ATE425132T1 - Neues verfahren zur stereoselektiven reduktion von beta-ketoestern - Google Patents

Neues verfahren zur stereoselektiven reduktion von beta-ketoestern

Info

Publication number: ATE425132T1
Authority: AT; Austria
Prior art keywords: sub; beta; new method; aryl; alkyl
Prior art date: 2003-04-22

Application number

AT03816679T

Other languages

English (en)

Inventor

Tom Puthiaparampil

Acharya Poornaprajna

Chandrashekar Aswathanarayanappa

Madhavan Sridharan

Sambasivam Ganesh

Original Assignee

Biocon Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-22

Filing date

2003-04-22

Publication date

2009-03-15

2003-04-22 Application filed by Biocon Ltd filed Critical Biocon Ltd

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE425132T1 publication Critical patent/ATE425132T1/de

Links

238000000034 method Methods 0.000 title abstract 2
238000011916 stereoselective reduction Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000001072 heteroaryl group Chemical group 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
239000003638 chemical reducing agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

AT03816679T 2003-04-22 2003-04-22 Neues verfahren zur stereoselektiven reduktion von beta-ketoestern ATE425132T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2003/000166 WO2004094343A1 (en)	2003-04-22	2003-04-22	NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ß-KETOESTERS

Publications (1)

Publication Number	Publication Date
ATE425132T1 true ATE425132T1 (de)	2009-03-15

Family

ID=33307096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03816679T ATE425132T1 (de)	2003-04-22	2003-04-22	Neues verfahren zur stereoselektiven reduktion von beta-ketoestern

Country Status (10)

Country	Link
US (1)	US7232920B2 (de)
EP (1)	EP1631533B1 (de)
AT (1)	ATE425132T1 (de)
AU (1)	AU2003231926A1 (de)
DE (1)	DE60326654D1 (de)
DK (1)	DK1631533T3 (de)
ES (1)	ES2323366T3 (de)
PT (1)	PT1631533E (de)
SI (1)	SI1631533T1 (de)
WO (1)	WO2004094343A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7851624B2 (en) *	2003-12-24	2010-12-14	Teva Pharamaceutical Industries Ltd.	Triol form of rosuvastatin and synthesis of rosuvastatin
US20070179166A1 (en) *	2003-12-24	2007-08-02	Valerie Niddam-Hildesheim	Process for preparation of statins with high syn to anti ratio
CN102827030B (zh) *	2012-09-24	2014-05-07	复旦大学	一种 (3r, 5r)-3, 5-二羟基-6-氰基己酸酯的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4645854A (en) *	1985-04-25	1987-02-24	Merck & Co., Inc.	Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
DE3638761A1 (de) *	1986-11-13	1988-05-26	Schering Ag	Verbesserte ketoreduktion von carbacyclinzwischenprodukten
CA2028538A1 (en) *	1989-10-27	1991-04-28	Hideaki Natsugari	4-substituted isoquinolone derivatives, their production and use
FR2670206B1 (fr) *	1990-12-11	1993-01-22	Rhone Poulenc Sante	Procede de preparation de derives de l'acide dihydroxy-3,5 pentanouique.
HRP960312B1 (en)	1995-07-17	2001-10-31	Warner Lambert Co	NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R, R)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
JP2000515882A (ja) *	1996-07-29	2000-11-28	ワーナー―ランバート・コンパニー	（ｓ）―３，４―ジヒドロキシ酪酸の保護されたエステルを合成するための改善された方法
IL135562A (en) *	1997-12-19	2005-08-31	Warner Lambert Exp Ltd	Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis
IL155890A0 (en)	2000-11-16	2003-12-23	Teva Pharma	HYDROLYSIS OF [R(R,R)]-2-(4-FLUOROPHENYL)-beta,delta-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE
US6777552B2 (en)	2001-08-16	2004-08-17	Teva Pharmaceutical Industries, Ltd.	Processes for preparing calcium salt forms of statins
AU2002328835A1 (en)	2001-07-06	2003-01-21	Teva Pharmaceutical Industries Ltd	Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
HUP0401014A2 (hu)	2001-07-06	2004-08-30	Teva Pharmaceutical Industries Ltd.	Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül
CA2448917A1 (en)	2001-07-06	2003-01-16	Reinhold Ohrlein	Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
EP1425287A4 (de)	2001-08-16	2005-09-07	Teva Pharma	Verfahren zur herstellung von calciumsalzformen von statinen
US20030175338A1 (en)	2002-02-14	2003-09-18	Singh Romi Barat	Formulations of atorvastatin stabilized with alkali metal additions

2003
- 2003-04-22 AU AU2003231926A patent/AU2003231926A1/en not_active Abandoned
- 2003-04-22 EP EP03816679A patent/EP1631533B1/de not_active Expired - Lifetime
- 2003-04-22 SI SI200331564T patent/SI1631533T1/sl unknown
- 2003-04-22 PT PT03816679T patent/PT1631533E/pt unknown
- 2003-04-22 WO PCT/IN2003/000166 patent/WO2004094343A1/en not_active Application Discontinuation
- 2003-04-22 US US10/483,479 patent/US7232920B2/en not_active Expired - Fee Related
- 2003-04-22 ES ES03816679T patent/ES2323366T3/es not_active Expired - Lifetime
- 2003-04-22 DE DE60326654T patent/DE60326654D1/de not_active Expired - Lifetime
- 2003-04-22 DK DK03816679T patent/DK1631533T3/da active
- 2003-04-22 AT AT03816679T patent/ATE425132T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1631533B1 (de)	2009-03-11
DE60326654D1 (de)	2009-04-23
SI1631533T1 (sl)	2009-08-31
ES2323366T3 (es)	2009-07-14
EP1631533A1 (de)	2006-03-08
AU2003231926A1 (en)	2004-11-19
US7232920B2 (en)	2007-06-19
EP1631533A4 (de)	2007-04-25
US20040259946A1 (en)	2004-12-23
DK1631533T3 (da)	2009-06-02
WO2004094343A1 (en)	2004-11-04
PT1631533E (pt)	2009-06-04

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Legal Events

Date	Code	Title	Description
2009-11-15	UEP	Publication of translation of european patent specification	Ref document number: 1631533 Country of ref document: EP
2011-01-15	REN	Ceased due to non-payment of the annual fee

Date

Code

Title

Description

2009-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1631533

Country of ref document: EP

2011-01-15

REN

Ceased due to non-payment of the annual fee