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AR089408A1 - NUCLEOSIDS REPLACED, NUCLEOTIDES AND ANALOGS OF THE SAME TO BE EMPLOYED IN THE TREATMENT OF VIRAL DISEASES - Google Patents

NUCLEOSIDS REPLACED, NUCLEOTIDES AND ANALOGS OF THE SAME TO BE EMPLOYED IN THE TREATMENT OF VIRAL DISEASES

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Publication number
AR089408A1
AR089408A1 ARP120104913A ARP120104913A AR089408A1 AR 089408 A1 AR089408 A1 AR 089408A1 AR P120104913 A ARP120104913 A AR P120104913A AR P120104913 A ARP120104913 A AR P120104913A AR 089408 A1 AR089408 A1 AR 089408A1
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AR
Argentina
Prior art keywords
optionally substituted
group
alkyl
independently
hydrogen
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ARP120104913A
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Spanish (es)
Inventor
Wang Guangyi
Beigelman Leonid
Smith David
Prhavc Marija
Deval Jerome
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Alios Biopharma Inc
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Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of AR089408A1 publication Critical patent/AR089408A1/en

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Abstract

En la presente, se divulgan nucleósidos, nucleótidos y análogos de los mismos, composiciones farmacéuticas que incluyen uno o más nucleósidos, nucleótidos y análogos de los mismos y métodos para sintetizarlos. En la presente, también se divulgan su uso en el tratamiento de una enfermedad y/o una afección -las cuales incluyen una infección causada por un paramixovirus y/o por un ortomixovirus-. Reivindicación 1: Un compuesto seleccionado entre la fórmula (1), la fórmula (2) y la fórmula (3), o una sal farmacéuticamente aceptable de lo que antecede, en la cual: B¹A, B¹B y B¹C son, independientemente, una base heterocíclica opcionalmente sustituida o una base heterocíclica opcionalmente sustituida con un grupo amino protegido; R¹A se selecciona del grupo que consiste en hidrógeno, un acilo opcionalmente sustituido, un aminoácido con enlace O opcionalmente sustituido, o un resto del grupo de fórmulas (4); cuando la línea punteada (- - - - -) de la fórmula (1) es un enlace simple, R²A es CH₂ y R³A está ausente; cuando la línea punteada (- - - - -) de la fórmula (1) está ausente, R²A se selecciona del grupo que consiste en un alquilo C₁₋₆ opcionalmente sustituido, un alquenilo C₂₋₆ opcionalmente sustituido, un alquinilo C₂₋₆ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido, un -O-alquilo C₁₋₆ opcionalmente sustituido, un -O-alquenilo C₃₋₆ opcionalmente sustituido, un -O-alquinilo C₃₋₆ opcionalmente sustituido y ciano y R³A se selecciona del grupo que consiste en OH, -OC(=O)RA y un aminoácido con enlace O opcionalmente sustituido; R¹B se selecciona del grupo que consiste en O⁻, OH, un resto del grupo de fórmulas (5), un aminoácido con enlace opcionalmente sustituido N y un derivado de éster de aminoácido con enlace N opcionalmente sustituido; R¹C y R²C se seleccionan, independientemente, del grupo que consiste en O⁻, OH, un alcoxi C₁₋₆ opcionalmente sustituido, un resto del grupo de formulas (6), un aminoácido con enlace N opcionalmente sustituido y un derivado éster de aminoácido con enlace N opcionalmente sustituido; o R¹C es un compuesto de formula (7) y R²C es O⁻ o OH; R²B y R³C se seleccionan, independientemente, del grupo que consiste en un alquilo C₁₋₆ opcionalmente sustituido, un alquenilo C₂₋₆ opcionalmente sustituido, un alquinilo C₂₋₆ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido, un -O-alquilo C₁₋₆ opcionalmente sustituido, un -O-alquenilo C₃₋₆ opcionalmente sustituido, un -O-alquinilo C₃₋₆ opcionalmente sustituido y ciano; R⁴C se selecciona del grupo que consiste en OH, -OC(=O)RC y un aminoácido con enlace O opcionalmente sustituido; R⁴A, R³B y R⁵C son, independientemente, un halógeno; R⁵A, R⁴B y R⁶C son, independientemente, hidrógeno o halógeno; R⁶A, R⁷A y R⁸A se seleccionan, independientemente, del grupo que consiste entre estar ausente o ser hidrógeno, o un alquilo C₁₋₂₄ opcionalmente sustituido, un alquenilo C₂₋₂₄ opcionalmente sustituido, un alquinilo C₂₋₂₄ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido, un cicloalquenilo C₃₋₆ opcionalmente sustituido, un arilo opcionalmente sustituido, un heteroarilo opcionalmente sustituido, un aril(alquilo C₁₋₆) opcionalmente sustituido, un *-(CR¹⁵AR¹⁶A)ₚ-O-alquilo C₁₋₂₄ opcionalmente sustituido, un *-(CR¹⁷AR¹⁸A)q-O-alquenilo C₁₋₂₄ opcionalmente sustituido, o un resto seleccionado del grupo de formulas (8); o R⁶A es el compuesto de formula (9) y R⁷A esta ausente o es hidrógeno; o R⁶A y R⁷A se toman en conjunto para formar una parte seleccionada del grupo que consiste en un resto de formula (10) opcionalmente sustituido y un resto de formula (11) opcionalmente sustituido, donde los oxígenos conectados a R⁶A y R⁷A, el fósforo y la parte forman un sistema de anillos de seis a diez miembros; R⁹A se selecciona, independientemente, del grupo que consiste en un alquilo C₁₋₂₄ opcionalmente sustituido, un alquenilo C₂₋₂₄ opcionalmente sustituido, un alquinilo C₂₋₂₄ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido, un cicloalquenilo C₃₋₆ opcionalmente sustituido, NR³⁰AR³¹A, aminoácido con enlace N opcionalmente sustituido y un derivado de éster de aminoácido con enlace N opcionalmente sustituido; R¹⁰A y R¹¹A son, independientemente, un aminoácido con enlace N opcionalmente sustituido o un derivado de éster de aminoácido con enlace N opcionalmente sustituido; R¹²A, R¹³A y R¹⁴A independientemente, están ausentes o son hidrógeno; cada R¹⁵A, cada R¹⁶A, cada R¹⁷A y cada R¹⁸A son, independientemente, hidrógeno, un alquilo C₁₋₂₄ opcionalmente sustituido o alcoxi; R¹⁹A, R²⁰A, R²²A, R²³A, R⁵B, R⁶B, R⁸B y R⁹B, R⁹C, R¹⁰C, R¹²C y R¹³C se seleccionan, independientemente, del grupo que consiste en hidrógeno, un alquilo C₁₋₂₄ opcionalmente sustituido y un arilo opcionalmente sustituido; R²¹A, R²⁴A, R⁷B, R¹⁰B, R¹¹C y R¹⁴C se seleccionan, independientemente, del grupo que consiste en hidrógeno, un alquilo C₁₋₂₄ opcionalmente sustituido, un arilo opcionalmente sustituido, un -O-alquilo C₁₋₂₄ opcionalmente sustituido y un -O-arilo opcionalmente sustituido; R¹⁶C, R¹⁷C y R¹⁸C, independientemente, están ausentes o son hidrógeno; R²⁶A y R²⁷A son, independientemente, -CºN o un sustituyente opcionalmente sustituido, seleccionado del grupo que consiste en organilcarbonilo C₂₋₈, alcoxicarbonilo C₂₋₈ y organilaminocarbonilo C₂₋₈; R²⁸A se selecciona del grupo que consiste en hidrógeno, un alquilo C₁₋₂₄ opcionalmente sustituido, un alquenilo C₂₋₂₄ opcionalmente sustituido, un alquinilo C₂₋₂₄ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido y un cicloalquenilo C₃₋₆ opcionalmente sustituido; R³⁰A y R³¹A se seleccionan, independientemente, del grupo que consiste en hidrógeno, un alquilo C₁₋₂₄ opcionalmente sustituido, un alquenilo C₂₋₂₄ opcionalmente sustituido, un alquinilo C₂₋₂₄ opcionalmente sustituido, un cicloalquilo C₃₋₆ opcionalmente sustituido y un cicloalquenilo C₃₋₆ opcionalmente sustituido; para la fórmula (3), - - - - - es un enlace simple o un enlace doble; cuando - - - - - es un enlace simple, cada R⁷C y cada R⁸C es, independientemente, hidrógeno o halógeno; y cuando - - - - - es un enlace doble, cada R⁷C está ausente y cada R⁸C es, independientemente, hidrógeno o halógeno; RA y RC son, independientemente, un alquilo C₁₋₂₄ opcionalmente sustituido; m y n son, independientemente, 0 ó 1; p y q se seleccionan, independientemente, del grupo que consiste en 1, 2 y 3; r es 1 ó 2; Z¹A, Z²A, Z³A, Z⁴A, Z¹B, Z²B y Z¹C son, independientemente, O ó S; y con la condición de que cuando la línea punteada (- - - - -) de la fórmula (1) esté ausente; R¹A sea un resto de formula (12) en la cual R⁸A es un fenilo o alquilo C₁₋₄ insustituido, opcionalmente, para-sustituido, con un halógeno o metilo y R⁹A es éster metílico, éster etílico, éster isopropílico, éster n-butílico, éster bencílico o éster fenílico de un aminoácido seleccionado del grupo que consiste en glicina, alanina, valina, leucina, fenilalanina, triptófano, metionina y prolina; R³A es OH; R⁴A es fluoro; R⁵A es fluoro o hidrógeno; y B¹A es un uracilo insustituido; entonces R²A no pueda ser -OCH₃; con la condición de que cuando la línea punteada (- - - - -) de la fórmula (1) esté ausente; R¹A sea H; R³ sea OH; R⁴A sea fluoro; R⁵A sea fluoro; y B¹A sea una citosina insustituida; entonces R²A no pueda ser alenilo; con la condición de que cuando la línea punteada (- - - - -) de la fórmula (1) esté ausente; R¹A sea H; R³A es OH; R⁴A sea fluoro; R⁵A sea hidrógeno; y B¹A sea una timina insustituida; entonces R²A no pueda ser alquilo C₁ sustituido con un N-amido; y con la condición de que cuando la línea punteada (- - - - -) de la fórmula (1) esté ausente; R¹A sea H; R³A sea OH; R⁴A sea fluoro; R⁵A sea fluoro; y B¹A sea una citosina insustituida; entonces R²A no pueda ser etinilo.Here, nucleosides, nucleotides and analogs thereof, pharmaceutical compositions including one or more nucleosides, nucleotides and analogs thereof and methods for synthesizing them are disclosed. Here, its use is also disclosed in the treatment of a disease and / or a condition - which include an infection caused by a paramyxovirus and / or an orthomyxovirus. Claim 1: A compound selected from formula (1), formula (2) and formula (3), or a pharmaceutically acceptable salt from the foregoing, in which: B¹A, B¹B and B¹C are, independently, a base optionally substituted heterocyclic or a heterocyclic base optionally substituted with a protected amino group; R¹A is selected from the group consisting of hydrogen, an optionally substituted acyl, an optionally substituted O-linked amino acid, or a moiety of the group of formulas (4); when the dotted line (- - - - -) of the formula (1) is a single bond, R²A is CH₂ and R³A is absent; when the dotted line (- - - - -) of the formula (1) is absent, R²A is selected from the group consisting of an optionally substituted C₁₋₆ alkyl, an optionally substituted C₂₋₆ alkenyl, an optionally C₂₋₆ alkynyl substituted, an optionally substituted C₃₋₆ cycloalkyl, an optionally substituted -O-C₁₋₆ alkyl, an optionally substituted C--O-alkenyl, an optionally substituted C₃₋₆ -O-alkynyl and cyano and R³A is selected from the group consisting of OH, -OC (= O) RA and an optionally substituted O-linked amino acid; R¹B is selected from the group consisting of O⁻, OH, a remainder of the group of formulas (5), an optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative; R¹C and R²C are independently selected from the group consisting of O⁻, OH, an optionally substituted C₁₋₆ alkoxy, a remainder of the group of formulas (6), an optionally substituted N-linked amino acid and an amino acid ester derivative with optionally substituted N bond; or R¹C is a compound of formula (7) and R²C is O⁻ or OH; R²B and R³C are independently selected from the group consisting of an optionally substituted C₁₋₆ alkyl, an optionally substituted C₂₋₆ alkenyl, an optionally substituted C₂₋₆ alkynyl, an optionally substituted C₃₋₆ cycloalkyl, an -O-alkyl Optionally substituted C₁₋₆, an optionally substituted CO -O-alkenyl, an optionally substituted C₃₋₆ -O-alkynyl and cyano; R⁴C is selected from the group consisting of OH, -OC (= O) RC and an optionally substituted O-linked amino acid; R⁴A, R³B and R⁵C are, independently, a halogen; R⁵A, R⁴B and R⁶C are, independently, hydrogen or halogen; R⁶A, R⁷A and R⁸A are independently selected from the group consisting of being absent or being hydrogen, or an optionally substituted C₁₋₂₄ alkyl, an optionally substituted C al alkenyl, an optionally substituted C alqu alkynyl, a C₃₋ cycloalkyl ₆ optionally substituted, an optionally substituted C₃₋₆ cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aryl (C₁₋₆ alkyl), an optionally substituted * - (CR¹⁵AR¹⁶A) ₚ-O-C, alkyl, an optionally substituted * - (CR¹⁷AR¹⁸A) qO-alkenyl, or a moiety selected from the group of formulas (8); or R⁶A is the compound of formula (9) and R⁷A is absent or is hydrogen; or R⁶A and R⁷A are taken together to form a part selected from the group consisting of an optionally substituted formula residue (10) and optionally substituted formula (11) residue, where the oxygens connected to R⁶A and R⁷A, the phosphorus and the part forms a system of rings of six to ten members; R⁹A is independently selected from the group consisting of an optionally substituted C₁₋₂₄ alkyl, an optionally substituted C₂₋₂₄ alkenyl, an optionally substituted C₂₋₂₄ alkynyl, an optionally substituted C₃₋₆ cycloalkyl, an optionally substituted C₃₋₆ cycloalkenyl , NR³⁰AR³¹A, optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative; R¹⁰A and R¹¹A are, independently, an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester derivative; R¹²A, R¹³A and R¹⁴A independently, are absent or are hydrogen; each R¹⁵A, each R¹⁶A, each R¹⁷A and each R¹⁸A are, independently, hydrogen, an optionally substituted C₁₋₂₄ alkyl or alkoxy; R¹⁹A, R²⁰A, R²²A, R²³A, R⁵B, R⁶B, R⁸B and R⁹B, R⁹C, R¹⁰C, R¹²C and R¹³C are independently selected from the group consisting of hydrogen, an optionally substituted C₁₋₂₄ alkyl and an optionally substituted aryl; R²¹A, R²⁴A, R⁷B, R¹⁰B, R¹¹C and R¹⁴C are independently selected from the group consisting of hydrogen, an optionally substituted C₁₋₂₄ alkyl, an optionally substituted aryl, an optionally substituted -O-C-alkyl and an -O -aryl optionally substituted; R¹⁶C, R¹⁷C and R¹⁸C, independently, are absent or hydrogen; R²⁶A and R²⁷A are, independently, -CºN or an optionally substituted substituent, selected from the group consisting of C₂₋₈ organylcarbonyl, C₂₋₈ alkoxycarbonyl and C₂₋₈ organylaminocarbonyl; R²⁸A is selected from the group consisting of hydrogen, an optionally substituted C₁₋₂₄ alkyl, an optionally substituted C₂₋₂₄ alkenyl, an optionally substituted C₂₋₂₄ alkynyl, an optionally substituted C₃₋₆ cycloalkyl and an optionally substituted C₃₋₆ cycloalkenyl; R³⁰A and R³¹A are independently selected from the group consisting of hydrogen, an optionally substituted C₁₋₂₄ alkyl, an optionally substituted C₂₋₂₄ alkenyl, an optionally substituted C₂₋₂₄ alkynyl, an optionally substituted C₃₋₆ cycloalkyl and a C₃ cycloalkenyl ₋₆ optionally substituted; for formula (3), - - - - - is a single bond or a double bond; when - - - - - is a single bond, each R⁷C and each R⁸C is, independently, hydrogen or halogen; and when - - - - - is a double bond, each R⁷C is absent and each R⁸C is independently hydrogen or halogen; RA and RC are, independently, an optionally substituted C₁₋₂₄ alkyl; m and n are, independently, 0 or 1; p and q are independently selected from the group consisting of 1, 2 and 3; r is 1 or 2; Z¹A, Z²A, Z³A, Z⁴A, Z¹B, Z²B and Z¹C are, independently, O or S; and with the proviso that when the dotted line (- - - - -) of the formula (1) is absent; R¹A is a moiety of formula (12) in which R⁸A is an optionally unsubstituted phenyl or C₁₋₄ alkyl with a halogen or methyl and R⁹A is methyl ester, ethyl ester, isopropyl ester, n-butyl ester , benzyl ester or phenyl ester of an amino acid selected from the group consisting of glycine, alanine, valine, leucine, phenylalanine, tryptophan, methionine and proline; R³A is OH; R⁴A is fluoro; R⁵A is fluoro or hydrogen; and B¹A is an unsubstituted uracil; then R²A cannot be -OCH₃; with the proviso that when the dotted line (- - - - -) of the formula (1) is absent; R¹A be H; R³ be OH; R seaA be fluoro; R seaA be fluoro; and B¹A is an unsubstituted cytosine; then R²A cannot be alenil; with the proviso that when the dotted line (- - - - -) of the formula (1) is absent; R¹A be H; R³A is OH; R seaA be fluoro; R⁵A is hydrogen; and B¹A is an unsubstituted thymine; then R²A cannot be C₁ alkyl substituted with an N-amido; and with the proviso that when the dotted line (- - - - -) of the formula (1) is absent; R¹A be H; R³A is OH; R seaA be fluoro; R seaA be fluoro; and B¹A is an unsubstituted cytosine; then R²A cannot be ethynyl.

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Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
EP2619216A4 (en) 2010-09-22 2014-04-02 Alios Biopharma Inc Substituted nucleotide analogs
CA2819041A1 (en) 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
SI2794627T1 (en) 2011-12-22 2019-02-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
PT2827875T (en) * 2012-03-21 2019-02-11 Janssen Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2013142125A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
JP6140815B2 (en) 2012-05-25 2017-05-31 ヤンセン・サイエンシズ・アイルランド・ユーシー Uracil Spirooxetane Nucleoside
HUE053946T2 (en) 2012-12-21 2021-08-30 Janssen Biopharma Inc 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv
US9598457B2 (en) 2012-12-21 2017-03-21 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TW201532606A (en) 2013-04-05 2015-09-01 Alios Biopharma Inc Hepatitis C viral infection treatment using a combination of compounds
EP3424938B1 (en) 2013-06-26 2020-07-22 Janssen BioPharma, Inc. 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof
TW201542578A (en) 2013-06-26 2015-11-16 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2015017675A2 (en) * 2013-07-31 2015-02-05 Isis Pharmaceuticals, Inc. Methods and compounds useful in conditions related to repeat expansion
UA117375C2 (en) 2013-09-04 2018-07-25 Медівір Аб Hcv polymerase inhibitors
CN104447923B (en) * 2013-09-23 2018-03-30 中国药科大学 Methyl nucleoside derivatives of 2 ' deoxidation, 2 ' fluorine 2 ' and preparation method thereof and the purposes in pharmacy
SG11201602595TA (en) 2013-10-11 2016-04-28 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US20160271160A1 (en) 2013-10-17 2016-09-22 Medivir Ab Hcv polymerase inhibitors
UA119050C2 (en) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections
US10683321B2 (en) * 2013-12-18 2020-06-16 Idenix Pharmaceuticals Llc 4′-or nucleosides for the treatment of HCV
MX2016010105A (en) 2014-02-06 2016-11-15 Riboscience Llc 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication.
JP6191989B2 (en) * 2014-02-12 2017-09-06 学校法人東京理科大学 Adenine derivative or pharmacologically acceptable salt thereof, method for producing the same, and use thereof
LT3160476T (en) 2014-06-24 2021-04-12 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof for use in the treatment of viral infection
CA2952959C (en) 2014-06-24 2023-03-07 Alios Biopharma, Inc. Use of nucleosides and nucleotides to treat filoviridae viral infection
WO2016014398A1 (en) * 2014-07-22 2016-01-28 Alios Biopharma, Inc. Methods for treating paramyxoviruses
TWI678369B (en) * 2014-07-28 2019-12-01 美商基利科學股份有限公司 Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidines useful for treating respiratory syncitial virus infections
PE20170673A1 (en) * 2014-08-05 2017-05-22 Alios Biopharma Inc COMBINATION THERAPY TO TREAT A PARAMYXOVIRUS
TWI673283B (en) * 2014-08-21 2019-10-01 美商基利科學股份有限公司 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides
US10358458B2 (en) * 2014-09-26 2019-07-23 Riboscience Llc 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication
US10479807B2 (en) 2014-10-08 2019-11-19 Epigenetics Phrama LLC Silylated pyrimidine prodrugs and methods of their use
US9908914B2 (en) * 2014-10-28 2018-03-06 Alios Biopharma, Inc. Methods of preparing substituted nucleoside analogs
MA41213A (en) * 2014-12-19 2017-10-24 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES OF THEM
MA41441A (en) 2014-12-19 2017-12-12 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES OF THEM
US20190022116A1 (en) * 2014-12-26 2019-01-24 Emory University N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto
WO2016145103A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562113A (en) 2016-05-10 2019-04-02 C4医药公司 Loop coil degron body for target protein degradation
CN107501247A (en) * 2016-06-14 2017-12-22 安徽贝克联合制药有限公司 A kind of preparation method of uridine analog derivative
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
TW201811339A (en) 2016-08-12 2018-04-01 美商艾洛斯生物製藥公司 Substituted nucleosides, nucleotides and analogs thereof
US10472364B2 (en) 2016-09-09 2019-11-12 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
US20180117042A1 (en) 2016-10-27 2018-05-03 Alios Biopharma, Inc. Methods for treating respiratory syncytial virus infection
CN111491634A (en) 2017-07-31 2020-08-04 詹纽瑞治疗公司 Organic phosphate derivatives
WO2019113462A1 (en) 2017-12-07 2019-06-13 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN111712509A (en) * 2017-12-15 2020-09-25 詹森生物科技公司 Cyclic dinucleotides as STING agonists
US20220280513A1 (en) * 2019-07-18 2022-09-08 The Board Of Trustees Of The Leland Stanford Junior University Enhancing the antiviral efficacy of rna virus inhibition by combination with modulators of pyrimidine metabolism
US11708637B2 (en) * 2019-08-13 2023-07-25 The Regents Of The University Of California Methods of supporting a graphene sheet disposed on a frame support
TW202245800A (en) 2020-02-18 2022-12-01 美商基利科學股份有限公司 Antiviral compounds
TWI777411B (en) 2020-02-18 2022-09-11 美商基利科學股份有限公司 Antiviral compounds
TWI794742B (en) 2020-02-18 2023-03-01 美商基利科學股份有限公司 Antiviral compounds
AR121620A1 (en) 2020-03-20 2022-06-22 Gilead Sciences Inc 4-C-SUBSTITUTED-2-HALO-2-DEOXIADENOSINE NUCLEOSIDE PRODRUGS AND METHODS OF PREPARATION AND USE THEREOF
WO2021195011A1 (en) * 2020-03-24 2021-09-30 Intrinsic Medicine, Inc. Immunomodulatory oligosaccharides for the treatment of viral respiratory infection
CN111892636A (en) * 2020-08-07 2020-11-06 山东大学 Synthesis method of azvudine
WO2022046631A1 (en) 2020-08-24 2022-03-03 Gilead Sciences, Inc. Phospholipid compounds and uses thereof
TW202344257A (en) 2020-10-16 2023-11-16 美商基利科學股份有限公司 Phospholipid compounds and uses thereof
CN112279877B (en) * 2020-12-15 2021-08-06 南京颐媛生物医学研究院有限公司 Nucleoside phosphate and synthesis method thereof
KR20230170745A (en) 2021-04-16 2023-12-19 길리애드 사이언시즈, 인코포레이티드 Method for producing carbanucleosides using amides
AU2022328698A1 (en) 2021-08-18 2024-02-01 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
WO2024015916A2 (en) * 2022-07-13 2024-01-18 Thomas Jefferson University 4'-alkyne-2'-deoxycytidine-based compounds and anti-cancer uses thereof
WO2024159117A1 (en) * 2023-01-26 2024-08-02 The Regents Of The University Of California Antiviral prodrugs, intermediate-and long-acting formulations, and methods
CN116425703B (en) * 2023-03-27 2024-05-31 浙大宁波理工学院 Method for deuterating C2-position exocyclic methyl of saturated cyclic ether compound

Family Cites Families (306)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH563405A5 (en) 1971-09-10 1975-06-30 Duschinsky Robert Dr Schweiz I
IL51342A (en) 1977-01-27 1980-11-30 Abic Ltd Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them
US4230698A (en) 1978-05-12 1980-10-28 Research Corporation 2-Substituted arabinofuranosyl nucleosides and nucleotides
US4211773A (en) 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
AU5118979A (en) 1978-10-16 1980-04-24 Takeda Chemical Industries Ltd. 2,6-diaminoebularines
US4652554A (en) 1982-02-22 1987-03-24 St. Jude Children's Research Hospital Nitro-substituted 1-β-D-arabinofuranosylcytosines
JPS60228497A (en) 1984-04-27 1985-11-13 Sumitomo Chem Co Ltd Novel adenylic acid derivative
US4713383A (en) 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
US4626526A (en) 1984-10-26 1986-12-02 Warner-Lambert Company (S)-N6 -2-hydroxypropyladenosines
US4855304A (en) 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
JPS61219478A (en) 1985-03-26 1986-09-29 Potsupuribetsuto Fastener Kk Method and equipment for detecting welding
PL144471B1 (en) 1985-04-22 1988-05-31 Polska Akad Nauk Centrum Method of obtaining novel 3',5'-cyclic adensine dithiophosphate
US4762823A (en) 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US4797495A (en) 1985-11-22 1989-01-10 Burroughs Wellcome Co. Benzo[c]carbazole propanediol compound and salts thereof
AU596406B2 (en) 1986-04-14 1990-05-03 Shell Internationale Research Maatschappij B.V. Halogenated heterocyclic ethers, the preparation thereof and their use as herbicides
WO1988003147A1 (en) 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
SU1417408A1 (en) 1986-12-02 1995-09-10 Г.П. Акулов Process for preparing tritium marked deoxyadenosine (ad)
JPH0699467B2 (en) 1987-03-04 1994-12-07 ヤマサ醤油株式会社 2 ▲ '▼ -Deoxy-2 ▲' ▼ (S) -alkylpyrimidine nucleoside derivative
AU598946B2 (en) 1987-06-24 1990-07-05 Howard Florey Institute Of Experimental Physiology And Medicine Nucleoside derivatives
DE3730542A1 (en) 1987-09-11 1989-04-06 Hoechst Ag MEDICINAL PRODUCTS CONTAINING SPECIFIC 6-MERCAPTOPURIN DERIVATIVES, USE OF THESE 6-MERCAPTOPURIN DERIVATIVES, METHOD FOR PRODUCING THE MEDICINAL PRODUCTS AND SOME NEW 6-MERCAPTOPURIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US4880784A (en) 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
HU204843B (en) 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
US5616702A (en) 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives
MX9203459A (en) 1988-11-15 1992-08-01 Merrell Pharma Inc NEW DERIVATIVES OF 2'-HALOMETILIDENO, 2'-ETENILIDENO AND 2'-ETINILCITIDINA, URIDINA AND GUANOSINA.
AU4479189A (en) 1988-11-21 1990-06-21 Syntex (U.S.A.) Inc. Antiviral agents
SE462497B (en) 1988-11-30 1990-07-02 Clas Fredrik Runesson Kaelland CAUSED TO ACTIVATE DETERMINATION POLYMERASES
FR2642074B1 (en) 1989-01-20 1994-04-29 Oris Ind POLYHYDROXYLATED MOLECULE DERIVATIVES FOR THE INTRODUCTION OF AT LEAST ONE BRANCH INTO AN OLIGONUCLEOTIDE
US5296348A (en) 1989-05-16 1994-03-22 The Wistar Institute Of Anatomy And Biology Methods for screening monoclonal antibodies for therapeutic use
DE3916871A1 (en) 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh MODIFIED PHOSPHORAMIDITE PROCESS FOR THE PREPARATION OF MODIFIED NUCLEIC ACIDS
DE3924424A1 (en) 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR USE IN THE SEQUENCING OF NUCLEIC ACID
JPH0699711B2 (en) 1989-07-25 1994-12-07 花王株式会社 Liquid detergent composition
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
ATE269870T1 (en) 1989-10-24 2004-07-15 Isis Pharmaceuticals Inc 2'-MODIFIED OLIGONUCLEOTIDES
EP0604409B1 (en) 1990-01-11 2004-07-14 Isis Pharmaceuticals, Inc. Oligonucleotide analogs for detecting and modulating rna activity and gene expression
US5852188A (en) 1990-01-11 1998-12-22 Isis Pharmaceuticals, Inc. Oligonucleotides having chiral phosphorus linkages
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5578718A (en) 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
US5514786A (en) 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
US5457191A (en) 1990-01-11 1995-10-10 Isis Pharmaceuticals, Inc. 3-deazapurines
CA2037767A1 (en) 1990-03-23 1991-09-24 Mark D. Wittman Conversion of amines to hydroxylamines
US5658731A (en) 1990-04-09 1997-08-19 Europaisches Laboratorium Fur Molekularbiologie 2'-O-alkylnucleotides as well as polymers which contain such nucleotides
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5478813A (en) 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
GB9012899D0 (en) 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
JP2559917B2 (en) 1990-06-15 1996-12-04 三共株式会社 Pyrimidine nucleoside derivative
DE4019892A1 (en) 1990-06-22 1992-01-02 Boehringer Ingelheim Kg New xanthine derivs. are selective A1 adenosine antagonists - useful for treating CNS disorders (e.g. senile dementia) and heart and circulation disorders
MY106399A (en) 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5138045A (en) 1990-07-27 1992-08-11 Isis Pharmaceuticals Polyamine conjugated oligonucleotides
IL99125A0 (en) 1990-08-10 1992-07-15 Gensia Pharma Derivatives of imidazole analog of aica riboside and their use
US5777100A (en) 1990-08-10 1998-07-07 Gensia Inc. AICA riboside analogs
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
US5420115A (en) * 1990-09-10 1995-05-30 Burroughs Wellcome Co. Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
AU665184B2 (en) 1991-01-23 1995-12-21 Gensia, Inc. Adenosine kinase inhibitors
US5171849A (en) 1991-04-19 1992-12-15 The Ohio State University Research Foundation 2' and 3' Carboranyl uridines and their diethyl ether adducts
US5446031A (en) 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
GB9111580D0 (en) 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5192764A (en) 1991-05-30 1993-03-09 Research Foundation Of State Of N.Y. Pyrazinone n-oxide nucleosides and analogs thereof
US5508407A (en) 1991-07-10 1996-04-16 Eli Lilly And Company Retroviral protease inhibitors
JPH0551395A (en) 1991-08-21 1993-03-02 Teijin Ltd Pentafluoropropionylated (deoxy)uridine and method for measuring (deoxy)uridine using the same compound
US5268376A (en) 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
DE4131579A1 (en) 1991-09-23 1993-03-25 Boehringer Mannheim Gmbh THIADIAZOLO (4,3-A) PYRIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM
CA2079413C (en) 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
IT1249732B (en) 1991-11-26 1995-03-09 Angeletti P Ist Richerche Bio ANTISENSE OLIGONUCLEOTIDES.
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
EP1256589A3 (en) 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomers containing modified pyrimidines
FR2684997A1 (en) 1991-12-12 1993-06-18 Centre Nat Rech Scient DERIVATIVES OF 9- (BETA-D-XYLOFURANNOSYL) ADENINE AND 1- (BETA-D-XYLOFURANNOSYL) CYTOSINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2688003B1 (en) 1992-02-28 1995-06-30 Univ Limoges NUCLEOSIDE DERIVATIVES, THEIR PREPARATION AND THEIR BIOLOGICAL APPLICATIONS.
US5543507A (en) 1992-03-05 1996-08-06 Isis Pharmaceuticals, Inc. Covalently cross-linked oligonucleotides
DE69320646T2 (en) 1992-04-10 1999-01-14 Merrell Pharmaceuticals Inc., Cincinnati, Ohio METHOD FOR TREATING CANCER BY COMBINATION THERAPY WITH 2'-HALOMETHYLIDEN DERIVATIVES AND AN S- OR M-PHASE-SPECIFIC ANTINEOPLASTIC ACTIVE SUBSTANCE
IL105325A (en) 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5808139A (en) 1992-04-21 1998-09-15 Ligand Pharmaceuticals Incorporated Non-steroid progesterone receptor agonist and antagonist and compounds and methods
CA2133961C (en) 1992-05-12 1998-03-31 James R. Mccarthy A process for the preparation of ribonucleotide reductase inhibitors
US5625056A (en) 1992-05-26 1997-04-29 Biolog Life Science Institute Derivatives of cyclic guanosine-3',5'-monophosphorothioate
DE4217679C2 (en) 1992-05-26 1998-02-19 Genieser Hans Gottfried Dr Cyclic guanosine 3 ', 5'-phosphorothioate derivatives
DE69333842T2 (en) 1992-07-23 2006-04-27 Isis Pharmaceuticals, Inc., Carlsbad Novel 2'-O-alkyl nucleosides and phosphoramidites, processes for their preparation and their uses
WO1994022890A1 (en) 1993-03-31 1994-10-13 Sterling Winthop Inc. Novel 5'-substituted nucleosides and oligomers produced therefrom
DE69435319D1 (en) 1993-09-17 2010-12-16 Gilead Sciences Inc nucleotide analogs
DE4341161A1 (en) 1993-12-02 1995-06-08 Michael Prof Dr Zeppezauer Membrane-active agent for disrupting DNA biosynthesis
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
JPH07242544A (en) 1994-03-01 1995-09-19 Takeda Chem Ind Ltd Antineoplastic agent
US5681940A (en) 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
US6004939A (en) 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
DK0879056T3 (en) 1996-01-23 2002-08-19 Icn Pharmaceuticals Modulation of Th1 / Th2 cytokine expression by ribavirin in activated T lymphocytes
JPH09328497A (en) * 1996-04-12 1997-12-22 Yamasa Shoyu Co Ltd 4'-fluoromethylnucleoside
ES2195970T3 (en) 1996-10-16 2003-12-16 Ribapharm Inc L-RIBAVIRINA AND USES OF THE SAME.
EP0961775B1 (en) 1996-10-16 2004-07-14 ICN Pharmaceuticals, Inc. Purine l-nucleosides, analogs and uses thereof
US20030064945A1 (en) 1997-01-31 2003-04-03 Saghir Akhtar Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
EP2341057A3 (en) * 1997-09-12 2011-11-23 Exiqon A/S Oligonucleotide Analogues
US20030203862A1 (en) 1998-03-26 2003-10-30 Miraglia Loren J. Antisense modulation of MDM2 expression
US6127121A (en) 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
WO1999061583A2 (en) 1998-05-28 1999-12-02 Incara Pharmaceuticals Corp. Carbohydrate-based scaffold compounds, combinatorial libraries and methods for their construction
DE19855963A1 (en) 1998-12-04 2000-06-08 Herbert Schott Amphiphilic glyceryl nucleotides, process for their preparation and their use
JP2002540118A (en) * 1999-03-18 2002-11-26 エクシコン エ／エス Xylo-LNA analog
DE60033927T2 (en) * 1999-05-04 2007-11-29 Santaris Pharma A/S L-RIBO-LNA ANALOGUE
ATE250623T1 (en) * 1999-05-12 2003-10-15 Yamasa Corp 4'-C-ETHYNYL PURINE NUCLEOSIDES
JP4076114B2 (en) 1999-05-12 2008-04-16 ヤマサ醤油株式会社 4'-C-ethynylpurine nucleoside compounds
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
KR20020092904A (en) 1999-08-27 2002-12-12 아이씨엔 파마슈티컬스, 인코포레이티드 Pyrrolo[2,3-d]pyrimidine nucleoside analogs
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
CA2390821A1 (en) 1999-12-16 2001-06-21 Peter G. Klimko Inhibitors of adenosine kinase for the treatment of optic nerve and retinal damage
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6815542B2 (en) 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
JP2002322192A (en) * 2000-08-10 2002-11-08 Sankyo Co Ltd 2'-o,4'-crosslinked nucleoside triphosphate
JP2004313002A (en) 2000-10-12 2004-11-11 Mitsui Chemicals Inc Method for producing nucleoside
WO2002031176A1 (en) 2000-10-12 2002-04-18 Mitsui Chemicals, Inc. Process for producing nucleoside
DK2251015T3 (en) * 2000-10-18 2013-05-13 Gilead Pharmasset Llc Modified nucleotides to treat viral infections and abnormal cell proliferation
DE60203702T2 (en) 2001-01-16 2006-03-02 Can-Fite Biopharma Ltd. USE OF AN ADENOSINE A3 RECEPTOR AGONIST TO INHIBIT VIRUS REPLICATION
EP1355916B1 (en) * 2001-01-22 2007-01-10 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
JP2002302498A (en) 2001-04-03 2002-10-18 Mitsui Chemicals Inc Method for industrially producing nucleoside
US20040204481A1 (en) 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
WO2003070912A2 (en) 2001-06-06 2003-08-28 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
WO2002097114A2 (en) 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
JP2003012690A (en) 2001-07-03 2003-01-15 Mitsui Chemicals Inc Method of producing nucleotide using substituted imidazole derivative or substituted benzimidazole derivative
JP2003055392A (en) 2001-08-08 2003-02-26 Mitsui Chemicals Inc Method for producing 1-phosphorylated sugar and method for producing nucleocide
US20040235761A1 (en) 2001-08-14 2004-11-25 Yousuke Furuta Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
US6962991B2 (en) 2001-09-12 2005-11-08 Epoch Biosciences, Inc. Process for the synthesis of pyrazolopyrimidines
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7037718B2 (en) 2001-10-26 2006-05-02 Cornell Research Foundation, Inc. Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof
AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
US7125982B1 (en) 2001-12-05 2006-10-24 Frayne Consultants Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
WO2003062255A2 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. Sugar modified nucleosides as viral replication inhibitors
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
JP2005525358A (en) 2002-02-28 2005-08-25 ビオタ インコーポレーティッド Nucleotide mimetics and their prodrugs
US20040023901A1 (en) 2002-02-28 2004-02-05 Cook Phillip D. Nucleoside 5'-monophosphate mimics and their prodrugs
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
JP2003310293A (en) 2002-04-26 2003-11-05 Mitsui Chemicals Inc Method for producing nucleoside compound
DE60315444T2 (en) 2002-05-08 2008-04-30 Santaris Pharma A/S SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
US20040014957A1 (en) 2002-05-24 2004-01-22 Anne Eldrup Oligonucleotides having modified nucleoside units
JP4902958B2 (en) 2002-06-07 2012-03-21 ユニバーシテール・メディッシュ・セントラム・ユトレヒト Novel compounds for modulating the activity of exchange protein (Epac) directly activated by cAMP
EP2799442A1 (en) 2002-06-28 2014-11-05 IDENIX Pharmaceuticals, Inc. Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections
PL374781A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
KR20050055630A (en) 2002-06-28 2005-06-13 이데닉스 (케이만) 리미티드 1'-, 2' and 3'-modified nucleoside derivatives for treating flaviviridae infections
AU2003259735A1 (en) 2002-08-08 2004-02-25 Sirna Therapeutics, Inc. Small-mer compositions and methods of use
US7094768B2 (en) 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
WO2004037159A2 (en) 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
US20040229840A1 (en) 2002-10-29 2004-11-18 Balkrishen Bhat Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
PL377287A1 (en) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
US7393954B2 (en) 2002-12-12 2008-07-01 Reliable Biopharmaceutical Corporation Process for the production of pentostatin aglycone and pentostatin
US7002006B2 (en) 2003-02-12 2006-02-21 Isis Pharmaceuticals, Inc. Protection of nucleosides
PL219609B1 (en) 2003-02-19 2015-06-30 Masanori Baba Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
WO2004080466A1 (en) 2003-03-07 2004-09-23 Ribapharm Inc. Cytidine analogs and methods of use
EP1613261A4 (en) 2003-04-09 2011-01-26 Novo Nordisk As Intracellular formation of peptide conjugates
US20040259934A1 (en) 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
WO2005020884A2 (en) 2003-05-14 2005-03-10 Idenix (Cayman) Limited Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
US20040229839A1 (en) 2003-05-14 2004-11-18 Biocryst Pharmaceuticals, Inc. Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
JP2007504152A (en) 2003-08-27 2007-03-01 ビオタ， インコーポレイテッド Novel tricyclic nucleosides or nucleotides as therapeutic agents
NZ576775A (en) 2003-09-18 2010-12-24 Isis Pharmaceuticals Inc Modulation of eIF4E expression
AU2004280256A1 (en) 2003-10-08 2005-04-21 Organix, Inc. Pyrovalerone analogs and therapeutic uses thereof
DE10348044A1 (en) 2003-10-15 2005-05-19 Imtm Gmbh Dual alanyl aminopeptidase and dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
US7144868B2 (en) 2003-10-27 2006-12-05 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2005044836A2 (en) 2003-11-05 2005-05-19 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
WO2005063246A1 (en) 2003-12-29 2005-07-14 Can-Fite Biopharma Ltd. Method for treatment of multiple sclerosis
DE102004009704A1 (en) 2004-02-27 2005-09-15 Dmitry Cherkasov New conjugates useful for labeling nucleic acids comprise a label coupled to nucleotide or nucleoside molecules through polymer linkers
GB0413726D0 (en) 2004-06-18 2004-07-21 Lauras As Compounds
CA2571675A1 (en) 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
ES2432113T3 (en) 2004-07-28 2013-11-29 Can-Fite Biopharma Ltd. Adenosine A3 receptor agonists for the treatment of dry eye disorders, including Sjogren's syndrome
US7825102B2 (en) 2004-07-28 2010-11-02 Can-Fite Biopharma Ltd. Treatment of dry eye conditions
EP1807440B1 (en) 2004-11-03 2020-02-19 The University of Kansas Novobiocin analogues as anticancer agents
US7622451B2 (en) 2004-11-03 2009-11-24 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
WO2006097320A2 (en) 2005-03-17 2006-09-21 Genovoxx Gmbh Macromolecular nucleotide links and methods for their use
WO2006048884A1 (en) 2004-11-08 2006-05-11 Can-Fite Biopharma Ltd. Therapeutic treatment of accelerated bone resorption
JP2006131596A (en) 2004-11-09 2006-05-25 Univ Nagoya Method for producing nucleotide and derivative thereof
US8399428B2 (en) * 2004-12-09 2013-03-19 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
WO2006063717A2 (en) 2004-12-16 2006-06-22 Febit Biotech Gmbh Polymerase-independent analysis of the sequence of polynucleotides
RS52458B (en) 2005-02-04 2013-02-28 Millennium Pharmaceuticals Inc. Inhibitors of e1 activating enzymes
EP1858889A1 (en) 2005-03-08 2007-11-28 Biota Scientific Management Pty. Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
WO2007144686A1 (en) 2005-03-09 2007-12-21 Idenix (Cayman) Limited Nucleosides with non-natural bases as anti-viral agents
JP2006248949A (en) 2005-03-09 2006-09-21 Univ Nagoya Nucleoside derivative, nucleotide derivative and manufacturing method thereof
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
EP1877054A2 (en) 2005-03-30 2008-01-16 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
WO2006116512A1 (en) 2005-04-26 2006-11-02 The Board Of Trustees Of The University Of Illinois, Urbana, Il Nucleoside compounds and methods of use thereof
WO2007006544A2 (en) 2005-07-12 2007-01-18 Vrije Universiteit Brussel Cyclic adenosine monophosphate compounds for the treatment of immune-related disorders
WO2007020018A1 (en) 2005-08-12 2007-02-22 Universite Libre De Bruxelles Use of purinergic and pyrimidinergic receptor agonists for dendritic cells based immunotherapies
CA2618335C (en) 2005-08-15 2015-03-31 F.Hoffmann-La Roche Ag Antiviral phosphoramidates of 4'-substituted pronucleotides
CN101321775B (en) 2005-10-03 2012-05-23 大学健康网络 ODCASE inhibitors for the treatment of malaria
EP1947092B1 (en) 2005-11-09 2015-04-15 Tosoh Corporation Method for producing nucleic acid base having perfluoroalkyl group
WO2007113538A1 (en) 2006-04-03 2007-10-11 Astrazeneca Ab Substituted adenines and the uses thereof
WO2007149554A2 (en) 2006-06-22 2007-12-27 The Johns Hopkins University Methods for restoring neural function
GB0614947D0 (en) 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
KR20150036358A (en) 2006-08-08 2015-04-07 밀레니엄 파머슈티컬스 인코퍼레이티드 Heteroaryl compounds useful as inhibitors of e1 activating enzymes
DE102006037786A1 (en) 2006-08-11 2008-03-20 Resprotect Gmbh Nucleosides, pharmaceuticals containing them and their use
GB0618235D0 (en) 2006-09-15 2006-10-25 Lauras As Process
US20100056468A1 (en) 2007-01-08 2010-03-04 University Health Network Pyrimidine Derivatives As Anticancer Agents
WO2008086042A2 (en) 2007-01-10 2008-07-17 Chisari Francis V Preventing infection by a measles or respiratory syncytial virus
NZ578556A (en) 2007-01-12 2012-04-27 Biocryst Pharm Inc Antiviral nucleoside analogs
WO2008089439A2 (en) 2007-01-18 2008-07-24 Fred Hutchinson Cancer Research Center Methods and compositions for enhancing lifespan involving sirtuin-modulating compounds and chalcogenides
EP2993473A1 (en) 2007-01-30 2016-03-09 Pharmacyclics, Inc. Methods for determining cancer resistance to histone deacetylase inhibitors
JP2010518015A (en) 2007-01-31 2010-05-27 アリオス バイオファーマ インク． 2-5A analogs and methods for using them
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
JP2008214305A (en) 2007-03-07 2008-09-18 Kotobuki Seiyaku Kk Substituted amine derivative and pharmaceutical composition containing the same as active ingredient
WO2008117047A1 (en) 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolo[3, 4-d]pyrimidine derivatives as antibacterial compounds
WO2008117046A1 (en) 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolo [4, 3-d] pyrimidines as antibacterial compounds
US7964580B2 (en) * 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20080255038A1 (en) 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
EP1980568A1 (en) 2007-04-13 2008-10-15 Eberhard Karls Universität Tübingen Ethinylated hetero dinucleotide phosphate analoga, method for their manufacture and application thereof
SI2014771T1 (en) 2007-06-25 2015-04-30 Anadys Pharmaceuticals, Inc. Continuous enzymatic hydrolysis process
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
CN100532388C (en) 2007-07-16 2009-08-26 郑州大学 2'-fluorine-4'-substituted-nucleosides analog, preparation method and uses thereof
EP2019100A1 (en) 2007-07-19 2009-01-28 Santhera Pharmaceuticals (Schweiz) AG Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators
US20090076062A1 (en) 2007-09-13 2009-03-19 Juergen Klaus Maibaum Organic Compounds
GB0718575D0 (en) 2007-09-24 2007-10-31 Angeletti P Ist Richerche Bio Nucleoside derivatives as inhibitors of viral polymerases
EP2227234B1 (en) 2007-10-15 2014-05-07 Can-Fite Biopharma Ltd. Method for inducing hepatocyte proliferation and uses thereof
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
US20090181921A1 (en) 2007-12-21 2009-07-16 Alios Biopharma Inc. 2-5a analogs and their methods of use
WO2009086192A1 (en) 2007-12-21 2009-07-09 Alios Biopharma, Inc. Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
MX2010009207A (en) 2008-02-22 2011-03-03 Irm Llc Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors.
US8445669B2 (en) 2008-04-10 2013-05-21 Hamari Chemicals, Ltd. Production process of ethynylthymidine compounds from 5-methyluridine as a starting material
WO2009126293A2 (en) 2008-04-11 2009-10-15 Yale University Potent chimeric nrti-nnrti bifunctional inhibitors of hiv-1 reverse transcriptase
WO2009129120A2 (en) 2008-04-15 2009-10-22 Rfs Pharma, Llc Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
US20090274686A1 (en) 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
DE102008035299A1 (en) 2008-07-29 2010-02-04 Resprotect Gmbh Conjugate, particularly bromovinyl-deoxyuridine for manufacture medicament for inhibiting or suppressing metastasis including distant metastases in cytostatic treatment, includes heat shock protein and nucleoside
GB0815315D0 (en) 2008-08-21 2008-09-24 Univ Leiden Organ protection
GB0815968D0 (en) 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
US20110171192A1 (en) 2008-09-05 2011-07-14 Hiroshi Tomiyama Substituted amine derivative and medicinal composition comprising same as the active ingredient
US8163707B2 (en) * 2008-09-15 2012-04-24 Enanta Pharmaceuticals, Inc. 4′-allene-substituted nucleoside derivatives
AU2009298802A1 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
US20120059045A1 (en) 2008-10-24 2012-03-08 Isis Pharmaceuticals, Inc. Methods of using oligomeric compounds comprising 2'-substituted nucleosides
EP2376515A1 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Synthesis of purine nucleosides
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
US8609627B2 (en) 2009-02-06 2013-12-17 Rfs Pharma, Llc Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
EP2403863B1 (en) * 2009-03-02 2013-08-28 Alnylam Pharmaceuticals Inc. Nucleic acid chemical modifications
US20100240604A1 (en) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Protected nucleotide analogs
US20100249068A1 (en) 2009-03-20 2010-09-30 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
US20120149657A1 (en) 2009-05-12 2012-06-14 Southern Research Institute 2'-fluoro arabino nucleosides and use thereof
EP2264169A1 (en) 2009-06-15 2010-12-22 Qiagen GmbH Modified siNA
US20100331397A1 (en) 2009-06-24 2010-12-30 Alios Biopharma, Inc. 2-5a analogs and their methods of use
WO2011005860A2 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
TW201111378A (en) 2009-09-11 2011-04-01 Bayer Schering Pharma Ag Substituted (heteroarylmethyl) thiohydantoins
WO2011057204A2 (en) 2009-11-06 2011-05-12 The Johns Hopkins University Lrrk2-mediated neuronal toxicity
US9198972B2 (en) 2010-01-28 2015-12-01 Alnylam Pharmaceuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
WO2011133871A2 (en) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
KR101701510B1 (en) 2010-07-09 2017-02-01 엘지이노텍 주식회사 Light emitting device
EA025311B1 (en) 2010-07-19 2016-12-30 Гайлид Сайэнсиз, Инк. Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
CN103052631B (en) 2010-07-22 2015-11-25 吉里德科学公司 Be used for the treatment of method and the compound of the infection of paramyxovirus coe virus
JP5640552B2 (en) 2010-08-23 2014-12-17 セイコーエプソン株式会社 Control device, display device, and control method of display device
WO2012040126A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
EP2619216A4 (en) 2010-09-22 2014-04-02 Alios Biopharma Inc Substituted nucleotide analogs
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
AR083221A1 (en) 2010-09-29 2013-02-06 Univ Nac Quilmes PROCESS TO PRODUCE NUCLEOSID DIALYLPHOSPHOTRIESTERS THROUGH ENZYMATIC TRANSESTERIFICATION AND DEPROTECTION OF THE SAME TO PRODUCE MONOPHOSPHATE NUCLEOSIDS
EP2646444B1 (en) 2010-12-03 2016-03-16 Epizyme, Inc. Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes
CA2819041A1 (en) 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
CN103403014B (en) 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(benzyl being substituted) phosphoramidate compounds and therapeutic use thereof
US9334300B2 (en) 2011-08-01 2016-05-10 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
CN103102345B (en) 2011-11-14 2015-06-03 广东东阳光药业有限公司 Aminoquinazoline derivative, salts thereof and application method
US9303016B2 (en) 2011-12-22 2016-04-05 Connexios Life Sciences Pvt. Ltd. Derivatives of aza adamantane and uses thereof
SI2794627T1 (en) 2011-12-22 2019-02-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MX354361B (en) 2011-12-22 2018-02-28 Connexios Life Sciences Pvt Ltd Cyclic amide derivatives as inhibitors of 11 - beta - hydroxysteroid dehydrogenase and uses thereof.
SI2794600T1 (en) 2011-12-22 2018-03-30 Novartis Ag 2,3-Dihydro-benzo(1,4)oxazine derivatives and related compounds as phosphoinositide-3 kinase (PI3K) inhibitors for the treatment of e.g. rheumatoid arthritis
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
AR089284A1 (en) 2011-12-22 2014-08-13 Galapagos Nv DIHYDROPIRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR THE TREATMENT OF INFLAMMATORY DISORDERS
SI2834258T1 (en) 2012-03-13 2017-04-26 Gilead Sciences, Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
WO2013138210A1 (en) 2012-03-14 2013-09-19 Ning Xi Substituted cyclic compounds and methods of use
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142125A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
PT2827875T (en) 2012-03-21 2019-02-11 Janssen Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2013142159A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
US20150057243A1 (en) 2012-04-02 2015-02-26 Northern University Compositions and Methods for the Inhibition of Methyltransferases
NZ702744A (en) 2012-05-22 2016-12-23 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
WO2014008236A1 (en) 2012-07-03 2014-01-09 Bristol-Myers Squibb Company Process for preparing diastereomerically enriched phosphoramidate derivatives of nucleoside compounds for treatment of viral infections
WO2014022639A1 (en) 2012-08-01 2014-02-06 Vertex Pharmaceuticals Incorporated Solid forms of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'h-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone
WO2014026198A1 (en) 2012-08-10 2014-02-13 Epizyme, Inc. Inhibitors of protein methyltransferase dot1l and methods of use thereof
US10294261B2 (en) 2012-09-04 2019-05-21 Kabushiki Kaisha Dnaform Compound, nucleic acid, labeling substance, and detection method
MX362855B (en) 2012-09-26 2019-02-20 Merck Patent Gmbh Quinazolinone derivatives as parp inhibitors.
CN104640858B (en) 2012-09-26 2018-11-06 霍夫曼-拉罗奇有限公司 Cyclic ethers pyrazoles -4- bases-heterocycle-benzamide compound and application method
RU2015119999A (en) 2012-10-29 2016-12-20 Кокристал Фарма, Инк. Pyrimidine Nucleosides and Their Monophosphate Drugs for the Treatment of Disease Infections and Cancer
GB201220843D0 (en) 2012-11-20 2013-01-02 Univ College Cork Nat Univ Ie Compound
HUE053946T2 (en) 2012-12-21 2021-08-30 Janssen Biopharma Inc 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv
US9598457B2 (en) 2012-12-21 2017-03-21 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2014134251A1 (en) 2013-02-28 2014-09-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US20140309413A1 (en) 2013-03-11 2014-10-16 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
TW201532606A (en) 2013-04-05 2015-09-01 Alios Biopharma Inc Hepatitis C viral infection treatment using a combination of compounds
TW201542578A (en) 2013-06-26 2015-11-16 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EP3424938B1 (en) 2013-06-26 2020-07-22 Janssen BioPharma, Inc. 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof
SG11201602595TA (en) 2013-10-11 2016-04-28 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
CA2952959C (en) 2014-06-24 2023-03-07 Alios Biopharma, Inc. Use of nucleosides and nucleotides to treat filoviridae viral infection
LT3160476T (en) 2014-06-24 2021-04-12 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof for use in the treatment of viral infection
CA2952812A1 (en) 2014-06-24 2015-12-30 Alios Biopharma, Inc. Methods of preparing substituted nucleotide analogs
WO2016014398A1 (en) 2014-07-22 2016-01-28 Alios Biopharma, Inc. Methods for treating paramyxoviruses
PE20170673A1 (en) 2014-08-05 2017-05-22 Alios Biopharma Inc COMBINATION THERAPY TO TREAT A PARAMYXOVIRUS
TWI673283B (en) 2014-08-21 2019-10-01 美商基利科學股份有限公司 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides
US9981175B2 (en) 2014-09-12 2018-05-29 Dan DeLaRosa Taekwondo bag
US9908914B2 (en) 2014-10-28 2018-03-06 Alios Biopharma, Inc. Methods of preparing substituted nucleoside analogs
MA41441A (en) 2014-12-19 2017-12-12 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES OF THEM
MA41213A (en) 2014-12-19 2017-10-24 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES OF THEM
TW201811339A (en) 2016-08-12 2018-04-01 美商艾洛斯生物製藥公司 Substituted nucleosides, nucleotides and analogs thereof
US20180117042A1 (en) 2016-10-27 2018-05-03 Alios Biopharma, Inc. Methods for treating respiratory syncytial virus infection

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