AR080297A1 - Derivados de guanidina, una composicion farmaceutica que los comprende y su uso para el tratamiento del dolor. - Google Patents
Derivados de guanidina, una composicion farmaceutica que los comprende y su uso para el tratamiento del dolor.Info
- Publication number
- AR080297A1 AR080297A1 ARP110100560A ARP110100560A AR080297A1 AR 080297 A1 AR080297 A1 AR 080297A1 AR P110100560 A ARP110100560 A AR P110100560A AR P110100560 A ARP110100560 A AR P110100560A AR 080297 A1 AR080297 A1 AR 080297A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halogen
- independently selected
- substituents independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Su uso en medicina, en particular como agonistas opioides. Reivindicacion 1: Un compuesto de formula (1) caracterizado porque Ar1 es fenilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH, alquilo C1-3 y halogeno, o Ar1 es fenilo condensado a un heterociclo de 5 o 6 miembros opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halogeno, OH y =O, Ar2 es fenilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH, alquilo C1-3 y halogeno, o Ar2 es fenilo condensado a un heterociclo de 5 o 6 miembros opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halogeno, OH y =O, Gu es guanidinilo (o una forma tautomérica del mismo) opcionalmente sustituido con hasta 4 sustituyentes seleccionados independientemente entre alquilo C1-3, R1 es independientemente H o alquilo C1-5 opcionalmente sustituido con Y, en el que Y es halogeno, S(O)m-(alquilo C1-3), CO2-R5 o Gu, en la que R5 es H o alquilo C1-6, y m es 0, 1 0 2, R2 es independientemente H o alquilo C1-3, o R1 y R2junto con el átomo de carbono al que están unidos pueden ser un grupo ciclopropilo, uno de R3 y R4 es H y el otro es Q, en el que Q es H, NH2, NHC(O)(alquilo C1-6), Gu, NHC(O)(CH2)nNH2, NHC(O)(CH2)nGu o (CH2)nGu, en los que n es 1, 2, 3, 4 o 5, o un tautomero del mismo o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30799310P | 2010-02-25 | 2010-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR080297A1 true AR080297A1 (es) | 2012-03-28 |
Family
ID=43778553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110100560A AR080297A1 (es) | 2010-02-25 | 2011-02-24 | Derivados de guanidina, una composicion farmaceutica que los comprende y su uso para el tratamiento del dolor. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110207654A1 (es) |
| EP (1) | EP2539358A1 (es) |
| JP (1) | JP2013520489A (es) |
| AR (1) | AR080297A1 (es) |
| CA (1) | CA2789606A1 (es) |
| TW (1) | TW201138763A (es) |
| UY (1) | UY33240A (es) |
| WO (1) | WO2011104649A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5898767B2 (ja) * | 2011-07-13 | 2016-04-06 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | エンケファリン類似体 |
| CN103793181B (zh) * | 2012-11-05 | 2019-05-24 | 腾讯科技（深圳）有限公司 | 一种多层关联存储架构的数据同步方法及数据同步系统 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58146507A (ja) * | 1982-02-24 | 1983-09-01 | Asai Gerumaniumu Kenkyusho:Kk | モルヒネ様作用増強剤 |
| JPS60193999A (ja) * | 1984-02-16 | 1985-10-02 | ジー．デイ．サール アンド コンパニー | 新規ペプチドアミド化合物 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| DE69332826T2 (de) * | 1992-11-12 | 2004-01-29 | Sod Conseils Rech Applic | Opioidpeptide |
| SE9600769D0 (sv) * | 1996-02-28 | 1996-02-28 | Astra Ab | Compounds useful as analgesic |
| SE9701718D0 (sv) * | 1997-05-07 | 1997-05-07 | Astra Ab | Analgesic peptidomimetic compounds |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US6114310A (en) | 1998-01-23 | 2000-09-05 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| CA2663984C (en) | 2006-10-18 | 2012-02-21 | Pfizer Products Inc. | Biaryl ether urea compounds |
| EP1995241B1 (en) | 2007-03-23 | 2010-03-17 | ICAgen, Inc. | Inhibitors of ion channels |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| EP2173743A2 (en) | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Sodium channel inhibitors |
| RS53941B1 (en) | 2009-01-12 | 2015-08-31 | Pfizer Limited | SULFONAMID DERIVATIVES |
-
2011
- 2011-02-11 JP JP2012554454A patent/JP2013520489A/ja active Pending
- 2011-02-11 CA CA2789606A patent/CA2789606A1/en not_active Abandoned
- 2011-02-11 WO PCT/IB2011/050580 patent/WO2011104649A1/en active Application Filing
- 2011-02-11 EP EP11707708A patent/EP2539358A1/en not_active Withdrawn
- 2011-02-24 US US13/034,155 patent/US20110207654A1/en not_active Abandoned
- 2011-02-24 AR ARP110100560A patent/AR080297A1/es not_active Application Discontinuation
- 2011-02-24 TW TW100106220A patent/TW201138763A/zh unknown
- 2011-02-24 UY UY0001033240A patent/UY33240A/es unknown
-
2012
- 2012-09-07 US US13/606,519 patent/US8598123B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW201138763A (en) | 2011-11-16 |
| JP2013520489A (ja) | 2013-06-06 |
| CA2789606A1 (en) | 2011-09-01 |
| US20120329724A1 (en) | 2012-12-27 |
| US8598123B2 (en) | 2013-12-03 |
| US20110207654A1 (en) | 2011-08-25 |
| WO2011104649A1 (en) | 2011-09-01 |
| UY33240A (es) | 2011-09-30 |
| EP2539358A1 (en) | 2013-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |