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CN105343704A - Drug for treating migraine - Google Patents

Drug for treating migraine Download PDF

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Publication number
CN105343704A
CN105343704A CN201510796107.6A CN201510796107A CN105343704A CN 105343704 A CN105343704 A CN 105343704A CN 201510796107 A CN201510796107 A CN 201510796107A CN 105343704 A CN105343704 A CN 105343704A
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CN
China
Prior art keywords
parts
radix
radix angelicae
treatment
migraine
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510796107.6A
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Chinese (zh)
Inventor
吴斌
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Individual
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Individual
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Priority to CN201510796107.6A priority Critical patent/CN105343704A/en
Publication of CN105343704A publication Critical patent/CN105343704A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/424Gynostemma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a drug for treating migraine, and the drug comprises the following raw ingredients by weight: 17 parts of angelica, 11 parts of radix angelicae, 10 parts of walnut kernel, 9 parts of philippine flemingia root, 15 parts of corydalis tuber, 9 parts of rhizoma smilacis glabrae, 10 parts of cortex albiziae, 8 parts of gynostemma and 9 parts of alangium platanifolium. The angelica is used for activating blood to promote menstruation; the radix angelicae is used for opening aperture and relieving pains, the walnut kernel is used for warming and tonifying lung and kidney, the philippine flemingia root is used for is used for dispersing blood stasis and detoxifying, the corydalis tuber is used for activating blood and promoting circulation of qi, the rhizoma smilacis glabrae is used for dehumidification detoxification, the cortex albiziae is used for is used for resolving stagnation for tranquilization, the gynostemma is used for is used for clearing away heat and toxic materials, and the alangium platanifolium is used for dispersing stasis and relieving pains, the various drugs are in combined use to together play the effects of dispelling wind, dispelling cold, opening aperture and relieving pains for effective treatment of migraine. Clinical experiments prove the drug can be safe and effective in the treatment of the migraine.

Description

One is used for the treatment of migrainous medicine
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to one and be used for the treatment of migrainous medicine.
Background technology
Migraine is clinical modal primary headache type; clinical in show effect with middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.
Clinical manifestation: 1) Migraine without aura is modal migraines, accounts for 80%.
2) migraine without aura accounts for migraineur's 10%.Before outbreak, can there be asthenia, the absent minded and prodrome such as to yawn a few hours to a few days
3) retinal migraine is the uniocular vision obstacle of the completely reversibility repeatedly occurred, and comprises flicker, dim spot or blind, and accompanies migraine, normal at interictal ophthalmologic examination
4) there is branch hole myoparalysis of having a headache in ophthalmoplegic migraine Headache attacks simultaneously or in 4 days, oculomotorius is the most often got involved, and often has the ptosis, platycoria, and some cases can involve coaster and abducent nerve simultaneously.
Current doctor trained in Western medicine clinical treatment migraine medication multiselect Naproxen Sustained Release Tablet, ibuprofen modified release capsule, Ankahuangmin Tablets, aspirin etc.But cure the symptoms, not the disease more, easily cause Relapse rate to show effect.
Medical material involved in the present invention is recorded in all as seen " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide one and is used for the treatment of migrainous medicine, by selecting suitable medical material and proportioning thereof, reaches the migrainous object of safe and effective healing.
In order to achieve the above object, the present invention is by the following technical solutions:
One is used for the treatment of migrainous medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Angelicae Sinensis 17 parts, the Radix Angelicae Dahuricae 11 parts, Semen Juglandis 10 parts, Radix Flemingiae Philippinensis 9 parts, Rhizoma Corydalis 15 parts, Rhizoma Smilacis Glabrae 9 parts, Cortex Albiziae 10 parts, Herb Gynostemmae Pentaphylli 8 parts, Radix Alangii 9 parts.
Inventor thinks: the cause of disease such as wind and cold or blood stasis is dragged for a long time and do not controlled, and pathogenic factor invades passages through which vital energy circulates and to deposit obstructed one-tenth disease.Manner is unclear, and wind and cold is not loose is disease close to home.Expelling wind and cold, removing obstruction in the collateral to relieve pain should be noted during treatment.
The present invention uses: Radix Angelicae Sinensis promoting blood circulation to restore menstrual flow; Radix Angelicae Dahuricae understand things pain-stopping; Semen Juglandis temperature compensation lung kidney; Radix Flemingiae Philippinensis repercussive detoxifies; Rhizoma Corydalis is invigorated blood circulation promoting the circulation of QI; Rhizoma Smilacis Glabrae removing dampness and detoxicating; Cortex Albiziae resolving stagnation for tranquilization; Herb Gynostemmae Pentaphylli heat-clearing and toxic substances removing; The pain relieving of Radix Alangii scattered silt.All medicines share, and effect of long memorial wind, dissipating cold, removing obstruction in the collateral to relieve pain, effectively treats migraine altogether.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects migraineur 70 example for 2012 altogether between year December of December ~ 2014, all from Neurology Clinic, and 35 ~ 50 years old age, male 25 example, women 45 example.The course of disease 1 year ~ 8 years.
Diagnostic criteria: according to the diagnostic criteria of ICHD2 migraine
Do you feel sick and (are sick in the stomach during headache or stomach discomfort?), work capacity decline (nearest March have at least one sky because of headache limitation of activity?) and photophobia (be subject to light during headache to bother?).If answered certainly according to three problems 2, then migrainous positive predictive value is 93%, if 3 problems are all answered certainly, its positive predictive value reaches 98%.
Meet above-mentioned diagnostic criteria, the patient that the age is greater than 18 years old.
Exclusion standard: trimester of pregnancy, women breast-feeding their children; Merge serious cardiopulmonary hepatorenal disease person.
2, test method
The decoct that the oral the present invention of all patients obtains according to embodiment 1, every day 3 times.4 weeks courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Judge according to " migraine disease diagnosis and efficacy assessment standard ".
1. effective: patient's Headache attacks disappears or the number of times of clinical episodes reduces >75%
2. effective: the degree of patient's headache alleviates gradually and the number of times of clinical episodes reduces to 50% ~ 75%;
3. invalid: the number of times of patient's Headache attacks has reduced <50% or clinical symptoms is unchanged
3.2 therapeutic outcome
Effective 54 examples of 70 routine patients, effective 12 examples, invalid 4 examples, total effective rate 94%.There is laxativeness in treatments period 2 example, has no other obvious adverse reaction.It is safe and effective that visible the present invention is used for the treatment of migraine, has the value applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Radix Angelicae Sinensis 17 grams, the Radix Angelicae Dahuricae 11 grams, Semen Juglandis 10 grams, Radix Flemingiae Philippinensis 9 grams, Rhizoma Corydalis 15 grams, Rhizoma Smilacis Glabrae 9 grams, Cortex Albiziae 10 grams, Herb Gynostemmae Pentaphylli 8 grams, Radix Alangii 9 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of migraine.Oral, every bu morning, noon and afternoon take for three times.
Embodiment 2
Take: Radix Angelicae Sinensis 17 grams, the Radix Angelicae Dahuricae 11 grams, Semen Juglandis 10 grams, Radix Flemingiae Philippinensis 9 grams, Rhizoma Corydalis 15 grams, Rhizoma Smilacis Glabrae 9 grams, Cortex Albiziae 10 grams, Herb Gynostemmae Pentaphylli 8 grams, Radix Alangii 9 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of migraine.Oral, daily once.
Embodiment 3
Take: Radix Angelicae Sinensis 17 grams, the Radix Angelicae Dahuricae 11 grams, Semen Juglandis 10 grams, Radix Flemingiae Philippinensis 9 grams, Rhizoma Corydalis 15 grams, Rhizoma Smilacis Glabrae 9 grams, Cortex Albiziae 10 grams, Herb Gynostemmae Pentaphylli 8 grams, Radix Alangii 9 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of migraine.Oral, every bu is taken for twice sooner or later.

Claims (4)

1. one kind is used for the treatment of migrainous medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Angelicae Sinensis 17 parts, the Radix Angelicae Dahuricae 11 parts, Semen Juglandis 10 parts, Radix Flemingiae Philippinensis 9 parts, Rhizoma Corydalis 15 parts, Rhizoma Smilacis Glabrae 9 parts, Cortex Albiziae 10 parts, Herb Gynostemmae Pentaphylli 8 parts, Radix Alangii 9 parts.
2. be used for the treatment of migrainous medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 17 parts, the Radix Angelicae Dahuricae 11 parts, Semen Juglandis 10 parts, Radix Flemingiae Philippinensis 9 parts, Rhizoma Corydalis 15 parts, Rhizoma Smilacis Glabrae 9 parts, Cortex Albiziae 10 parts, Herb Gynostemmae Pentaphylli 8 parts, Radix Alangii 9 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. be used for the treatment of migrainous medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 17 parts, the Radix Angelicae Dahuricae 11 parts, Semen Juglandis 10 parts, Radix Flemingiae Philippinensis 9 parts, Rhizoma Corydalis 15 parts, Rhizoma Smilacis Glabrae 9 parts, Cortex Albiziae 10 parts, Herb Gynostemmae Pentaphylli 8 parts, Radix Alangii 9 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. be used for the treatment of migrainous medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 17 parts, the Radix Angelicae Dahuricae 11 parts, Semen Juglandis 10 parts, Radix Flemingiae Philippinensis 9 parts, Rhizoma Corydalis 15 parts, Rhizoma Smilacis Glabrae 9 parts, Cortex Albiziae 10 parts, Herb Gynostemmae Pentaphylli 8 parts, Radix Alangii 9 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
CN201510796107.6A 2015-11-18 2015-11-18 Drug for treating migraine Pending CN105343704A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510796107.6A CN105343704A (en) 2015-11-18 2015-11-18 Drug for treating migraine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510796107.6A CN105343704A (en) 2015-11-18 2015-11-18 Drug for treating migraine

Publications (1)

Publication Number Publication Date
CN105343704A true CN105343704A (en) 2016-02-24

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Country Status (1)

Country Link
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721591A (en) * 2015-04-01 2015-06-24 淄博夸克医药技术有限公司 Traditional Chinese medicine for treating migraine
CN105031303A (en) * 2015-07-01 2015-11-11 路贝贝 Drug for treating migraine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721591A (en) * 2015-04-01 2015-06-24 淄博夸克医药技术有限公司 Traditional Chinese medicine for treating migraine
CN105031303A (en) * 2015-07-01 2015-11-11 路贝贝 Drug for treating migraine

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