Radix Isatidis 300 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 100 gram Rhizoma Dryopteris Crassirhizomatiss 200 gram Radix Rhodiolaes 60 gram Mentholums 5 grams
Herba Ephedrae 100 gram Semen Armeniacae Amarums 60 gram Herba Houttuyniae 300 gram Radix Glycyrrhizaes 60 grams
Gypsum Fibrosum 300 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 8 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 10 times of amount ethanol extractions of 90% 2 times, 3 hours for the first time, 2.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 11 times of water gagings decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) with step (4) gained dried cream powder, step (2) gained volatile oil and Mentholum are made pill according to a conventional method, get pill 905 balls.
Experimental example 1:
For confirming the bronchitic curative effect of Drug therapy of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by embodiment 1 method, carried out following clinical experimental study:
1 data and method
1.1 the whole cases of physical data all are selected from Hebei Yi Ling hospital inpatient, amount to 187 examples, are divided into two groups of medicine group of the present invention and matched groups at random.Medicine group 95 examples of the present invention, wherein male 48 examples, women 47 examples, 47 years old mean age, acute bronchitis 40 examples, chronic bronchitis 55 examples; Matched group 92 examples, wherein male 44 examples, women 48 examples, 45 years old mean age, acute bronchitis 36 examples, chronic bronchitis 56 examples; By statistics, two groups at aspect comparing difference not statistically significants (P＞0.05) such as sex, age, typings, has comparability.
1.2 case is selected: the diagnostic criteria with reference to acute bronchitis or chronic bronchitis in " new Chinese medicine clinical research guideline " is formulated.(1) include standard in: meet acute bronchitis or acute episode of chronic bronchitis, 18～70 years old age is all as including case in.(2) exclusion standard: the chronic cough person of panting that factors such as tuberculosis, tumor, fungus, irritant gas allergy cause; The concurrent severe cardiac of acute/chronic bronchitis functional defect person; Merge serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, psychotic; Age is at under-18s or more than 70 years old; Gestation or women breast-feeding their children; To this product allergy sufferers.
1.3 Therapeutic Method: matched group: adopt the conventional Comprehensive Treatment of doctor trained in Western medicine: 1. control infection, give empirical therapeutic scheme earlier, levofloxacin 0.2g or ceftriaxone sodium injection (production of Beijing Yuekang Pharmaceutical Group Co., Ltd.) 3g adds normal saline 100ml intravenous drip (skin test), the two share serious symptom person, every day 2 times, treat to adjust medication again after the repayment of antibacterial culturing and drug sensitivity tests; 2. apophlegmatisant is selected mucosolvan (Tianjin Medicine Research Academy Pharmaceutical Co., Ltd's production) for use, and each 30mg is every day 3 times, oral; 3. the person that do not pant gives the anti-asthmatic aminophylline, each 100mg is every day 4 times, oral; 4. the hyperpyrexia person cooling of suiting the medicine to the illness is handled.Treating 7 days is 1 course of treatment, continuous use observe the curative effect after 2 courses of treatment.Medicine group of the present invention: give determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs on the treatment of control group basis, add medicine of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd's production), 4/time, 3 times/day, be 7 days the course of treatment.
1.4 criterion of therapeutical effect is with reference to the criterion of therapeutical effect of acute bronchitis in " new Chinese medicine clinical research guideline " or chronic bronchitis, clinic control: cough, expectoration, pant and the pulmonary rale complete obiteration, followed up a case by regular visits to for two weeks and do not have recurrence; Produce effects: cough, pant and pulmonary rale disappears substantially; Take a turn for the better: cough, expectoration, pant and pulmonary rale improves; Invalid: cough, expectoration, asthma and pulmonary rale no change or increase the weight of.
1.5 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, enumeration data χ
2The t check is adopted in check, measurement data, and curative effect relatively adopts rank test.
2 results
2.1 two groups of acute bronchitis clinical efficacies
By statistics, two groups of curative effect comparison medicine group of the present invention matched groups (P＜0.05) that are higher than evident in efficacy, two groups of total effective rate comparison medicine group of the present invention total effective rates are significantly higher than matched group (P＜0.05), the results are shown in Table 1.
Acute bronchitis clinical efficacy comparison of table 1 liang group (example, %)
2.2 two groups of chronic bronchitis clinical efficacies
By statistics, two groups of curative effect comparison medicine group of the present invention matched groups (P＜0.05) that are higher than evident in efficacy, two groups of total effective rate comparison medicine group of the present invention total effective rates are significantly higher than matched group (P＜0.05), the results are shown in Table 2.
Chronic bronchitis clinical efficacy comparison of table 2 liang group (example, %)
3 conclusions:
This experiment adds medicine of the present invention on the basis of doctor trained in Western medicine conventional therapy, clinical efficacy significantly is better than adopting merely the doctor trained in Western medicine conventional therapy, confirms that fully medicine of the present invention can effectively treat acute/chronic bronchitis.
Claims (10)
1, the application in a kind of Chinese medicine composition preparation treatment bronchitis medicine is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
2, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
3, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
4, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
5, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
6, according to each described application of claim 1-5, it is characterized in that the active component of described Chinese medicine composition is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times of water gaging decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, the powder that gets dry extract, standby;
Step (4) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
7, according to each described application of claim 1-5, the preparation formulation that it is characterized in that this Chinese medicine composition is capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
8,, it is characterized in that described capsule made by following steps according to each described application of claim 1-5:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times of water gaging decocts to boiling, add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder being added suitable acceptable accessories granulates;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing incapsulates, promptly.
9,, it is characterized in that described tracheitis is a chronic bronchitis according to each described application of claim 1-5.
10,, it is characterized in that described tracheitis is an acute bronchitis according to each described application of claim 1-5.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370783A (en) * | 2010-08-19 | 2012-03-14 | 北京以岭药业有限公司 | Application of traditional Chinese drug composition in preparation of drugs for treating lung injury caused by smoking |
| CN102406748A (en) * | 2011-11-22 | 2012-04-11 | 荣成市交通诊所 | Traditional Chinese medicine composition for treating infantile bronchitis |
| CN103520460A (en) * | 2013-10-25 | 2014-01-22 | 刘雁 | Traditional Chinese medicine for treating chronic bronchitis |
| CN103536828A (en) * | 2013-10-11 | 2014-01-29 | 陈英娣 | Traditional Chinese medicine for treating bronchiectasia |
| CN104920743A (en) * | 2015-07-20 | 2015-09-23 | 青海省通天河藏药制药有限责任公司 | Preparation method for anti-fatigue substitutional tea |
| CN111066700A (en) * | 2020-01-19 | 2020-04-28 | 西藏民族大学 | Application of salidroside in combination with isoniazid in prolonging survival time of sea branch bacterial plaque horse fish model |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1194752C (en) * | 2003-07-01 | 2005-03-30 | 河北以岭医药研究院有限公司 | Anti-virus Chinese medicine composition and preparation process thereof |
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2008
- 2008-04-24 CN CN200810104909.6A patent/CN101564458B/en active Active
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| Title |
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| 易爱纯 等: "《新特药评介手册II》", 31 January 2006, 中南大学出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370783A (en) * | 2010-08-19 | 2012-03-14 | 北京以岭药业有限公司 | Application of traditional Chinese drug composition in preparation of drugs for treating lung injury caused by smoking |
| CN102406748A (en) * | 2011-11-22 | 2012-04-11 | 荣成市交通诊所 | Traditional Chinese medicine composition for treating infantile bronchitis |
| CN102406748B (en) * | 2011-11-22 | 2013-05-22 | 李燕 | Chinese medicinal composition for treating child bronchitis |
| CN103536828A (en) * | 2013-10-11 | 2014-01-29 | 陈英娣 | Traditional Chinese medicine for treating bronchiectasia |
| CN103536828B (en) * | 2013-10-11 | 2016-06-22 | 朱育盼 | One treats bronchiectasic Chinese medicine |
| CN103520460A (en) * | 2013-10-25 | 2014-01-22 | 刘雁 | Traditional Chinese medicine for treating chronic bronchitis |
| CN104920743A (en) * | 2015-07-20 | 2015-09-23 | 青海省通天河藏药制药有限责任公司 | Preparation method for anti-fatigue substitutional tea |
| CN111066700A (en) * | 2020-01-19 | 2020-04-28 | 西藏民族大学 | Application of salidroside in combination with isoniazid in prolonging survival time of sea branch bacterial plaque horse fish model |
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| CN101564458B (en) | 2014-01-29 |
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Address after: 102600, Daxing District Zhongguancun science and Technology Industrial Park, Daxing pharmaceutical industry base, Tian Fu Street, No. 17, Beijing Applicant after: Beijing Yiling Pharmaceutical Co., Ltd. Address before: 102600 Beijing Huang Cun town, Beijing biological engineering and pharmaceutical industry base, Tianhe West Road, No. 19, Daxing District Applicant before: Beijing Yiling Pharmaceutical Co., Ltd. |
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