Nothing Special   »   [go: up one dir, main page]

BR9507758A - Fração de copolímero-1 e composição para o tratamento de esclerose múltipla - Google Patents

Fração de copolímero-1 e composição para o tratamento de esclerose múltipla

Info

Publication number
BR9507758A
BR9507758A BR9507758A BR9507758A BR9507758A BR 9507758 A BR9507758 A BR 9507758A BR 9507758 A BR9507758 A BR 9507758A BR 9507758 A BR9507758 A BR 9507758A BR 9507758 A BR9507758 A BR 9507758A
Authority
BR
Brazil
Prior art keywords
copolymer
composition
fraction
treatment
multiple sclerosis
Prior art date
Application number
BR9507758A
Other languages
English (en)
Inventor
Eliezer Konfino
Michael Seja
Dvora Teitelbaum
Ruth Arnon
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26939072&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9507758(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of BR9507758A publication Critical patent/BR9507758A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyamides (AREA)
BR9507758A 1994-05-24 1995-05-23 Fração de copolímero-1 e composição para o tratamento de esclerose múltipla BR9507758A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24803794A 1994-05-24 1994-05-24
US34424894A 1994-11-23 1994-11-23
PCT/US1995/006551 WO1995031990A1 (en) 1994-05-24 1995-05-23 Copolymer-1 improvements in compositions of copolymers

Publications (1)

Publication Number Publication Date
BR9507758A true BR9507758A (pt) 1997-09-23

Family

ID=26939072

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9507758A BR9507758A (pt) 1994-05-24 1995-05-23 Fração de copolímero-1 e composição para o tratamento de esclerose múltipla
BRPI9507758-8A BRPI9507758B1 (pt) 1994-05-24 1995-05-23 fração de copolímero-1; composição para o tratamento de esclerose múltipla; composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI9507758-8A BRPI9507758B1 (pt) 1994-05-24 1995-05-23 fração de copolímero-1; composição para o tratamento de esclerose múltipla; composição farmacêutica

Country Status (31)

Country Link
US (11) US5800808A (pt)
EP (1) EP0762888B1 (pt)
JP (2) JPH10500955A (pt)
KR (1) KR100403750B1 (pt)
CN (2) CN1310673C (pt)
AT (1) ATE212857T1 (pt)
AU (1) AU2602195A (pt)
BR (2) BR9507758A (pt)
CA (1) CA2191088C (pt)
CZ (1) CZ292247B6 (pt)
DE (2) DE10299030I1 (pt)
DK (1) DK0762888T3 (pt)
EE (1) EE03423B1 (pt)
ES (1) ES2172586T3 (pt)
FI (1) FI120236B (pt)
GE (1) GEP20002205B (pt)
HK (1) HK1008657A1 (pt)
HU (1) HU223473B1 (pt)
IL (2) IL113812A (pt)
LU (1) LU90987I2 (pt)
MD (1) MD1443G2 (pt)
NL (1) NL300096I2 (pt)
NO (1) NO324528B1 (pt)
NZ (1) NZ287335A (pt)
PL (1) PL181026B1 (pt)
PT (1) PT762888E (pt)
SI (1) SI0762888T1 (pt)
SK (1) SK283699B6 (pt)
TJ (1) TJ392B (pt)
UA (1) UA62908C2 (pt)
WO (1) WO1995031990A1 (pt)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077509A (en) * 1990-03-30 2000-06-20 Autoimmune, Inc. Peptide fragments of myelin basic protein
US6252040B1 (en) 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US7090982B2 (en) 1991-10-22 2006-08-15 The Governors Of The University Of Alberta Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US5858964A (en) * 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
IL119989A0 (en) * 1997-01-10 1997-04-15 Yeda Res & Dev Pharmaceutical compositions for oral treatment of multiple sclerosis
WO1999041247A1 (en) * 1998-02-13 1999-08-19 Autoimmune, Inc. TREATMENT OF MULTIPLE SCLEROSIS USING COP-1 AND Th2-ENHANCING CYTOKINES
JP2003521448A (ja) 1998-07-23 2003-07-15 ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 合成ペプチドおよび自己免疫疾患治療のための使用方法
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
CA2337688C (en) 1998-07-23 2016-04-05 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with copolymer 1 and related copolymers
US6514938B1 (en) 1998-09-25 2003-02-04 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6800287B2 (en) * 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
DE69940888D1 (de) 1998-09-25 2009-06-25 Yeda Res & Dev Copolymer-1-verwandte polypeptide für die verwendung als molekulargewichtsmarker und zur therapie
WO2000020010A1 (en) * 1998-10-02 2000-04-13 Yeda Research And Development Co., Ltd. Alternate day administration of copolymer 1 for treating autoimmune diseases
US7083777B1 (en) 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
KR100822695B1 (ko) * 2000-01-20 2008-04-17 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 코폴리머 1 및 관련된 펩티드들 및 폴리펩티드 및 이들로처치된 티세포들의 신경보호 요법을 위한 사용
DE60120648D1 (de) * 2000-02-18 2006-07-27 Yeda Res & Dev Formulierungen von copolymer 1 (glatirameracetat) zur oralen, nasalen und pulmonalen verabreichung
ZA200206457B (en) * 2000-02-18 2003-08-13 Yeda Res & Dev Oral, nasal and pulmonary dosage formulations of copolymer 1.
US20020077278A1 (en) * 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
HUP0302333A3 (en) * 2000-06-05 2005-07-28 Teva Pharma The use of glatiramer acetate (copolymer 1) for the preparation of pharmaceutical compositions available in the treatment of central nervous system disorders
DE60116467T2 (de) * 2000-06-07 2006-11-02 Yeda Research And Development Co., Ltd. Verwendung des Copolymer-1 Peptids sowie von damit verwandten Peptiden und Polypeptiden und von damit behandelten T-Zellen zur Neuroprotektion gegen die Toxizität von Glutamat
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
WO2001097785A2 (en) * 2000-06-20 2001-12-27 Caprion Pharmaceuticals Inc. Basic copolymers for the treatment of prion-related-disease
IL137460A0 (en) 2000-07-24 2001-07-24 Yeda Res & Dev Identifying antigen clusters for monitoring a global state of an immune system
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
GB2369896A (en) 2000-12-06 2002-06-12 Marconi Comm Ltd Tunable optical filter actuator
KR100442122B1 (ko) * 2001-07-31 2004-07-30 한국전기연구원 영구 자석을 이용한 브러시리스 발전기
JP4369234B2 (ja) * 2001-12-04 2009-11-18 テバ ファーマシューティカル インダストリーズ リミティド グラチラマー・アセテートの強度の測定のための方法
DK1429800T3 (da) * 2001-12-06 2009-04-27 Yeda Res & Dev Vaccine og anvendelse deraf til behandling af amyotrofisk lateral sklerose
AU2002360696A1 (en) * 2001-12-21 2003-07-30 Ilex Oncology, Inc. Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment for multiple sclerosis
WO2004060265A2 (en) 2003-01-07 2004-07-22 Yeda Research And Development Co. Ltd. Eye-drop vaccine containing copolymer 1 for therapeutic immunization
AU2004206120B2 (en) * 2003-01-21 2009-09-24 Yeda Research And Development Co. Ltd. COP 1 for treatment of inflammatory bowel diseases
CA2518079A1 (en) * 2003-03-04 2004-10-28 Teva Pharmaceutical Industries, Ltd. Combination therapy with glatiramer acetate and alphacalcidol for the treatment of multiple sclerosis
JP2006522135A (ja) 2003-03-31 2006-09-28 ザ ブライアム アンド ウィミンズ ホスピタル インコーポレーテッド 喘息およびアレルギーの処置のための両性イオン免疫調節剤
EA200600877A1 (ru) * 2003-10-31 2006-12-29 Тева Фармасьютикал Индастриз, Лтд. Наночастицы для доставки лекарств
JP5456235B2 (ja) 2003-11-12 2014-03-26 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 神経変性疾患を治療するためのワクチン及び方法
CA2548310C (en) 2003-12-09 2014-02-18 Yeda Research And Development Co. Ltd. Method and vaccine comprising copolymer 1 for treatment of psychiatric disorders
US20090214580A1 (en) * 2004-02-02 2009-08-27 Houghten Richard A Peptide mixtures with immunomodulatory activity
EP1725603A2 (en) * 2004-03-01 2006-11-29 Peptimmune, Inc. Methods and compositions for treatment of autoimmune diseases
JP2007535498A (ja) * 2004-03-03 2007-12-06 テバ ファーマシューティカル インダストリーズ リミティド グラチラマー・アセテートおよびリルゾールでの併用療法
US20050260770A1 (en) * 2004-04-01 2005-11-24 Cohen Irun R Antigen array and diagnostic uses thereof
RU2410115C2 (ru) 2004-05-07 2011-01-27 Пептиммьюн, Инк. Способы лечения заболеваний с помощью статистических сополимеров
US7655221B2 (en) * 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
US20060194725A1 (en) * 2004-05-07 2006-08-31 James Rasmussen Methods of treating disease with random copolymers
AU2005259991B2 (en) 2004-06-25 2011-05-26 Id Biomedical Corporation Of Quebec Compositions and methods for treating neurological disorders
ATE536363T1 (de) * 2004-09-09 2011-12-15 Teva Pharma Verfahren zur herstellung von mischungen von trifluoroacetyl-glatirameracetat bei verwendung von hydrobromsäure
HUE028833T2 (en) * 2004-09-09 2017-01-30 Yeda Res & Dev Polypeptide mixtures, compositions containing them, process for their preparation, and applications
AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
US8324641B2 (en) * 2007-06-29 2012-12-04 Ledengin, Inc. Matrix material including an embedded dispersion of beads for a light-emitting device
EP1827108B1 (en) * 2004-11-29 2015-04-08 Yeda Research And Development Co., Ltd. Induction of neurogenesis and stem cell therapy in combination with copolymer 1
WO2006083608A1 (en) * 2005-02-02 2006-08-10 Teva Pharmaceutical Industries, Ltd. Process for producing polypeptide mixtures using hydrogenolysis
RS52867B (en) * 2005-02-17 2013-12-31 Teva Pharmaceutical Industries Ltd. GLATIRAMER ACETATOM AND RAZAGILIN COMBINED THERAPY FOR MULTIPLE SCLEROSIS
US20100167983A1 (en) * 2007-10-22 2010-07-01 Teva Pharmaceutical Industries, Ltd. Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
EP1891233A4 (en) * 2005-04-25 2010-03-24 Yeda Res & Dev MARKERS ASSOCIATED WITH THERAPY EFFECTIVENESS OF GLATIRAMERATE ACETATE
WO2007081975A2 (en) * 2006-01-11 2007-07-19 Teva Pharmaceutical Industries, Ltd. Method of treating multiple sclerosis
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
CA2649296A1 (en) 2006-04-13 2007-10-25 Peptimmune, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
WO2007127977A2 (en) * 2006-04-28 2007-11-08 Momenta Pharmaceuticals, Inc. Methods of evaluating peptide mixtures
KR100831796B1 (ko) * 2006-05-29 2008-05-28 엘지전자 주식회사 타임 쉬프트 기능을 내장한 영상표시기기 및 그 재생 방법
US9089509B2 (en) 2006-06-28 2015-07-28 Yeda Research And Development Co., Ltd. Method of treatment of age-related macular degeneration
CN101511862A (zh) * 2006-07-05 2009-08-19 莫门塔制药股份有限公司 制备共聚物-1的改进方法
CA2690402A1 (en) 2007-06-21 2008-12-24 Momenta Pharmaceuticals, Inc. Copolymer assay
US20090029766A1 (en) * 2007-07-26 2009-01-29 Lutnick Howard W Amusement gaming access and authorization point
CA2705046C (en) * 2007-07-31 2015-03-03 Natco Pharma Limited Process for the preparation glatiramer acetate (copolymer-1)
WO2009051797A1 (en) 2007-10-16 2009-04-23 Peptimmune, Inc. Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
WO2009062132A2 (en) 2007-11-09 2009-05-14 California Institute Of Technology Immunomodulating compounds and related compositions and methods
EA201070656A1 (ru) * 2007-11-28 2010-12-30 Тева Фармасьютикал Индастриз, Лтд. Способ задержки начала проявления клинически определенного рассеянного склероза
ES2449865T5 (es) † 2008-04-16 2022-11-18 Momenta Pharmaceuticals Inc Análisis de composiciones de copolímeros de aminoácidos
ES2537022T3 (es) * 2008-08-07 2015-06-01 Sigma-Aldrich Co. Llc Preparación de polilisina y poliornitina de bajo peso molecular con alto rendimiento
CN102112485B (zh) * 2008-08-07 2013-11-27 台湾神隆股份有限公司 乙酸格拉默(glatiramer acetate)的合成
US9617313B2 (en) 2008-12-24 2017-04-11 Synthon Bv Process for purifying a polymer mixture
ES2523732T5 (es) 2009-04-03 2023-10-23 Momenta Pharmaceuticals Inc Control de composiciones de copolímeros
US9150609B2 (en) 2009-06-04 2015-10-06 Council Of Scientific & Industrial Research Process for the preparation of copolymer-1 using a polymer supported dialkylamine initiator
US8920373B2 (en) 2009-07-15 2014-12-30 Teva Pharmaceutical Industries, Ltd. Reduced volume formulation of glatiramer acetate and methods of administration
PL2275086T3 (pl) * 2009-07-15 2012-09-28 Teva Pharma Formulacja octanu glatirameru o zredukowanej objętości oraz sposoby podawania
US8691790B2 (en) * 2009-07-27 2014-04-08 James Layne Boucher Therapy of neurological inflammatory diseases with (5'-deoxy-5'-adenosyl) cobamamide, recombinant human growth hormone, interleukins IL-1, IL-6, IL-11, epidermal growth factor, and physiotherapy
KR20160038057A (ko) 2009-08-20 2016-04-06 에다 리서치 앤드 디벨럽먼트 컴퍼니 리미티드 글라티라머 아세테이트를 포함하는 약제
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
AU2010337822B2 (en) 2010-01-04 2016-03-17 Mapi Pharma Limited Depot systems comprising glatiramer or a pharmacologically acceptable salt thereof
US8377885B2 (en) 2010-01-04 2013-02-19 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
EP2523668A1 (en) 2010-01-13 2012-11-21 Ramot at Tel-Aviv University Ltd Treatment of multiple sclerosis
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
EP2555753B1 (en) 2010-04-07 2018-08-01 California Institute of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
KR20130062936A (ko) * 2010-04-27 2013-06-13 닥터 레디스 레보러터리즈 리미티드 폴리펩티드 및 그의 염의 제조
JP2013530949A (ja) 2010-05-20 2013-08-01 エル ラウンド ジューン 抗原特異的Ｔｒｅｇ並びに関連する組成物、方法及びシステム
RU2013108828A (ru) * 2010-07-29 2014-09-10 Др. Редди'С Лабораторис Лтд. Маркеры молекулярной массы глатирамера ацетата
BR112013008573A2 (pt) 2010-10-11 2016-07-12 Teva Pharma citocinas biomarcadoras como indicadores de resposta clínica a acetato de glatirâmer.
WO2012123959A2 (en) 2011-02-14 2012-09-20 Usv Limited Copolymer-1, process for preparation and analytical methods thereof
WO2012143924A1 (en) 2011-04-21 2012-10-26 Mapi Pharma Ltd. Random pentapolymer for treatment of autoimmune diseases
WO2012150495A1 (en) 2011-05-05 2012-11-08 National Institute Of Immunology Synthetic peptides and random copolymers for the treatment of autoimmune disorders
WO2013009864A1 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Structure assessment of heterogeneous polypeptide mixtures
WO2013009885A2 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Evaluation of copolymer diethylamide
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate
CN103957705A (zh) 2011-10-10 2014-07-30 泰华制药工业有限公司 适用于预测对醋酸格拉替雷的临床反应的单核苷酸多态性
WO2013139728A1 (en) 2012-03-19 2013-09-26 Synthon Bv Glatiramer acetate human monocyte cell-based potency assay
EP2642290A1 (en) 2012-03-19 2013-09-25 Synthon BV Glatiramer acetate human monocytic cell line-based potency assay
US20140045740A1 (en) * 2012-08-13 2014-02-13 Momenta Pharmaceuticals, Inc. Analysis of glatiramer acetate
WO2014058976A2 (en) 2012-10-10 2014-04-17 Teva Pharmaceutical Industries Ltd. Biomarkers predictive for clinical response for glatiramer acetate
WO2014060942A2 (en) * 2012-10-20 2014-04-24 Mahesh Kandula Compositions and methods of for the treatment of multiple sclerosis and neurodegenerative diseases
WO2014128079A1 (en) 2013-02-19 2014-08-28 Synthon B.V. Glatiramer acetate multidose formulation
DK2774639T3 (en) 2013-03-08 2015-01-12 Teva Pharma Reusable injection device for a syringe
ES2529242T3 (es) 2013-03-08 2015-02-18 Teva Pharmaceutical Industries, Ltd. Dispositivo inyector reutilizable para jeringuilla
CA2903805A1 (en) 2013-03-14 2014-10-02 Mylan Inc. Glatiramer acetate response biomarker mrna potency assay
WO2014173463A1 (en) 2013-04-26 2014-10-30 Synthon Bv Glatiramer acetate human monocytic cell line-based potency assay
CA2911826C (en) 2013-05-10 2022-08-23 California Institute Of Technology Probiotic prevention and treatment of colon cancer
CN103265624B (zh) * 2013-05-27 2015-04-22 成都圣诺生物制药有限公司 格拉替雷的制备方法
CN104371012A (zh) * 2013-08-12 2015-02-25 深圳翰宇药业股份有限公司 一种合成醋酸格拉替雷的方法
UY35790A (es) 2013-10-21 2015-05-29 Teva Pharma Marcadores genéticos que predicen la respuesta al acetato de glatiramer
EP3060684A4 (en) * 2013-10-24 2017-06-07 Mylan Inc. Human t cell line assay for evaluating the immunologic identity of glatiramer acetate preparations
WO2015101988A1 (en) 2013-12-31 2015-07-09 Yeda Research And Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
KR102248804B1 (ko) 2014-03-12 2021-05-11 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
CN104844697B (zh) 2014-09-26 2018-10-23 深圳翰宇药业股份有限公司 醋酸格拉替雷的制备方法
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
WO2016139659A1 (en) 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
WO2016201342A1 (en) 2015-06-10 2016-12-15 California Institute Of Technology Sepsis treatment and related compositions methods and systems
EP3337321A4 (en) 2015-08-19 2019-07-17 President and Fellows of Harvard College LIPIDED PSA COMPOSITIONS AND METHOD
EP3147667B1 (en) 2015-09-24 2019-06-12 CHEMI S.p.A. Analysis of the molecular weight distribution of complex polypeptide mixtures
EP3170836B1 (en) 2015-11-23 2018-10-24 Chemi SPA Rp-hplc analysis of complex polypeptide mixtures
CN107522774B (zh) * 2016-06-22 2021-07-02 深圳翰宇药业股份有限公司 一种醋酸格拉替雷制备过程中哌啶残留量的实时控制方法
WO2018002930A1 (en) 2016-06-30 2018-01-04 Stem Cell Medicine Ltd. Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells
EP3484441A4 (en) 2016-07-15 2020-03-18 President and Fellows of Harvard College GLYCOLIPID COMPOSITIONS AND METHODS OF USE
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
ES2979169T3 (es) 2016-08-28 2024-09-24 Mapi Pharma Ltd Proceso para la preparación de micropartículas que contienen acetato de glatiramero
DK3506921T3 (da) 2016-08-31 2023-07-31 Mapi Pharma Ltd Depotsystemer, der omfatter glatirameracetat
AU2018242998B2 (en) 2017-03-26 2023-11-02 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis
CA3062123A1 (en) 2017-05-15 2018-11-22 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with adipose-derived stem cells
CA3062964A1 (en) 2017-05-15 2018-11-22 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells
WO2019175869A1 (en) 2018-03-12 2019-09-19 Yeda Research And Development Co. Ltd Treatment of a heart disease

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US4444760A (en) 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
JPS6053535A (ja) 1983-09-02 1985-03-27 Nitto Boseki Co Ltd 規則性ポリアミノ酸樹脂の製造方法
SU1182051A1 (ru) 1984-04-28 1985-09-30 Таджикский государственный университет им.В.И.Ленина Политрипептиды,обладающие энантовой селективностью в реакци х гидролиза @ -нитрофениловых эфиров карбобензокси - @ - и @ -аланина
EP0228448B1 (en) 1985-06-18 1991-08-28 Emory University Use of biologically active copolymers for the manufacture of a medicament for stimulating the growth of an animal
DD257174A3 (de) 1985-12-20 1988-06-08 Ve Forschungszentrum Biotechno Verfahren zur herstellung der peptide z-ala-ala-lon-p-nitranilid oder z-asp-phe-ome mit metalloprotease
SU1469826A1 (ru) 1986-05-30 1995-11-20 Институт Высокомолекулярных Соединений Ан Ссср Сополимер l-лизина с l-глутаминовой кислотой, содержащий дофаминовые боковые группы, обладающий пролонгированной гипотензивной активностью и компенсаторным эффектом при геморрагическом шоке, и способ его получения
US4828706A (en) 1988-03-07 1989-05-09 Spectrum Medical Industries Process for performing a dialysis operation
US4908404A (en) * 1988-08-22 1990-03-13 Biopolymers, Inc. Synthetic amino acid-and/or peptide-containing graft copolymers
DE8900366U1 (de) * 1989-01-13 1989-08-03 Indag Gesellschaft für Industriebedarf mbH, 69214 Eppelheim Folienbeutel
CA2009996A1 (en) * 1989-02-17 1990-08-17 Kathleen S. Cook Process for making genes encoding random polymers of amino acids
SU1690368A1 (ru) 1989-07-20 1995-08-20 Институт Высокомолекулярных Соединений Ан Ссср Статистические сополимеры в качестве низкотоксичных веществ, обладающих пролонгированным гипотензивным действием, и способ их получения
DE3930733A1 (de) 1989-09-14 1991-03-28 Roehm Gmbh Verfahren zur herstellung eines komplexierten arzneimittels
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
CN1073980A (zh) * 1991-11-12 1993-07-07 纳幕尔杜邦公司 胶原样多肽
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US6214791B1 (en) * 1997-01-10 2001-04-10 Yeda Research And Development Co. Ltd. Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1
EP0983020A1 (en) 1997-05-06 2000-03-08 Quanta Vision, Inc. Tissue analysis apparatus
KR100822695B1 (ko) * 2000-01-20 2008-04-17 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 코폴리머 1 및 관련된 펩티드들 및 폴리펩티드 및 이들로처치된 티세포들의 신경보호 요법을 위한 사용
US6936539B2 (en) * 2003-09-24 2005-08-30 Micron Technology, Inc. Antireflective coating for use during the manufacture of a semiconductor device

Also Published As

Publication number Publication date
AU2602195A (en) 1995-12-18
NO964976D0 (no) 1996-11-22
PL317331A1 (en) 1997-04-01
JPH10500955A (ja) 1998-01-27
CN1152874A (zh) 1997-06-25
CN1174753C (zh) 2004-11-10
US20030064914A1 (en) 2003-04-03
SI0762888T1 (en) 2002-08-31
HU223473B1 (hu) 2004-07-28
US7625861B2 (en) 2009-12-01
US20070117757A1 (en) 2007-05-24
NL300096I1 (nl) 2002-10-01
DK0762888T3 (da) 2002-05-27
PL181026B1 (pl) 2001-05-31
IL113812A0 (en) 1995-08-31
ATE212857T1 (de) 2002-02-15
IL113812A (en) 2000-06-29
US6054430A (en) 2000-04-25
EE9600170A (et) 1997-06-16
CA2191088C (en) 2004-09-28
JP3715600B2 (ja) 2005-11-09
US6342476B1 (en) 2002-01-29
TJ392B (en) 2004-10-13
US20050171286A1 (en) 2005-08-04
JP2003105000A (ja) 2003-04-09
KR970703154A (ko) 1997-07-03
HU9603243D0 (en) 1997-01-28
CA2191088A1 (en) 1995-11-30
NO964976L (no) 1997-01-23
US6620847B2 (en) 2003-09-16
MD1443F1 (en) 2000-04-30
NO324528B1 (no) 2007-11-12
FI120236B (fi) 2009-08-14
GEP20002205B (en) 2000-08-25
NL300096I2 (nl) 2003-02-03
BRPI9507758B1 (pt) 2021-03-16
US6362161B1 (en) 2002-03-26
EE03423B1 (et) 2001-06-15
NZ287335A (en) 1999-02-25
DE69525340T2 (de) 2002-09-19
US5800808A (en) 1998-09-01
US5981589A (en) 1999-11-09
EP0762888A4 (pt) 1997-04-16
FI964600A (fi) 1996-12-05
DE10299030I1 (de) 2003-01-23
DE69525340D1 (de) 2002-03-21
HUT75672A (en) 1997-05-28
CZ341096A3 (en) 1997-06-11
LU90987I2 (fr) 2003-02-25
WO1995031990A1 (en) 1995-11-30
CZ292247B6 (cs) 2003-08-13
KR100403750B1 (ko) 2006-02-13
US6939539B2 (en) 2005-09-06
CN1310673C (zh) 2007-04-18
US20120077754A1 (en) 2012-03-29
HK1008657A1 (en) 1999-05-14
EP0762888B1 (en) 2002-02-06
EP0762888A1 (en) 1997-03-19
SK149396A3 (en) 1997-08-06
US8367605B2 (en) 2013-02-05
MD1443G2 (ro) 2000-11-30
ES2172586T3 (es) 2002-10-01
US20040106554A1 (en) 2004-06-03
US7199098B2 (en) 2007-04-03
IL133890A0 (en) 2001-04-30
CN1626238A (zh) 2005-06-15
US6048898A (en) 2000-04-11
PT762888E (pt) 2002-07-31
UA62908C2 (uk) 2004-01-15
FI964600A0 (fi) 1996-11-15
SK283699B6 (sk) 2003-12-02

Similar Documents

Publication Publication Date Title
BR9507758A (pt) Fração de copolímero-1 e composição para o tratamento de esclerose múltipla
DK0792287T3 (da) Peptidanaloger af humant basisk myelinprotein
DK0611522T3 (da) Synergistiske mikrobicide sammensætninger
HK1025737A1 (en) Treatment of multiple sclerosis through ingestion of copolymer-1
BR9814040A (pt) Agudo no pulmão com fibrose com antagonistas de avb6
FR2679914B1 (fr) Composition de caoutchouc de la serie des dienes connjuguees.
DE69421474D1 (de) Emulgierte Polysiloxanzusammensetzungen
BG102215A (en) Compounds and pharmaceutical compositions containing them
NO995229D0 (no) Anvendelse av sinkhyaluronat mot peptisk ulcus
DE69405919D1 (de) Zusammensetzungen zur Behandlung von Keratinfasern
ES2083861T3 (es) Copolimeros de siloxano que contienen grupos viniloxi, su fabricacion y su utilizacion.
EA199700032A1 (ru) Дезинфицирующий состав "велтолен"
DE68913995D1 (de) Zusammensetzung zur behandlung progressiver myopie.
ES2094930T3 (es) Nueva proteina inhibidora de trombina aislada de garrapatas.
HUP9901183A2 (hu) Készítmények és eljárások az orális mukozitisz megakadályozására és kezelésére
BR9709007A (pt) Uso de azaspirano substituìdo no tratamento da asma.

Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
B12B Appeal against refusal [chapter 12.2 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI-52400.003199/09 ORIGEM: JUIZO DA 38A VARA FEDERAL DO RIO DE JANEIRO PROCESSO:2009.51.01.805772-0 NO.MANDADO: MTL.0038.000081-2/2009 MANDADO DE INTIMACAO AUTOR: YEDA RESEARCH AND DEVELOPMENT CO LTD REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI.

B15N Others concerning applications: notification of judicial decision

Free format text: NOTIFICACAO DE DECISAO JUDICIAL (INPI-52400.003199/09 ORIGEM: JUIZO DA 31A VARA FEDERAL DO RIO DE JANEIRO PROCESSO N.O 2009.51.01.805772-0 AUTOR: YEDA RESEARCH AND DEVELOPMENT CO LTD REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI) ANTE O EXPOSTO, JULGO PROCEDENTE O PEDIDO SUBSIDIARIO, PARA DECLARAR A NULIDADE DO ATO ADMINISTRATIVO QUE NEGOU PROVIMENTO AO RECURSO ADMINISTRATIVO DO PEDIDO DE PATENTE PI9507758-8. DEVE O INPI EMITIR NOVO PARECER, A PARTIR DA APRESENTACAO PELA AUTORA DE QUADRO REIVINDICATORIO REVISTO. FICA LIVRE A AUTARQUIA PARA APRECIA-LO, DANDO OU NAO PROVIMENTO AO RECURSO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/1995, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/1995, OBSERVADAS AS CONDICOES LEGAIS

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 23/05/2015.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI NO 52402.012444/2020-11 17A VARA FEDERAL CIVEL DA SJDF PARECER DE FORCA EXECUTORIA OFICIO N. 02206/2020/GCM/ER-REG-PRF1/PGF/AGU PROCESSO JUDICIAL: 1068993-97.2020.4.01.3400 IMPETRANTE: YEDA RESEARCH AND DEVELOPMENT LTD. IMPETRADO: INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL - INPI DECISAO: DEFIRO PARCIALMENTE O PEDIDO DE TUTELA DE URGENCIA, PARA DETERMINAR A SUSPENSAO DOS EFEITOS DO DESPACHO 16.1 REFERENTE A CONCESSAO DA PATENTE PI 9507758-8, DE SORTE A ASSEGURAR PROTECAO A ALUDIDA PATENTE ATE A PROLACAO DE SENTENCA NESTE FEITO, NA FORMA DO ART. 42 DA LEI N. 9.279/1996.

B16D Grant of patent or certificate of addition of invention cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 16.1 NA RPI NO 2551 DE 26/11/2019, CONFORME INPI NO 52402.012444/2020-11 17A VARA FEDERAL CIVEL DA SJDF PARECER DE FORCA EXECUTORIA OFICIO N.02206/2020/GCM/ER-REG-PRF1/PGF/AGU PROCESSO JUDICIAL: 1068993-97.2020.4.01.3400 IMPETRANTE: YEDA RESEARCH AND DEVELOPMENT LTD. IMPETRADO: INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL - INPI.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI NO 52402.012444/2020-11 NUMERO DO PROCESSO JUDICIAL: 00424.179512/2020-79 (REF. 1068993-97.2020.4.01.3400) TRIBUNAL REGIONAL FEDERAL DA 1A REGIAO INTERESSADOS: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E YEDA RESEARCH AND DEVELOPMENT LTD. DECISAO: ANTE O EXPOSTO, CONHECO DOS EMBARGOS DE DECLARACAO E DOU-LHES PROVIMENTO, PARA CORRIGIR ERRO MATERIAL NA DECISAO EMBARGADA, DE MODO QUE DETERMINO A REPUBLICACAO DO DESPACHO 16.1, AO TEMPO EM QUE SUSPENDO OS EFEITOS DO DESPACHO 21.1, DE MODO A ASSEGURAR A PROTECAO A PATENTE PI9507758-8, ATE A PROLACAO DE SENTENCA NESTE FEITO, NA FORMA DO ART. 42 DA LEI N.9.279/1996.

B21I Extinguishment of a patent or of a certificate of addition of invention: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 21.1 NA RPI NO 2597 DE 13/10/2020 POR TER SIDO INDEVIDA.

B16D Grant of patent or certificate of addition of invention cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 16.4 NA RPI NO 2609 DE 05/01/2021 POR TER SIDO INDEVIDA.NUP: 00424.179512/2020-79 (REF. 1068993-97.2020.4.01.3400) RPI 2613 - CODIGO 19.1

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/1995, OBSERVADAS AS CONDICOES LEGAIS.

B19A Notification of judicial decision: notification of judicial decision

Free format text: PROCESSO INPI NO 52402.012444/2020-11 NUP: 00424.179512/2020-79 (REF. 1068993-97.2020.4.01.3400) INTERESSADOS: YEDA RESEARCH AND DEVELOPMENT LTD. E OUTROS SENTENCA: O PROCESSO EM EPIGRAFE FOI SENTENCIADO, OCASIAO EM QUE O JUIZ JULGOU IMPROCEDENTE O PEDIDO E REVOGOU EXPRESSAMENTE A ANTERIOR DECISAO DE TUTELA ANTECIPADA, CONFORME SE VE (SEQ. 143 DO NUP 00424.179512/2020-79): "ANTE O EXPOSTO, JULGO IMPROCEDENTE O PEDIDO CONTIDO NA INICIAL, NOS TERMOS DO ART. 487, INCISO I, DO CPC. OUTROSSIM, REVOGO A TUTELA DE URGENCIA ANTERIORMENTE DEFERIDA."