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AU511711B2 - 6-Oxo and 5, 6-Dihalo prostaglandin analogues - Google Patents

6-Oxo and 5, 6-Dihalo prostaglandin analogues

Info

Publication number
AU511711B2
AU511711B2 AU31067/77A AU3106777A AU511711B2 AU 511711 B2 AU511711 B2 AU 511711B2 AU 31067/77 A AU31067/77 A AU 31067/77A AU 3106777 A AU3106777 A AU 3106777A AU 511711 B2 AU511711 B2 AU 511711B2
Authority
AU
Australia
Prior art keywords
dihalo
oxo
prostaglandin analogues
prostaglandin
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU31067/77A
Other versions
AU3106777A (en
Inventor
U. F. and Smith H. W Anen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/829,678 external-priority patent/US4124601A/en
Priority claimed from US05/829,679 external-priority patent/US4205178A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU3106777A publication Critical patent/AU3106777A/en
Application granted granted Critical
Publication of AU511711B2 publication Critical patent/AU511711B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU31067/77A 1976-12-30 1977-11-30 6-Oxo and 5, 6-Dihalo prostaglandin analogues Expired AU511711B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US75567576A 1976-12-30 1976-12-30
US75567476A 1976-12-30 1976-12-30
USUS755,674 1976-12-30
USUS755,675 1976-12-30
USUS829.679 1977-09-02
US05/829,678 US4124601A (en) 1976-12-30 1977-09-02 Certain 5-halo-6,9α-epoxy-14-bromo(or chloro)-PGF1 compounds
US05/829,679 US4205178A (en) 1976-12-30 1977-09-02 6-Keto prostaglandin E-type compounds

Publications (2)

Publication Number Publication Date
AU3106777A AU3106777A (en) 1979-06-07
AU511711B2 true AU511711B2 (en) 1980-09-04

Family

ID=27505671

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31067/77A Expired AU511711B2 (en) 1976-12-30 1977-11-30 6-Oxo and 5, 6-Dihalo prostaglandin analogues

Country Status (7)

Country Link
JP (1) JPS5811438B2 (en)
AU (1) AU511711B2 (en)
BE (1) BE862547A (en)
DE (1) DE2753986C2 (en)
FR (1) FR2376134A1 (en)
GB (1) GB1565604A (en)
NL (1) NL190600C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU620543B2 (en) * 1987-03-13 1992-02-20 Schering Aktiengesellschaft 6-oxoprostaglandin-e derivatives, process for their production and their pharmaceutical application

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
FI71138C (en) * 1976-12-31 1986-11-24 Erba Farmitalia FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER
IT1098350B (en) * 1977-07-28 1985-09-07 Upjohn Co PROSTAGLANDINIC DERIVATIVES
JPS6022710B2 (en) * 1977-09-16 1985-06-03 小野薬品工業株式会社 Prostaglandin-like compounds
IT1089247B (en) * 1977-12-30 1985-06-18 Erba Carlo Spa 5-6-DI HYDRO-PROSTACYCLINE DERIVATIVES
DE2834248A1 (en) * 1978-08-04 1980-02-28 Hoechst Ag NEW PROSTAGLAND DERIVATIVES IN THE DELTA 2-PGF TIEF 2 AND DELTA 2-PGE TIEF 2 SERIES
DE2834249A1 (en) * 1978-08-04 1980-02-28 Hoechst Ag NEW PROSTAGLAND DERIVATIVES IN THE DELTA 2-11-DESOXY-PGF TIEF 2 BZW. PGE DEEP 2 SERIES
DE2913856A1 (en) * 1979-04-06 1980-10-23 Hoechst Ag NEW PROSTAGLAND DERIVATIVES IN THE 6-KETO-PGE TIEF 1 SERIES
DE2946116A1 (en) * 1979-11-15 1981-05-27 Hoechst Ag, 6000 Frankfurt NEW PROSTAGLAND DERIVATIVES IN THE 6-KETO-PGA (DOWN ARROW) SERIES 1 (DOWN ARROW)
DE3315356A1 (en) * 1982-04-30 1983-11-17 Ono Pharmaceutical Co. Ltd., Osaka USE OF PROSTAGLANDINE ANALOGS
JPS5920267A (en) * 1982-07-22 1984-02-01 Ono Pharmaceut Co Ltd Prostaglandin e1-mimic compound, its preparation and treating agent containing said compound
JPS62277352A (en) * 1986-01-30 1987-12-02 Ono Pharmaceut Co Ltd Novel 6-keto-prostaglandin e1 derivative, production thereof and remedy for cytopathy containing said derivative as active component
US4981872A (en) * 1987-01-19 1991-01-01 Sankyo Company Limited Prostaglandin derivatives, their preparation and their therapeutic use
DE3704825A1 (en) * 1987-02-16 1988-08-25 Froelich Juergen PROSTAGLANDIN E1 DERIVATIVES AS PHARMACEUTICAL ACTIVE SUBSTANCES AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, IN PARTICULAR FOR TRANSCUTANEAL USE
US5219885A (en) * 1987-02-16 1993-06-15 Froelich Juergen Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration
JPH053100Y2 (en) * 1988-04-28 1993-01-26
KR20020016938A (en) * 1999-08-05 2002-03-06 야스이 쇼사꾸 Neuropathy improvers containing nitrogenous compounds as the active ingredient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU620543B2 (en) * 1987-03-13 1992-02-20 Schering Aktiengesellschaft 6-oxoprostaglandin-e derivatives, process for their production and their pharmaceutical application

Also Published As

Publication number Publication date
JPS5811438B2 (en) 1983-03-02
NL190600B (en) 1993-12-16
GB1565604A (en) 1980-04-23
NL7714172A (en) 1978-07-04
FR2376134B1 (en) 1985-04-12
FR2376134A1 (en) 1978-07-28
AU3106777A (en) 1979-06-07
DE2753986A1 (en) 1978-07-06
JPS5384942A (en) 1978-07-26
BE862547A (en) 1978-06-30
NL190600C (en) 1994-05-16
DE2753986C2 (en) 1986-05-07

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