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NO20053211L - Forbindelser for behandling av metabolske forstyrrelser. - Google Patents

Forbindelser for behandling av metabolske forstyrrelser.

Info

Publication number
NO20053211L
NO20053211L NO20053211A NO20053211A NO20053211L NO 20053211 L NO20053211 L NO 20053211L NO 20053211 A NO20053211 A NO 20053211A NO 20053211 A NO20053211 A NO 20053211A NO 20053211 L NO20053211 L NO 20053211L
Authority
NO
Norway
Prior art keywords
carbon atoms
alkyl
ring
hydrogen
formula
Prior art date
Application number
NO20053211A
Other languages
English (en)
Other versions
NO20053211D0 (no
NO334606B1 (no
Inventor
Reid W Von Borstel
Shalini Sharma
Kirvin L Hodge
Albert Lee
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of NO20053211D0 publication Critical patent/NO20053211D0/no
Publication of NO20053211L publication Critical patent/NO20053211L/no
Publication of NO334606B1 publication Critical patent/NO334606B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Midler anvendelige for behandling av forskjellige metabolske lidelser, så som insulinresistens-syndrom, diabetes, hyperlipidemi, fettleversykdom, kakeksi, fedme, aterosklerose og arteriosklerose er beskrevet. Formel (I) hvor n er 1 eller 2; m er 0, 1, 2,4 eller 5; q er 0 eller 1; t er 0 eller 1; Rer alkyl som har fra 1 til 3 karbonatomer; Rer hydrogen, halogen, alkyl som har fra 1 til 3 karbonatomer eller alkoksy som har fra 1 til 3 karbonatomer; A er fenyl, usubstituert eller substituert med 1 eller 2 grupper valgt fra: halogen, alkyl som har 1 eller 2 karbonatomer, perfluormetyl, alkoksy som har 1 eller 2 karbonatomer og perfluormetoksy; eller sykloalkyl som har fra 3 til 6 ring-karbonatomer hvor sykloalkyl er usubstituert eller ett eller to ring-karbonatomer uavhengig er mono-substituert med metyl eller etyl; eller en 5- eller 6-leddet heteroaromatisk ring som har 1 eller 2 ring-heteroatomer valgt fra N, S og 0 og den heteroaromatiske ring er kovalent bundet til resten av forbindelsen med formel I ved et ringkarbon; og Rer hydrogen eller alkyl som har 1 eller 2 karbonatomer. Alternativt når Rer hydrogen, kan det biologisk aktive middel være et farmasøytisk akseptabelt salt av forbindelsen med formel (I).
NO20053211A 2003-02-13 2005-06-30 Forbindelser, farmasøytiske preparater inneholdende slike samt slike forbindelser og preparater for behandling av metabolske forstyrrelser NO334606B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44716803P 2003-02-13 2003-02-13
PCT/US2004/003718 WO2004073611A2 (en) 2003-02-13 2004-02-09 Compounds for the treatment of metabolic disorders

Publications (3)

Publication Number Publication Date
NO20053211D0 NO20053211D0 (no) 2005-06-30
NO20053211L true NO20053211L (no) 2005-10-20
NO334606B1 NO334606B1 (no) 2014-04-22

Family

ID=32908414

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053211A NO334606B1 (no) 2003-02-13 2005-06-30 Forbindelser, farmasøytiske preparater inneholdende slike samt slike forbindelser og preparater for behandling av metabolske forstyrrelser

Country Status (19)

Country Link
US (3) US7615575B2 (no)
EP (2) EP2266946A3 (no)
JP (2) JP4697962B2 (no)
KR (1) KR101106631B1 (no)
CN (1) CN1750758B (no)
AU (2) AU2004212905B2 (no)
BR (1) BRPI0407506A (no)
CA (1) CA2513092C (no)
ES (1) ES2530235T3 (no)
HK (1) HK1079400A1 (no)
IL (1) IL169332A (no)
MX (1) MXPA05008600A (no)
NO (1) NO334606B1 (no)
NZ (1) NZ542072A (no)
PL (1) PL377712A1 (no)
RU (2) RU2005128501A (no)
UA (1) UA81013C2 (no)
WO (1) WO2004073611A2 (no)
ZA (1) ZA200504558B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101910B2 (en) * 2001-06-12 2006-09-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2502297C (en) * 2002-11-01 2011-12-13 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
NZ542072A (en) * 2003-02-13 2007-11-30 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
RU2358722C2 (ru) 2003-04-15 2009-06-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических расстройств
US7361686B2 (en) 2003-04-22 2008-04-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN100348186C (zh) * 2003-04-30 2007-11-14 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
AU2004266673B2 (en) * 2003-08-20 2010-08-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1868595B1 (en) * 2005-04-01 2012-01-11 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) * 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
NZ569728A (en) * 2006-01-25 2010-11-26 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
CA2637375A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7947735B2 (en) * 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US20090176885A1 (en) * 2006-02-02 2009-07-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637884A1 (en) 2006-02-13 2007-08-23 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
MX2008011022A (es) * 2006-02-28 2008-09-10 Wellstat Therapeutics Corp Compuestos para el tratamiento de trastornos metabolicos.
EP2001461A4 (en) * 2006-03-31 2010-06-09 Wellstat Therapeutics Corp COMBINATION TREATMENT FOR METABOLISM DISEASES
CA2651598A1 (en) * 2006-05-18 2007-11-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US20100234464A1 (en) * 2006-06-09 2010-09-16 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
NZ574664A (en) * 2006-08-17 2012-06-29 Wellstat Therapeutics Corp Combination treatment for metabolic disorders comprising an incretin mimetic such as exendin or a dppv iv inhibitor
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
JP5496913B2 (ja) * 2008-01-15 2014-05-21 ウェルスタット セラピューティクス コーポレイション 代謝異常の治療のための化合物
AU2013200226B2 (en) * 2008-03-13 2015-01-15 Wellstat Therapeutics Corporation Compounds and method for reducing uric acid
RU2501555C2 (ru) * 2008-03-13 2013-12-20 Веллстат Терапьютикс Корпорейшн Соединения и способ снижения мочевой кислоты
JP5806221B2 (ja) 2009-10-13 2015-11-10 ウェルスタット セラピューティクス コーポレイション 尿酸を減少させる３−置換化合物
US20130331452A1 (en) 2010-09-08 2013-12-12 Wellstat Therapeutics Corporation Benzoic acid compounds for reducing uric acid
CN102399148B (zh) * 2010-09-14 2014-03-05 中国科学院成都生物研究所 一类降血脂化合物及其制备方法和用途
FR2976943B1 (fr) * 2011-06-23 2013-07-12 Metabolys Derives de piperazine, leurs procedes de preparation et leurs utilisations dans le traitement de l'insulinoresistance
DK3203998T3 (da) * 2014-10-10 2021-05-31 Liminal Biosciences Ltd Substituerede aromatiske forbindelser og farmaceutiske sammensætninger til forebyggelse og behandling af diabetes
US10702488B2 (en) * 2017-12-19 2020-07-07 Theriac Biomedical Inc. PPAR-γ activators, HDAC inhibitors and their therapeutical usages
US11497723B1 (en) * 2017-12-19 2022-11-15 Tony Antakly PPAR-gamma activators, HDAC inhibitors and their therapeutical usages
JP2022504707A (ja) * 2018-10-11 2022-01-13 ビーエーエスエフ アーエス 芳香族化合物およびその医薬用途

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2100341A (en) * 1934-11-24 1937-11-30 United Shoe Machinery Corp Shoe bottom coating machine
GB1393854A (en) * 1973-02-26 1975-05-14 Pfizer Benzoic acid compounds and pharmaceutical compositions containing them
US4098816A (en) * 1973-08-23 1978-07-04 Beecham Group Limited Polycyclic oxy-aromatic acid
AR203883A1 (es) * 1974-01-14 1975-10-31 Isf Spa Procedimiento para la preparacion de acido 4-ciclopropilmetilenoxi-3-clorofenilacetico
CS175831B1 (no) 1974-12-17 1977-05-31
GB1561350A (en) 1976-11-05 1980-02-20 May & Baker Ltd Benzamide derivatives
DE2962737D1 (en) * 1978-11-14 1982-06-24 Sagami Chem Res Process for the preparation of aromatically substituted acetic acids
DE3575127D1 (de) 1984-02-14 1990-02-08 Hirai Hidefumi Herstellung substituierter ungesaettigter sechsgliedriger ringverbindungen aus phenolabkoemmlingen.
EP0279630B1 (en) 1987-02-16 1993-10-13 Konica Corporation Developer for light-sensitive lithographic printing plate capable of processing commonly the negative-type and the positive type and developer composition for light-sensitive material
JPH0770025B2 (ja) 1987-09-16 1995-07-31 富士通株式会社 薄膜磁気ヘッドの製造方法
US4923501A (en) 1987-11-04 1990-05-08 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivatives, processes for their production, and herbicidal method and compositions
DE3738406A1 (de) * 1987-11-12 1989-05-24 Henkel Kgaa Sebosuppressive topische zubereitungen
JPH01216961A (ja) 1988-02-25 1989-08-30 Takeda Chem Ind Ltd １２−リポキシゲネース阻害剤
GB8806471D0 (en) * 1988-03-18 1988-04-20 Tisdale M J Biologically active material characterised by catabolic activity generally associated with cachexia inducing tumours
US4897397A (en) * 1988-12-16 1990-01-30 Schering Corporation Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents
JPH0348603A (ja) 1989-07-14 1991-03-01 Wakayama Pref Gov 抗菌防臭材料
HUT60458A (en) 1991-02-01 1992-09-28 Sandoz Ag Process for producing benzyloxyphenyl derivatives and pharmaceutical compositions comprising same
US5589492A (en) * 1992-04-10 1996-12-31 Smithkline Beecham Plc Heterocyclic compounds and their use in the treatment of Type-II diabetes
WO1994005153A1 (en) 1992-09-09 1994-03-17 E.I. Du Pont De Nemours And Company Herbicidal benzene compounds
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JPH06293700A (ja) 1993-04-08 1994-10-21 Nippon Soda Co Ltd ６−クロロサリチル酸の製造法
GB9315595D0 (en) 1993-07-28 1993-09-08 Res Inst Medicine Chem New compounds
JPH07206658A (ja) 1994-01-12 1995-08-08 Shiseido Co Ltd 尋常性座瘡治療剤
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
JPH08119959A (ja) 1994-10-20 1996-05-14 Oyo Seikagaku Kenkyusho キサントン誘導体及びこれを有効成分とするモノアミン酸化酵素阻害剤
US5728718A (en) 1994-12-20 1998-03-17 The United States Of America As Represented By The Department Of Health And Human Services 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
US5530157A (en) 1995-02-16 1996-06-25 Scios Nova Inc. Anti-inflammatory benzoic acid derivatives
FR2730731B1 (fr) 1995-02-20 1997-04-04 Rhone Poulenc Chimie Procede de carboxylation d'un ether aromatique
AU4953796A (en) 1995-03-15 1996-10-02 Sanyko Company, Limited Dipeptide compounds having ahpba structure
JPH08325250A (ja) 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規置換フェノール誘導体
US5519133A (en) 1995-06-02 1996-05-21 American Cyanamid Co. 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
AU1698997A (en) 1996-01-16 1997-08-11 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
JP4073489B2 (ja) 1996-05-24 2008-04-09 ニューロサーチ・アクティーゼルスカブ 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法
EP1270571B1 (en) 1996-07-19 2006-09-06 Takeda Pharmaceutical Company Limited Heterocyclic compounds, their production and use
AU725403B2 (en) * 1996-09-13 2000-10-12 Merck & Co., Inc. Thrombin inhibitors
JPH1087489A (ja) 1996-09-13 1998-04-07 Sankyo Co Ltd Ａｈｐｂａ構造含有ジペプチド化合物を有効成分とする医薬
JP3981771B2 (ja) 1996-10-19 2007-09-26 株式会社クレハ ２−ベンジルオキシ−６−アルコキシ安息香酸誘導体、その製造方法及び、農園芸用殺菌剤
WO1999011255A1 (fr) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Regulateurs du recepteur active par les agents de proliferation des peroxysomes
EP1015453A4 (en) 1997-09-09 2001-09-19 Merck & Co Inc TYPE 3- (IODOPHENOXYMETHYL) CARBAPENEM ANTIBACTERIALS
CA2304285A1 (en) 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Sulfonyl derivatives
CN1103332C (zh) 1997-10-14 2003-03-19 旭化成株式会社 联苯基－5－链烷羧酸衍生物和其应用
BR9909781A (pt) 1998-04-20 2000-12-19 Fujisawa Pharmaceutical Co Composto de formula (i), processo para sua preparação, composição farmacêutica compreendendo dito composto, seu uso e método.
JP4154773B2 (ja) 1998-11-13 2008-09-24 住友電気工業株式会社 単結晶製造方法および装置
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
CA2325358C (en) 1999-11-10 2005-08-02 Pfizer Products Inc. 7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein b
WO2001036351A2 (en) * 1999-11-19 2001-05-25 Corvas International, Inc. Plasminogen activator inhibitor antagonists related applications
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
US6632765B1 (en) 2000-06-23 2003-10-14 Chervon U.S.A. Inc. Catalyst regeneration via reduction with hydrogen
PL214670B1 (pl) 2000-06-28 2013-08-30 Amgen Inc Chinolinylowe modulatory PPAR-gamma, kompozycja je zawierajaca, zwiazek do zastosowania w leczeniu lub zapobieganiu chorobom oraz zastosowanie zwiazku do wytwarzania leku
AU2001267878A1 (en) 2000-07-05 2002-01-14 Ajinomoto Co. Inc. Hypoglycemics
UY26911A1 (es) 2000-08-29 2002-03-22 Abbott Lab Ácidos amino (oxo) acéticos inhibidores de la proteina tirosina fosfatasa
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7101910B2 (en) * 2001-06-12 2006-09-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DE10135027A1 (de) * 2001-07-18 2003-02-06 Solvay Pharm Gmbh Verwendung Trifluoracetylalkyl-substituierter Phenyl-, Phenol- und Benzoylderivate in der Behandlung und/oder Prophylaxe von Obestias und deren Begleit- und/oder Folgeerkrankungen
AU2003211384B2 (en) * 2002-02-21 2008-12-11 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivative and use thereof
CA2502297C (en) * 2002-11-01 2011-12-13 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DE10257785A1 (de) * 2002-12-11 2004-07-01 Bayer Healthcare Ag Isophthalsäurederivate
EP1593667A4 (en) * 2003-02-12 2009-03-04 Takeda Pharmaceutical AMINE DERIVATIVE
NZ542072A (en) * 2003-02-13 2007-11-30 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
JP4282345B2 (ja) 2003-03-12 2009-06-17 株式会社日立製作所 半導体集積回路装置
RU2358722C2 (ru) 2003-04-15 2009-06-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических расстройств
US7361686B2 (en) * 2003-04-22 2008-04-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN100348186C (zh) * 2003-04-30 2007-11-14 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
US7470807B2 (en) * 2003-08-14 2008-12-30 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivatives and use thereof
AU2004266673B2 (en) 2003-08-20 2010-08-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2536089A1 (en) 2003-08-20 2005-03-03 Eli Lilly And Company Ppar modulators
US7541455B2 (en) * 2003-12-22 2009-06-02 Ventana Medical Systems, Inc. Microwave mediated synthesis of nucleic acid probes
EP1868595B1 (en) 2005-04-01 2012-01-11 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
NZ569728A (en) 2006-01-25 2010-11-26 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
US7947735B2 (en) 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US20090176885A1 (en) 2006-02-02 2009-07-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637884A1 (en) 2006-02-13 2007-08-23 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2651598A1 (en) 2006-05-18 2007-11-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

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US7605181B2 (en) 2009-10-20
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AU2008229824A1 (en) 2008-10-30
AU2004212905A1 (en) 2004-09-02
US20080015254A1 (en) 2008-01-17
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