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BR112014006763A2 - n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1 - Google Patents

n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1

Info

Publication number
BR112014006763A2
BR112014006763A2 BR112014006763A BR112014006763A BR112014006763A2 BR 112014006763 A2 BR112014006763 A2 BR 112014006763A2 BR 112014006763 A BR112014006763 A BR 112014006763A BR 112014006763 A BR112014006763 A BR 112014006763A BR 112014006763 A2 BR112014006763 A2 BR 112014006763A2
Authority
BR
Brazil
Prior art keywords
cyclopenta
hexahydro
difluoro
amides
phenyl
Prior art date
Application number
BR112014006763A
Other languages
English (en)
Inventor
Pinard Emmanuel
Hilpert Hans
Woltering Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014006763A2 publication Critical patent/BR112014006763A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • User Interface Of Digital Computer (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1". a presente invenção refere-se a n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas de fórmula i i, tendo atividade inibitória de bace1, fabricação, composições farmacêuticas que as contêm e uso como substâncias terapeuticamente ativas. os compostos ativos da presente invenção são úteis no tratamento terapêutico e/ou profilático de, por exemplo, doença de alzheimer.
BR112014006763A 2011-09-21 2012-09-18 n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1 BR112014006763A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11182172 2011-09-21
PCT/EP2012/068287 WO2013041499A1 (en) 2011-09-21 2012-09-18 N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as bace1 inhibitors

Publications (1)

Publication Number Publication Date
BR112014006763A2 true BR112014006763A2 (pt) 2017-03-28

Family

ID=46852012

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014006763A BR112014006763A2 (pt) 2011-09-21 2012-09-18 n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1

Country Status (11)

Country Link
US (2) US8476264B2 (pt)
EP (1) EP2758393A1 (pt)
JP (1) JP2014526534A (pt)
KR (1) KR20140069183A (pt)
CN (1) CN103827110A (pt)
AR (1) AR087915A1 (pt)
BR (1) BR112014006763A2 (pt)
CA (1) CA2844654A1 (pt)
MX (1) MX2014003408A (pt)
RU (1) RU2014113679A (pt)
WO (1) WO2013041499A1 (pt)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
US8999980B2 (en) 2009-12-11 2015-04-07 Shionogi & Co., Ltd. Oxazine derivatives
KR20100075786A (ko) * 2010-05-19 2010-07-05 세창인스트루먼트(주) 웹사이트 영역취합시스템 및 그 방법
CN103631475A (zh) * 2012-08-29 2014-03-12 腾讯科技（深圳）有限公司 切换窗口的方法和装置
JP2016501827A (ja) * 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
CA2902212C (en) 2013-03-01 2020-10-13 Amgen Inc. Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
MX2015011618A (es) 2013-03-08 2015-12-17 Amgen Inc Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso.
ES2709509T3 (es) 2013-08-12 2019-04-16 Pharmacyclics Llc Procedimientos para el tratamiento de cáncer amplificado por HER2
TW201623295A (zh) 2014-04-11 2016-07-01 塩野義製藥股份有限公司 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物
CN105278824B (zh) * 2014-07-31 2018-06-26 维沃移动通信有限公司 一种终端设备的截屏方法及其终端设备
CN106795147B (zh) 2014-08-08 2020-09-22 美国安进公司 作为β-分泌酶抑制剂的环丙基稠合噻嗪-2-胺化合物和使用方法
CN107406440B (zh) 2015-03-20 2021-05-07 豪夫迈·罗氏有限公司 Bace1抑制剂
TW202014191A (zh) 2018-04-27 2020-04-16 日商鹽野義製藥股份有限公司 具有選擇性ｂａｃｅ１抑制活性的四氫哌喃并衍生物
CN110109593B (zh) * 2019-04-29 2021-04-02 维沃移动通信有限公司 一种截屏方法及终端设备
TWI810101B (zh) * 2022-10-27 2023-07-21 南亞塑膠工業股份有限公司 碟鏈系統
CN118567763A (zh) * 2023-02-28 2024-08-30 摩托罗拉移动有限责任公司 主要内容的自动屏幕截图捕获

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395145A (en) * 1966-08-17 1968-07-30 Warner Lambert Pharmaceutical 2-aryl-1-oxa-3-azaspiro [5, 5] undec-2-enes
US20080092077A1 (en) * 2006-09-14 2008-04-17 Cqgt, Llc Interactive streaming news headline display
CN102186841A (zh) * 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
JP5554346B2 (ja) * 2009-12-09 2014-07-23 塩野義製薬株式会社 含硫黄複素環誘導体を含有するアルツハイマー症の治療用または予防用医薬組成物
US7964594B1 (en) * 2009-12-10 2011-06-21 Hoffmann-La Roche Inc. Amino oxazine derivatives
US8999980B2 (en) 2009-12-11 2015-04-07 Shionogi & Co., Ltd. Oxazine derivatives
UA103272C2 (uk) 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2

Also Published As

Publication number Publication date
EP2758393A1 (en) 2014-07-30
US20130073953A1 (en) 2013-03-21
JP2014526534A (ja) 2014-10-06
CN103827110A (zh) 2014-05-28
US20130072478A1 (en) 2013-03-21
KR20140069183A (ko) 2014-06-09
US8476264B2 (en) 2013-07-02
RU2014113679A (ru) 2015-10-27
MX2014003408A (es) 2014-04-10
CA2844654A1 (en) 2013-03-28
AR087915A1 (es) 2014-04-23
WO2013041499A1 (en) 2013-03-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2480 DE 17-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.