CN105663030A - Hydrogel composition and application prepared from same - Google Patents
Hydrogel composition and application prepared from same Download PDFInfo
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- CN105663030A CN105663030A CN201610051715.9A CN201610051715A CN105663030A CN 105663030 A CN105663030 A CN 105663030A CN 201610051715 A CN201610051715 A CN 201610051715A CN 105663030 A CN105663030 A CN 105663030A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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Abstract
The invention relates to hydrogel composition and an application prepared from the same. The hydrogel composition comprises components in percentage by weight as follows: 5%-10% of polyacrylate, 15%-41% of polyalcohol, 47%-76% of pure water and 0.01%-9% of a function reagent, and a range of a weight ratio of the pure water to polyalcohol is 1.1-5. When the hydrogel composition or the application is applied to the skin of a human body, the temperature of the skin of the human body can be rapidly reduced by 5 DEG C or higher and can be rapidly reduced to be in the temperature range (15 DEG C or higher) which can be borne by the skin, and the condition of frostbite of the skin due to continuous reduction of the temperature of the skin can be prevented. Besides, when the hydrogel composition and the application are applied to the injured part caused by burns and scalds, the temperature can be reduced to the temperature range which can be borne by the skin, and the hydrogel composition and the application are remarkably helpful to wound healing in the future.
Description
The application is the divisional application of the patent application " hydrogel constituent and the application being made up of it " of the application number 201210226348.3 that on June 29th, 2012 submits to.
Technical field
The present invention relates to a kind of application, particularly to the application of a kind of hydrogel constituent.
Background technology
Processing the most key step of burn and scald is cooling damaged part, and consult periodical Burn, 2000,28,173-176 disclosed contents, it may be appreciated that cooling damaged part preferably can use the cold water of 8 DEG C～25 DEG C, and the time rinsing damaged part is about 15 minutes～20 minutes, comparatively ideal temperature, about 15 DEG C, does not just result in damaged part cold injury, so that the problem that damaged part healing in the future is not easily occurs. There are many commodity that can reduce shell temperature on the market at present, for instance iced bag, ice pillow, heat radiation patch etc., it is applied to because of the impaired position of burn and scald, there is inconvenient problem with use in described commodity, so still needing to development when processing for burn and scald, can play the application cooling down damaged part effect.
The direction that application formula in general patch is mainly designed to towards alleviating muscle or Joint Inflammation pain is improved, and so that effective ingredient can be effectively released, and is easily absorbed by the skin of human body, and plays antiinflammatory or analgesic effect.
TWI227145 discloses the application of a kind of hydrophilic percutaneous absorbtion. this application has the effect of anti-inflammatory analgesic and comprises the sodium polyacrylate (polysodiumacrylate) of 1 weight %～10 weight %, the gelatin (gelatin) of 1 weight %～10 weight %, the polyvinyl alcohol (polyvinylalcohol) of 1 weight %～10 weight %, the Kaolin (kaolin) of 1 weight %～10 weight %, the polyhydric alcohol (glycol) of 5 weight %～30 weight %, the copolymer (copolymer) of 0.1 weight %～10 weight %, the sodium carboxymethyl cellulose (sodiumcarboxymethylcellulose) of 0.5 weight %～10 weight %, and 10 pure water of weight %～80 weight %, and, also added Mentholum.But, above-mentioned application is in preparation and uses and still suffers from problems, for instance this sodium carboxymethyl cellulose need to be present in pH and more than 7～9 just can stablize, but human skin is had injury by the application of meta-alkalescence. Furthermore, when this sodium carboxymethyl cellulose and gelatin exist, it is easy to form precipitate simultaneously, cause that application is unstable, and this application be not used on the damaged part of burn and scald.
In order to reach desirable burn and scald application condition, the purpose of cooling damaged part can be rapidly reached during with process burn and scald, still need to develop a kind of application with iced effect and high-biocompatibility, to protect the damaged part of burn and scald.
Summary of the invention
The first object of the present invention is in that to provide a kind of hydrogel constituent with iced effect.
Subject hydrogel constituent, comprises:
The polyacrylate of 5 weight %～10 weight %;
The polyhydric alcohol of 15 weight %～41 weight %;
The pure water of 47 weight %～76 weight %; And
The functional reagent of 0.01 weight %～9 weight %,
And the weight ratio of this pure water and polyhydric alcohol ranges for 1.1～5.
The weight ratio of subject hydrogel constituent, described pure water and polyhydric alcohol ranges for 3～5.
Subject hydrogel constituent, counts with the total amount of described hydrogel constituent for 100 weight %, and the content range of described pure water is 67 weight %～76 weight %.
Subject hydrogel constituent, counts with the total amount of described hydrogel constituent for 100 weight %, and the content range of described polyhydric alcohol is 15 weight %～22 weight %.
Subject hydrogel constituent, it also comprises polyvinyl alcohol, and with the total amount of described polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of described polyvinyl alcohol is 0.5 weight portion～5.5 weight portion.
Subject hydrogel constituent, it also comprises soda acid regulator, and with the total amount of described polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of described soda acid regulator is 0.6 weight portion～3 weight portion.
Subject hydrogel constituent, it comprises: the polyacrylate of 8 weight %～9.5 weight %, the glycerol of 15 weight %～39 weight %, 50 weight %～73 weight % pure water, the Mentholum of 0.3 weight %～0.4 weight %, the carboxyl ethylene polymer of 0.3 weight %～1.5 weight %, the cetyl isopropyl propionate of 0.9 weight %～1 weight %, the sorbitol ester based compound of 0.3 weight %～0.4 weight %, and 1 sodium benzoate of weight %～1.5 weight %, and with described polyacrylate, glycerol, pure water, Mentholum, carboxyl ethylene polymer, cetyl isopropyl propionate, the total amount of sorbitol ester based compound and sodium benzoate is 100 parts by weight, the content range of described polyvinyl alcohol is 0.5 weight portion～3.2 weight portion, the content range of described soda acid regulator is 0.6 weight portion～0.7 weight portion.
Subject hydrogel constituent, it comprises: the polyacrylate of 5 weight %～5.5 weight %, the glycerol of 15 weight %～22 weight %, the pure water of 67 weight %～76 weight %, the polyacrylic acid of 0.3 weight %～0.45 weight %, the Mentholum of 0.3 weight %～0.4 weight %, the Myrj 45 of 0.3 weight %～0.4 weight %, the titanium dioxide of 0.01 weight %～0.1 weight %, the Kaolin of 0.01 weight %～0.1 weight %, and 2.5 gelatin of weight %～4.5 weight %, and with described polyacrylate, glycerol, pure water, polyacrylic acid, Mentholum, Myrj 45, titanium dioxide, the total amount of Kaolin and gelatin is 100 parts by weight, the content range of described polyvinyl alcohol is 3.19 weight portion～5.5 weight portions, the content range of described soda acid regulator is 2 weight portion～3 weight portions.
The second object of the present invention is in that to provide a kind of application with iced effect.
Application of the present invention, comprises: hydrogel constituent as above.
The beneficial effects of the present invention is: by the regulation and control of this pure water Yu the weight ratio of polyhydric alcohol, make this hydrogel constituent or application after iced, for human skin, iced effect can be played rapidly and allow human epidermal skin lower the temperature more than 5 DEG C, and the temperature of human epidermal skin can be made rapidly to be down to temperature range (more than about 15 DEG C) that skin can bear, without making the temperature of skin continue to reduce again, cause skin cold injury. Furthermore, when this hydrogel constituent and application are used for the position because burn and scald is impaired, can promptly cool down this damaged part, pain and burning sensation that damaged part bring are greatly reduced, and cool the temperature to the temperature range that skin can bear, there is obvious help for wound healing in the future.
Accompanying drawing explanation
Fig. 1 is curve chart, and the iced effect of the embodiment of the present invention 8 is described;
Fig. 2 is curve chart, and the iced effect of ice pack is described; And
Fig. 3 is curve chart, and the iced effect of the embodiment of the present invention 1 and 2 is described.
Detailed description of the invention
Subject hydrogel constituent comprises the polyacrylate of 5 weight %～10 weight %; The polyhydric alcohol of 15 weight %～41 weight %; The pure water of 47 weight %～76 weight %; And 0.01 functional reagent of weight %～9 weight %, and the weight ratio of this pure water and polyhydric alcohol ranges for 1.1～5. It is preferred that the weight ratio of this pure water and polyhydric alcohol ranges for 3～5.
It is preferred that the total amount with this hydrogel constituent is counted for 100 weight %, the content range of this pure water is 67 weight %～76 weight %.
It is preferred that this polyhydric alcohol is selected from glycerol, Sorbitol (sorbitol), or their combination. It is preferred that the total amount with this hydrogel constituent is counted for 100 weight %, the content range of this polyhydric alcohol is 15 weight %～22 weight %.
Regulated and controled by the part by weight of polyhydric alcohol with pure water, it is possible to delay the speed of pure water volatilization so that this iced effect can be more lasting. And this hydrogel constituent or application are after iced, for human skin, iced effect can be played rapidly and allow human epidermal skin lower the temperature more than 5 DEG C, simultaneously, and the temperature of human epidermal skin can be made rapidly to be down to temperature range (more than about 15 DEG C) that skin can bear, without making the temperature of skin continue to reduce again, cause skin cold injury. Furthermore, when this hydrogel constituent and application are used for the position because burn and scald is impaired, can promptly cool down this damaged part, pain and burning sensation that damaged part bring are greatly reduced, and temperature is down to the temperature range that skin can bear, there is obvious help for wound healing in the future. The hydrogel constituent of the present invention also apply be applicable to the acute position wounded, sprain or dampen, as the application of best ice compress type.
This polyacrylate can be used alone or as a mixture, and this polyacrylate is including but not limited to sodium polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, polyacrylic acid monoethanol ammonium, polyacrylic acid diethanol ammonium, or polyacrylic acid triethanol ammonium etc. It is preferred that this polyacrylate is sodium polyacrylate.
This functional reagent can be used alone or as a mixture, and this functional reagent is including but not limited to solvent (solvent), emulsifying agent (emulsifier), suspending agent (suspendingagent), dispersant (dispersant), surfactant (surfactant), binding agent (bindingagent), excipient (excipient), stabilizer (stabilizingagent), chelating agen (chelatingagent), diluent (diluent), freshener, preservative (preservative), thickening agent (viscosity-increasingagent), filler (filler), gellant (gellingagent) or lubricant (lubricant) etc.This solvent is including but not limited to isopropanol. This emulsifying agent is including but not limited to Myrj 45 (polyoxyethylenestearate), carboxyl ethylene polymer (carboxyvinylpolymer), alkyl acid isopropyl ester, or sorbitol ester based compound (sorbitanester-basedcompounds) etc. This preservative is including but not limited to sodium benzoate, methyl parahydroxybenzoate, ethylparaben, or propyl p-hydroxybenzoate etc. This filler is including but not limited to Kaolin or titanium dioxide etc. This freshener is including but not limited to Mentholum or Borneolum Syntheticum etc. This thickening agent is including but not limited to polyacrylic acid.
It is preferred that this Myrj 45 is as shown in following formula (I):
In formula (I), n represents the integer of 2～150.
It is preferred that this carboxyl ethylene polymer is molecular weight 300～115, the acrylic acid polymer of 000. This carboxyl ethylene polymer can be used alone or as a mixture, and this carboxyl ethylene polymer is including but not limited to carbomer910 (molecular weight 3,000～7,000), carbomer934 (molecular weight 30,500～39,400), carbomer934P (molecular weight 29,400～39,400), carbomer940 (molecular weight 40,000～60,000), carbomer941 (molecular weight 4,, or carbomer1342 (molecular weight 9 000～11,000), 500～26,500). In embodiments of the invention, concrete such as carbomer934 (molecular weight 30,500～39,400) of this carboxyl ethylene polymer.
It is preferred that this alkyl acid isopropyl ester is selected from cetyl isopropyl propionate (isopropylpalmitate), myristyl isopropyl propionate (isopropylmyristate), or their combination. In embodiments of the invention, this alkyl acid isopropyl ester is cetyl isopropyl propionate.
Preferably, this sorbitol ester based compound is selected from polyoxyethylene sorbitan monolaurate (polyoxyethylenesorbitanmonolaurate), polyoxyethylene sorbitan monopalmitate (polyoxyethylenesorbitanmonopalmitate), polyoxyethylene sorbitan monostearate (polyoxyethylenesorbitanmonostearate), polyoxyethylene sorbitan tristearate anhydride (polyoxyethylenesorbitantristearate), polyoxyethylene sorbitan monooleate (polyoxyethylenesorbitanmonooleate), polyoxyethylene sorbitan trioleate (polyoxyethylenesorbitantrioleate), Span-20 (sorbitanmonolaurate), sorbitan monopalmitate (sorbitanmonopalmitate), sorbitan monostearate (sorbitanmonostearate), sorbitan tristearate (sorbitantristearate), sorbitan monooleate (sorbitanmonooleate), sorbitan trioleate (sorbitantrioleate), or their combination. in embodiments of the invention, this sorbitol ester based compound is polyoxyethylene sorbitan monooleate, model: tween80, and count with the total amount of this hydrogel constituent for 100 weight %, the content range of this sorbitol ester based compound is 0.3 weight %.
It is preferred that this hydrogel constituent also comprises polyvinyl alcohol, and with the total amount of this polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of this polyvinyl alcohol is 0.5 weight portion～5.5 weight portion.
It is preferred that this hydrogel constituent also comprises soda acid regulator, and with the total amount of this polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of this soda acid regulator is 0.6 weight portion～3 weight portion. The kind of this soda acid regulator is not particularly limited, as long as this hydrogel constituent can be made to have skin-friendly. This soda acid regulator can be used alone or as a mixture, and this soda acid regulator is including but not limited to tartaric acid or sodium hydroxide etc. It is preferred that regulated and controled the pH of the hydrogel constituent of the present invention 4.5～7 by this soda acid regulator, can have good skin-friendly.
In an embodiment of the present invention, this hydrogel constituent comprises the pure water of the polyacrylate of 8 weight %～9.5 weight %, the glycerol of 15 weight %～39 weight %, 50 weight %～73 weight %, the Mentholum of 0.3 weight %～0.4 weight %, the carboxyl ethylene polymer of 0.3 weight %～1.5 weight %, the cetyl isopropyl propionate of 0.9 weight %～1 weight %, the sorbitol ester based compound of 0.3 weight %～0.4 weight %, and 1 sodium benzoate of weight %～1.5 weight %, and with this polyacrylate, glycerol, pure water, Mentholum, carboxyl ethylene polymer, cetyl isopropyl propionate, the total amount of sorbitol ester based compound and sodium benzoate is 100 parts by weight, the content range of this polyvinyl alcohol is 0.5 weight portion～3.2 weight portion, the content range of this soda acid regulator is 0.6 weight portion～0.7 weight portion.
In an embodiment of the present invention, this hydrogel constituent comprises the polyacrylate of 5 weight %～5.5 weight %, the glycerol of 15 weight %～22 weight %, the pure water of 67 weight %～76 weight %, the polyacrylic acid of 0.3 weight %～0.45 weight %, the Mentholum of 0.3 weight %～0.4 weight %, the Myrj 45 of 0.3 weight %～0.4 weight %, the titanium dioxide of 0.01 weight %～0.1 weight %, the Kaolin of 0.01 weight %～0.1 weight %, and 2.5 gelatin of weight %～4.5 weight %, and with this polyacrylate, glycerol, pure water, polyacrylic acid, Mentholum, Myrj 45, titanium dioxide, the total amount of Kaolin and gelatin is 100 parts by weight, the content range of this polyvinyl alcohol is 3.19 weight portion～5.5 weight portions, the content range of this soda acid regulator is 2 weight portion～3 weight portions.
This hydrogel constituent can adopt general hybrid mode by polyacrylate, polyhydric alcohol, pure water and functional reagent, and optionally adds polyvinyl alcohol or soda acid regulator Homogeneous phase mixing, can obtain subject hydrogel constituent.
Application of the present invention comprises hydrogel constituent as above. This application may be, but not limited to: Emulsion (emulsion), gel (gel), ointment (ointment), cream (cream), paster (patch), liniment (embrocation), aerosol (aerosol), spraying (spray), emulsion (lotion), serum (serum), paste (paste), foam (foam) and drop (drop). The preparation of this application can adopt conventional method for making, so no longer repeating in detail.
In embodiments of the invention, this application is paster, and this paster is to be formed on base material by subject hydrogel constituent. The preparation method of this paster can according to the mode being typically prepared, so repeating no more. This base material is not particularly limited, and it is including but not limited to adhesive-bonded fabric.This paster has preferably conformable and will not stick damaged part, and has preferably fissility, during to avoid paster to tear off damaged part, causes the advantages such as damaged part secondary injury.
<embodiment>
[embodiment 1～12] hydrogel constituent and application
By polyacrylate and glycerol Homogeneous phase mixing, form the first component; By pure water, soda acid regulator and functional reagent Homogeneous phase mixing, form second component; Then, by this first component and second component Homogeneous phase mixing, can be prepared by hydrogel constituent. The kind of this raw material and make consumption as shown in table 1.
Hydrogel constituent described above is respectively formed on base material, treats that maturation can form paster.
[assessment item]
1. iced effect: the paster of embodiment 1,2,8,9 and 12 is placed in 4 DEG C of refrigerators more than 8 hours, the nearly elbow place of both hands forearm of testee it is immediately placed in after taking-up, test with infra red thermograph (model: NECG100W2) again, within every 10 seconds, take 1 picture (frame), test 15 minutes, totally 90 pictures export result.
2. fissility: by being covered each by one layer of cellophane on the paster of embodiment 1～12, treat that cellophane removes, whether sight glasses paper has hydrogel constituent remain.
3. cohesiveness: be respectively placed in by the paster of embodiment 1～12 at 24 DEG C～27 DEG C, according to the ball experimental test of continent pharmacopeia, its range of viscosities is that No. 9 steel ball～No. 20 steel balls are preferred, and is more preferably No. 13 steel balls.
From the result of Fig. 1 and Fig. 3, when the weight ratio of this pure water Yu glycerol ranges for 1.15～4.95, this hydrogel constituent is used for human skin, human skin can be made rapidly to lower the temperature more than 5 DEG C, and can effectively maintain more than 15 minutes, and reach iced effect, and the temperature of human skin can be made to be down to temperature range (more than 15 DEG C) that skin can bear.
Though by the result of Fig. 2 it can be seen that use ice pack ice compress that human skin can be made rapidly to lower the temperature more than 21 DEG C, but it can make the temperature of human skin to reducing by 12 DEG C, it is possible to can make human skin top layer cold injury, and cause the more serious injury of damaged part.
In sum, regulation and control by this pure water Yu the weight ratio of polyhydric alcohol, this hydrogel constituent or application are after iced, for human skin, human skin can be made rapidly to lower the temperature more than 5 DEG C, and reach iced effect, and the temperature of human skin can be made to be down to temperature range (more than 15 DEG C) that skin can bear, without making the temperature of skin continue to reduce again, cause skin cold injury. Furthermore, when this hydrogel constituent and application are used for the position because burn and scald is impaired, can promptly cool down this damaged part, pain and burning sensation that damaged part bring are greatly reduced, and temperature is down to the temperature range that skin can bear, obvious help is had, so the purpose of the present invention really can be reached for wound healing in the future.
Claims (7)
1. a hydrogel constituent, it is characterised in that comprise:
The polyacrylate of 5 weight %～10 weight %;
The polyhydric alcohol of 15 weight %～41 weight %;
The pure water of 47 weight %～76 weight %; And
The functional reagent of 0.01 weight %～9 weight %,
And the weight ratio of described pure water and polyhydric alcohol ranges for 1.1～5, and the pH value range of described hydrogel constituent is 4.5～7.
2. hydrogel constituent according to claim 1, it is characterised in that the weight ratio of described pure water and polyhydric alcohol ranges for 3～5.
3. hydrogel constituent according to claim 1, it is characterised in that count for 100 weight % with the total amount of described hydrogel constituent, the content range of described pure water is 67 weight %～76 weight %.
4. hydrogel constituent according to claim 1, it is characterised in that count for 100 weight % with the total amount of described hydrogel constituent, the content range of described polyhydric alcohol is 15 weight %～22 weight %.
5. hydrogel constituent according to claim 4, it is characterized in that, it also comprises polyvinyl alcohol, and with the total amount of described polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of described polyvinyl alcohol is 0.5 weight portion～5.5 weight portion.
6. hydrogel constituent according to claim 4, it is characterized in that, it also comprises soda acid regulator, and with the total amount of described polyacrylate, polyhydric alcohol, pure water and functional reagent for 100 parts by weight, the content range of described soda acid regulator is 0.6 weight portion～3 weight portion.
7. an application, it is characterised in that comprise: hydrogel constituent according to any one of claim 1 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610051715.9A CN105663030A (en) | 2012-06-29 | 2012-06-29 | Hydrogel composition and application prepared from same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610051715.9A CN105663030A (en) | 2012-06-29 | 2012-06-29 | Hydrogel composition and application prepared from same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210226348.3A Division CN103505405B (en) | 2012-06-29 | 2012-06-29 | Hydrogel constituent and the application being formed by it |
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| Publication Number | Publication Date |
|---|---|
| CN105663030A true CN105663030A (en) | 2016-06-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610051715.9A Pending CN105663030A (en) | 2012-06-29 | 2012-06-29 | Hydrogel composition and application prepared from same |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678308A (en) * | 2002-07-29 | 2005-10-05 | 兴和株式会社 | Indometacin preparation for external use |
| CN101209232A (en) * | 1997-11-20 | 2008-07-02 | 株式会社资生堂 | Composition for external use |
| CN102144989A (en) * | 2011-04-28 | 2011-08-10 | 天津瑞德药业有限公司 | Preparation method of hydrogel cataplasm and prepared cataplasm with effect of relieving swelling and pains |
-
2012
- 2012-06-29 CN CN201610051715.9A patent/CN105663030A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209232A (en) * | 1997-11-20 | 2008-07-02 | 株式会社资生堂 | Composition for external use |
| CN1678308A (en) * | 2002-07-29 | 2005-10-05 | 兴和株式会社 | Indometacin preparation for external use |
| CN102144989A (en) * | 2011-04-28 | 2011-08-10 | 天津瑞德药业有限公司 | Preparation method of hydrogel cataplasm and prepared cataplasm with effect of relieving swelling and pains |
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