BR112018010429A2 - ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados - Google Patents
ácidos nucleicos que se direcionam a ácidos nucleicos engenheiradosInfo
- Publication number
- BR112018010429A2 BR112018010429A2 BR112018010429-9A BR112018010429A BR112018010429A2 BR 112018010429 A2 BR112018010429 A2 BR 112018010429A2 BR 112018010429 A BR112018010429 A BR 112018010429A BR 112018010429 A2 BR112018010429 A2 BR 112018010429A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acids
- polynucleotide sequences
- structures
- engineered polynucleotide
- nucleic acid
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 102000011931 Nucleoproteins Human genes 0.000 abstract 1
- 108010061100 Nucleoproteins Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
a presente descrição fornece sequências polinucleotídicas engenheiradas que formam estruturas e complexos de nucleoproteínas que compreendem tais sequências polinucleotídicas engenheiradas que formam estruturas e proteínas que se ligam aos ácidos nucleicos. são descritas as sequências de ácidos nucleicos que codificam as sequências polinucleotídicas engenheiradas que formam estruturas, bem como cassetes de expressão, vetores e células que compreendem tais sequências polinucleotídicas. também é descrita uma variedade de métodos para produção e utilização das sequências polinucleotídicas engenheiradas que formam estruturas
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562263232P | 2015-12-04 | 2015-12-04 | |
US62/263,232 | 2015-12-04 | ||
PCT/US2016/064860 WO2017096328A1 (en) | 2015-12-04 | 2016-12-02 | Engineered nucleic-acid targeting nucleic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018010429A2 true BR112018010429A2 (pt) | 2018-11-27 |
Family
ID=57750577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018010429-9A BR112018010429A2 (pt) | 2015-12-04 | 2016-12-02 | ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados |
Country Status (18)
Country | Link |
---|---|
US (4) | US9771600B2 (pt) |
EP (2) | EP3564371B1 (pt) |
JP (1) | JP6707133B2 (pt) |
KR (1) | KR102093570B1 (pt) |
CN (1) | CN108473981B (pt) |
AU (2) | AU2016363024B2 (pt) |
BR (1) | BR112018010429A2 (pt) |
CA (1) | CA3004757C (pt) |
DK (1) | DK3371310T3 (pt) |
ES (1) | ES2735773T3 (pt) |
HK (1) | HK1252755B (pt) |
IL (1) | IL259148B (pt) |
MX (1) | MX2018005392A (pt) |
NZ (2) | NZ742040A (pt) |
RU (1) | RU2018117360A (pt) |
SG (1) | SG11201803593QA (pt) |
WO (1) | WO2017096328A1 (pt) |
ZA (1) | ZA201802968B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ742040A (en) | 2015-12-04 | 2019-08-30 | Caribou Biosciences Inc | Engineered nucleic-acid targeting nucleic acids |
BR112018074531B1 (pt) * | 2016-06-02 | 2021-01-19 | Sigma-Aldrich Co. Llc | composição que compreende um sistema de nuclease e seu uso, kit, método in vitro para aumentar a eficiência da modificação do genoma-alvo e método para detectar uma sequência cromossômica |
WO2018201086A1 (en) | 2017-04-28 | 2018-11-01 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
US11584955B2 (en) * | 2017-07-14 | 2023-02-21 | Shanghai Tolo Biotechnology Company Limited | Application of Cas protein, method for detecting target nucleic acid molecule and kit |
US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
WO2019041296A1 (zh) * | 2017-09-01 | 2019-03-07 | 上海科技大学 | 一种碱基编辑系统及方法 |
CN111225975A (zh) * | 2017-09-11 | 2020-06-02 | 加利福尼亚大学董事会 | 抗体介导的cas9向哺乳动物细胞的递送 |
US20210093679A1 (en) | 2018-02-05 | 2021-04-01 | Novome Biotechnologies, Inc. | Engineered gut microbes and uses thereof |
CN111699254A (zh) | 2018-02-08 | 2020-09-22 | 齐默尔根公司 | 使用crispr在棒状杆菌属中进行基因组编辑 |
JP2021523745A (ja) | 2018-05-16 | 2021-09-09 | シンテゴ コーポレイション | ガイドrna設計および使用のための方法およびシステム |
CN112567031B (zh) * | 2018-08-09 | 2024-08-06 | G+Flas生命科学有限公司 | 新型crispr相关蛋白及其用途 |
CN109517722B (zh) * | 2018-09-28 | 2022-04-01 | 德拜至臻医学科技(杭州)有限公司 | 一种捕获特定微量细胞的装置及其制作和使用方法 |
JP2022520139A (ja) | 2018-10-12 | 2022-03-29 | セラダプティブ インク | β-リン酸三カルシウム結合配列を含むポリペプチドとその使用 |
WO2020176389A1 (en) | 2019-02-25 | 2020-09-03 | Caribou Biosciences, Inc. | Plasmids for gene editing |
CN114901302A (zh) | 2019-11-05 | 2022-08-12 | 成对植物服务股份有限公司 | Rna编码的dna置换等位基因的组合物和方法 |
WO2021194604A2 (en) * | 2020-03-06 | 2021-09-30 | Theradaptive, Inc. | Therapeutic compositions comprising graft materials and beta-tcp binding peptides and uses thereof |
IL308806A (en) | 2021-06-01 | 2024-01-01 | Arbor Biotechnologies Inc | Gene editing systems including nuclease crisper and their uses |
CN114540325B (zh) * | 2022-01-17 | 2022-12-09 | 广州医科大学 | 靶向dna去甲基化的方法、融合蛋白及其应用 |
CN116377104B (zh) * | 2022-11-14 | 2024-01-12 | 海南省农业科学院蔬菜研究所 | 一种快菜高温胁迫内参基因及其引物及应用 |
US20240301447A1 (en) | 2023-02-15 | 2024-09-12 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10087431B2 (en) | 2010-03-10 | 2018-10-02 | The Regents Of The University Of California | Methods of generating nucleic acid fragments |
EP3078753B1 (en) | 2010-05-10 | 2018-04-18 | The Regents of The University of California | Methods using endoribonuclease compositions |
KR20140066193A (ko) * | 2011-09-01 | 2014-05-30 | 힙 이노베이션 테크놀러지 엘엘씨 | 라이너가 설치된 대퇴골 컵 |
US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
MY189533A (en) * | 2012-05-25 | 2022-02-16 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
US9688971B2 (en) | 2012-06-15 | 2017-06-27 | The Regents Of The University Of California | Endoribonuclease and methods of use thereof |
WO2014022702A2 (en) | 2012-08-03 | 2014-02-06 | The Regents Of The University Of California | Methods and compositions for controlling gene expression by rna processing |
CN110669746B (zh) | 2012-10-23 | 2024-04-16 | 基因工具股份有限公司 | 用于切割靶dna的组合物及其用途 |
DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
US20140242664A1 (en) | 2012-12-12 | 2014-08-28 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
EP3825401A1 (en) | 2012-12-12 | 2021-05-26 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
PL2898075T3 (pl) | 2012-12-12 | 2016-09-30 | PROJEKTOWANIE i OPTYMALIZACJA ULEPSZONYCH SYSTEMÓW, SPOSOBY I KOMPOZYCJE ENZYMÓW DO MANIPULACJI SEKWENCJĄ | |
US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
BR112015022061B8 (pt) * | 2013-03-14 | 2024-02-27 | Caribou Biosciences Inc | Ácido nucleico de direcionamento de ácido nucleico guia de fita simples geneticamente manipulado, polinucleotídeo, método para clivar um ácido nucleico alvo e para ligar um ácido nucleico alvo, composição e kit |
CA2930877A1 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
WO2015089364A1 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
US20150376587A1 (en) | 2014-06-25 | 2015-12-31 | Caribou Biosciences, Inc. | RNA Modification to Engineer Cas9 Activity |
FI3250691T3 (fi) * | 2015-01-28 | 2023-08-24 | Caribou Biosciences Inc | Crispr hybridi dna/rna polynukleotidit ja käyttömenetelmät |
US9580727B1 (en) * | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
NZ742040A (en) * | 2015-12-04 | 2019-08-30 | Caribou Biosciences Inc | Engineered nucleic-acid targeting nucleic acids |
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2016
- 2016-12-02 NZ NZ742040A patent/NZ742040A/en unknown
- 2016-12-02 EP EP19171356.9A patent/EP3564371B1/en active Active
- 2016-12-02 DK DK16822804.7T patent/DK3371310T3/da active
- 2016-12-02 US US15/368,570 patent/US9771600B2/en active Active
- 2016-12-02 WO PCT/US2016/064860 patent/WO2017096328A1/en active Application Filing
- 2016-12-02 BR BR112018010429-9A patent/BR112018010429A2/pt unknown
- 2016-12-02 CN CN201680071016.9A patent/CN108473981B/zh active Active
- 2016-12-02 SG SG11201803593QA patent/SG11201803593QA/en unknown
- 2016-12-02 MX MX2018005392A patent/MX2018005392A/es unknown
- 2016-12-02 EP EP16822804.7A patent/EP3371310B1/en active Active
- 2016-12-02 NZ NZ756843A patent/NZ756843A/en unknown
- 2016-12-02 JP JP2018528798A patent/JP6707133B2/ja active Active
- 2016-12-02 ES ES16822804T patent/ES2735773T3/es active Active
- 2016-12-02 CA CA3004757A patent/CA3004757C/en active Active
- 2016-12-02 AU AU2016363024A patent/AU2016363024B2/en active Active
- 2016-12-02 RU RU2018117360A patent/RU2018117360A/ru not_active Application Discontinuation
- 2016-12-02 KR KR1020187019090A patent/KR102093570B1/ko active IP Right Grant
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2017
- 2017-09-14 US US15/703,992 patent/US9970029B1/en active Active
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2018
- 2018-05-03 IL IL259148A patent/IL259148B/en unknown
- 2018-05-04 US US15/971,863 patent/US10100333B2/en active Active
- 2018-05-07 ZA ZA2018/02968A patent/ZA201802968B/en unknown
- 2018-09-19 HK HK18112080.6A patent/HK1252755B/zh unknown
- 2018-10-04 US US16/152,337 patent/US11505808B2/en active Active
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2019
- 2019-10-07 AU AU2019240724A patent/AU2019240724B2/en active Active
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Legal Events
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: CARIBOU BIOSCIENCES, INC. (US) |