CH654571A5 - Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. - Google Patents

Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. Download PDF

Info

Publication number: CH654571A5
Authority: CH; Switzerland
Prior art keywords: urea; benzyl; butyl; formula; dimethylphenyl
Prior art date: 1982-01-26

Application number

CH404/83A

Other languages

German (de)

English (en)

Inventor

Vern Gordon Devries

Elwood Eugene Largis

Ransom Brown Conrow

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-01-26

Filing date

1983-01-25

Publication date

1986-02-28

1982-01-26 Priority claimed from US06/342,693 external-priority patent/US4473579A/en

1982-01-26 Priority claimed from US06/342,698 external-priority patent/US4387105A/en

1983-01-25 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1986-02-28 Publication of CH654571A5 publication Critical patent/CH654571A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Furan Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CH404/83A 1982-01-26 1983-01-25 Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen. CH654571A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/342,693 US4473579A (en)	1982-01-26	1982-01-26	Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en)	1982-01-26	1982-01-26	Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (1)

Publication Number	Publication Date
CH654571A5 true CH654571A5 (de)	1986-02-28

Family

ID=26993144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH404/83A CH654571A5 (de)	1982-01-26	1983-01-25	Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen.

Country Status (20)

Country	Link
KR (1)	KR890001808B1 (fr)
AT (1)	AT391313B (fr)
AU (1)	AU562699B2 (fr)
CH (1)	CH654571A5 (fr)
DE (1)	DE3247581A1 (fr)
DK (1)	DK160869C (fr)
ES (2)	ES519246A0 (fr)
FI (1)	FI85013C (fr)
FR (1)	FR2521134B1 (fr)
GB (1)	GB2113684B (fr)
GR (1)	GR77186B (fr)
HU (1)	HU200746B (fr)
IE (1)	IE54683B1 (fr)
IL (1)	IL67417A (fr)
IT (1)	IT1203647B (fr)
NL (1)	NL8300269A (fr)
NO (1)	NO158417C (fr)
PL (1)	PL143836B1 (fr)
PT (1)	PT76138A (fr)
SE (1)	SE462653B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2138804A (en) *	1983-04-27	1984-10-31	Sumitomo Chemical Co	Fungicidal N-phenylcarbamates
GB2149394B (en) *	1983-07-19	1986-09-24	American Cyanamid Co	Ureas
US4818899A (en) *	1986-12-03	1989-04-04	Minnesota Mining And Manufacturing Company	Second harmonic generation by carbamic acid derivatives
DE68911203T2 (de) *	1988-03-30	1994-04-14	Warner Lambert Co	N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
US5116848A (en) *	1988-03-30	1992-05-26	Warner-Lambert Company	N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
WO1991011994A1 (fr) *	1990-02-14	1991-08-22	Chugai Seiyaku Kabushiki Kaisha	Inhibiteur de la formation de lipoproteines denaturees de faible densite
US5668136A (en) *	1990-09-25	1997-09-16	Eisai Co., Ltd.	Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) *	1991-07-01	1993-05-28	Sandoz Ag	Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
CA2115915A1 (fr) *	1992-07-20	1994-02-03	Kenji Hayashi	Derives du benzene
AU8534198A (en) *	1997-08-05	1999-03-01	Novo Nordisk A/S	Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
US6455566B1 (en)	1997-09-03	2002-09-24	Wyeth	Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) *	1997-09-03	2000-12-21	American Home Prod	Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
JP2001501979A (ja) *	1998-01-21	2001-02-13	ザイモジェネティクス，インコーポレイティド	カルシトニン擬態物としてのジアルキルウレア
WO2009009122A2 (fr) *	2007-07-10	2009-01-15	Amgen Inc.	Dérivés de l'urée et de diamines associées, leurs procédés de fabrication, et leurs utilisations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL92838C (fr) *	1949-12-06
US2688039A (en) *	1952-02-08	1954-08-31	Ciba Pharm Prod Inc	Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) *	1964-09-25	1967-06-20	Shell Oil Co	Herbicidal phenylureas
US3335142A (en) *	1965-07-07	1967-08-08	American Cyanamid Co	Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) *	1969-05-26	1972-04-25	Lilly Co Eli	Methods of treating helminth infections with thiourea derivatives
US3728386A (en) *	1970-07-27	1973-04-17	Exxon Research Engineering Co	N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) *	1970-09-02	1975-12-23	Ciba Geigy Corp	Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) *	1973-03-01	1974-12-24	Pennwalt Corp	Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) *	1974-05-03	1975-09-02	Stauffer Chemical Co	1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) *	1979-07-14	1981-01-29	Bayer Ag	Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

1982
- 1982-12-05 IL IL67417A patent/IL67417A/xx not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/de not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/ko active
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 FI FI830247A patent/FI85013C/fi not_active IP Right Cessation
- 1983-01-25 SE SE8300370A patent/SE462653B/sv not_active IP Right Cessation
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/de not_active IP Right Cessation
- 1983-01-25 DK DK028683A patent/DK160869C/da not_active IP Right Cessation
- 1983-01-25 NO NO830238A patent/NO158417C/no unknown
- 1983-01-25 CH CH404/83A patent/CH654571A5/de not_active IP Right Cessation
- 1983-01-25 IT IT47605/83A patent/IT1203647B/it active
- 1983-01-25 NL NL8300269A patent/NL8300269A/nl not_active Application Discontinuation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/fr not_active Expired
- 1983-01-25 PL PL1983240284A patent/PL143836B1/pl unknown
- 1983-01-25 HU HU83227A patent/HU200746B/hu not_active IP Right Cessation
- 1983-01-25 ES ES519246A patent/ES519246A0/es active Granted
- 1983-01-25 PT PT76138A patent/PT76138A/pt not_active IP Right Cessation
1984
- 1984-04-11 ES ES531508A patent/ES8505943A1/es not_active Expired

Also Published As

Publication number	Publication date
DK160869B (da)	1991-04-29
FI85013B (fi)	1991-11-15
AU1068183A (en)	1983-08-04
SE8300370L (sv)	1983-07-27
HU200746B (en)	1990-08-28
GR77186B (fr)	1984-09-11
ES531508A0 (es)	1985-07-01
NO158417B (no)	1988-05-30
SE462653B (sv)	1990-08-06
IT8347605A0 (it)	1983-01-25
GB2113684A (en)	1983-08-10
DK28683A (da)	1983-07-27
DK160869C (da)	1991-10-14
KR890001808B1 (ko)	1989-05-23
FR2521134A1 (fr)	1983-08-12
ATA23983A (de)	1990-03-15
ES8406422A1 (es)	1984-08-01
ES519246A0 (es)	1984-08-01
KR840002773A (ko)	1984-07-16
AU562699B2 (en)	1987-06-18
IL67417A (en)	1989-10-31
SE8300370D0 (sv)	1983-01-25
FI85013C (fi)	1992-02-25
NL8300269A (nl)	1983-08-16
PL240284A1 (en)	1985-01-02
NO158417C (no)	1988-09-07
IE54683B1 (en)	1990-01-03
NO830238L (no)	1983-07-27
AT391313B (de)	1990-09-25
GB8301863D0 (en)	1983-02-23
PT76138A (en)	1983-02-01
PL143836B1 (en)	1988-03-31
GB2113684B (en)	1985-12-18
FR2521134B1 (fr)	1987-01-09
IE830146L (en)	1983-07-26
DE3247581A1 (de)	1983-08-04
FI830247L (fi)	1983-07-27
DK28683D0 (da)	1983-01-25
ES8505943A1 (es)	1985-07-01
FI830247A0 (fi)	1983-01-25
IT1203647B (it)	1989-02-15

Publication	Publication Date	Title
US4473579A (en)	1984-09-25	Antiatherosclerotic tetrasubstituted ureas and thioureas
CH654571A5 (de)	1986-02-28	Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen.
US4387105A (en)	1983-06-07	Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
DE2950019A1 (de)	1980-07-10	Imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2041771B2 (de)	1978-11-23	derivate
DE2634288B2 (fr)	1979-06-28
DE2446010A1 (de)	1975-04-03	4-(monoalkylamino)benzoesaeurederivate und verfahren zu ihrer herstellung
EP0001813A1 (fr)	1979-05-16	Dérivés d'imidazolidine, procédé pour leur préparation, intermédiaires pour utilisation dans ce procédé, compositions pharmceutiques les contenant et utilisation des composés actifs
DE2944783C2 (de)	1986-06-26	Diphenylätherverbindungen, Verfahren zu deren Herstellung und diese enthaltende Herbizide
DE2417216A1 (de)	1975-11-06	Fungizide
CH645352A5 (en)	1984-09-28	N-Lower alkyl-3-phenoxy-1-azetidinecarboxamides
DE60315973T2 (de)	2008-05-21	Hydroxy-tetrahydro-naphthalinylharnstoff-derivate
DE69120287T2 (de)	1996-10-10	Aminosulfonylharnstoff-acat-inhibitoren
DE2704989A1 (de)	1977-08-18	Arzneimittel, in diesen enthaltene neue verbindungen und verfahren zu ihrer herstellung
DE2802630A1 (de)	1978-08-03	6-ethoxy-1,2-dihydro-2,2,4-trimethylchinolinderivate und verfahren zu ihrer herstellung
AT394191B (de)	1992-02-10	Verfahren zur herstellung neuer n-alkyl-n-benzyl-n'-arylharnstoffe
DE2157272C3 (de)	1979-03-01	Verwendung von bis-(p-Chlorphenoxy)acetylharnstoff
EP0004529B1 (fr)	1981-06-17	Dérivés d'arylaminoimidazoline tantomères, procédé pour leur préparation et leur application comme analgésique dans des formulations pharmaceutiques
DE2419198A1 (de)	1974-11-14	Pyridincarboxamidsulfonylharnstoffe als hypoglykaemische mittel
DE2749520A1 (de)	1978-05-11	Harnstoffderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische und veterinaermedizinische zusammensetzungen
DE2355262B2 (de)	1981-07-16	1-Piperidinsulfonylharnstoffe, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2549417A1 (de)	1976-07-29	Neue benzolderivate
EP0728741B1 (fr)	2000-09-20	Benzènesulfonylurées et -thiourées substituées, procédé pour leur préparation, leur utilisation dans la production de préparations pharmaceutiques et médicaments les contenant
DE2817112C2 (fr)	1988-01-07
DE69528984T2 (de)	2003-09-04	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten

Legal Events

Date	Code	Title	Description
1996-09-13	PL	Patent ceased