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BE793185A - Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques - Google Patents

Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques

Info

Publication number
BE793185A
BE793185A BE793185DA BE793185A BE 793185 A BE793185 A BE 793185A BE 793185D A BE793185D A BE 793185DA BE 793185 A BE793185 A BE 793185A
Authority
BE
Belgium
Prior art keywords
biological cells
sorting particles
quickly analyzing
analyzing
quickly
Prior art date
Application number
Other languages
English (en)
Inventor
M J Fulwyler J A Steinkamp
J R Coulter
M J Fulwyler
J A Steinkamp
Original Assignee
Atomic Energy Commission
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE793185A publication Critical patent/BE793185A/fr

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1031Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1019Associating Coulter-counter and optical flow cytometer [OFC]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1024Counting particles by non-optical means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1028Sorting particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/103Particle shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406Control of droplet point
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477Multiparameters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
BE793185D 1971-12-23 Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques BE793185A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21147371A 1971-12-23 1971-12-23

Publications (1)

Publication Number Publication Date
BE793185A true BE793185A (fr) 1973-04-16

Family

ID=22787055

Family Applications (1)

Application Number Title Priority Date Filing Date
BE793185D BE793185A (fr) 1971-12-23 Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques

Country Status (11)

Country Link
US (1) US3710933A (fr)
JP (1) JPS5613266B2 (fr)
AU (1) AU468637B2 (fr)
BE (1) BE793185A (fr)
CA (1) CA971913A (fr)
DE (1) DE2261695C2 (fr)
FR (1) FR2164898B1 (fr)
GB (1) GB1380756A (fr)
NL (1) NL7216901A (fr)
NO (1) NO138305C (fr)
SE (1) SE388278B (fr)

Families Citing this family (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3819270A (en) * 1972-10-02 1974-06-25 Block Engineering Blood cell analyzer
US3791517A (en) * 1973-03-05 1974-02-12 Bio Physics Systems Inc Digital fluidic amplifier particle sorter
US3827555A (en) * 1973-03-05 1974-08-06 Bio Physics Systems Inc Particle sorter with segregation indicator
US3984307A (en) * 1973-03-05 1976-10-05 Bio/Physics Systems, Inc. Combined particle sorter and segregation indicator
US3907437A (en) * 1973-04-26 1975-09-23 Block Engineering Cell classification system
US3824402A (en) * 1973-06-04 1974-07-16 Energy Commission Dual parameter flow photometric apparatus and method
US3924947A (en) * 1973-10-19 1975-12-09 Coulter Electronics Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US4009435A (en) * 1973-10-19 1977-02-22 Coulter Electronics, Inc. Apparatus for preservation and identification of particles analyzed by flow-through apparatus
US4074939A (en) * 1973-12-19 1978-02-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for investigating fast chemical reactions by optical detection
US3910702A (en) * 1974-02-12 1975-10-07 Particle Technology Inc Apparatus for detecting particles employing apertured light emitting device
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US4071298A (en) * 1974-06-27 1978-01-31 Stanford Research Institute Laser Raman/fluorescent device for analyzing airborne particles
DE2543310C2 (de) * 1975-09-27 1982-04-29 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Einrichtung zum Zählen und Klassifizieren von in einer Flüssigkeit suspendierten Teilchen
FR2328960A1 (fr) * 1975-10-08 1977-05-20 Coulter Electronics Dispositif pour la preservation et l'identification de particules analysees par un dispositif a ecoulement traversant
US4053229A (en) * 1976-01-13 1977-10-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration 2°/90° Laboratory scattering photometer
SE400841B (sv) * 1976-02-05 1978-04-10 Hertz Carl H Sett att alstra en vetskestrale samt anordning for genomforande av settet
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4101276A (en) * 1976-06-02 1978-07-18 Beckman Instruments, Inc. Method and apparatus for signalling the introduction of chemical reaction components into a chemical analyzing system
JPS5319891A (en) * 1976-06-10 1978-02-23 Coulter Electronics Method and apparatus for folling drop formation and separation
US4095898A (en) * 1976-06-10 1978-06-20 Coulter Electronics, Inc. Particle analysis system with photochromic filter
NL180704C (nl) * 1976-06-14 Coulter Electronics Inrichting voor gelijktijdige optische meting van kenmerken van zich in een suspensie bevindende deeltjes.
DE2632962C3 (de) * 1976-07-22 1980-08-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Partikelseparator
DE2742838A1 (de) * 1977-09-23 1979-04-05 Zoeld Tibor Dr Phys Kanalzaehler zur zaehlung und groessenbestimmung von in einem elektrolyten suspendierten teilchen
DE2712360A1 (de) * 1977-03-22 1978-09-28 Zoeld Tibor Dr Phys Kanalzaehler zur zaehlung und groessenbestimmung von in einem elektrolyten suspendierten teilchen
US4097373A (en) * 1977-03-23 1978-06-27 John Caldwell Allred High speed particle sorter using a field emission electrode
US4203670A (en) * 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4191739A (en) * 1977-10-17 1980-03-04 General Electric Company Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis
US4343782A (en) * 1978-04-20 1982-08-10 Shapiro Howard M Cytological assay procedure
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
FR2431694A1 (fr) * 1978-07-18 1980-02-15 Berber Viktor Dispositif pour l'enregistrement granulometrique des particules presentes dans un liquide
US4577964A (en) * 1978-09-06 1986-03-25 Ortho Diagnostics, Inc. Apparatus and method for detecting platelets in whole blood
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
US4263508A (en) * 1979-04-20 1981-04-21 Research Corporation Pulse edge measurement for determining particle dimensional characteristics
US4347935A (en) * 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4298836A (en) * 1979-11-23 1981-11-03 Coulter Electronics, Inc. Particle shape determination
US4284495A (en) * 1979-12-10 1981-08-18 Newton William A Coating apparatus and method
US4284496A (en) * 1979-12-10 1981-08-18 Newton William A Particle guiding apparatus and method
US4329787A (en) * 1980-01-04 1982-05-18 Newton William A Droplet exploding and freezing apparatus and method
US4350892A (en) * 1980-07-31 1982-09-21 Research Corporation X'-, Y'-, Z'- axis multidimensional slit-scan flow system
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4352731A (en) * 1980-11-03 1982-10-05 Occidental Research Corporation Apparatus for selective wetting of particles
US4395676A (en) * 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
US4818103A (en) * 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) * 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
DE3266669D1 (en) * 1981-06-24 1985-11-07 Becton Dickinson Co Analyzer for simultaneously determining volume and light emission characteristics of particles
US4476231A (en) * 1981-07-22 1984-10-09 International Remote Imaging Systems, Inc. Method of analyzing the distribution of a reagent between particles and liquid in a suspension
JPS5821166A (ja) * 1981-07-30 1983-02-07 Fujitsu Ltd 被測定物質分離方式
US4444317A (en) * 1981-08-26 1984-04-24 Georg Wick Observation of immunofluorescene for distinguishing between specific and nonspecific binding of conjugates
JPS5847239A (ja) * 1981-09-14 1983-03-18 Nisshin Denki Seisakusho:Kk 液体クロマトグラフ装置
US4515274A (en) * 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
US4510438A (en) * 1982-02-16 1985-04-09 Coulter Electronics, Inc. Coincidence correction in particle analysis system
US4498766A (en) * 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
DE3233055C2 (de) * 1982-09-06 1994-07-28 Coulter Electronics Durchflußvorrichtung zur Untersuchung einzelner, in einer Flüssigkeit suspendierter Teilchen
DE3238353A1 (de) * 1982-10-15 1984-04-19 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer
JPS5995440A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd 光学測定方法と装置
CA1206559A (fr) * 1983-03-04 1986-06-24 Robert E. Auer Methode et dispositif de detection des fluctuations du moment de separation des gouttelettes dans un generateur de ces gouttelettes
US4521521A (en) * 1983-03-11 1985-06-04 E. I. Du Pont De Nemours And Company Particle reagent size distribution measurements for immunoassay
CH651930A5 (en) * 1983-03-24 1985-10-15 Coulter Corp Apparatus for analysis and sorting of particles
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
JPS59184841A (ja) * 1983-04-05 1984-10-20 ベクトン・デイツキンソン・アンド・カンパニ− サンプル中の白血球のサブクラスを識別する方法および装置
JPS59167065U (ja) * 1983-04-25 1984-11-08 日産ディーゼル工業株式会社 全油圧式パワ−ステアリング装置
US4564803A (en) * 1983-08-29 1986-01-14 Coulter Corporation Method and apparatus for removing foreign matter from a flow cell of a particle study device
JPS6080764A (ja) * 1983-10-12 1985-05-08 Agency Of Ind Science & Technol 微小粒子を識別する方法及びその装置
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4735504A (en) * 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles
JPS6078013U (ja) * 1983-11-02 1985-05-31 三洋電機株式会社 液晶表示器用基板
JPS60100785U (ja) * 1983-12-15 1985-07-09 シャープ株式会社 表示装置
US5188935A (en) * 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US4751179A (en) * 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US4661913A (en) * 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
EP0177718B1 (fr) * 1984-09-11 1989-12-06 Partec AG Procédé et dispositif pour le triage de particules microscopiques
US4916060A (en) * 1985-09-17 1990-04-10 Massachusetts Institute Of Technology Process for chemical measurement in small volume samples by fluorescent indicators
US4760328A (en) * 1986-05-05 1988-07-26 Integrated Ionics, Inc. Particle counter having electrodes and circuitry mounted on the pane of the orifice
EP0279000B1 (fr) * 1987-02-17 1993-07-21 Ratcom, Inc. Cytométrie à écoulement
US4987539A (en) * 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US4988619A (en) * 1987-11-30 1991-01-29 United States Department Of Energy Flow cytometry apparatus
US4837446A (en) * 1988-03-31 1989-06-06 International Paper Company Apparatus and process for testing uniformity of pulp
US4844610A (en) * 1988-04-29 1989-07-04 Becton, Dickinson And Company Backflow isolator and capture system
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
CA1324894C (fr) * 1989-03-31 1993-12-07 Maritime Scientific Services Ltd. Methode et appareil d'identification de particules
JPH02289808A (ja) * 1989-04-28 1990-11-29 Olympus Optical Co Ltd 照明光学系
GB2233759B (en) * 1989-06-12 1993-08-25 De Beers Ind Diamond Particulate ore sorting
US5030002A (en) * 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
DE69025256T2 (de) * 1989-10-11 1996-06-27 Canon Kk Gerät und Verfahren zur Trennung von Teilchen aus flüssigkeitssuspendierten Teilchen in Zusammenhang mit deren Eigenschaften
FR2653885B1 (fr) * 1989-10-27 1994-01-14 Abx Appareil pour le comptage et la determination d'au moins une sous-population leucocytaire.
JPH0354520A (ja) * 1990-03-15 1991-03-08 Sanyo Electric Co Ltd 液晶表示器の製造方法
US5194909A (en) * 1990-12-04 1993-03-16 Tycko Daniel H Apparatus and method for measuring volume and hemoglobin concentration of red blood cells
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
JP2537764Y2 (ja) * 1991-05-07 1997-06-04 日工株式会社 管体切り出し装置
US5558998A (en) * 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
US5232828A (en) * 1992-03-09 1993-08-03 Becton, Dickinson And Company Coating agents for cell recovery
US5859705A (en) * 1993-05-26 1999-01-12 The Dow Chemical Company Apparatus and method for using light scattering to determine the size of particles virtually independent of refractive index
US5464581A (en) * 1993-08-02 1995-11-07 The Regents Of The University Of California Flow cytometer
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US5641457A (en) * 1995-04-25 1997-06-24 Systemix Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
WO1997049925A1 (fr) 1996-06-27 1997-12-31 Weyerhaeuser Company Transporteur hydraulique
JP2001504389A (ja) 1996-10-21 2001-04-03 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ビーズを分配する装置と方法
DE19700648A1 (de) * 1997-01-10 1998-07-23 Basf Ag Verfahren und Vorrichtung zur Bestimmung der Größenverteilung von verschiedenartigen Partikeln in einer Probe
EP1017987B1 (fr) 1997-01-31 2005-06-15 The Horticulture And Food Research Institute Of New Zealand Limited Appareil et methode optiques
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
US6211477B1 (en) * 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6079836A (en) * 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
NZ527659A (en) 1998-07-30 2006-02-24 Colorado State University Thro Equine artificial insemination when there has been sex selection of the sperm to produce an equine of the desired sex
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US8148110B2 (en) * 1999-03-15 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by β-lactamase reporter fragment complementation
US7097973B1 (en) * 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
IL152714A (en) * 2000-05-09 2014-03-31 Xy Llc High-purity spermatozoa populations carrying chromosome-x and chromosome-y
CA2411462A1 (fr) * 2000-06-12 2001-12-20 Colorado State University Research Foundation Systeme de conduite de troupeau integre utilisant des populations isolees de spermatozoides porteurs du chromosome x et du chromosome y
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6849423B2 (en) * 2000-11-29 2005-02-01 Picoliter Inc Focused acoustics for detection and sorting of fluid volumes
US20020064809A1 (en) 2000-11-29 2002-05-30 Mutz Mitchell W. Focused acoustic ejection cell sorting system and method
WO2002043574A2 (fr) 2000-11-29 2002-06-06 Xy, Inc. Systeme de dissociation de spermatozoides congeles-decongeles porteurs d'un chromosome x de ceux porteurs d'un chromosome y
JP2004518127A (ja) * 2000-12-15 2004-06-17 サイトメーション, インコーポレイテッド 電気伝導性格納システム
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
AU2002251449B2 (en) * 2001-03-29 2008-01-31 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US7012689B2 (en) 2001-05-17 2006-03-14 Dako Colorado, Inc. Flow cytometer with active automated optical alignment system
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
AUPR846501A0 (en) * 2001-10-26 2001-11-15 Btf Pty Ltd A cytometer
EP1316792B1 (fr) * 2001-11-30 2009-09-16 Sysmex Corporation Analyseur de particules
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
EP1545203B1 (fr) 2002-08-01 2016-10-19 Xy, Llc Systeme de separation de cellules spermatiques basse pression
BRPI0313476B1 (pt) * 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7169548B2 (en) * 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
JP4050748B2 (ja) * 2002-09-27 2008-02-20 リオン株式会社 粒子測定装置
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US6941005B2 (en) * 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
EP2308418B1 (fr) 2003-03-28 2015-12-02 Inguran, LLC Buse de cytométrie en flux pour fournir du sperme d'animaux triés selon le sexe
CA2566749C (fr) 2003-05-15 2017-02-21 Xy, Inc. Tri efficace de cellules haploides pour systemes de cytometrie en flux
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
ES2494016T3 (es) * 2004-03-01 2014-09-12 Partec Gmbh Dispositivo para la medición de la luz, que procede desde partículas o desde células biológicas de tamaño microscópico
AU2005228893B2 (en) 2004-03-29 2010-08-19 Inguran, Llc Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations
EP2269617B1 (fr) 2004-07-22 2016-04-27 Inguran, LLC Suspensions de sperme pour trier des populations enrichies contenant les chromosomes X ou Y
ES2607527T3 (es) * 2004-07-27 2017-03-31 Beckman Coulter, Inc. Mejora de la discriminación en citometría de flujo con transformación geométrica implementada por ordenador
US7430046B2 (en) * 2004-07-30 2008-09-30 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US7392908B2 (en) * 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US20060284930A1 (en) * 2005-06-21 2006-12-21 George Mejalli Methods and arrangements for adjusting and aligning fluid dispensing devices and the like such as continuous ink jet printheads
CN101223560B (zh) * 2005-07-15 2012-12-12 百维吉伦特系统有限公司 病原体和颗粒的检测器系统和方法
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US20070059370A1 (en) * 2005-09-15 2007-03-15 Industrial Technology Research Institute Method and apparatus for fabricating nanoparticles
US8297959B2 (en) * 2006-05-03 2012-10-30 Terapia Celular, Ln, Inc. Systems for producing multilayered particles, fibers and sprays and methods for administering the same
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
EP2099573B1 (fr) * 2006-12-04 2013-01-02 The University Of Queensland Appareil et procédé de tri des particules
GB0720202D0 (en) 2007-10-16 2007-11-28 Cambridge Entpr Ltd Microfluidic systems
US9267918B2 (en) 2007-10-16 2016-02-23 Cambridge Enterprise Limited Microfluidic systems
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
FR2933192B1 (fr) * 2008-06-25 2010-09-17 Horiba Abx Sas Dispositif et procede de mesure electro optique destines a la classification et au comptage d'elements microscopiques.
RU2520848C2 (ru) 2008-06-30 2014-06-27 Микробикс Байосистемз Инк. Способ и прибор для сортировки клеток
JP5382852B2 (ja) 2009-02-06 2014-01-08 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
US8665439B2 (en) * 2009-06-30 2014-03-04 Microbix Biosystems, Inc. Method and apparatus for limiting effects of refraction in cytometry
AT508806B1 (de) * 2009-10-07 2013-06-15 Onkotec Gmbh Analysegerät und verfahren
US8589851B2 (en) * 2009-12-15 2013-11-19 Memoir Systems, Inc. Intelligent memory system compiler
JP4805415B2 (ja) * 2009-12-25 2011-11-02 古河電気工業株式会社 検体識別分取装置および検体識別分取方法
EP3671180B1 (fr) 2010-01-15 2023-03-08 On-chip Biotechnologies Co., Ltd. Procédé d'utilisation d'un appareil configuré pour séparer des particules biologiques
WO2012055048A1 (fr) * 2010-10-29 2012-05-03 The University Of British Columbia Procédés et appareil pour détecter des particules entraînées dans des fluides
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
ES2621347T3 (es) 2010-12-27 2017-07-03 Abbott Molecular Inc. Cuantificación de muestras de títulos altos por PCR digital
FR2970334A1 (fr) * 2011-01-07 2012-07-13 Horiba Abx Sas Dispositif d'inspection d'un fluide biologique
FR2971337B1 (fr) * 2011-02-04 2013-03-01 Horiba Abx Sas Dispositif et procede de mesures multiparametriques de microparticules dans un fluide
AU2012217757B2 (en) 2011-02-15 2015-12-03 Microbix Biosystems Inc. Methods, systems, and apparatus for performing flow cytometry
US10723497B2 (en) * 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
US9242248B2 (en) * 2011-09-16 2016-01-26 The University Of North Carolina At Charlotte Methods and devices for optical sorting of microspheres based on their resonant optical properties
US9841367B2 (en) 2011-09-16 2017-12-12 The University Of North Carolina At Charlotte Methods and devices for optical sorting of microspheres based on their resonant optical properties
US9347933B2 (en) 2011-12-20 2016-05-24 Becton, Dickinson And Company System and method to improve yield of sorted particles
WO2013101741A1 (fr) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Canaux fluidiques caractérisés par des gradients thermiques en coupe transversale
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
EP2696190B1 (fr) 2012-03-30 2016-04-13 Sony Corporation Appareil de fractionnement de microparticules et procédé d'optimisation de courant de fluide dans ledit appareil
JP6065527B2 (ja) * 2012-11-08 2017-01-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
JP6304034B2 (ja) 2013-01-28 2018-04-04 ソニー株式会社 微小粒子分取装置、微小粒子分取方法及びプログラム
JP2014174139A (ja) * 2013-03-13 2014-09-22 Sony Corp 流路デバイス、粒子分取装置、粒子流出方法、及び粒子分取方法
US11579072B2 (en) 2013-03-15 2023-02-14 Particles Plus, Inc. Personal air quality monitoring system
US10352844B2 (en) 2013-03-15 2019-07-16 Particles Plus, Inc. Multiple particle sensors in a particle counter
US9677990B2 (en) 2014-04-30 2017-06-13 Particles Plus, Inc. Particle counter with advanced features
US12044611B2 (en) 2013-03-15 2024-07-23 Particles Plus, Inc. Particle counter with integrated bootloader
US10983040B2 (en) 2013-03-15 2021-04-20 Particles Plus, Inc. Particle counter with integrated bootloader
CN107576634B (zh) * 2013-07-16 2021-07-23 成都深迈瑞医疗电子技术研究院有限公司 血液细胞分析仪及其细胞的识别方法与系统
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
JP6447506B2 (ja) 2013-10-16 2019-01-09 ソニー株式会社 粒子分取装置及び粒子分取方法
JP6136843B2 (ja) 2013-10-17 2017-05-31 ソニー株式会社 粒子分取装置、粒子分取方法及びプログラム
EP3063529A2 (fr) 2013-10-30 2016-09-07 Premium Genetics (UK) Ltd. Système microfluidique et procédé avec appareil à énergie focalisée
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
JP6465036B2 (ja) 2014-02-13 2019-02-06 ソニー株式会社 粒子分取装置、粒子分取方法、プログラム及び粒子分取システム
US8820538B1 (en) 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
FR3022998B1 (fr) 2014-06-30 2016-07-15 Alain Rousseau Techniques & Innovations Arteion Systeme et ensemble de cytometrie en flux, dispositif d’analyse comprenant un tel ensemble de cytometrie et ensemble comprenant un tel systeme de cytometrie
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
CN106662572B (zh) * 2015-02-12 2019-07-05 深圳迈瑞生物医疗电子股份有限公司 细胞分析仪、粒子分类方法及装置
SG11201706777QA (en) 2015-02-19 2017-09-28 Premium Genetics (Uk) Ltd Scanning infrared measurement system
US11725179B2 (en) 2015-05-12 2023-08-15 On-Chip Biotechnologies Co., Ltd. Single-particle analysis method, and system for performing said analysis
EP3343200B1 (fr) 2015-10-19 2021-12-15 Sony Group Corporation Dispositif de traitement d'image, dispositif de séparation de microparticules et procédé de traitement d'image
DE102016115891A1 (de) 2016-08-26 2018-03-01 Krones Aktiengesellschaft Abfüllanlage zum Befüllen eines Behälters mit einem Füllprodukt
CN116429665A (zh) 2016-09-16 2023-07-14 芯片生物技术株式会社 微粒分注装置、微粒分析装置、反应检测装置、以及使用它们的方法
US10466158B2 (en) 2017-04-11 2019-11-05 Sony Corporation Microparticle sorting apparatus and delay time determination method
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US11889830B2 (en) 2019-04-18 2024-02-06 Abs Global, Inc. System and process for continuous addition of cryoprotectant
US11307132B2 (en) * 2019-06-26 2022-04-19 Life Technologies Corporation Integrated biocontainment cell sorter
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
EP4143534B1 (fr) * 2020-06-26 2024-09-25 Hewlett-Packard Development Company, L.P. Éjection de particules cibles depuis des canaux d'éjection de fluide en recirculation
US11988591B2 (en) 2020-07-01 2024-05-21 Particles Plus, Inc. Modular optical particle counter sensor and apparatus
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3560754A (en) * 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means

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US3710933A (en) 1973-01-16
NL7216901A (fr) 1973-06-26
FR2164898B1 (fr) 1974-08-02
NO138305B (no) 1978-05-02
AU5020272A (en) 1974-06-20
FR2164898A1 (fr) 1973-08-03
JPS5613266B2 (fr) 1981-03-27
JPS4874292A (fr) 1973-10-06
DE2261695A1 (de) 1973-06-28
CA971913A (en) 1975-07-29
GB1380756A (en) 1975-01-15
AU468637B2 (en) 1974-06-20
SE388278B (sv) 1976-09-27
DE2261695C2 (de) 1987-04-09
NO138305C (no) 1978-08-09

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