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AR122141A1 - Inhibidor de trka - Google Patents

Inhibidor de trka

Info

Publication number
AR122141A1
AR122141A1 ARP210101385A ARP210101385A AR122141A1 AR 122141 A1 AR122141 A1 AR 122141A1 AR P210101385 A ARP210101385 A AR P210101385A AR P210101385 A ARP210101385 A AR P210101385A AR 122141 A1 AR122141 A1 AR 122141A1
Authority
AR
Argentina
Prior art keywords
pain
compound
trka inhibitor
trka
inhibitor
Prior art date
Application number
ARP210101385A
Other languages
English (en)
Inventor
David Andrew Coates
Ryan James Linder
Laia Malet-Sanz
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR122141A1 publication Critical patent/AR122141A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Registering, Tensioning, Guiding Webs, And Rollers Therefor (AREA)

Abstract

La presente invención se refiere a un compuesto de la siguiente estructura de fórmula (1) para su uso como inhibidor de TrkA, así como composiciones que incluyen este compuesto, y métodos de uso de este compuesto para el tratamiento del dolor, incluido el dolor posquirúrgico, el dolor por artritis reumatoide, el dolor neuropático y el dolor por osteoartritis.
ARP210101385A 2020-05-28 2021-05-20 Inhibidor de trka AR122141A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063031073P 2020-05-28 2020-05-28

Publications (1)

Publication Number Publication Date
AR122141A1 true AR122141A1 (es) 2022-08-17

Family

ID=76444680

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210101385A AR122141A1 (es) 2020-05-28 2021-05-20 Inhibidor de trka

Country Status (8)

Country Link
US (1) US11498915B2 (es)
EP (1) EP4126842B1 (es)
JP (1) JP7496440B2 (es)
CN (1) CN115667241B (es)
AR (1) AR122141A1 (es)
ES (1) ES2951556T3 (es)
TW (1) TW202210467A (es)
WO (1) WO2021242677A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1306704B1 (it) 1999-05-26 2001-10-02 Sirs Societa Italiana Per La R Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf.
CN102358903B (zh) 2003-07-15 2017-04-26 安姆根有限公司 作为选择性ngf途径抑制剂的人抗ngf中和抗体
WO2012009640A2 (en) 2010-07-16 2012-01-19 The Ohio State University B cell depletion for central nervous system injuries and methods and uses thereof
CA2832291C (en) 2011-04-05 2015-12-01 Pfizer Limited Pyrrolo[2,3-d)pyrimidine tropomyosin-related kinase inhibitors
EP2674439B1 (en) 2012-06-13 2017-02-01 Rottapharm Biotech S.r.l. Anti-TrkA antibodies, derivatives and uses thereof
WO2015143653A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143654A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
US20170197939A1 (en) 2014-04-15 2017-07-13 Pfizer Inc. Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety
WO2015170208A1 (en) 2014-05-03 2015-11-12 Semiconductor Energy Laboratory Co., Ltd. Film-like member support apparatus
WO2015170218A1 (en) * 2014-05-07 2015-11-12 Pfizer Inc. Tropomyosin-related kinase inhibitors
MA41097A (fr) 2014-12-05 2017-10-10 Glenmark Pharmaceuticals Sa Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses
AR114110A1 (es) 2018-02-28 2020-07-22 Lilly Co Eli Anticuerpo anti-trka

Also Published As

Publication number Publication date
JP7496440B2 (ja) 2024-06-06
EP4126842A1 (en) 2023-02-08
CN115667241A (zh) 2023-01-31
US11498915B2 (en) 2022-11-15
ES2951556T3 (es) 2023-10-23
JP2023527397A (ja) 2023-06-28
TW202210467A (zh) 2022-03-16
US20210371399A1 (en) 2021-12-02
CN115667241B (zh) 2024-04-16
EP4126842B1 (en) 2023-06-28
WO2021242677A1 (en) 2021-12-02

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