ATE490254T1 - Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer - Google Patents

Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer

Info

Publication number: ATE490254T1
Authority: AT; Austria
Prior art keywords: imidazoä1; aüpyridine; vegf; inhibitors; compounds
Prior art date: 2005-02-24

Application number

AT06735794T

Other languages

English (en)

Inventor

David Barda

Timothy Burkholder

Joshua Clayton

Yan Hao

Perry Heath

James Henry

John Knobeloch

David Mendel

Johnathan Mclean

David Remick

Mark Rempala

Zhao-Qing Wang

Yvonne Yip

Boyu Zhong

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-24

Filing date

2006-02-23

Publication date

2010-12-15

2006-02-23 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE490254T1 publication Critical patent/ATE490254T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT06735794T 2005-02-24 2006-02-23 Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer ATE490254T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65598105P	2005-02-24	2005-02-24
PCT/US2006/006283 WO2006091671A1 (en)	2005-02-24	2006-02-23	Imidazo (1, 2-a) pyridine compounds as vegf-r2 inhibitors

Publications (1)

Publication Number	Publication Date
ATE490254T1 true ATE490254T1 (de)	2010-12-15

Family

ID=36587138

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06735794T ATE490254T1 (de)	2005-02-24	2006-02-23	Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer

Country Status (34)

Country	Link
US (1)	US7666879B2 (de)
EP (1)	EP1904494B1 (de)
JP (1)	JP5055136B2 (de)
KR (1)	KR100904938B1 (de)
CN (1)	CN101128461B (de)
AR (1)	AR056186A1 (de)
AT (1)	ATE490254T1 (de)
AU (1)	AU2006216710B2 (de)
BR (1)	BRPI0609047A2 (de)
CA (1)	CA2599124C (de)
CR (1)	CR9331A (de)
CY (1)	CY1111154T1 (de)
DE (1)	DE602006018615D1 (de)
DK (1)	DK1904494T3 (de)
DO (1)	DOP2006000051A (de)
EA (1)	EA011691B1 (de)
ES (1)	ES2354716T3 (de)
HK (1)	HK1118284A1 (de)
HR (1)	HRP20100677T1 (de)
IL (1)	IL184717A (de)
MA (1)	MA29433B1 (de)
MX (1)	MX2007010326A (de)
NO (1)	NO20074666L (de)
NZ (2)	NZ560402A (de)
PE (1)	PE20061098A1 (de)
PL (1)	PL1904494T3 (de)
PT (1)	PT1904494E (de)
RS (1)	RS51590B (de)
SI (1)	SI1904494T1 (de)
TN (1)	TNSN07323A1 (de)
TW (1)	TW200640924A (de)
UA (1)	UA91535C2 (de)
WO (1)	WO2006091671A1 (de)
ZA (1)	ZA200707136B (de)

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US8131527B1 (en)	2006-12-22	2012-03-06	Astex Therapeutics Ltd.	FGFR pharmacophore compounds
AU2008226947B2 (en)	2007-03-08	2014-07-17	The Board Of Trustees Of The Leland Stanford Junior University	Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
AR068877A1 (es) *	2007-10-17	2009-12-09	Novartis Ag	Derivados heterociclicos de imidazol
GB0810902D0 (en) *	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
EP2337563B1 (de)	2008-09-08	2014-04-09	The Board of Trustees of The Leland Stanford Junior University	Modulatoren der aldehyddehydrogenase-aktivität und anwendungsverfahren für diese
CN102202669A (zh)	2008-10-28	2011-09-28	利兰·斯坦福青年大学托管委员会	醛脱氢酶调节剂及其使用方法
JO3265B1 (ar)	2008-12-09	2018-09-16	Novartis Ag	مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US8278302B2 (en)	2009-04-08	2012-10-02	Boehringer Ingelheim International Gmbh	Substituted piperidines as CCR3 antagonists
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
TW201124391A (en)	2009-10-20	2011-07-16	Lundbeck & Co As H	2-substituted-ethynylthiazole derivatives and uses of same
GB201009731D0 (en)	2010-06-10	2010-07-21	Pulmagen Therapeutics Inflamma	Kinase inhibitors
UA109290C2 (uk)	2010-10-07	2015-08-10		Спільні кристали і солі інгібіторів ccr3
WO2012149106A1 (en)	2011-04-29	2012-11-01	The Board Of Trustees Of The Leland Stanford Junior University	Compositions and methods for increasing proliferation of adult salivary stem cells
US8680280B2 (en)	2012-04-02	2014-03-25	Boehringer Ingelheim International Gmbh	Process for the manufacturing of CRR inhibitors
US10213421B2 (en)	2012-04-04	2019-02-26	Alkahest, Inc.	Pharmaceutical formulations comprising CCR3 antagonists
SG11201503299YA (en)	2012-09-28	2015-06-29	Univ Vanderbilt	Fused heterocyclic compounds as selective bmp inhibitors
WO2014082979A1 (en) *	2012-11-29	2014-06-05	F. Hoffmann-La Roche Ag	Imidazopyridine derivatives
CN105358531B (zh)	2013-03-14	2017-11-14	利兰-斯坦福大学初级学院的董事会	线粒体醛脱氢酶‑2调节剂和其使用方法
BR112016013734A2 (pt)	2013-12-16	2017-08-08	Asana Biosciences Llc	Composto, composição farmacêutica, kit, e uso de um composto
CN103772308B (zh) *	2013-12-31	2015-11-18	北京颖泰嘉和生物科技股份有限公司	5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法
WO2015187818A1 (en) *	2014-06-03	2015-12-10	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Benzimidazole analogues and related methods
EP3169671B1 (de)	2014-07-17	2019-08-21	Sunshine Lake Pharma Co., Ltd.	1-(5-(tert.-butyl)isoxazol-3-yl)-3-(4-((phenyl)ethynyl)phenyl)harnstoffderivate und verwandte verbindungen als flt3 inhibitoren zur behandlung von krebs
CN104163790B (zh) *	2014-08-19	2016-02-10	贵州威顿晶磷电子材料股份有限公司	一种2-氨基-4-甲基-5溴吡啶的制备工艺
US10829484B2 (en)	2015-07-28	2020-11-10	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
MX2018002631A (es) *	2015-09-03	2019-02-07	Univ Arizona	Inhibidores de molecula pequeña de dyrkia y usos de los mismos.
JP6921846B6 (ja) *	2016-03-16	2021-09-15	プレキシコンインコーポレーテッドＰｌｅｘｘｉｋｏｎＩｎｃ．	キナーゼ調節およびその適応症のための化合物および方法
EP3765460A1 (de)	2018-03-14	2021-01-20	Vanderbilt University	Hemmung von bmp-signalisierung, verbindungen, zusammensetzungen und verwendungen davon
WO2019245590A1 (en)	2018-06-18	2019-12-26	Avista Pharma Solutions, Inc.	Chemical compounds
WO2020142557A1 (en)	2018-12-31	2020-07-09	Biomea Fusion, Llc	Irreversible inhibitors of menin-mll interaction
US11174263B2 (en)	2018-12-31	2021-11-16	Biomea Fusion, Inc.	Inhibitors of menin-MLL interaction
CA3128346A1 (en)	2019-01-30	2020-08-06	Avista Pharma Solutions, Inc.	Synthetic process and novel intermediates
MX2021009082A (es)	2019-01-30	2021-09-08	Avista Pharma Solutions Inc	Compuestos quimicos.
US20220098204A1 (en) *	2019-02-18	2022-03-31	Shenzhen Targetrx, Inc.	Substituted fused aromatic ring derivative, composition and use thereof
AU2020301057A1 (en) *	2019-06-25	2022-01-27	Sinopsee Therapeutics	Compounds for treatment of eye disorders
CN112778294A (zh) *	2021-01-07	2021-05-11	苏州安睿药业有限公司	5-氨基异噁唑衍生物及其在制备多激酶抑制剂中的应用
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2006
- 2006-02-22 DO DO2006000051A patent/DOP2006000051A/es unknown
- 2006-02-23 AT AT06735794T patent/ATE490254T1/de active
- 2006-02-23 SI SI200630871T patent/SI1904494T1/sl unknown
- 2006-02-23 PE PE2006000219A patent/PE20061098A1/es not_active Application Discontinuation
- 2006-02-23 JP JP2007557126A patent/JP5055136B2/ja not_active Expired - Fee Related
- 2006-02-23 RS RS20110042A patent/RS51590B/en unknown
- 2006-02-23 CN CN2006800060044A patent/CN101128461B/zh not_active Expired - Fee Related
- 2006-02-23 BR BRPI0609047-8A patent/BRPI0609047A2/pt not_active IP Right Cessation
- 2006-02-23 AR ARP060100668A patent/AR056186A1/es not_active Application Discontinuation
- 2006-02-23 EA EA200701802A patent/EA011691B1/ru not_active IP Right Cessation
- 2006-02-23 WO PCT/US2006/006283 patent/WO2006091671A1/en active Application Filing
- 2006-02-23 DK DK06735794.7T patent/DK1904494T3/da active
- 2006-02-23 KR KR1020077019338A patent/KR100904938B1/ko not_active IP Right Cessation
- 2006-02-23 ES ES06735794T patent/ES2354716T3/es active Active
- 2006-02-23 NZ NZ560402A patent/NZ560402A/en not_active IP Right Cessation
- 2006-02-23 CA CA2599124A patent/CA2599124C/en not_active Expired - Fee Related
- 2006-02-23 AU AU2006216710A patent/AU2006216710B2/en not_active Ceased
- 2006-02-23 DE DE602006018615T patent/DE602006018615D1/de active Active
- 2006-02-23 UA UAA200709559A patent/UA91535C2/ru unknown
- 2006-02-23 US US11/816,416 patent/US7666879B2/en not_active Expired - Fee Related
- 2006-02-23 TW TW095106022A patent/TW200640924A/zh unknown
- 2006-02-23 MX MX2007010326A patent/MX2007010326A/es active IP Right Grant
- 2006-02-23 EP EP06735794A patent/EP1904494B1/de active Active
- 2006-02-23 PL PL06735794T patent/PL1904494T3/pl unknown
- 2006-02-23 NZ NZ584753A patent/NZ584753A/en not_active IP Right Cessation
- 2006-02-23 PT PT06735794T patent/PT1904494E/pt unknown
2007
- 2007-07-19 IL IL184717A patent/IL184717A/en not_active IP Right Cessation
- 2007-08-22 CR CR9331A patent/CR9331A/es not_active Application Discontinuation
- 2007-08-23 ZA ZA200707136A patent/ZA200707136B/xx unknown
- 2007-08-23 TN TNP2007000323A patent/TNSN07323A1/en unknown
- 2007-09-13 NO NO20074666A patent/NO20074666L/no not_active Application Discontinuation
- 2007-09-24 MA MA30233A patent/MA29433B1/fr unknown
2008
- 2008-08-25 HK HK08109446.3A patent/HK1118284A1/xx not_active IP Right Cessation
2010
- 2010-12-07 HR HR20100677T patent/HRP20100677T1/hr unknown
2011
- 2011-02-03 CY CY20111100115T patent/CY1111154T1/el unknown

Also Published As

Publication number	Publication date
EA200701802A1 (ru)	2008-02-28
MA29433B1 (fr)	2008-05-02
CR9331A (es)	2008-03-31
JP2008531574A (ja)	2008-08-14
PL1904494T3 (pl)	2011-04-29
NZ584753A (en)	2011-06-30
KR20070099029A (ko)	2007-10-08
US20090227622A1 (en)	2009-09-10
ZA200707136B (en)	2008-11-26
MX2007010326A (es)	2007-10-16
CN101128461B (zh)	2010-12-22
IL184717A (en)	2011-11-30
EA011691B1 (ru)	2009-04-28
EP1904494B1 (de)	2010-12-01
AU2006216710B2 (en)	2011-08-11
CN101128461A (zh)	2008-02-20
HK1118284A1 (en)	2009-02-06
JP5055136B2 (ja)	2012-10-24
AU2006216710A1 (en)	2006-08-31
NZ560402A (en)	2010-06-25
NO20074666L (no)	2007-11-09
PT1904494E (pt)	2010-12-23
AR056186A1 (es)	2007-09-26
BRPI0609047A2 (pt)	2010-11-16
RS51590B (en)	2011-08-31
UA91535C2 (en)	2010-08-10
DE602006018615D1 (de)	2011-01-13
SI1904494T1 (sl)	2011-02-28
IL184717A0 (en)	2007-12-03
CA2599124C (en)	2013-08-06
US7666879B2 (en)	2010-02-23
EP1904494A1 (de)	2008-04-02
PE20061098A1 (es)	2006-10-20
CY1111154T1 (el)	2015-06-11
TW200640924A (en)	2006-12-01
HRP20100677T1 (hr)	2011-01-31
TNSN07323A1 (en)	2008-12-31
DOP2006000051A (es)	2006-08-31
WO2006091671A1 (en)	2006-08-31
KR100904938B1 (ko)	2009-06-29
CA2599124A1 (en)	2006-08-31
DK1904494T3 (da)	2011-02-21
ES2354716T3 (es)	2011-03-17

Publication	Publication Date	Title
ATE490254T1 (de)	2010-12-15	Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer
LTPA2020501I1 (lt)	2020-02-10	Pakeistieji enaminokarbonilo junginiai
ATE493411T1 (de)	2011-01-15	Pyrroloä2, 3-büpyridin-4-yl- benzolsulfonamidverbindungen als ikk2-hemmer
LTPA2016036I1 (lt)	2017-01-10	Nitrokatechnolio dariniai, kaip COMT inhibitoriai
ATE511502T1 (de)	2011-06-15	Arylpropionamid-, arylacrylamid-, arylpropinamid- oder arylmethylharnstoffanaloge als faktor-xia- inhibitoren
CY2013047I1 (el)	2015-11-04	Ενωσεις διαρυλυδαντοϊνης
ATE452132T1 (de)	2010-01-15	Benzimidazolthiophenverbindungen als plk- inhibitoren
ATE512972T1 (de)	2011-07-15	Pyrrolopyrazole als wirksame kinaseinhibitoren
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