CL2018002787A1 - Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. - Google Patents
Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos.Info
- Publication number
- CL2018002787A1 CL2018002787A1 CL2018002787A CL2018002787A CL2018002787A1 CL 2018002787 A1 CL2018002787 A1 CL 2018002787A1 CL 2018002787 A CL2018002787 A CL 2018002787A CL 2018002787 A CL2018002787 A CL 2018002787A CL 2018002787 A1 CL2018002787 A1 CL 2018002787A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- methods
- compositions
- compounds
- substituted aminopurine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PROPORCIONAN EN LA PRESENTE MÉTODOS PARA EL TRATAMIENTO O PREVENCIÓN DE UN CÁNCER, QUE INCLUYEN TUMORES SÓLIDOS Y CÁNCERES HEMATOLÓGICOS, QUE COMPRENDEN ADMINISTRAR UNA CANTIDAD EFICAZ DE COMPUESTOS DE AMINOPURINA DE FÓRMULA (I) Y COMPOSICIONES QUE COMPRENDEN UNA CANTIDAD EFICAZ DE DICHOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662317412P | 2016-04-01 | 2016-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018002787A1 true CL2018002787A1 (es) | 2019-01-18 |
Family
ID=59959573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018002787A CL2018002787A1 (es) | 2016-04-01 | 2018-09-28 | Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US10576085B2 (es) |
EP (1) | EP3436018A4 (es) |
JP (1) | JP7014731B2 (es) |
KR (1) | KR102356433B1 (es) |
CN (1) | CN109069512B (es) |
AU (1) | AU2017241837B2 (es) |
BR (1) | BR112018070163A2 (es) |
CA (1) | CA3018986A1 (es) |
CL (1) | CL2018002787A1 (es) |
EA (1) | EA039392B1 (es) |
IL (1) | IL262007B2 (es) |
MX (1) | MX2018011992A (es) |
NZ (1) | NZ746554A (es) |
SG (2) | SG10202009589UA (es) |
WO (1) | WO2017173206A1 (es) |
Families Citing this family (24)
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GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
RS65069B1 (sr) | 2015-11-02 | 2024-02-29 | Blueprint Medicines Corp | Inhibitori ret-a |
WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
JP6888021B2 (ja) | 2016-03-31 | 2021-06-16 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | デングウイルス複製阻害剤としての置換インドール誘導体 |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
MX2018011970A (es) | 2016-04-01 | 2019-05-20 | Signal Pharm Llc | Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas. |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
LT3630724T (lt) | 2017-05-22 | 2021-08-25 | Janssen Pharmaceuticals, Inc. | Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai |
UA125407C2 (uk) | 2017-05-22 | 2022-03-02 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
IL273658B2 (en) | 2017-10-04 | 2024-10-01 | Celgene Corp | Compounds and methods for using cis-4-[2-{[(3S,4R)-3-fluoroxan-4-YL]amino}-8-(2,4,6-trichloroanilino)-9H-purine-9-YL]- 1-Methylcyclohexane-1-carboxamide |
ES2970041T3 (es) | 2018-04-03 | 2024-05-24 | Blueprint Medicines Corp | Inhibidor de RET para su uso en el tratamiento del cáncer que tiene una alteración de RET |
EP3833372A4 (en) * | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
CN114072207B (zh) * | 2019-04-16 | 2024-03-29 | 维瓦斯治疗公司 | 双环化合物 |
US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
WO2021102204A1 (en) * | 2019-11-20 | 2021-05-27 | Vivace Therapeutics, Inc. | Heteroaryl compounds |
TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
KR102664454B1 (ko) * | 2021-08-03 | 2024-05-09 | 한국생명공학연구원 | 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용 |
CN114681456A (zh) * | 2022-02-23 | 2022-07-01 | 中山大学附属第六医院 | Plx3397在结直肠癌的治疗中的用途 |
Family Cites Families (24)
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US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするdna |
IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
US7569571B2 (en) * | 2003-12-23 | 2009-08-04 | Novartis Ag | Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators |
US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
US20070225304A1 (en) * | 2005-09-06 | 2007-09-27 | Pharmacopeia Drug Discovery, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
WO2007062338A2 (en) | 2005-11-18 | 2007-05-31 | Astrazeneca Ab | Solid formulations |
WO2007134298A2 (en) | 2006-05-12 | 2007-11-22 | Myriad Genetics, Inc. | Therapeutic compounds and their use in cancer |
TWI398252B (zh) | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
MX2009003913A (es) | 2006-10-27 | 2009-04-24 | Signal Pharm Llc | Formas solidas que comprenden 4-[9-(tetrahidro-furano-3-il)-8-(2,4 ,6-trifluoro-fenilamino)-9h-purin-2-ilamino]-ciclohexan-1-ol, composiciones de las mismas, y su uso. |
PT2279731E (pt) | 2008-04-23 | 2013-08-30 | Farmasierra Mfg S L | Composição farmacêutica melhorada contendo ibuprofeno e codeína |
US20130034495A1 (en) | 2009-12-09 | 2013-02-07 | Marie Georges Beauchamps | Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol |
US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
US8680076B2 (en) * | 2010-10-25 | 2014-03-25 | Signal Pharmaceuticals, Llc | Methods of treatment, improvement and prevention using haloaryl substituted aminopurines |
US9466042B2 (en) | 2012-01-24 | 2016-10-11 | International Business Machines Corporation | Facilitating the design of information technology solutions |
WO2014172616A2 (en) | 2013-04-18 | 2014-10-23 | President And Fellows Of Harvard College | Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders |
GB201321737D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
RS61884B1 (sr) * | 2014-10-06 | 2021-06-30 | Signal Pharm Llc | Supstituisana aminopurinska jedinjenja, kompozicije koje ih sadrže i postupci za lečenje u kojima se koriste |
CN115131834A (zh) * | 2015-08-13 | 2022-09-30 | 小米科技有限责任公司 | 移动设备及其屏幕模组、指纹采集方法、装置及电子设备 |
MX2018011970A (es) * | 2016-04-01 | 2019-05-20 | Signal Pharm Llc | Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas. |
-
2017
- 2017-03-31 NZ NZ746554A patent/NZ746554A/en unknown
- 2017-03-31 JP JP2018551358A patent/JP7014731B2/ja active Active
- 2017-03-31 WO PCT/US2017/025252 patent/WO2017173206A1/en active Application Filing
- 2017-03-31 SG SG10202009589UA patent/SG10202009589UA/en unknown
- 2017-03-31 US US15/475,899 patent/US10576085B2/en active Active
- 2017-03-31 EP EP17776735.7A patent/EP3436018A4/en not_active Withdrawn
- 2017-03-31 CA CA3018986A patent/CA3018986A1/en not_active Abandoned
- 2017-03-31 KR KR1020187028514A patent/KR102356433B1/ko active IP Right Grant
- 2017-03-31 MX MX2018011992A patent/MX2018011992A/es unknown
- 2017-03-31 IL IL262007A patent/IL262007B2/en unknown
- 2017-03-31 AU AU2017241837A patent/AU2017241837B2/en active Active
- 2017-03-31 CN CN201780021651.0A patent/CN109069512B/zh active Active
- 2017-03-31 EA EA201892229A patent/EA039392B1/ru unknown
- 2017-03-31 BR BR112018070163A patent/BR112018070163A2/pt not_active Application Discontinuation
- 2017-03-31 SG SG11201808388QA patent/SG11201808388QA/en unknown
-
2018
- 2018-09-28 CL CL2018002787A patent/CL2018002787A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EA201892229A1 (ru) | 2019-03-29 |
US20170281633A1 (en) | 2017-10-05 |
JP2019510066A (ja) | 2019-04-11 |
JP7014731B2 (ja) | 2022-02-01 |
EP3436018A1 (en) | 2019-02-06 |
CN109069512B (zh) | 2022-06-14 |
AU2017241837A1 (en) | 2018-10-25 |
EP3436018A4 (en) | 2019-11-13 |
BR112018070163A2 (pt) | 2019-01-29 |
IL262007B (en) | 2022-12-01 |
EA039392B1 (ru) | 2022-01-21 |
SG10202009589UA (en) | 2020-10-29 |
WO2017173206A1 (en) | 2017-10-05 |
IL262007B2 (en) | 2023-04-01 |
US10576085B2 (en) | 2020-03-03 |
SG11201808388QA (en) | 2018-10-30 |
AU2017241837B2 (en) | 2021-07-22 |
NZ746554A (en) | 2023-03-31 |
IL262007A (en) | 2018-10-31 |
KR20180126497A (ko) | 2018-11-27 |
CN109069512A (zh) | 2018-12-21 |
CA3018986A1 (en) | 2017-10-05 |
KR102356433B1 (ko) | 2022-01-27 |
MX2018011992A (es) | 2019-01-24 |
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