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ATE143020T1 - Aminocarbonylcarbamate verwandt mit physostigmin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Aminocarbonylcarbamate verwandt mit physostigmin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number
ATE143020T1
ATE143020T1 AT90122731T AT90122731T ATE143020T1 AT E143020 T1 ATE143020 T1 AT E143020T1 AT 90122731 T AT90122731 T AT 90122731T AT 90122731 T AT90122731 T AT 90122731T AT E143020 T1 ATE143020 T1 AT E143020T1
Authority
AT
Austria
Prior art keywords
physostigmine
loweralkyl
aminocarbonyl
production
medicinal product
Prior art date
Application number
AT90122731T
Other languages
English (en)
Inventor
Edward Joseph Glamkowski
Yulin Chiang
Russell Richard Lee Hamer
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE143020T1 publication Critical patent/ATE143020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90122731T 1989-11-30 1990-11-28 Aminocarbonylcarbamate verwandt mit physostigmin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel ATE143020T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/443,682 US5077289A (en) 1989-11-30 1989-11-30 Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine

Publications (1)

Publication Number Publication Date
ATE143020T1 true ATE143020T1 (de) 1996-10-15

Family

ID=23761787

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90122731T ATE143020T1 (de) 1989-11-30 1990-11-28 Aminocarbonylcarbamate verwandt mit physostigmin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (23)

Country Link
US (1) US5077289A (de)
EP (1) EP0430201B1 (de)
JP (1) JPH0723378B2 (de)
KR (1) KR100215346B1 (de)
AT (1) ATE143020T1 (de)
AU (1) AU626740B2 (de)
CA (1) CA2031079C (de)
CZ (1) CZ280888B6 (de)
DE (1) DE69028605T2 (de)
DK (1) DK0430201T3 (de)
ES (1) ES2094742T3 (de)
FI (1) FI93451C (de)
GR (1) GR3021210T3 (de)
HU (1) HU207321B (de)
IE (1) IE75716B1 (de)
IL (1) IL96498A (de)
NO (1) NO175310C (de)
NZ (1) NZ236248A (de)
PL (1) PL165775B1 (de)
PT (1) PT96030B (de)
RU (1) RU2069664C1 (de)
YU (1) YU224790A (de)
ZA (1) ZA909590B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634654B2 (en) * 1990-05-11 1993-02-25 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments
US5173497A (en) * 1990-05-17 1992-12-22 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs
US5480651A (en) * 1992-03-16 1996-01-02 Regents Of The University Of California Composition and method for treating nicotine craving in smoking cessation
FI933264A (fi) * 1992-07-21 1994-01-22 Hoechst Roussel Pharma Foerfarande foer framstaellning av fysostigminkarbamatderivat fraon fysostigmin
US5409948A (en) * 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
US6495700B1 (en) 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog
US20050182044A1 (en) * 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (en) * 2004-06-01 2005-12-01 Axonyx, Inc. Transdermal delivery system for treatment of cognitive disorders
CA2509265A1 (en) * 2004-06-08 2005-12-08 Axonyx, Inc. Methods of delaying alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and hmg coa reductase inhibitor
EP1779867A4 (de) * 2004-07-01 2009-12-02 Eisai R&D Man Co Ltd Mittel zur förderung der nervenreveneration
US10888542B2 (en) 2014-02-28 2021-01-12 Sk Biopharmaceuticals Co., Ltd. Aminocarbonylcarbamate compounds
TWI655179B (zh) 2014-02-28 2019-04-01 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4680172A (en) * 1985-03-05 1987-07-14 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4765985A (en) * 1985-03-05 1988-08-23 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina
US4900748A (en) * 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use

Also Published As

Publication number Publication date
PL165775B1 (pl) 1995-02-28
EP0430201A2 (de) 1991-06-05
GR3021210T3 (en) 1996-12-31
RU2069664C1 (ru) 1996-11-27
PT96030A (pt) 1991-09-13
DK0430201T3 (de) 1997-06-16
KR910009707A (ko) 1991-06-28
AU626740B2 (en) 1992-08-06
IL96498A (en) 1994-08-26
FI93451C (fi) 1995-04-10
HUT57773A (en) 1991-12-30
HU908014D0 (en) 1991-06-28
NO905172L (no) 1991-05-31
JPH03181483A (ja) 1991-08-07
IL96498A0 (en) 1991-08-16
DE69028605T2 (de) 1997-03-06
NO175310B (no) 1994-06-20
NO175310C (no) 1994-09-28
PT96030B (pt) 1998-01-30
US5077289A (en) 1991-12-31
NZ236248A (en) 1993-02-25
NO905172D0 (no) 1990-11-29
DE69028605D1 (de) 1996-10-24
FI905855A0 (fi) 1990-11-28
FI905855A (fi) 1991-05-31
IE75716B1 (en) 1997-09-24
EP0430201A3 (en) 1992-01-02
CA2031079C (en) 2001-01-23
CA2031079A1 (en) 1991-05-31
KR100215346B1 (ko) 1999-08-16
ZA909590B (en) 1991-09-25
JPH0723378B2 (ja) 1995-03-15
YU224790A (sh) 1993-10-20
IE904308A1 (en) 1991-06-05
HU207321B (en) 1993-03-29
ES2094742T3 (es) 1997-02-01
EP0430201B1 (de) 1996-09-18
PL288016A1 (en) 1992-06-26
AU6708590A (en) 1991-06-06
CZ280888B6 (cs) 1996-05-15
CZ594890A3 (en) 1995-02-15
FI93451B (fi) 1994-12-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee