Nothing Special   »   [go: up one dir, main page]

CL2018002787A1 - Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. - Google Patents

Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos.

Info

Publication number
CL2018002787A1
CL2018002787A1 CL2018002787A CL2018002787A CL2018002787A1 CL 2018002787 A1 CL2018002787 A1 CL 2018002787A1 CL 2018002787 A CL2018002787 A CL 2018002787A CL 2018002787 A CL2018002787 A CL 2018002787A CL 2018002787 A1 CL2018002787 A1 CL 2018002787A1
Authority
CL
Chile
Prior art keywords
treatment
methods
compositions
compounds
substituted aminopurine
Prior art date
Application number
CL2018002787A
Other languages
English (en)
Inventor
Robert Hubbard
Heather Raymon
John F Boylan
Gordon L Bray
Ellen Filvaroff
David Mikolon
Tao Shi
Tam M Tran
Toshiya Tsuji
Lilly L Wong
Suichan Xu
Dan Zhu
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of CL2018002787A1 publication Critical patent/CL2018002787A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PROPORCIONAN EN LA PRESENTE MÉTODOS PARA EL TRATAMIENTO O PREVENCIÓN DE UN CÁNCER, QUE INCLUYEN TUMORES SÓLIDOS Y CÁNCERES HEMATOLÓGICOS, QUE COMPRENDEN ADMINISTRAR UNA CANTIDAD EFICAZ DE COMPUESTOS DE AMINOPURINA DE FÓRMULA (I) Y COMPOSICIONES QUE COMPRENDEN UNA CANTIDAD EFICAZ DE DICHOS COMPUESTOS.
CL2018002787A 2016-04-01 2018-09-28 Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. CL2018002787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662317412P 2016-04-01 2016-04-01

Publications (1)

Publication Number Publication Date
CL2018002787A1 true CL2018002787A1 (es) 2019-01-18

Family

ID=59959573

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018002787A CL2018002787A1 (es) 2016-04-01 2018-09-28 Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos.

Country Status (15)

Country Link
US (1) US10576085B2 (es)
EP (1) EP3436018A4 (es)
JP (1) JP7014731B2 (es)
KR (1) KR102356433B1 (es)
CN (1) CN109069512B (es)
AU (1) AU2017241837B2 (es)
BR (1) BR112018070163A2 (es)
CA (1) CA3018986A1 (es)
CL (1) CL2018002787A1 (es)
EA (1) EA039392B1 (es)
IL (1) IL262007B2 (es)
MX (1) MX2018011992A (es)
NZ (1) NZ746554A (es)
SG (2) SG10202009589UA (es)
WO (1) WO2017173206A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
RS65069B1 (sr) 2015-11-02 2024-02-29 Blueprint Medicines Corp Inhibitori ret-a
WO2017167953A1 (en) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
JP6888021B2 (ja) 2016-03-31 2021-06-16 ヤンセン ファーマシューティカルズ,インコーポレーテッド デングウイルス複製阻害剤としての置換インドール誘導体
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102359766B1 (ko) 2016-04-01 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체
MX2018011970A (es) 2016-04-01 2019-05-20 Signal Pharm Llc Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas.
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
LT3630724T (lt) 2017-05-22 2021-08-25 Janssen Pharmaceuticals, Inc. Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai
UA125407C2 (uk) 2017-05-22 2022-03-02 Янссен Фармасьютікалз, Інк. Заміщені похідні індоліну як інгібітори реплікації вірусів денге
IL273658B2 (en) 2017-10-04 2024-10-01 Celgene Corp Compounds and methods for using cis-4-[2-{[(3S,4R)-3-fluoroxan-4-YL]amino}-8-(2,4,6-trichloroanilino)-9H-purine-9-YL]- 1-Methylcyclohexane-1-carboxamide
ES2970041T3 (es) 2018-04-03 2024-05-24 Blueprint Medicines Corp Inhibidor de RET para su uso en el tratamiento del cáncer que tiene una alteración de RET
EP3833372A4 (en) * 2018-08-10 2022-06-08 Blueprint Medicines Corporation TREATMENT OF EGFR MUTANT CANCER
CN114072207B (zh) * 2019-04-16 2024-03-29 维瓦斯治疗公司 双环化合物
US12122787B2 (en) 2019-09-20 2024-10-22 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
WO2021102204A1 (en) * 2019-11-20 2021-05-27 Vivace Therapeutics, Inc. Heteroaryl compounds
TW202202498A (zh) * 2020-07-01 2022-01-16 大陸商四川海思科製藥有限公司 一種並環雜環衍生物及其在醫藥上的應用
KR102664454B1 (ko) * 2021-08-03 2024-05-09 한국생명공학연구원 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용
CN114681456A (zh) * 2022-02-23 2022-07-01 中山大学附属第六医院 Plx3397在结直肠癌的治疗中的用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするdna
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FI109088B (fi) 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
US7569571B2 (en) * 2003-12-23 2009-08-04 Novartis Ag Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators
US7521446B2 (en) * 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US20070225304A1 (en) * 2005-09-06 2007-09-27 Pharmacopeia Drug Discovery, Inc. Aminopurine derivatives for treating neurodegenerative diseases
WO2007062338A2 (en) 2005-11-18 2007-05-31 Astrazeneca Ab Solid formulations
WO2007134298A2 (en) 2006-05-12 2007-11-22 Myriad Genetics, Inc. Therapeutic compounds and their use in cancer
TWI398252B (zh) 2006-05-26 2013-06-11 Novartis Ag 吡咯并嘧啶化合物及其用途
MX2009003913A (es) 2006-10-27 2009-04-24 Signal Pharm Llc Formas solidas que comprenden 4-[9-(tetrahidro-furano-3-il)-8-(2,4 ,6-trifluoro-fenilamino)-9h-purin-2-ilamino]-ciclohexan-1-ol, composiciones de las mismas, y su uso.
PT2279731E (pt) 2008-04-23 2013-08-30 Farmasierra Mfg S L Composição farmacêutica melhorada contendo ibuprofeno e codeína
US20130034495A1 (en) 2009-12-09 2013-02-07 Marie Georges Beauchamps Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol
US8603527B2 (en) 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
US8680076B2 (en) * 2010-10-25 2014-03-25 Signal Pharmaceuticals, Llc Methods of treatment, improvement and prevention using haloaryl substituted aminopurines
US9466042B2 (en) 2012-01-24 2016-10-11 International Business Machines Corporation Facilitating the design of information technology solutions
WO2014172616A2 (en) 2013-04-18 2014-10-23 President And Fellows Of Harvard College Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
RS61884B1 (sr) * 2014-10-06 2021-06-30 Signal Pharm Llc Supstituisana aminopurinska jedinjenja, kompozicije koje ih sadrže i postupci za lečenje u kojima se koriste
CN115131834A (zh) * 2015-08-13 2022-09-30 小米科技有限责任公司 移动设备及其屏幕模组、指纹采集方法、装置及电子设备
MX2018011970A (es) * 2016-04-01 2019-05-20 Signal Pharm Llc Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas.

Also Published As

Publication number Publication date
EA201892229A1 (ru) 2019-03-29
US20170281633A1 (en) 2017-10-05
JP2019510066A (ja) 2019-04-11
JP7014731B2 (ja) 2022-02-01
EP3436018A1 (en) 2019-02-06
CN109069512B (zh) 2022-06-14
AU2017241837A1 (en) 2018-10-25
EP3436018A4 (en) 2019-11-13
BR112018070163A2 (pt) 2019-01-29
IL262007B (en) 2022-12-01
EA039392B1 (ru) 2022-01-21
SG10202009589UA (en) 2020-10-29
WO2017173206A1 (en) 2017-10-05
IL262007B2 (en) 2023-04-01
US10576085B2 (en) 2020-03-03
SG11201808388QA (en) 2018-10-30
AU2017241837B2 (en) 2021-07-22
NZ746554A (en) 2023-03-31
IL262007A (en) 2018-10-31
KR20180126497A (ko) 2018-11-27
CN109069512A (zh) 2018-12-21
CA3018986A1 (en) 2017-10-05
KR102356433B1 (ko) 2022-01-27
MX2018011992A (es) 2019-01-24

Similar Documents

Publication Publication Date Title
CL2018002787A1 (es) Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos.
CL2019000221A1 (es) Compuestos de tiazolo-piridina sustituida como inhibidores de malt1.
ECSP19042682A (es) Compuestos de 7-feniletilamino-4h-pirimido[4,5-d][1,3]-oxazin-2-ona como inhibidores de idh1 e idh2 mutantes
PE20200733A1 (es) Inhibidores de kras g 12c y metodos para su uso
PH12018502535A1 (en) Substituted carbonucleoside derivatives useful as anticancer agents
EA201990495A1 (ru) Биарильные соединения, применимые в качестве иммуномодуляторов
EA201890857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
UY37134A (es) Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4
BR112017027954A2 (pt) métodos de tratamento de tumores de célula epitelioide
EA201791563A1 (ru) Замещенные нуклеозидные производные, полезные в качестве агентов против рака
MX2020009223A (es) Anticuerpos anti-fgfr2iiib afucosilados.
BR112015022047A2 (pt) métodos para tratar câncer de bexiga
CL2015002767A1 (es) Compuestos terapéuticos y composiciones
DOP2021000017A (es) Compuestos de pirimidina y composiciones farmaceuticas para prevenir o tratar cánceres que incluyen los mismos
BR112012030699A2 (pt) métodos para tratar câncer de bexiga
BR112015026297A2 (pt) terapia combinada composta por um inibidor tor quinase e um composto de 5-quinazolinona substituído para o tratamento de câncer
EA201790779A1 (ru) Замещенные аминопуриновые соединения, их композиции и способы лечения с использованием таких соединений
CL2017001336A1 (es) Nuevos aminoácidos ester fosforamidatos 2' y/o 5', 3' deoxiadenosina derivativos como compuestos anticancerígenos
CR20150483A (es) Composiciones y métodos para el diagnóstico y tratamiento del cáncer hepático
PH12017501879A1 (en) Methods for treating cancer
EA201891514A1 (ru) Комбинированная терапия ингибитором бромодомена и экстратерминального белка
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
CL2017001209A1 (es) Inhibidor de cinasa aurora a
EA201790189A1 (ru) Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе
CR20150653A (es) Compuestos nuevos para el tratamiento del cáncer