CN101138622A

CN101138622A - Prescription of mouth ulcer bilayer film and technique of preparing the same

Info

Publication number: CN101138622A
Application number: CNA2007100148403A
Authority: CN
Inventors: 程令梅; 马春亮; 郭瑞宝; 李德民; 张曙光
Original assignee: JINAN THIRD HOSPITAL
Current assignee: JINAN THIRD HOSPITAL
Priority date: 2007-08-24
Filing date: 2007-08-24
Publication date: 2008-03-12
Anticipated expiration: 2027-08-24
Also published as: CN100571760C

Abstract

The present invention pertains to the art of Chinese medicine, in particular to a recipe of an oral ulcer bilayer formulation and a preparation process. The formulation of the present invention includes the following ingredients in share by weight: 25-40 percents of coptis root, 15-25 percents of liquorice, 12-20 percents of radix notoginseng, 12-20 percents of villous amomum fruit, 0.15-0.20 percents of borneol and 8-15 percents of mint. The preparation process is that the villous amomum fruit and mint are extracted to get a naphtha; the residues, coptis root and liquorice are decocted with water; the radix notoginseng is extracted in an alcohol; all the extracted is merged with borneol, mint oil and PVA added, which is made into a single-layer membrane; then an ethyl cellulose is added to form a bilayer. The present invention has the advantages of nourishing yin and lowering fire, invigorating blood circulation and eliminating stasis, promoting granulation and relieving pain, safety and reliability, convenient use and high curative effect, which can be widely promoted and applied.

Description

The prescription of mouth ulcer bilayer film and preparation technology

Technical field

The invention belongs to tcm field, particularly a kind of mouth ulcer bilayer film prescription and preparation technology.

Background technology

Recurrent oral ulceration is one of modal disease in the oral mucosal disease, occupies the oral mucosal disease first place.Because primary disease decreases and occurs in the oral cavity, and has the characteristics of cyclic recurrence, bring very big influence for patient's physical and mental health, have a strong impact on patient's quality of life.At present treatment recurrent oral ulceration doctor trained in Western medicine is mainly used immunosuppressant, immunostimulant, and gonadal hormone, vitamin and part are burnt etc., and side effect is big, and curative effect is also owed Cui, and the anti-recurrence effect is poor.

Summary of the invention

The present invention seeks to be directly used in the affected part, oral cavity according to China's a kind of Chinese herbal medicine that utilizes of traditional medical theory development, good effect, the prescription of the mouth ulcer bilayer film that has no side effect and preparation technology, prescription of the present invention is: this mouth ulcer bilayer film contains Rhizoma Coptidis 25～40%, Radix Glycyrrhizae 15～25%, Radix Notoginseng 12～20%, Fructus Amomi 12～20%, Borneolum Syntheticum 0.15～0.20% and Herba Menthae 8～15% by weight percentage.

Preparation technology is: Fructus Amomi, Herba Menthae are extracted volatile oil, and residue and Rhizoma Coptidis, Radix Glycyrrhizae water decoct, and Radix Notoginseng is used pure lixiviate, and extract obtained merging adds the volatile oil that Borneolum Syntheticum extracts, and PVA makes monofilm, adds ethyl cellulose again and makes duplicature.

The present invention has nourishing YIN to lower pathogenic fire, blood circulation promoting and blood stasis dispelling, granulation promoting analgesic effect, and safe and reliable, and it is convenient to use, and the advantage that curative effect is high can be applicable

The specific embodiment

Prescription of the present invention is: this duplicature contains Rhizoma Coptidis 25～40%, Radix Glycyrrhizae 15～25%, Radix Notoginseng 12～20%, Fructus Amomi 12～20%, Borneolum Syntheticum 0.15～0.20% and Herba Menthae 8～15% by weight percentage.

Preparation technology of the present invention is:

A, Fructus Amomi 12～20%, Herba Menthae 8～15% that will be by weight percentage extracted volatile oil with steam distillation together, collect the volatile oil that extracts, and sealing is preserved, and is standby.

B, Fructus Amomi, Herba Menthae are extracted residue behind the volatile oil with after by weight percentage Rhizoma Coptidis 25～40%, Radix Glycyrrhizae 15～25% mixes, put in the container, add the water of 5 times of amounts, soaked 1 hour, decocted 1 hour, collect decocting liquid, the water that residue adds 5 times of amounts decocted 1 hour again, and filtered through gauze merges 2 times decocting liquid, filtrate concentrates, add 2-3 and doubly measure 85% ethanol, left standstill 24 hours, double gauze filters precipitation, filtrate is put and is reclaimed ethanol in the retracting device, filtrate is concentrated into thick extractum, and 60 degree are dry, pulverize, make powder, standby.

C, the Radix Notoginseng 12～20% of inciting somebody to action by weight percentage are ground into coarse powder, insert in the flask, add 3-5 and doubly measure 75% soak with ethanol, reflux, extract, 2-3 time, each 1 hour, double gauze filtered, and merges 2 times filtrate, filtrate is put and is reclaimed ethanol in the retracting device, filtrate is concentrated into thick extractum, and 60 degree are dry, pulverize, make powder, standby.

D, the ratio of pressing column weight amount percentage ratio prepare membrane: polyvinyl alcohol 70-75%, the mixed dust formulation of the powder of b, c step preparation are the volatile oil 1% that makes in 20%, a step, glycerol 2-5%, tween 80 1-2%.Get polyvinyl alcohol and soak, heat in the water-bath, make dissolving, gauze filters, and makes serosity.Get the volatile oil that a step makes, add glycerol, tween 80 grinds all, adds in the serosity, stirs evenly, and slowly adds the mixed dust formulation of the powder of b, c step preparation, stirs and makes dissolving.Add the Borneolum Syntheticum 0.15～0.20% of inciting somebody to action by weight percentage again, stir evenly, make into uniform serosity, place certain hour, remove bubble.The medicine serosity that makes is inserted on the film applicator, paint thickness and evenly be the thick coating of 2-3mm, through the hot air drying of 80-100 degree, film forming is made the medicine film rapidly.

E, get ethyl cellulose, slowly add in the entry, swelling makes into uniform serosity.To starch

Liquid is inserted on the film applicator, goes on foot coating one deck ethyl cellulose film on the pharmaceutical film of making at d, through the hot air drying of 80-100 degree, forms duplicature.

F, duplicature is divided into the square sheet of 10mm * 10mm size, every is equivalent to contain crude drug 0.03g, every bag of a slice packaging seal.

Among this side, Rhizoma Coptidis heat-clearing and toxic substances removing, pathogenic fire purging pain relieving are with being monarch drug.The pseudo-ginseng blood-circulation-invigovating subduing swelling and relieving pain; Radix Glycyrrhizae gives birth to air making-up and spleen enlivening, heat-clearing and toxic substances removing, and two medicines are shared to be minister.Fructus Amomi removes throat ability to speak superficial heat, and anti-simultaneously Rhizoma Coptidis bitter cold injures one's stomach; The Borneolum Syntheticum subduing swelling and relieving pain; Mint smell is gently clear, and Xin Liang leads off, and three medicines are adjuvant drug altogether.The double property of medicine double as messenger drug that is in harmonious proportion of Radix Glycyrrhizae.Full side's Six-element gathers the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling altogether.

Effect cures mainly: nourishing YIN to lower pathogenic fire, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.Be used for recurrent oral ulceration, oral ulcer is shown effect repeatedly, local swelling, pain unbearably, xerostomia is desire drink not, oliguria with reddish urine, the few tongue of red tongue, thready and rapid pulse.

The consumption usage: external, paste the affected part, day 3-5 time.

Model case

Example one, Zhao XX, woman, 36 years old, teacher, first visit date: on August 9th, 2005.Oral ulcer is shown effect year surplus in the of ten repeatedly.Bring out when tired or nervous whenever, ulcer continues healing in about ten days more, and warp before increases the weight of, and dark through color, clot is many, the red tongue with yellow fur thready and rapid pulse.Give mouth ulcer bilayer film and paste the affected part, day 5 times, pain obviously alleviates after one day, has not influenced feed.Ulcer healing after three days.

Example two, Korea Spro X, man, 53 years old, peasant, the oral ulcer more than two decades that shows effect repeatedly.The first visit date: on August 4th, 2004.Ulcer previously outbreak in January once heals about a week, this ulcer outbreak two days, and taking medicine certainly, thing is invalid examines.Now feel ulcer pain unbearably, influence feed sleep.Give the mouth ulcer bilayer film external, day 5 times, pain alleviates gradually behind the medicine, ulcer healing after three days.

Example three, poplar X, woman, 19 years old, student, first visit date: on June 20th, 2005.Oral ulcer medical history 3 years.This ulcer outbreak one day, pain influence feed is had a medical check-up and is seen that the lip of the tongue has one 0.8cm * 0.5cm ulcer, gives the mouth ulcer bilayer film external, pain relief two days later, ulcer heals gradually.

Claims

1. the prescription of a mouth ulcer bilayer film is characterized in that it being that this duplicature contains Rhizoma Coptidis 25～40%, Radix Glycyrrhizae 15～25%, Radix Notoginseng 12～20%, Fructus Amomi 12～20%, Borneolum Syntheticum 0.15～0.20% and Herba Menthae 8～15% by weight percentage.

2. the method for preparing the described mouth ulcer bilayer film of claim 1 is characterized in that it being to make by the following method:

E, get ethyl cellulose, slowly add in the entry, swelling makes into uniform serosity.Serosity is inserted on the film applicator, go on foot at d and be coated with the hot air drying of one deck ethyl cellulose film on the pharmaceutical film of making, form duplicature through the 80-100 degree.

3. preparation method according to claim 2 is characterized in that it being the square sheet that duplicature is divided into 10mm * 10mm size, and every is equivalent to contain crude drug 0.03g, every bag of a slice packaging seal.