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BR112022003335A2 - Conjugados de il-2 e métodos de uso para tratar doenças autoimunes - Google Patents

Conjugados de il-2 e métodos de uso para tratar doenças autoimunes

Info

Publication number
BR112022003335A2
BR112022003335A2 BR112022003335A BR112022003335A BR112022003335A2 BR 112022003335 A2 BR112022003335 A2 BR 112022003335A2 BR 112022003335 A BR112022003335 A BR 112022003335A BR 112022003335 A BR112022003335 A BR 112022003335A BR 112022003335 A2 BR112022003335 A2 BR 112022003335A2
Authority
BR
Brazil
Prior art keywords
conjugates
methods
autoimmune diseases
treat autoimmune
kits
Prior art date
Application number
BR112022003335A
Other languages
English (en)
Inventor
E Caffaro Carolina
Jerod Ptacin
Marcos Milla
Original Assignee
Synthorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthorx Inc filed Critical Synthorx Inc
Publication of BR112022003335A2 publication Critical patent/BR112022003335A2/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

conjugados de il-2 e métodos de uso para tratar doenças autoimunes. são descritos neste documento composições, kits e métodos compreendendo conjugados de interleucina (il) (por exemplo, conjuga-dos de il-2) úteis para o tratamento de uma ou mais indicações. também são descritos aqui composições farmacêuticas e kits compreendendo um ou mais dos conjugados de interleucina (por exemplo, conjugados de il-2).
BR112022003335A 2019-09-10 2020-09-09 Conjugados de il-2 e métodos de uso para tratar doenças autoimunes BR112022003335A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962898478P 2019-09-10 2019-09-10
US201962900488P 2019-09-14 2019-09-14
US201962930987P 2019-11-05 2019-11-05
US201962953075P 2019-12-23 2019-12-23
US202063042393P 2020-06-22 2020-06-22
PCT/US2020/049954 WO2021050554A1 (en) 2019-09-10 2020-09-09 Il-2 conjugates and methods of use to treat autoimmune diseases

Publications (1)

Publication Number Publication Date
BR112022003335A2 true BR112022003335A2 (pt) 2022-05-24

Family

ID=72644922

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022003335A BR112022003335A2 (pt) 2019-09-10 2020-09-09 Conjugados de il-2 e métodos de uso para tratar doenças autoimunes

Country Status (13)

Country Link
US (1) US20210070827A1 (pt)
EP (1) EP4028060A1 (pt)
JP (1) JP2022547078A (pt)
KR (1) KR20220061158A (pt)
CN (1) CN114746122A (pt)
AU (1) AU2020347154A1 (pt)
BR (1) BR112022003335A2 (pt)
CA (1) CA3150082A1 (pt)
CO (1) CO2022001210A2 (pt)
IL (1) IL291018A (pt)
MX (1) MX2022002740A (pt)
TW (1) TW202124385A (pt)
WO (1) WO2021050554A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111183149A (zh) 2017-08-03 2020-05-19 辛索克斯公司 用于治疗自身免疫疾病的细胞因子缀合物
CN115315436A (zh) * 2020-01-10 2022-11-08 明峰治疗股份公司 修饰的il-2多肽及其用途
TW202228786A (zh) * 2020-10-09 2022-08-01 美商欣爍克斯公司 Il-2接合物的免疫腫瘤學療法
IL301611A (en) * 2020-10-09 2023-05-01 Synthorx Inc Combined immuno-oncology treatment with pairs of IL-2 and pembrolizumab
TW202302148A (zh) * 2021-02-12 2023-01-16 美商欣爍克斯公司 使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
US20240255492A1 (en) * 2021-06-08 2024-08-01 Merck Sharp & Dohme Llc Functional cell-based potency assay for measuring biological activity of interleukin 2 (il-2) analogs
WO2023241653A1 (zh) * 2022-06-17 2023-12-21 舒泰神(北京)生物制药股份有限公司 白介素-2(il-2)突变体及其用途
WO2024133935A1 (en) 2022-12-23 2024-06-27 Ablynx Nv Protein-based conjugation carriers

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