ATE510534T1 - Naltrexonhydrochlorid-zusammensetzungen - Google Patents
Naltrexonhydrochlorid-zusammensetzungenInfo
- Publication number
- ATE510534T1 ATE510534T1 AT03716588T AT03716588T ATE510534T1 AT E510534 T1 ATE510534 T1 AT E510534T1 AT 03716588 T AT03716588 T AT 03716588T AT 03716588 T AT03716588 T AT 03716588T AT E510534 T1 ATE510534 T1 AT E510534T1
- Authority
- AT
- Austria
- Prior art keywords
- naltrexone hydrochloride
- hydrochloride compositions
- compositions
- naltrexone
- stabilizing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36452102P | 2002-03-14 | 2002-03-14 | |
PCT/US2003/007932 WO2003077867A2 (en) | 2002-03-14 | 2003-03-14 | Naltrexone hydrochloride compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE510534T1 true ATE510534T1 (de) | 2011-06-15 |
Family
ID=28041930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03716588T ATE510534T1 (de) | 2002-03-14 | 2003-03-14 | Naltrexonhydrochlorid-zusammensetzungen |
Country Status (15)
Country | Link |
---|---|
US (2) | US20030229111A1 (de) |
EP (2) | EP1482912B1 (de) |
JP (2) | JP4683842B2 (de) |
KR (1) | KR20040098660A (de) |
CN (1) | CN1652752A (de) |
AT (1) | ATE510534T1 (de) |
AU (1) | AU2003220290B2 (de) |
BR (1) | BR0308452A (de) |
CA (2) | CA2748620C (de) |
CO (1) | CO5611137A2 (de) |
ES (1) | ES2616981T3 (de) |
IL (1) | IL163911A0 (de) |
MX (1) | MXPA04008772A (de) |
RU (1) | RU2004130441A (de) |
WO (1) | WO2003077867A2 (de) |
Families Citing this family (49)
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---|---|---|---|---|
DK1041987T3 (da) | 1997-12-22 | 2006-08-21 | Euro Celtique Sa | Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon |
EE05171B1 (et) | 2000-02-08 | 2009-06-15 | Euro-Celtique, S.A. | Peroraalne ravimvorm, mis sisaldab opioidagonisti vabanevas vormis ja eraldatud opioidantagonisti, meetod selle valmistamiseks ning selle kasutamine meditsiinis |
JP4522652B2 (ja) | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ, インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
GEP20064022B (en) | 2002-04-05 | 2007-01-10 | Euro Celtique Sa | Pharmaceutical formulations comprising oxycodone and naloxone |
ES2358896T3 (es) * | 2002-08-15 | 2011-05-16 | Euro-Celtique S.A. | Composiciones farmacéuticas que comprenden un analgésico opioide. |
PT1615646E (pt) | 2003-04-08 | 2015-02-12 | Progenics Pharm Inc | Formulações farmacêuticas com metilnaltrexona |
MY135852A (en) * | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
US20060194826A1 (en) * | 2003-09-25 | 2006-08-31 | Euro-Celtique S.A. | Pharmaceutical combinations of hydrocodone and naltrexone |
CN1938004B (zh) * | 2004-03-30 | 2011-12-21 | 欧洲凯尔特公司 | 包含吸附剂和不利剂的抗篡改剂型 |
EP1604666A1 (de) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
US8465776B2 (en) * | 2006-08-04 | 2013-06-18 | Ethypharm | Granule and orally disintegrating tablet comprising oxycodone |
TWI489984B (zh) * | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
TWI553009B (zh) | 2007-03-29 | 2016-10-11 | 普吉尼製藥公司 | 末梢性類鴉片受體拮抗劑及其用途 |
BRPI0809579B8 (pt) | 2007-03-29 | 2021-05-25 | Progenics Pharm Inc | formas cristalinas e seus usos |
CA2682550C (en) | 2007-03-29 | 2016-05-17 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
MX2009011554A (es) | 2007-04-26 | 2010-01-25 | Toray Industries | Preparacion solida estable conteniendo un derivado de 4,5-epoximorfinano. |
EP2168579B1 (de) * | 2007-05-21 | 2017-10-11 | Toray Industries, Inc. | Orale zubereitung mit einer spezifischen orgnanischen säure und verfahren zur verbesserung der auflösungseigenschaft und chemischen stabilität der oralen zubereitung |
EP2065038A1 (de) | 2007-11-30 | 2009-06-03 | Pharnext | Neue therapeutische Ansätze zur Behandlung der Charcot-Marie-Tooth Krankheit |
US8471022B2 (en) | 2008-02-06 | 2013-06-25 | Progenics Pharmaceuticals, Inc. | Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone |
US20110250278A1 (en) * | 2008-07-01 | 2011-10-13 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
CN101658489B (zh) * | 2008-08-27 | 2011-11-23 | 海南四环心脑血管药物研究院有限公司 | 一种盐酸纳美芬注射液及其制备方法 |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
JP5648480B2 (ja) | 2008-10-24 | 2015-01-07 | 東レ株式会社 | 4,5−エポキシモルヒナン誘導体を含有する安定な錠剤 |
MX347106B (es) | 2009-03-10 | 2017-04-12 | Euro-Celtique S A * | Coposiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona. |
EP2263665A1 (de) | 2009-06-02 | 2010-12-22 | Pharnext | Neue Zusammensetzungen zur Behandlung von CMT und verwandten Erkrankungen |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
WO2011052499A1 (ja) * | 2009-10-28 | 2011-05-05 | 第一三共株式会社 | 貯蔵安定性が改善された医薬組成物 |
SG10201501821RA (en) | 2010-03-11 | 2015-05-28 | Wyeth Llc | Oral formulations and lipophilic salts of methylnaltrexone |
CN103002881B (zh) | 2010-05-10 | 2015-09-02 | 欧洲凯尔特公司 | 载有活性剂的颗粒与额外活性剂的组合 |
CN103002882B (zh) | 2010-05-10 | 2016-03-02 | 欧洲凯尔特公司 | 不含活性剂之颗粒及包含其之片剂的制备 |
TWI560170B (en) * | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
CA2881144A1 (en) * | 2012-11-09 | 2014-05-09 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
EP3003268B1 (de) | 2013-06-05 | 2018-07-25 | Pharnext | Stabile orale lösungen für kombinierte api |
KR20160034352A (ko) | 2013-07-23 | 2016-03-29 | 유로-셀티큐 에스.에이. | 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물 |
UA116405C2 (uk) | 2013-11-13 | 2018-03-12 | Євро-Селтік С.А. | Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику |
CN105582011A (zh) * | 2014-10-24 | 2016-05-18 | 江苏国丹生物制药有限公司 | 溴甲纳曲酮固体组合物及其制备方法 |
EP3352823B1 (de) * | 2015-09-24 | 2021-04-21 | Pain Therapeutics, Inc. | Kristalline salze von naloxon und naltrexon |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
CA3043591A1 (en) * | 2016-10-18 | 2018-04-26 | Antheia, Inc. | Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids |
US11185540B2 (en) * | 2017-04-12 | 2021-11-30 | Pardon My Scotch Llc. | Extended release compositions of opioid antagonists and phosphodiesterase 5 inhibitors |
WO2020012245A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions |
WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
CA3145794A1 (en) | 2019-07-10 | 2021-01-14 | Intas Pharmaceuticals Ltd. | Naltrexone formulation |
EP4062973A4 (de) * | 2019-11-20 | 2023-11-29 | Shionogi & Co., Ltd | 6,7-ungesättigtes-7-carbamoyl-morphinanderivat enthaltende feste formulierung |
WO2022173402A1 (en) * | 2021-02-09 | 2022-08-18 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A film coated tablet comprising naltrexone hydrochloride |
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US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
US4587118A (en) * | 1981-07-15 | 1986-05-06 | Key Pharmaceuticals, Inc. | Dry sustained release theophylline oral formulation |
FR2609632B1 (fr) * | 1987-01-21 | 1991-03-29 | Shelly Marc | Nouvelle application therapeutique de la 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinon-6-one et les compositions pharmaceutiques destinees a cet usage |
US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
US5994392A (en) * | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
JP3456211B2 (ja) * | 1991-09-27 | 2003-10-14 | 藤沢薬品工業株式会社 | 持続性製剤 |
US6271239B1 (en) * | 1992-04-13 | 2001-08-07 | Regents Of The University Of Minnesota | Delta opioid receptor-selective benzylidene-substituted morphinans |
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US5472943A (en) | 1992-09-21 | 1995-12-05 | Albert Einstein College Of Medicine Of Yeshiva University, | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists |
US5580876A (en) | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
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DK1041987T3 (da) * | 1997-12-22 | 2006-08-21 | Euro Celtique Sa | Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon |
US6166211A (en) * | 1999-03-19 | 2000-12-26 | Endo Pharmaceuticals, Inc. | Sequential benzylic oxidations of the naloxone ring system |
GB9908921D0 (en) * | 1999-04-19 | 1999-06-16 | Britannia Pharmaceuticals Ltd | Spray dispenser for opiod antagonists |
US6071918A (en) * | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
EE05171B1 (et) * | 2000-02-08 | 2009-06-15 | Euro-Celtique, S.A. | Peroraalne ravimvorm, mis sisaldab opioidagonisti vabanevas vormis ja eraldatud opioidantagonisti, meetod selle valmistamiseks ning selle kasutamine meditsiinis |
WO2001085257A2 (en) * | 2000-05-05 | 2001-11-15 | Pain Therapeutics, Inc. | Opioid antagonist compositions and dosage forms |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
PT1414451E (pt) * | 2001-08-06 | 2009-07-31 | Euro Celtique Sa | Formulações agonistas de opióides com antagonista libertável e sequestrado |
MY135852A (en) * | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
-
2003
- 2003-03-14 US US10/389,238 patent/US20030229111A1/en not_active Abandoned
- 2003-03-14 AU AU2003220290A patent/AU2003220290B2/en not_active Expired
- 2003-03-14 EP EP03716588A patent/EP1482912B1/de not_active Expired - Lifetime
- 2003-03-14 CA CA2748620A patent/CA2748620C/en not_active Expired - Lifetime
- 2003-03-14 EP EP10010921.4A patent/EP2289492B1/de not_active Expired - Lifetime
- 2003-03-14 WO PCT/US2003/007932 patent/WO2003077867A2/en active IP Right Grant
- 2003-03-14 BR BRPI0308452-3A patent/BR0308452A/pt not_active IP Right Cessation
- 2003-03-14 RU RU2004130441/15A patent/RU2004130441A/ru not_active Application Discontinuation
- 2003-03-14 CA CA2478558A patent/CA2478558C/en not_active Expired - Lifetime
- 2003-03-14 AT AT03716588T patent/ATE510534T1/de not_active IP Right Cessation
- 2003-03-14 KR KR10-2004-7013905A patent/KR20040098660A/ko not_active Application Discontinuation
- 2003-03-14 JP JP2003575921A patent/JP4683842B2/ja not_active Expired - Lifetime
- 2003-03-14 IL IL16391103A patent/IL163911A0/xx unknown
- 2003-03-14 MX MXPA04008772A patent/MXPA04008772A/es unknown
- 2003-03-14 ES ES10010921.4T patent/ES2616981T3/es not_active Expired - Lifetime
- 2003-03-14 CN CNA038103737A patent/CN1652752A/zh active Pending
-
2004
- 2004-09-13 CO CO04090752A patent/CO5611137A2/es not_active Application Discontinuation
-
2009
- 2009-02-12 JP JP2009029529A patent/JP5291483B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-20 US US15/298,483 patent/US20170100337A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5291483B2 (ja) | 2013-09-18 |
CA2478558A1 (en) | 2003-09-25 |
KR20040098660A (ko) | 2004-11-20 |
EP2289492A3 (de) | 2011-12-21 |
RU2004130441A (ru) | 2005-05-20 |
US20030229111A1 (en) | 2003-12-11 |
CA2748620C (en) | 2014-03-11 |
EP1482912A4 (de) | 2006-11-15 |
MXPA04008772A (es) | 2004-12-06 |
WO2003077867A2 (en) | 2003-09-25 |
CN1652752A (zh) | 2005-08-10 |
JP2005531515A (ja) | 2005-10-20 |
US20170100337A1 (en) | 2017-04-13 |
IL163911A0 (en) | 2005-12-18 |
CA2748620A1 (en) | 2003-09-25 |
EP2289492A2 (de) | 2011-03-02 |
AU2003220290A1 (en) | 2003-09-29 |
CO5611137A2 (es) | 2006-02-28 |
EP1482912B1 (de) | 2011-05-25 |
EP2289492B1 (de) | 2016-12-07 |
BR0308452A (pt) | 2006-06-06 |
EP1482912A2 (de) | 2004-12-08 |
AU2003220290B2 (en) | 2007-06-14 |
JP4683842B2 (ja) | 2011-05-18 |
WO2003077867A3 (en) | 2004-09-02 |
CA2478558C (en) | 2012-09-11 |
ES2616981T3 (es) | 2017-06-15 |
JP2009143948A (ja) | 2009-07-02 |
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