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AU2001271611A1 - Oxindole derivatives - Google Patents

Oxindole derivatives

Info

Publication number
AU2001271611A1
AU2001271611A1 AU2001271611A AU7161101A AU2001271611A1 AU 2001271611 A1 AU2001271611 A1 AU 2001271611A1 AU 2001271611 A AU2001271611 A AU 2001271611A AU 7161101 A AU7161101 A AU 7161101A AU 2001271611 A1 AU2001271611 A1 AU 2001271611A1
Authority
AU
Australia
Prior art keywords
oxindole derivatives
oxindole
derivatives
methods
pyrrolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001271611A
Inventor
Scott Howard Dickerson
David Harold Drewry
James Andrew Linn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2001271611A1 publication Critical patent/AU2001271611A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oxindole derivatives, specifically pyrrolo[3,2-f]quinoline-2-ones, which are useful as CDK4 inhibitors are described herein. The described invention also includes methods of making such oxindole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
AU2001271611A 2000-09-01 2001-06-28 Oxindole derivatives Abandoned AU2001271611A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23024100P 2000-09-01 2000-09-01
US60230241 2000-09-01
PCT/US2001/020703 WO2002020524A1 (en) 2000-09-01 2001-06-28 Oxindole derivatives

Publications (1)

Publication Number Publication Date
AU2001271611A1 true AU2001271611A1 (en) 2002-03-22

Family

ID=22864461

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001271611A Abandoned AU2001271611A1 (en) 2000-09-01 2001-06-28 Oxindole derivatives

Country Status (8)

Country Link
US (1) US6720332B2 (en)
EP (1) EP1313732B1 (en)
JP (1) JP2004508372A (en)
AT (1) ATE281455T1 (en)
AU (1) AU2001271611A1 (en)
DE (1) DE60106947T2 (en)
ES (1) ES2230337T3 (en)
WO (1) WO2002020524A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1183025B1 (en) * 1999-05-19 2009-01-14 PainCeptor Pharma Corp. Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
MXPA04005939A (en) 2002-01-22 2005-01-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES.
SI1648889T1 (en) * 2003-07-11 2009-02-28 Warner Lambert Co Isethionate salt of a selective cdk4 inhibitor
JP2007513967A (en) * 2003-12-11 2007-05-31 セラヴァンス， インコーポレーテッド Compositions for use in the treatment of cell proliferative diseases driven by mutant receptor tyrosine kinases
US7304074B2 (en) 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
US9376664B2 (en) 2010-06-14 2016-06-28 The Scripps Research Institute Reprogramming of cells to a new fate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
EP1313732B1 (en) 2004-11-03
JP2004508372A (en) 2004-03-18
EP1313732A1 (en) 2003-05-28
ES2230337T3 (en) 2005-05-01
WO2002020524A1 (en) 2002-03-14
DE60106947D1 (en) 2004-12-09
DE60106947T2 (en) 2005-11-10
US6720332B2 (en) 2004-04-13
US20030195189A1 (en) 2003-10-16
ATE281455T1 (en) 2004-11-15

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