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AR026990A1 - Antagonistas de neurokinina selectivos - Google Patents

Antagonistas de neurokinina selectivos

Info

Publication number
AR026990A1
AR026990A1 ARP000106707A ARP000106707A AR026990A1 AR 026990 A1 AR026990 A1 AR 026990A1 AR P000106707 A ARP000106707 A AR P000106707A AR P000106707 A ARP000106707 A AR P000106707A AR 026990 A1 AR026990 A1 AR 026990A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
heteroaryl
selective
conr13r14
Prior art date
Application number
ARP000106707A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR026990A1 publication Critical patent/AR026990A1/es

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    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
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    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Se describe el compuesto representado por la formula estructural (1)o su sal farmacéuticamente aceptable, en donde Ar1 y Ar2 son heteroarilo optativamentesustituido o fenilo optativamente sustituido: X1 es -O-, -S-, -SO-, -SO2-, -NR12-, -NCOR12- o -N R12SO2R15-; Q se selecciona entre el grupo que consiste en laformula (2) X2 es -O-, -S-o NR5-; Y es =O, =S o =NR11; Y 1 es H alquilo C1-6, -NR17R13, -SCH3, R19-aril(CH2(n6-, R19-heteroaril-(CH2)n6-, (CH2)n6-heterocicloalquil, -(C1-C3)alquil-NH-C(O)O( C1-6)alquilo o -NHC(O)R15, R5 es H o -(CH2)n1-G, en donde n1 es 0-5, G es H, -CF3, -CHF2, -CH2F, OH, -O-(alquilo C1-6), -SO2R13, -O-(cicloalquilo C3-8), NR13R14, -SO2NR13R14, -NR13SO2R15, -NR13COR12, -NR12(CONR13R14), -CONR13R14, -COOR12, cicloalquil o C3-8, R19-heteroarilo,y siempre y cuando n1=O, G no es H; R1, R2, R3 y R7 SON h, alquilo, cicloalquilo, -CHF2, -CH2F o -CF3; o R1 y R2, junto con el carbono al cual están unidos,forman un anillo alquileno; o R1 y R2 juntos son =O; R6 es R7 o OH; y las variables restantes son como se definieron en la memoria descriptiva, también sedescriben métodos paa el tratamietno de enfermedades susceptibles de tratamiento con antagonistas de neurokinina con dichos compuestos, y composicionesfarmacéuticas q ue comprenden dichos compuestos. También se describen composiciones farmacéuticas que comprenden una cantidad efectiva de uncompuesto de acuerdocon al reivindicacion 1, por lo meno sun portador farmacéuticamente aceptable, y en combinacion con una ca ntidad efectiva de un inhibidor de la recaptacion deserotonina selectivo.
ARP000106707A 1999-12-17 2000-12-15 Antagonistas de neurokinina selectivos AR026990A1 (es)

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