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BR112018010429A2 - ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados - Google Patents

ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados

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Publication number
BR112018010429A2
BR112018010429A2 BR112018010429-9A BR112018010429A BR112018010429A2 BR 112018010429 A2 BR112018010429 A2 BR 112018010429A2 BR 112018010429 A BR112018010429 A BR 112018010429A BR 112018010429 A2 BR112018010429 A2 BR 112018010429A2
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BR
Brazil
Prior art keywords
nucleic acids
polynucleotide sequences
structures
engineered polynucleotide
nucleic acid
Prior art date
Application number
BR112018010429-9A
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English (en)
Inventor
Daniel Donohoue Paul
Paul May Andrew
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Caribou Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caribou Biosciences, Inc. filed Critical Caribou Biosciences, Inc.
Publication of BR112018010429A2 publication Critical patent/BR112018010429A2/pt

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases RNAses, DNAses
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/51Physical structure in polymeric form, e.g. multimers, concatemers
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/52Physical structure branched
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

a presente descrição fornece sequências polinucleotídicas engenheiradas que formam estruturas e complexos de nucleoproteínas que compreendem tais sequências polinucleotídicas engenheiradas que formam estruturas e proteínas que se ligam aos ácidos nucleicos. são descritas as sequências de ácidos nucleicos que codificam as sequências polinucleotídicas engenheiradas que formam estruturas, bem como cassetes de expressão, vetores e células que compreendem tais sequências polinucleotídicas. também é descrita uma variedade de métodos para produção e utilização das sequências polinucleotídicas engenheiradas que formam estruturas
BR112018010429-9A 2015-12-04 2016-12-02 ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados BR112018010429A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562263232P 2015-12-04 2015-12-04
US62/263,232 2015-12-04
PCT/US2016/064860 WO2017096328A1 (en) 2015-12-04 2016-12-02 Engineered nucleic-acid targeting nucleic acids

Publications (1)

Publication Number Publication Date
BR112018010429A2 true BR112018010429A2 (pt) 2018-11-27

Family

ID=57750577

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010429-9A BR112018010429A2 (pt) 2015-12-04 2016-12-02 ácidos nucleicos que se direcionam a ácidos nucleicos engenheirados

Country Status (18)

Country Link
US (4) US9771600B2 (pt)
EP (2) EP3564371B1 (pt)
JP (1) JP6707133B2 (pt)
KR (1) KR102093570B1 (pt)
CN (1) CN108473981B (pt)
AU (2) AU2016363024B2 (pt)
BR (1) BR112018010429A2 (pt)
CA (1) CA3004757C (pt)
DK (1) DK3371310T3 (pt)
ES (1) ES2735773T3 (pt)
HK (1) HK1252755B (pt)
IL (1) IL259148B (pt)
MX (1) MX2018005392A (pt)
NZ (2) NZ742040A (pt)
RU (1) RU2018117360A (pt)
SG (1) SG11201803593QA (pt)
WO (1) WO2017096328A1 (pt)
ZA (1) ZA201802968B (pt)

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WO2018201086A1 (en) 2017-04-28 2018-11-01 Editas Medicine, Inc. Methods and systems for analyzing guide rna molecules
US11584955B2 (en) * 2017-07-14 2023-02-21 Shanghai Tolo Biotechnology Company Limited Application of Cas protein, method for detecting target nucleic acid molecule and kit
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
WO2019041296A1 (zh) * 2017-09-01 2019-03-07 上海科技大学 一种碱基编辑系统及方法
CN111225975A (zh) * 2017-09-11 2020-06-02 加利福尼亚大学董事会 抗体介导的cas9向哺乳动物细胞的递送
US20210093679A1 (en) 2018-02-05 2021-04-01 Novome Biotechnologies, Inc. Engineered gut microbes and uses thereof
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JP2021523745A (ja) 2018-05-16 2021-09-09 シンテゴ コーポレイション ガイドrna設計および使用のための方法およびシステム
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JP2022520139A (ja) 2018-10-12 2022-03-29 セラダプティブ インク β-リン酸三カルシウム結合配列を含むポリペプチドとその使用
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CN114901302A (zh) 2019-11-05 2022-08-12 成对植物服务股份有限公司 Rna编码的dna置换等位基因的组合物和方法
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IL308806A (en) 2021-06-01 2024-01-01 Arbor Biotechnologies Inc Gene editing systems including nuclease crisper and their uses
CN114540325B (zh) * 2022-01-17 2022-12-09 广州医科大学 靶向dna去甲基化的方法、融合蛋白及其应用
CN116377104B (zh) * 2022-11-14 2024-01-12 海南省农业科学院蔬菜研究所 一种快菜高温胁迫内参基因及其引物及应用
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Also Published As

Publication number Publication date
WO2017096328A1 (en) 2017-06-08
SG11201803593QA (en) 2018-06-28
EP3564371B1 (en) 2020-05-27
CN108473981B (zh) 2022-04-12
EP3564371A1 (en) 2019-11-06
CA3004757C (en) 2020-07-21
RU2018117360A3 (pt) 2020-01-09
US9771600B2 (en) 2017-09-26
US9970029B1 (en) 2018-05-15
ZA201802968B (en) 2019-02-27
KR102093570B1 (ko) 2020-03-25
NZ742040A (en) 2019-08-30
US10100333B2 (en) 2018-10-16
EP3371310A1 (en) 2018-09-12
IL259148A (en) 2018-07-31
EP3371310B1 (en) 2019-05-01
HK1252755B (zh) 2020-02-07
AU2016363024B2 (en) 2020-01-30
JP2019500867A (ja) 2019-01-17
AU2019240724A1 (en) 2019-10-24
DK3371310T3 (da) 2019-08-05
HK1252755A1 (zh) 2019-05-31
JP6707133B2 (ja) 2020-06-10
AU2019240724B2 (en) 2021-02-18
US20180251788A1 (en) 2018-09-06
US20180119173A1 (en) 2018-05-03
RU2018117360A (ru) 2020-01-09
US20170159073A1 (en) 2017-06-08
AU2016363024A1 (en) 2018-05-17
MX2018005392A (es) 2019-05-30
US11505808B2 (en) 2022-11-22
CA3004757A1 (en) 2017-06-08
ES2735773T3 (es) 2019-12-20
US20190100775A1 (en) 2019-04-04
KR20180085795A (ko) 2018-07-27
IL259148B (en) 2021-08-31
NZ756843A (en) 2021-07-30
CN108473981A (zh) 2018-08-31

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Owner name: CARIBOU BIOSCIENCES, INC. (US)