CN100402074C - A Chinese medicinal ointment for promoting wound healing after anal fistula operation and preparation method thereof - Google Patents
A Chinese medicinal ointment for promoting wound healing after anal fistula operation and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a traditional Chinese medicine ointment for promoting wound healing after hemorrhoids and fistula operations and a preparation method thereof. The traditional Chinese medicine ointment is prepared by reasonably proportioning and scientifically processing keel, calamine, calcined gypsum, succinum, cuttlefish bone, stir-fried fankincense, prepared myrrh, calamitas urinae hominis, tendrilleaf fritillary bulb, pearl, natural indigo, calculus bovis, artificial bezoar, calomelas, dragon blood and borneol. The traditional Chinese medicine ointment for promoting wound healing after hemorrhoids and fistula operations can be matched with operation radical treatment for use, and can quickly heal operation wound surfaces from the aspects of microcirculation improvement, wound surface venous return separation promotion, phagotrophy system start, foreign matter elimination, infection control, blood flow motive power improvement, thrombosis resistance, the increase of the effective concentration of partial growth factors on wound surfaces, the acceleration of collagenous fiber synthesis and cell proliferation at wound surface points, the acceleration of recombination of collagenous fiber and cells on wound surfaces, etc. The ointment has significant application effect, and can be broadly used for patients after hemorrhoids and fistula operations.
Description
Technical field
The invention belongs to a kind of Chinese medicine unguentum, particularly a kind of Chinese medicine unguentum that promotes wound healing after anal fistula operation and preparation method thereof.
Background technology
Hemorrhoid complicated by anal fistula is a kind of commonly encountered diseases that influences human health, and sickness rate is high, and in normal population, total incidence accounts for 87%, and its source of disease is many because of liver, stomach damp invasion of lower energizer, causes the large intestine anal regions that noxious dampness foul smell is arranged, formation focus of a specified duration.The influence of the external pressure when being stressed during constipation or sitting quietly for a long time can further worsen or split, and causes hemorrhagely, even causes to infect and develops complications exacerbated.Treatment for hemorrhoid complicated by anal fistula has several different methods, as operation, washout, clothes for oral administration, outer, electrotherapy etc.Take western medicine, general curative effect is slower, can not effect a radical cure; The general curative effect of operative treatment is very fast, but all there is the tendency of certain delayed healing and disunion in postoperative wound surface.Adopt at present the prescription of traditional Chinese medicine composition for treating also more, if any be the Chinese medicine of main component preparation with Moschus, Semen Strychni, this kind Chinese medicine all can not be taken hyperpietic and anemia of pregnant woman; What also have is primary raw material with Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae, Radix Sanguisorbae, Borneolum Syntheticum, makes ointment, and perfusion is used to affected area, though this medicine has curative effect preferably, can not combine with operative treatment, is used for wound healing promoting, therefore, cures still slower.
Summary of the invention
The object of the present invention is to provide a kind of can combining with operative treatment, and can infection, consumer edema, the sepage of minimizing wound tissue, promote wound healing, not only have the fast effect of curative effect, but also have the Chinese medicine unguentum of the promotion wound healing after anal fistula operation of radical cure effect.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine unguentum of aforesaid promotion wound healing after anal fistula operation.
For reaching above purpose; the technical solution adopted in the present invention is: the Chinese medicine unguentum of this promotion wound healing after anal fistula operation; it is characterized in that it is made by the following weight parts Chinese medicinal raw materials: Os Draconis 220-260g; Calamina 90-110g, Gypsum Fibrosum Preparatum 110-134g, succinum 20-40g; Endoconcha Sepiae 110-136g; Olibanum (processed) 30-60g, Myrrha (processed) 30-60g, calamitas urinae hominis 60-80g; Bulbus Fritillariae Cirrhosae 20-30g; Margarita 2-6g, Indigo Naturalis 70-80g, Calculus Bovis 2-6g; artificial Calculus Bovis 6-10g; Calomelas 38-60g, Sanguis Draxonis 40-60g, Borneolum Syntheticum 9-11g.
This promotes the Chinese medicine unguentum of wound healing after anal fistula operation, and the weight portion proportioning of its raw material of Chinese medicine is: Os Draconis 243g, Calamina 97g; Gypsum Fibrosum Preparatum 121g, succinum 29g, Endoconcha Sepiae 122g; Olibanum (processed) 48g, Myrrha (processed) 48g, calamitas urinae hominis 73g; Bulbus Fritillariae Cirrhosae 24g, Margarita 4g, Indigo Naturalis 73g; Calculus Bovis 4g, artificial Calculus Bovis 8g, Calomelas 48g; Sanguis Draxonis 48g, Borneolum Syntheticum 10g.
The preparation method of the Chinese medicine unguentum of aforesaid promotion wound healing after anal fistula operation, its production stage is:
(1), earlier with Os Draconis, Calamina, Gypsum Fibrosum, Margarita, Olibanum, Myrrha respectively by 2002 version " Shandong Province's Chinese medicine processing standard " concoct;
(2), in above cooperation ratio weighing Os Draconis 220-260g, Calamina 90-110g, Gypsum Fibrosum Preparatum 110-140g, succinum 20-40g, Endoconcha Sepiae 110-136g, Olibanum (processed) 30-60g, Myrrha (processed) 30-60g, calamitas urinae hominis 60-80g, Bulbus Fritillariae Cirrhosae 20-30g, Margarita 2-6g, Indigo Naturalis 70-80g, Calculus Bovis 2-6g, artificial Calculus Bovis 6-10g, Calomelas 38-60g, Sanguis Draxonis 40-60g, Borneolum Syntheticum 9-11g, and divide into groups, with Os Draconis, Calamina, Gypsum Fibrosum Preparatum, succinum, Endoconcha Sepiae, Olibanum (processed), Myrrha (processed), the calamitas urinae hominis, Bulbus Fritillariae Cirrhosae, Margarita is as first group of medicine, with Indigo Naturalis, Calculus Bovis, the artificial Calculus Bovis is standby as second group of medicine, with Calomelas, Sanguis Draxonis, the independent weighing of Borneolum Syntheticum is good standby as the 3rd group of medicine;
(3), earlier load weighted first group of medicine dried, pulverizes, crosses the 100-120 mesh sieve, is mixed into first group of medicament mixed powder; Load weighted second group of medicine by the ground and mixed method, put in the mortar, mixed while grinding, cross the 100-120 mesh sieve, mixing becomes second group of medicament mixed powder; Adopt the bottoming chromatography to mix earlier to first group of medicament mixed powder and second group of medicament mixed powder, adopt the equivalent incremental method to mix again, till first group of medicament mixed powder added, after the 100-120 mesh sieve, mixing was repeatedly won, two groups of medicament mixed powder; Calomelas, Sanguis Draxonis, Borneolum Syntheticum list ground 100 mesh sieves, became the 3rd group of medicine powder, because of the 3rd group of medicine is volatile medicine, so single bag is standby;
(4), take by weighing white vaseline 8000g, lanoline 1000g, dimethyl sulfoxide 10g, as substrate, substrate is put in the evaporating dish, heating in water bath dissolves, in the time of in keeping 65-75 ℃ of scope of temperature, constantly stir on one side, produce more than slowly adding on one side first, two groups of medicament mixed powder, when temperature rises to 100 ℃, kept 15-20 minute, stop the heating cooling, when temperature is reduced to 30 ℃-40 ℃, again with the Calomelas in volatile the 3rd group of medicine powder, Sanguis Draxonis powder, Borneolum Syntheticum powder slowly adds respectively, stirring to make this Chinese medicine unguentum, but last packing.
The pharmacology of this Chinese medicine unguentum is:
Os Draconis are the skeleton fossil of mammals in ancient times (as Hippocampal cortex, rhinoceros class, deer class, bovine, resemble class etc.).Remove silt impurity, store in dry place, the time spent smashes, give birth to or forge usefulness.Meridian distribution of property and flavor, sweet, puckery, be slightly cold GUIXIN, Liver Channel.Have suppressing the hyperactive liver and subsiding YANG, tranquillizing and allaying excitement, the astringent or styptic treatment for spontaneous sweating effect of convergence, forge Os Draconis and grind external into powder, have moisture absorption to hold back the skin ulcer effect.
Calamina is a carbonate mineral calcite family smithsonite, the main zinc carbonate (ZnCo that contains
3).Excavate afterwash, dry, remove roguing stone.This medicine body is light, frangible, feeble QI, and it is little puckery to distinguish the flavor of.Nature and flavor with return through: sweet, put down, return the stomach warp.Has the detoxifcation improving acuity of vision and removing nebula, the antipruritic effect of holding back skin ulcer of removing dampness.Be used for that conjunctival congestion and swelling pain, marginal blepharitis, nebula film bulbar conjunctiva polyp, ulcer being unable to heal, dense water are dripping, eczema, skin pruritus.Other has data to show: Calamina has certain bacteriostasis, and health tissues and newborn epithelial tissue are had protective effect, can make the inflammation limitation after the medication very soon; and can impel the granulation of outstanding wound surface and slough to liquefy; make the wound surface cleaning smooth, be easy to repair, receive the effect that rotten flesh is to the greatest extent given birth to.Calamina in this Chinese medicine unguentum has the convergence secretion inhibitor or partially absorbs the effect of wound surface juice, minimizing suppuration, protection wound surface.
Gypsum Fibrosum Preparatum is a Sulfates mineral anhydrite family Gypsum Fibrosum, main hydrous calcium sulfate (CaSo
42H2.), after excavating, remove silt and assorted stone.This medicine is sweet, hot, Great Cold, attach to the lung and stomach meridians.Has the effect that clearing away heat-fire, relieving restlessness quench the thirst.Be mainly used in fever caused by exogenous pathogenic factors, hyperpyrexia excessive thirst, dyspnea and cough due to lung-heat, stomach a heatable brick bed Sheng, headache toothache.Gypsum Fibrosum Preparatum can be restrained mucosa and be reduced secretion, is used for skin infection and festers and do not hold back, and eczema is invaded excessive and burn due to hot liquid or fire etc.
Succinum for ancient times pinaceae plant bury in underground the fossil sample material that condenses for a long time year in year out and be transformed.Sweet, flat, GUIXIN, liver, urinary bladder channel.Effect with tranquillizing the mind by relieving convulsion, blood circulation promoting and blood stasis dispelling.Be mainly used in malaise, infantile convulsion, demented, epilepsy, stranguria with blood, stranguria caused by urinary stone pyretic stranguria.Especially be suitable for illness such as the treatment skin ulcer swells and ache bitterly, scrofula disease, goiter, incised wound wound.
Endoconcha Sepiae is the then dry inner shell of section animal sepiella maindroni de Rochebrune sepiella maind roni deRochebrune or golden cuttlefish sepia esculenta Hoyle of mullet.One-tenth, puckery, warm.Return spleen, kidney channel.Has the effect that astringing to arrest bleeding, relieving leukorrhea by astringents, antacid are held back skin ulcer.Be mainly used in Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, the metrorrhagia seminal emission acid regurgitation of having blood in stool, have a stomachache of having blood in stool; The external treatment bleeding due to trauma, the many pus of skin ulcer.Heal, change gastric content pH value, reduction pepsin activity, promotion union of fracture, shortening healing time, promotion fibrocyte and osteoblast hypertrophy and ossify with gastric acid, promotion ulcer surface in the energy.
Olibanum (processed) be Burseraceae dungarunga Boswellia carterii Birdw and belong to together, resin system that plant skin zone oozes out uses.Hot, bitter, warm.Return liver, the heart, spleen channel.Effect with promoting blood circulation and stopping pain, lock pain, detumescence and promoting granulation.Be usually used under all pains of stagnation of blood stasis (as trusted subordinate's stasis of blood pain, dysmenorrhea and traumatic injury, diseases such as carbuncle pain and rheumatic arthralgia), skin infection is not regained after bursting for a long time, can promote multinuclear leucocyte to increase behind the oral Olibanum (processed), to engulf dead hemocyte, improve metabolism, thereby antiinflammation is arranged, and can be used to anticorrosion and the elimination halitosis, quicken inflammation and ooze out drainage, absorption, promote wound healing.
Myrrha (processed) be Burseraceae shrub or arbor not loblolly tree or other congener skin zones oleo-gum-resin system of oozing out use.This medicine suffering, hardship, flat.GUIXIN, liver, spleen channel.Effect with promoting blood circulation and stopping pain, detumescence and promoting granulation.Be mainly used in control traumatic injury be retarded by silt swell and ache, surgery carbuncle and painful swelling, skin infection do not close up after bursting for a long time, and all pains of all stasis trusted subordinates.Pharmacological evaluation shows, various pathogens is had in various degree inhibitory action; And prevent that speckle from forming.
The calamitas urinae hominis: salty, flat, nontoxic, can removing fire from the liver, three warmers fight bladder fire, pathogenic fire reducing, main effect is that disappear congestion, heat-clearing and toxic substances removing, erosion prevention and muscle growing, hemostasis is treated aphtha, throat, ability to speak and given birth to skin ulcer, cures mainly thrush, suppurative tonsillitis, oral ulcer etc.
Bulbus Fritillariae Cirrhosae is liliaceous plant Bulbus Fritillariae Cirrhosae Fritiuaria cirrhosa D.Don, dark violet Bulbus Fritillariae Uninbracteatae Fritillaria unibrac teataHsiao etk, c.Hsia, Gansu Bulbus Fritillariae Uninbracteatae FritillariaPrzewalskii Maxim, or the dry squama base of Bulbus Fritillariae cirrhosae Fritillaria delavayi Fianch.Former three is practised title " loose shellfish " and " blue or green shellfish " respectively by the character difference, and the latter practises title " lubei ".Adopt control when summer, Qiu Erji or snow melting, remove fibrous root, rough bark and silt dry or cold drying.This medicine hardship, sweet, be slightly cold.Return lung, heart channel.Effect with clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be mainly used in lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Bulbus Fritillariae Cirrhosae fluidextract, fritimine all have phlegm-dispelling functions in various degree; Bulbus Fritillariae Uninbracteatae total alkali and non-alkaloid part all have antitussive effect; The Bulbus Fritillariae Uninbracteatae total alkali still has antiulcer action.Fritimine has hypotensive effect; Imperialine also can spasmolytic; Experiment in vitro shows that Bulbus Fritillariae Cirrhosae has the effect that suppresses escherichia coli and Staphylococcus aureus.
Margarita is the Margarita that pearl shell animal Pteria martensii Dunker Pteria martensii (Dunker) Unionidae animal hydriopsis cumingii Hyriopsis cumingii (lea) or cristaria plicata Cristaria plicata bivalve irriates such as (leach) form.In animal body, take out cleaning, drying.This medicine is sweet, salty, cold.GUIXIN, Liver Channel.Effect with the arresting convulsion of calming the nerves, the removing nebula that makes eye bright, removing toxic substances and promoting granulation is mainly used in palpitation with fear insomnia, infantile convulsion epilepsy, order life nebula, skin infection is not held back.Had a guilty conscience heat, then manner is floating more; High heat-phlegm fan, the then frightened fault of mind; Deficiency of the liver has heat, and then order is given birth to cataracta.The heat of separating two warps is promptly arranged, can grow the moon of two warps again, and tranquilizing by nourishing the heart is arranged, the merit of relieving convulsion bob expectorant, the removing nebula that makes eye bright is so the disease two of deficiency of YIN excess of YIN gets its usefulness.Be used for the swollen ulcer drug ulcer being unable to heal, the energy removing toxic substances and promoting granulation that applies closes up.Oral administration and externally is attacked to imitate and is developed simultaneously.
Indigo Naturalis is dried powder or the agglomerate that the base of leaf leaf of acanthaceous vegetable acanthaceous indigo Baphica canthus cusia (Nees) Bremek. polygonaceae plant polygonum tinctorium ait. Polygonum tinctorium Ai or cruciferae isatis Isatisind igoticg Fort gets through value processing.This medicine is navy blue powder, and body gently, easily fly upward; Or be irregular porous agglomerate, with hand rubbing twist with the fingers smalls.Little have careless fishy smell, lightly seasoned.Salty, tremble with fear, return Liver Channel.Effect with heat-clearing and toxic substances removing, removing heat from blood arresting convulsion.Be mainly used in that noxious dampness is sent out speckle, heat in blood is told nosebleed, chest pain hemoptysis, skin ulcer, mumps, sore throat, pediatric epilepsy scared; Be usually used in eczema, eczema, dispute throat ulcer again.Other have data show the immersion of Indigo Naturalis ethanol external to anthrax bacillus, pneumobacillus, dysentery bacterium, comma bacillus, gold-coloured staphylococci and Staphylococcus albus etc., inhibitory action is all arranged.
Calculus Bovis is the exsiccant cholelithiasis of bovid cattle Bog tqurus domesticus Gmelin, when slaughtering an ox, as finding that Calculus Bovis is arranged, being elimination bile, with middle yellow the taking-up, removes outside thin film, dries in the shade.This medicine is sweet, cool.GUIXIN, Liver Channel.Have clear away heart-fire, eliminating phlegm, have one's ideas straightened out, the effect of cool liver, endogenous wind stopping, detoxifcation.Be mainly used in calentura coma, middle wind-phlegm fan, frightenedly not busyly twitch, epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.This medicine contains bile acid, cholochrome, bilirubin, cholesterol, biliverdin, vitamin D and several amino acids; Also contain sodium, calcium, magnesium, ferrum, copper, phosphorus and carotene and mucin, fatty acid and peptide constituents.There is the artificial Calculus Bovis the present, is to extract processing and manufacturing and form through artificial from Fel Bovis seu Bubali or Fel Sus domestica, and its performance, effect are similar to natural Calculus Bovis, and are widely adopted, but the too late natural Calculus Bovis of power; Be used for pyretic toxicity diseases such as laryngopharynx swelling and pain, carbuncle sore tumefacting virus more.Epidemic febrile disease, hyperpyrexia, coma, tiqueur still are advisable with natural Calculus Bovis.
Calomelas is white glossiness flakey or flakes crystalline powder.Odorless, almost tasteless, meet slowly deepening of light color.Hot, cold, poisonous, return large intestine, small intestine meridian.But external parasite killing, counteracting toxic substances, hold back skin ulcer; The removing food stagnancy that can eliminate the phlegm for oral administration, the outer is used for scabies, stubborn dermatitis, ecthyma, syphilis, skin infection, eczema, so be suitable for pruritus especially, create infections and festers, dermatosis such as have an itch that pus is dripping.
Sanguis Draxonis is that the resin that oozes out of babassu Sanguis Draxonis Daemonor ops draco Bl fruit is through being processed into.Levigation is brick-red, feeble QI, lightly seasoned, and is insoluble in water, softening in hot water.Nature and flavor with return through: sweet, salty, flat, GUIXIN, Liver Channel.Effect with removing blood stasis and relieving pain, hemopoietic granulation promoting.1. be used for traumatic hemorrhage, ulcer being unable to heal, external has hemostasia and promoting granulation to hold back the effect of skin ulcer.2. be used for traumatic injury, swelling and pain due to blood stasis, the eliminating stasis to stop pain effect is arranged.
Borneolum Syntheticum is the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or the trunk of Borneolum Syntheticum claims " borneol " through distilling the crystallization of cooling off and getting.This medicine suffering, hardship, be slightly cold.GUIXIN, spleen, lung meridian have the effect of the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be mainly used in that calentura coma, convulsion are fainted, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.Contain in the borneol and revolve Borneolum Syntheticum, Diterpenes composition such as doubly rich ter penoids such as Humuleno, B one elemene, caryophyllene and oleanolic acid, alphitolic acid, asiatic acid, dryobalanone, erythrodiol.Synthetic borneol mainly contains Borneolum Syntheticum, isoborneol, Camphora etc.Natural Broneolum Syntheticum and synthetic borneol all have bacteriostasis, and have the division and the growth that promote neurogliocyte to use; Sensory nerve there is slight stimulation and pain relieving; Gentle antisepsis is still arranged.Experiment in vitro has the hog cholera of inhibition bacterium, escherichia coli, the effect of staphylococcus aureus growth.This medicine has putrefaction-removing granulation-promoting, easing pain and diminishing inflammation, bactericidal haemostatic, putrefaction removing and holds back the skin ulcer effect, is applicable to ulcer or the postoperative wound surface person of not holding back.
Sanguis Draxonis in this Chinese medicine unguentum side and blood close up, Olibanum (processed), Myrrha (processed) promoting blood circulation and stopping pain, and detumescence and promoting granulation, Os Draconis granulation promoting removing dampness, Calomelas are longer than and are attacked sore, and removing dampness is held back skin ulcer, killing parasites for relieving itching, Gypsum Fibrosum Preparatum convergence mucosa reduces secretion.The Endoconcha Sepiae astringing to arrest bleeding is held back the skin ulcer evacuation of pus.Indigo Naturalis, Calculus Bovis, Margarita, Borneolum Syntheticum are with having heat-clearing and toxic substances removing, the merit of mass dissipating and swelling eliminating.All medicines share, and have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dissipate with short, the heat clearing away poison holding, to promote the evacuation of pus of skin infection ulceration, putrefaction removing is held back skin ulcer, the effect of granulation promoting.
The Chinese medicine unguentum that adopts this promotion wound healing after anal fistula operation did on one's body that xylol causes that mice auricle swelling influence, on Carrageenan cause rat toes swelling influence and to the test of mice hot plate analgesia influence mice, and the Chinese medicine unguentum xylol that proves this promotion wound healing after anal fistula operation causes mice auricle swelling the obvious suppression effect; The rat toes rate that swells and ache obviously reduces; The stomachache that Dichlorodiphenyl Acetate causes has the obvious suppression effect, and the mouse writhing number of times obviously reduces, and in the test, does not find that wound surface has stimulation, does not see that anaphylaxis takes place.In bacteriostatic test, by resistant activity test to 7 strains, 123 strain bacterium, the sensitivity of having observed antimicrobial spectrum, bacterial strain distributes, minimal inhibitory concentration, the result shows: this promotes that the Chinese medicine unguentum antimicrobial spectrum of hemorrhoid complicated by anal fistula art wound healing is more extensive, staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, bacillus pyocyaneus, Fructus Lycii acidfast bacilli, Bacillus proteus, Salmonella, escherichia coli, dysentery bacterium, enterococcus there are inhibitory action in various degree, especially staphylococcus aureus are suppressed obviously.
The using method of the Chinese medicine unguentum of this promotion wound healing after anal fistula operation is: at first to the hemorrhoid complicated by anal fistula treatment that undergos surgery, second day after operation greatly after an action of the bowels, earlier with after the demibain of compound recipe cyanines mustard fumigation and washing agent, reuse should promote the Chinese medicine unguentum external application surgical wound surface of wound healing after anal fistula operation, press the external application of wound surface size, till applying full whole wound surface, the gauze wrapping, immobilization with adhesive tape, once, do not defecate after defecating in general one day, change once after demibain every day yet, one day 2 times stool is changed 2 times, changes dressings at last to surgical wound surface and all heals.
Adopt Chinese medicine unguentum clinical treatment 166 examples of this promotion wound healing after anal fistula operation, wherein male 79 examples, women 87 examples; Age 12-70 year; The course of disease 1 thoughtful 30 years.Ring-shaped mixed hemorrhoids 20 examples, high anal fistula 30 examples, low level complexity anal fistula 50 examples, anal fissure companion connective tissue external hemorrhoid 26 examples, perianal abscess is once cut radical cure 40 examples.Other has 150 examples to compare, and its sex, age, the course of disease, sick kind and postoperative wound surface size have comparability with observation group.
Find out from the treatment comparing result: the treatment group natural law that on average heals is 15.2 days, on average heal natural law 21.0 days of matched group, wherein: ring-type is mixed Zhi 20 examples in the treatment group, healing time is 12～17 days, average out to 14 days, and 20 15～21 days routine ring-shaped mixed hemorrhoids wound healing times in the matched group, average 17 days, the treatment group on average healed 3 days in advance than matched group; High anal fistula 30 examples in the treatment group, healing time is 20～31 days, average out to 24 days, and high anal fistula 28 examples in the matched group, healing time is 25-40 days, average 32 days, the treatment group was than matched group healing in 8 days in advance; Low level complexity anal fistula 50 examples in the treatment group, healing time is 16～21 days, average 19 days, and matched group 48 examples, healing time is 18-23 days, average out to 22 days, and the treatment group shifts to an earlier date 3 days than matched group; Anal fissure in the treatment group is mixed connective tissue external hemorrhoid 26 examples, and healing time is 11～14 days, and average 12 days, and 20 routine healing times are 14-17 days in the matched group, average 16 days, the treatment group was than matched group healing in 4 days in advance; Perianal abscess in the treatment group is once cut radical cure 40 examples, and healing time is 12-42 days, and average 19 days, and 34 routine healing times in the matched group are 20～52 days, average 27 days, the treatment group on average shifted to an earlier date 8 days than matched group.
The continuous days comparison sheet in treatment group and matched group wound healing each stage of process
The wound healing evaluation criteria:
Wound healing is pressed four-stage: 1. blood coagulation, prevent that blood further runs off, and guarantee the mechanical strength at wound place; 2. inflammatory reaction is that wound separates with venous return, starts the system of engulfing and eliminates foreign body, control infection; 3. granulation tissue forms, and comprises the propagation of the synthetic and cell of collagen at the wound place; 4. reorganization comprises reconfiguring of collagen fiber and cell, to improve maximum mechanical strength.Any one link of this four-stage is affected, and all may prolong the wound healing time.
Beneficial effect of the present invention is: can be used with surgical radical treatment, and can from microcirculation improvement, promote the wound surface venous return separately, starting engulfs system, eliminates foreign body, control infection, improves hemodynamic, antithrombotic forms, increase the wound surface local growth factor valid density, quicken the synthetic and cell of collagen fiber in the propagation of wound surface, quicken aspect such as reconfiguring of wound surface collagen fiber and cell and start with, cause the surgical wound surface quickly-healing, effect is obvious.
Embodiment
Embodiment 1
Take by weighing raw material of Chinese medicine by following weight portion proportioning: Os Draconis 243g, Calamina 97g, Gypsum Fibrosum Preparatum 121g, succinum 29g, Endoconcha Sepiae 122g, Olibanum (processed) 48g; Myrrha (processed) 48g, calamitas urinae hominis 73g, Bulbus Fritillariae Cirrhosae 24g, Margarita 4g, Indigo Naturalis 73g; Calculus Bovis 4g, artificial Calculus Bovis 8g, Calomelas 48g, Sanguis Draxonis 48g, Borneolum Syntheticum 10g.
Load weighted above raw material of Chinese medicine is made the Chinese medicine unguentum that promotes the post-operative hemorrhoids and anal fistula healing by following production stage:
(1) at first with Os Draconis, Calamina, Gypsum Fibrosum, Margarita, Olibanum, Myrrha respectively by 2002 version " Shandong Province's Chinese medicine processing standard " concoct;
(2) with above load weighted Os Draconis, Calamina, Gypsum Fibrosum Preparatum, succinum, Endoconcha Sepiae, Olibanum (processed), Myrrha (processed), calamitas urinae hominis, Bulbus Fritillariae Cirrhosae, Margarita as first group of medicine, above load weighted Indigo Naturalis, Calculus Bovis, artificial Calculus Bovis is standby as second group of medicine, above load weighted Calomelas, Sanguis Draxonis, the independent weighing of Borneolum Syntheticum is good standby as the 3rd group of medicine;
(3), earlier load weighted first group of medicine dried, pulverizes, crosses 110 mesh sieves, is mixed into first group of medicament mixed powder; Load weighted second group of medicine by the ground and mixed method, put in the mortar, mixed while grinding, cross 110 mesh sieves, mixing becomes second group of medicament mixed powder; To first group of medicament mixed powder and second group of medicament mixed powder, adopt earlier the bottoming chromatography to mix, adopt the equivalent incremental method to mix again, till first group of medicament mixed powder added, after 100 mesh sieves, mixing was repeatedly won, two groups of medicament mixed powder; Calomelas, Sanguis Draxonis, Borneolum Syntheticum list ground 100 mesh sieves, were the 3rd group of medicine powder, and single bag is standby;
(4), take by weighing white vaseline 8000g, lanoline 1000g, dimethyl sulfoxide 10g, as substrate, substrate is put in the evaporating dish, heating in water bath dissolves, in the time of in keeping 70 ℃ of scopes of temperature, constantly stir on one side, produce more than slowly adding on one side first, two groups of medicament mixed powder, when temperature rises to 100 ℃, kept 20 minutes, stop the heating cooling, when temperature is reduced to 38 ℃, again with the Calomelas in volatile the 3rd group of medicine powder, Sanguis Draxonis powder, Borneolum Syntheticum powder slowly adds respectively, stirring to make the Chinese medicine unguentum that promotes wound healing after anal fistula operation, but last packing.
Model case
Patient Yang Guidong, the man, 36 years old, admission number 10491 because of in the swollen thing distending pain companion of the anus anus swollen thing being arranged, needed hand rest to show effect repeatedly 10 years from anal prolapse, increases the weight of 2 years.In income hemorrhoid department ward on March 30th, 2004, the back diagnosis of being admitted to hospital; The ring-shaped mixed hemorrhoids III phase, outside epidural anesthesia is descending, prick art in the stripping, postoperative is changed dressings 2 times every day, after the sterilization of povidone iodine cotton balls, wound surface is crowded with Chinese medicine unguentum of this promotion post-operative hemorrhoids and anal fistula healing, the gauze wrapping, immobilization with adhesive tape, wound surface is healed entirely behind the first quarter moon altogether, does not see other side effect.Treat similar case totally 12 examples with this prescription, all in 12-16 days, heal, do not see other side effect.
Embodiment 2
Take by weighing raw material of Chinese medicine by following weight portion proportioning: Os Draconis 220g, Calamina 106g, Gypsum Fibrosum Preparatum 130g, succinum 38g, Endoconcha Sepiae 110g, Olibanum (processed) 30g; Myrrha (processed) 40g, calamitas urinae hominis 75g, Bulbus Fritillariae Cirrhosae 28g, Margarita 5g, Indigo Naturalis 78g; Calculus Bovis 5g, artificial Calculus Bovis 7g, Calomelas 60g, Sanguis Draxonis 58g, Borneolum Syntheticum 10g.Its production stage such as embodiment 1, but all adopt 100 mesh sieves after pulverizing.
Model case
Patient Han Yingzhang, man, 26 years old, admission number: 26690, because of 3 pus mouths, the swelling water of suppurating is arranged around the anus, showed effect repeatedly 5 years, increased the weight of 10 days, in income hemorrhoid complicated by anal fistula ward on August 12nd, 2005, AD: low level complexity anal fistula, at the descending segmentation of the epidural anesthesia drain hanging wire postoperative of windowing, change dressings once a day, with after the sterilization of povidone iodine cotton balls, wound surface is crowded with this Chinese medicine unguentum when changing dressings, the gauze wrapping, immobilization with adhesive tape 28 days, wound surface is healed entirely, does not see other side effect.Have 17 examples with the similar case of this prescription treatment, all in 17-21 days, heal, do not see other side effect.
Embodiment 3
Take by weighing raw material of Chinese medicine by following weight portion proportioning: Os Draconis 260g, Calamina 90g, Gypsum Fibrosum Preparatum 110g, succinum 28g, Endoconcha Sepiae 110g, Olibanum (processed) 30g; Myrrha (processed) 35g, calamitas urinae hominis 80g, Bulbus Fritillariae Cirrhosae 30g, Margarita 5g, Indigo Naturalis 80g; Calculus Bovis 5g, artificial Calculus Bovis 7g, Calomelas 60g, Sanguis Draxonis 60g, Borneolum Syntheticum 10g.Its production stage such as embodiment 1, but all adopt 100 mesh sieves after pulverizing.
Model case
Patient QiMin, woman, 24 years old, admission number 24130, in income hemorrhoid department ward on May 13rd, 2005, be diagnosed as anal fissure companion connective tissue external hemorrhoid, after the underwent operative treatment, change dressings every day 2 times, after the sterilization of povidone iodine cotton balls, wound surface is crowded with Chinese medicine unguentum of this promotion post-operative hemorrhoids and anal fistula healing, the gauze wrapping, immobilization with adhesive tape after 13 days wound surface heal entirely, do not see other side effect.Treat similar case totally 10 examples with this prescription, other side effect are not seen in all healings in 11～14 days.
Claims (3)
1. Chinese medicine unguentum that promotes wound healing after anal fistula operation is characterized in that it is made by the following weight parts Chinese medicinal raw materials: Os Draconis 220-260g, Calamina 90-110g; Gypsum Fibrosum Preparatum 110-134g, succinum 20-40g, Endoconcha Sepiae 110-136g; Olibanum (processed) 30-60g, Myrrha (processed) 30-60g, calamitas urinae hominis 60-80g; Bulbus Fritillariae Cirrhosae 20-30g, Margarita 2-6g, Indigo Naturalis 70-80g; Calculus Bovis 2-6g, artificial Calculus Bovis 6-10g, Calomelas 38-60g; Sanguis Draxonis 40-60g, Borneolum Syntheticum 9-11g.
2. the Chinese medicine unguentum of promotion wound healing after anal fistula operation according to claim 1 is characterized in that its raw material of Chinese medicine weight portion proportioning is: Os Draconis 243g, Calamina 97g; Gypsum Fibrosum Preparatum 121g, succinum 29g, Endoconcha Sepiae 122g; Olibanum (processed) 48g, Myrrha (processed) 48g, calamitas urinae hominis 73g; Bulbus Fritillariae Cirrhosae 24g, Margarita 4g, Indigo Naturalis 73g; Calculus Bovis 4g, artificial Calculus Bovis 8g, Calomelas 48g; Sanguis Draxonis 48g, Borneolum Syntheticum 10g.
3. the preparation method of the Chinese medicine unguentum of promotion wound healing after anal fistula operation as claimed in claim 1 is characterized in that its production stage is:
(1), earlier with Os Draconis, Calamina, Gypsum Fibrosum, Margarita, Olibanum, Myrrha respectively by 2002 version " Shandong Province's Chinese medicine processing standard " concoct;
(2), in above cooperation ratio weighing Os Draconis 220-260g, Calamina 90-110g, Gypsum Fibrosum Preparatum 110-140g, succinum 20-40g, Endoconcha Sepiae 110-136g, Olibanum (processed) 30-60g, Myrrha (processed) 30-60g, calamitas urinae hominis 60-80g, Bulbus Fritillariae Cirrhosae 20-30g, Margarita 2-6g, Indigo Naturalis 70-80g, Calculus Bovis 2-6g, artificial Calculus Bovis 6-10g, Calomelas 38-60g, Sanguis Draxonis 40-60g, Borneolum Syntheticum 9-11g, and divide into groups, with Os Draconis, Calamina, Gypsum Fibrosum Preparatum, succinum, Endoconcha Sepiae, Olibanum (processed), Myrrha (processed), the calamitas urinae hominis, Bulbus Fritillariae Cirrhosae, Margarita is as first group of medicine, with Indigo Naturalis, Calculus Bovis, the artificial Calculus Bovis is standby as second group of medicine, with Calomelas, Sanguis Draxonis, the independent weighing of Borneolum Syntheticum is good standby as the 3rd group of medicine;
(3), earlier load weighted first group of medicine dried, pulverizes, crosses the 100-120 mesh sieve, is mixed into first group of medicament mixed powder; Load weighted second group of medicine by the ground and mixed method, put in the mortar, mixed while grinding, cross the 100-120 mesh sieve, mixing becomes second group of medicament mixed powder; To first group of medicament mixed powder and second group of medicament mixed powder, adopt earlier the bottoming chromatography to mix, adopt the equivalent incremental method to mix again, till first group of medicament mixed powder added, after the 100-120 mesh sieve, mixing was repeatedly won, two groups of medicament mixed powder; Calomelas, Sanguis Draxonis, Borneolum Syntheticum list ground 100 mesh sieves, became the 3rd group of medicine powder;
(4), take by weighing white vaseline 8000g, lanoline 1000g, dimethyl sulfoxide 10g, as substrate, with substrate put in the evaporating dish, heating in water bath dissolves, in the time of in keeping 65-75 ℃ of scope of temperature, constantly stir on one side, first and second group medicament mixed powder of producing more than slowly adding on one side, when temperature rises to 100 ℃, kept 15-20 minute, stop the heating cooling, when temperature is reduced to 30 ℃-40 ℃, again Calomelas, Sanguis Draxonis powder, Borneolum Syntheticum powder in volatile the 3rd group of medicine powder are slowly added respectively, stirring to make this Chinese medicine unguentum, but last packing.
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| CN103961690A (en) * | 2014-05-25 | 2014-08-06 | 张勇 | External ointment for treating bedsore and preparation method thereof |
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| CN102068577B (en) * | 2011-01-05 | 2012-09-26 | 王广志 | Traditional Chinese medicine (TCM) composition and application thereof |
| CN102198205B (en) * | 2011-04-28 | 2012-10-10 | 上海市金山区中心医院枫泾分院 | Lianzhi powder and preparation method thereof |
| CN105687846A (en) * | 2016-03-11 | 2016-06-22 | 张雪燕 | Medicine composition for treating postoperative complications of hemorrhoids and fistula and application of medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1183950C (en) * | 2003-04-16 | 2005-01-12 | 吉林敖东延边药业股份有限公司 | Chinese herbal medicine preparation for treating burns |
| CN1615969A (en) * | 2004-09-15 | 2005-05-18 | 史敬杰 | Chinese medicine preparation pus drawing out plaster for treating pasteur cystic, furuncle, furunculosis and carbuncle |
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| CN1183950C (en) * | 2003-04-16 | 2005-01-12 | 吉林敖东延边药业股份有限公司 | Chinese herbal medicine preparation for treating burns |
| CN1615969A (en) * | 2004-09-15 | 2005-05-18 | 史敬杰 | Chinese medicine preparation pus drawing out plaster for treating pasteur cystic, furuncle, furunculosis and carbuncle |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961690A (en) * | 2014-05-25 | 2014-08-06 | 张勇 | External ointment for treating bedsore and preparation method thereof |
| CN103961690B (en) * | 2014-05-25 | 2016-01-20 | 张勇 | A kind of external-applied ointment and preparation method for the treatment of decubital ulcer |
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