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BR112015023489A2 - uso de rnas-guia truncads (tru - grnas) para aumentar a especificidade de edição de genoma com rna guiado - Google Patents

uso de rnas-guia truncads (tru - grnas) para aumentar a especificidade de edição de genoma com rna guiado

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Publication number
BR112015023489A2
BR112015023489A2 BR112015023489A BR112015023489A BR112015023489A2 BR 112015023489 A2 BR112015023489 A2 BR 112015023489A2 BR 112015023489 A BR112015023489 A BR 112015023489A BR 112015023489 A BR112015023489 A BR 112015023489A BR 112015023489 A2 BR112015023489 A2 BR 112015023489A2
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BR
Brazil
Prior art keywords
rna
grnas
tru
guide
guided
Prior art date
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BR112015023489A
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English (en)
Other versions
BR112015023489B1 (pt
Inventor
Keith Joung J
D Sander Jeffry
Maeder Morgan
Fu Yanfang
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Massachusetts Gen Hospital
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Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of BR112015023489A2 publication Critical patent/BR112015023489A2/pt
Publication of BR112015023489B1 publication Critical patent/BR112015023489B1/pt

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Abstract

abstract methods for increasing specificity of rna-guided genome editing, e.g., editing using crispr/cas9 systems, using truncated guide rnas (tru-grnas). tradução do resumo resumo patente de invenção: "uso de rnas-guia truncads (tru - grnas) para aumentar a especificidade de edição de genoma com rna guiado". métodos para aumentar a especificidade de edição do genoma rna - guiado, por exemplo, a edição usando sistemas crispr/ cas9, usando guia de rnas truncada (tru- grnas).
BR112015023489-5A 2013-03-15 2014-03-14 Métodos para aumentar a especificidade de edição de genoma orientado por rna em uma célula, de indução de uma ruptura em uma região alvo de uma molécula de dna de fita dupla em uma célula e de modificação de uma região alvo de uma molécula de dna de fita dupla em uma célula BR112015023489B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361799647P 2013-03-15 2013-03-15
US61/799,647 2013-03-15
US201361838178P 2013-06-21 2013-06-21
US201361838148P 2013-06-21 2013-06-21
US61/838,148 2013-06-21
US61/838,178 2013-06-21
US201361921007P 2013-12-26 2013-12-26
US61/921,007 2013-12-26
PCT/US2014/029068 WO2014144592A2 (en) 2013-03-15 2014-03-14 Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing

Publications (2)

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BR112015023489A2 true BR112015023489A2 (pt) 2017-10-10
BR112015023489B1 BR112015023489B1 (pt) 2022-06-07

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BR112015023489-5A BR112015023489B1 (pt) 2013-03-15 2014-03-14 Métodos para aumentar a especificidade de edição de genoma orientado por rna em uma célula, de indução de uma ruptura em uma região alvo de uma molécula de dna de fita dupla em uma célula e de modificação de uma região alvo de uma molécula de dna de fita dupla em uma célula

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US (16) US9567604B2 (pt)
EP (10) EP3467125B1 (pt)
JP (11) JP6657069B2 (pt)
KR (8) KR102210322B1 (pt)
CN (6) CN110540991B (pt)
AU (10) AU2014228981B2 (pt)
BR (1) BR112015023489B1 (pt)
CA (4) CA2907198C (pt)
ES (1) ES2713503T3 (pt)
IL (2) IL289396B2 (pt)
WO (4) WO2014144288A1 (pt)
ZA (1) ZA201506814B (pt)

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