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ATE552256T1 - Neuartige form von tiotropium-bromid und herstellungsverfahren dafür - Google Patents

Neuartige form von tiotropium-bromid und herstellungsverfahren dafür

Info

Publication number
ATE552256T1
ATE552256T1 AT09010563T AT09010563T ATE552256T1 AT E552256 T1 ATE552256 T1 AT E552256T1 AT 09010563 T AT09010563 T AT 09010563T AT 09010563 T AT09010563 T AT 09010563T AT E552256 T1 ATE552256 T1 AT E552256T1
Authority
AT
Austria
Prior art keywords
tiotropium bromide
production
novel form
novel
tiotropium
Prior art date
Application number
AT09010563T
Other languages
English (en)
Inventor
Nicola Diulgheroff
Francesca Scarpitta
Alessandro Pontiroli
Adrienne Kovacsne-Mezei
Judith Aronhime
Alexandr Jegorov
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38115166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE552256(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE552256T1 publication Critical patent/ATE552256T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT09010563T 2005-12-19 2006-12-19 Neuartige form von tiotropium-bromid und herstellungsverfahren dafür ATE552256T1 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US75453005P 2005-12-27 2005-12-27
US76143706P 2006-01-23 2006-01-23
US77405106P 2006-02-15 2006-02-15
US78031006P 2006-03-07 2006-03-07
US83218906P 2006-07-20 2006-07-20
US85122306P 2006-10-12 2006-10-12
US85274006P 2006-10-18 2006-10-18

Publications (1)

Publication Number Publication Date
ATE552256T1 true ATE552256T1 (de) 2012-04-15

Family

ID=38115166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09010563T ATE552256T1 (de) 2005-12-19 2006-12-19 Neuartige form von tiotropium-bromid und herstellungsverfahren dafür

Country Status (17)

Country Link
US (4) US8163913B2 (de)
EP (2) EP2123650B1 (de)
JP (3) JP5086267B2 (de)
KR (1) KR101395881B1 (de)
CN (1) CN102731494A (de)
AT (1) ATE552256T1 (de)
BR (1) BRPI0608427A2 (de)
CA (1) CA2627729A1 (de)
DK (1) DK1869035T4 (de)
ES (2) ES2396978T5 (de)
IL (1) IL187947A0 (de)
MX (1) MX2007009988A (de)
PL (2) PL2123650T3 (de)
PT (1) PT1869035E (de)
RS (1) RS52663B2 (de)
TW (1) TW200732340A (de)
WO (1) WO2007075858A2 (de)

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US9108962B2 (en) * 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
JP5086267B2 (ja) * 2005-12-19 2012-11-28 シコール インコーポレイティド 臭化チオトロピウムの新規な形態およびそれを製造する方法
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
US20110028508A1 (en) * 2008-01-10 2011-02-03 Gemerocs [UK] Limited Novel process for the preparation of scopine esters
EP2172190A1 (de) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalierbare Partikel mit Tiotropium
AU2009312582B2 (en) * 2008-11-04 2014-03-27 Cipla Limited Tiotropium bromide having a low degree of crystallinity
JP2012507574A (ja) * 2008-11-04 2012-03-29 シプラ・リミテッド 医薬エアロゾル組成物
EP2462140A2 (de) * 2009-08-07 2012-06-13 Generics [UK] Limited Triotropiumbromid-anhydrat
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2705838A1 (de) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium-Zubereitungen
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
SI2914593T1 (sl) 2012-11-05 2017-05-31 Zentiva, K.S. Stabilizacija tiotropijevih solvatov
RU2015146871A (ru) 2013-04-01 2017-05-10 Пулматрикс, Инк. Сухие порошки с тиотропием
EP2789611A1 (de) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. Kristalline Form von Tiotropiumbromid
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
WO2020013330A1 (ja) * 2018-07-13 2020-01-16 協和発酵バイオ株式会社 ユーコミン酸の非溶媒和物結晶及びその製造方法
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
EP4108230A1 (de) 2021-06-24 2022-12-28 Laboratoires SMB Neue trockenpulverzusammensetzung von tiotropium zur inhalation

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DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
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CA2606552A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
JP5086267B2 (ja) * 2005-12-19 2012-11-28 シコール インコーポレイティド 臭化チオトロピウムの新規な形態およびそれを製造する方法
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
EP1923393A1 (de) 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Kristalline Form von Tiotropiumbromid mit Harnstoff
EP2020403A1 (de) * 2007-08-02 2009-02-04 Esteve Quimica, S.A. Verfahren zur Auflösung von Zopiclon und Zwischenprodukten
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
EP2462140A2 (de) * 2009-08-07 2012-06-13 Generics [UK] Limited Triotropiumbromid-anhydrat

Also Published As

Publication number Publication date
RS52663B2 (sr) 2018-05-31
CA2627729A1 (en) 2007-07-05
EP2123650B1 (de) 2012-04-04
PT1869035E (pt) 2013-01-10
EP2123650A1 (de) 2009-11-25
US20120165364A1 (en) 2012-06-28
DK1869035T4 (en) 2015-11-16
ES2396978T3 (es) 2013-03-01
ES2396978T5 (es) 2015-12-04
US20140057935A1 (en) 2014-02-27
US20120108625A1 (en) 2012-05-03
EP1869035A2 (de) 2007-12-26
JP2009513675A (ja) 2009-04-02
CN102731494A (zh) 2012-10-17
JP2012176975A (ja) 2012-09-13
JP5567610B2 (ja) 2014-08-06
US20070225314A1 (en) 2007-09-27
US8846926B2 (en) 2014-09-30
RS52663B (en) 2013-06-28
US8163913B2 (en) 2012-04-24
WO2007075858A2 (en) 2007-07-05
DK1869035T3 (da) 2013-01-14
TW200732340A (en) 2007-09-01
PL1869035T3 (pl) 2013-04-30
ES2384486T3 (es) 2012-07-05
MX2007009988A (es) 2008-02-22
KR101395881B1 (ko) 2014-05-21
EP1869035B2 (de) 2015-08-12
KR20080078779A (ko) 2008-08-28
EP1869035B1 (de) 2012-10-03
JP2012136538A (ja) 2012-07-19
JP5086267B2 (ja) 2012-11-28
PL1869035T5 (pl) 2016-01-29
PL2123650T3 (pl) 2012-09-28
IL187947A0 (en) 2008-03-20
BRPI0608427A2 (pt) 2009-12-29
WO2007075858A3 (en) 2007-11-01

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