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AR241654A1 - Procedimiento para producir activador de plasminogeno de tejido humano. - Google Patents

Procedimiento para producir activador de plasminogeno de tejido humano.

Info

Publication number
AR241654A1
AR241654A1 AR83292915A AR29291583A AR241654A1 AR 241654 A1 AR241654 A1 AR 241654A1 AR 83292915 A AR83292915 A AR 83292915A AR 29291583 A AR29291583 A AR 29291583A AR 241654 A1 AR241654 A1 AR 241654A1
Authority
AR
Argentina
Prior art keywords
dna
activator
human tissue
tissue plasminogen
plasminogen activator
Prior art date
Application number
AR83292915A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR241654(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of AR241654A1 publication Critical patent/AR241654A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR ACTIVADOR DE PLASMINOGENO DE TEJIDO HUMANO, QUE COMPRENDE: A) PREPARAR UN VECTOR DE EXPRESION REPLICABLE CAPAZ DE EXPRESAR UNA SECUENCIA DE ADN CODIFICANTE DE ACTIVADOR DE PLASMINOGENO DE TEJIDO HUMANO EN UNA CELULA HUESPED QUE COMPRENDA CELULAS HUESPEDES PROCARIOTICAS QUE SON E. COLI, ENTEROBACTERIACES, CELULAS HUESPEDES EUCARIOTICAS QUE SON LEVADURA O LINEASCELULARES, ELEGIDAS ENTRE VERO, HELA Y CHO MEDIANTE LIGACION DE DICHO ADN CODIFICANTE DE DICHO ACTIVADOR OPERABLEMENTE EN LA DIRECCION 3 PARTIR DE UNA SECUENCIA DE ADN PROMOTOR, B) TRANSFORMAR UN CULTIVO DE CELULAS HUESPEDES CON EL VECTOR PARA OBTENER CELULAS HUESPEDES RECOMBINANTES QUE HOSPEDEN AL VECTOR, C) CULTIVAR LAS CELULAS HUESPEDES RECOMBINANTES SEGUIDO POR EXPRESION DE LA SECUENCIA DE ADN QUE CODIFICA EL ACTIVADOR PARA PRODUCIR EL ACTIVADOR, Y D) RECUPERAR EL ACTIVADOR A PARTIR DE LAS CELULAS O DEL MEDIO DE CULTIVO. SE REPRESENTA LA SECUENCIA DE AMINOACIDOS ADN CODIFICANTE.
AR83292915A 1982-05-05 1983-05-03 Procedimiento para producir activador de plasminogeno de tejido humano. AR241654A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (1)

Publication Number Publication Date
AR241654A1 true AR241654A1 (es) 1992-10-30

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
AR83292915A AR241654A1 (es) 1982-05-05 1983-05-03 Procedimiento para producir activador de plasminogeno de tejido humano.

Country Status (26)

Country Link
EP (1) EP0093619B2 (es)
JP (2) JPH0216981A (es)
AR (1) AR241654A1 (es)
BG (1) BG60253B2 (es)
BR (1) BR8302318A (es)
CA (1) CA1293211C (es)
CS (1) CS248705B2 (es)
CY (1) CY1341A (es)
DD (1) DD210303A5 (es)
DE (3) DE3316297A1 (es)
DK (1) DK174236B1 (es)
ES (1) ES522085A0 (es)
FR (1) FR2526443B1 (es)
GB (1) GB2119804B (es)
GR (1) GR79202B (es)
HK (1) HK88586A (es)
IE (1) IE54975B1 (es)
IL (1) IL68561A (es)
KE (1) KE3647A (es)
MY (1) MY8700119A (es)
NO (2) NO831575L (es)
OA (1) OA07419A (es)
PL (1) PL152438B1 (es)
PT (1) PT76636B (es)
RO (1) RO90639B (es)
ZW (1) ZW10483A1 (es)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
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EP0093619B2 (en) 1996-09-18
DE93619T1 (de) 1987-08-13
DK174236B1 (da) 2002-10-07
GB2119804A (en) 1983-11-23
IE831024L (en) 1983-11-05
GR79202B (es) 1984-10-22
BR8302318A (pt) 1984-01-10
MY8700119A (en) 1987-12-31
PT76636A (en) 1983-06-01
BG60253B1 (bg) 1994-03-24
DE3316297C2 (es) 1989-09-21
HK88586A (en) 1986-11-28
ES8501629A1 (es) 1984-12-16
NO831575L (no) 1983-11-07
CA1293211C (en) 1991-12-17
GB2119804B (en) 1986-02-26
DE3380567D1 (en) 1989-10-19
AU563031B2 (en) 1987-06-25
NO852065L (no) 1983-11-07
JPH05137583A (ja) 1993-06-01
PL152438B1 (en) 1990-12-31
DD210303A5 (de) 1984-06-06
IL68561A (en) 1991-01-31
EP0093619A1 (en) 1983-11-09
IE54975B1 (en) 1990-04-11
GB8312221D0 (en) 1983-06-08
AU1414283A (en) 1983-11-10
JPH0216981A (ja) 1990-01-19
PT76636B (en) 1986-01-10
BG60253B2 (bg) 1994-03-24
IL68561A0 (en) 1983-09-30
CY1341A (en) 1987-01-16
FR2526443B1 (fr) 1985-12-06
FR2526443A1 (fr) 1983-11-10
DK198883A (da) 1983-12-20
DE3316297A1 (de) 1983-11-17
JPH0448440B2 (es) 1992-08-06
DK198883D0 (da) 1983-05-04
ES522085A0 (es) 1984-12-16
JP2564444B2 (ja) 1996-12-18
EP0093619B1 (en) 1989-09-13
CS248705B2 (en) 1987-02-12
ZW10483A1 (en) 1983-09-21
KE3647A (en) 1986-07-25
OA07419A (fr) 1984-11-30
RO90639B (ro) 1987-01-31
PL241805A1 (en) 1984-07-30
RO90639A (ro) 1987-01-30

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