NO930709L - NEW CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC APPLICATION - Google Patents

NEW CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC APPLICATION

Info

Publication number: NO930709L
Authority: NO; Norway
Prior art keywords: preparation; new; therapeutic application; cholecystokinin antagonists; cholecystokinin
Prior art date: 1990-08-31

Application number

NO93930709A

Other languages

Norwegian (no)

Other versions

NO312298B1 (en

NO930709D0 (en

Inventor

David Christopher Horwell

David Charles Rees

William Howard Roark

Bruce David Roth

Janak Khimchand Padia

Juergen Kleinschroth

Reginald Stewart Richardson

Edward Roberts

Ann Holmes

Bharat Kalidas Trivedi

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-31

Filing date

1993-02-26

Publication date

1993-04-15

1993-02-26 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1993-02-26 Publication of NO930709D0 publication Critical patent/NO930709D0/en

1993-04-15 Publication of NO930709L publication Critical patent/NO930709L/en

2002-04-22 Publication of NO312298B1 publication Critical patent/NO312298B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Addiction (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

NO19930709A 1990-08-31 1993-02-26 Analogous Process for Preparation of Therapeutically Active Indole Derivatives NO312298B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US57662890A	1990-08-31	1990-08-31
US72665591A	1991-07-12	1991-07-12
PCT/US1991/006180 WO1992004045A1 (en)	1990-08-31	1991-08-29	Novel cholecystokinin antagonists, their preparation and therapeutic use

Publications (3)

Publication Number	Publication Date
NO930709D0 NO930709D0 (en)	1993-02-26
NO930709L true NO930709L (en)	1993-04-15
NO312298B1 NO312298B1 (en)	2002-04-22

Family

ID=27077012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19930709A NO312298B1 (en)	1990-08-31	1993-02-26	Analogous Process for Preparation of Therapeutically Active Indole Derivatives

Country Status (9)

Country	Link
EP (1)	EP0547178A4 (en)
JP (1)	JPH06502627A (en)
KR (1)	KR100222634B1 (en)
CA (1)	CA2088195A1 (en)
IE (1)	IE67290B1 (en)
NO (1)	NO312298B1 (en)
NZ (1)	NZ239595A (en)
PT (1)	PT98842B (en)
WO (1)	WO1992004045A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5217957A (en) *	1991-08-20	1993-06-08	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5380872A (en) *	1992-07-14	1995-01-10	Glaxo Inc.	Modulators of cholecystokinin
WO1994018229A1 (en) *	1993-02-03	1994-08-18	Fisons Corporation	1,2,4-triazinone derivatives and their use in therapy
GB9304500D0 (en) *	1993-03-05	1993-04-21	Glaxo Spa	Heterocyclic compounds
CA2255966A1 (en)	1996-08-22	1998-02-26	Warner-Lambert Company	Non-peptide bombesin receptor antagonists
US6645968B2 (en)	1999-08-03	2003-11-11	Abbott Laboratories	Potassium channel openers
US6846836B2 (en)	2003-04-18	2005-01-25	Bristol-Myers Squibb Company	N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
ES2567135T3 (en)	2003-08-29	2016-04-20	The Brigham And Women's Hospital, Inc.	Hydantoin derivatives as inhibitors of cell necrosis
MX2009002781A (en)	2006-09-15	2009-03-30	Reviva Pharmaceuticals Inc	Synthesis, methods of using, and compositions of cycloalkylmethylamines.
WO2010075561A1 (en)	2008-12-23	2010-07-01	President And Fellows Of Harvard College	Small molecule inhibitors of necroptosis
GB0919194D0 (en)	2009-11-02	2009-12-16	Lytix Biopharma As	Compounds
WO2012003501A2 (en)	2010-07-02	2012-01-05	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
US9725452B2 (en)	2013-03-15	2017-08-08	Presidents And Fellows Of Harvard College	Substituted indoles and pyrroles as RIP kinase inhibitors
SG11201704764PA (en)	2014-12-11	2017-07-28	Harvard College	Inhibitors of cellular necrosis and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4757151A (en) *	1985-11-14	1988-07-12	Warner-Lambert Company	2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
CA1291031C (en) *	1985-12-23	1991-10-22	Nikolaas C.J. De Jaeger	Method for the detection of specific binding agents and their correspondingbindable substances
US4814463A (en) *	1985-12-31	1989-03-21	Biomeasure, Inc.	CCK antagonists
FR2606963B1 (en) *	1986-11-14	1989-01-13	Cit Alcatel	SUBMARINE REPEATER BOX
EP0336356A3 (en) *	1988-04-05	1991-09-25	Abbott Laboratories	Derivatives of tryptophan as cck antagonists
NZ234264A (en) *	1989-06-29	1993-05-26	Warner Lambert Co	N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5244915A (en) *	1990-08-31	1993-09-14	Warner-Lambert Company	Amico acid derivatives cyclized at the c-terminal

1991
- 1991-08-29 KR KR1019930700601A patent/KR100222634B1/en not_active IP Right Cessation
- 1991-08-29 CA CA002088195A patent/CA2088195A1/en not_active Abandoned
- 1991-08-29 WO PCT/US1991/006180 patent/WO1992004045A1/en not_active Application Discontinuation
- 1991-08-29 EP EP19910918880 patent/EP0547178A4/en not_active Withdrawn
- 1991-08-29 NZ NZ239595A patent/NZ239595A/en unknown
- 1991-08-29 JP JP3517185A patent/JPH06502627A/en active Pending
- 1991-08-30 PT PT98842A patent/PT98842B/en not_active IP Right Cessation
- 1991-08-30 IE IE307791A patent/IE67290B1/en not_active IP Right Cessation
1993
- 1993-02-26 NO NO19930709A patent/NO312298B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU651390B2 (en)	1994-07-21
AU8749291A (en)	1992-03-30
NZ239595A (en)	1994-06-27
EP0547178A4 (en)	1994-07-06
NO312298B1 (en)	2002-04-22
PT98842B (en)	1999-01-29
WO1992004045A1 (en)	1992-03-19
IE67290B1 (en)	1996-03-20
JPH06502627A (en)	1994-03-24
KR930703349A (en)	1993-11-29
CA2088195A1 (en)	1992-03-01
EP0547178A1 (en)	1993-06-23
KR100222634B1 (en)	1999-10-01
PT98842A (en)	1992-08-31
NO930709D0 (en)	1993-02-26
IE913077A1 (en)	1992-03-11

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NO952677D0 (en)	1995-07-06	New dihydropyrrolopyridinone and oxazolopyridinone compounds, their preparation and pharmaceutical preparations
NO930709D0 (en)	1993-02-26	NEW CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC APPLICATION
DK388989D0 (en)	1989-08-08	ACYLCYANOGUANIDINES, THEIR PREPARATION AND USE
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NO971424D0 (en)	1997-03-25	Novel heterocyclic substituted imidazoloquinoxalidones, their preparation and use
NO973230D0 (en)	1997-07-11	New peptides, their preparation and use
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DK196389D0 (en)	1989-04-24	N-SUBSTITUTED N-AMINO-PYRROLES, THEIR PREPARATION AND USE
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Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees