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NO20042024L - 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer - Google Patents

4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer

Info

Publication number
NO20042024L
NO20042024L NO20042024A NO20042024A NO20042024L NO 20042024 L NO20042024 L NO 20042024L NO 20042024 A NO20042024 A NO 20042024A NO 20042024 A NO20042024 A NO 20042024A NO 20042024 L NO20042024 L NO 20042024L
Authority
NO
Norway
Prior art keywords
hydroxyphenyl
alkoxy
treatment
pde4 inhibitors
pyrrolidone derivatives
Prior art date
Application number
NO20042024A
Other languages
English (en)
Norwegian (no)
Inventor
Hans Juergen Ernst Hess
Allen Hopper
Ashok Tehim
Michael De Vivo
Ruiping Liu
Erik Kuester
Original Assignee
Memory Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp filed Critical Memory Pharm Corp
Publication of NO20042024L publication Critical patent/NO20042024L/no

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
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  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
NO20042024A 2001-10-16 2004-05-14 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer NO20042024L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32931401P 2001-10-16 2001-10-16
PCT/US2002/032834 WO2003032981A1 (en) 2001-10-16 2002-10-16 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes

Publications (1)

Publication Number Publication Date
NO20042024L true NO20042024L (no) 2004-05-14

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NO20042024A NO20042024L (no) 2001-10-16 2004-05-14 4-(4-alkoksy-3-hydroksyfenyl)-2-pyrrolidonderivater som PDE4-inhibitorer for behandling av nevrologiske syndromer

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US (3) US7235579B2 (es)
EP (1) EP1435944B1 (es)
JP (2) JP4484515B2 (es)
KR (2) KR20090080573A (es)
CN (1) CN1604776A (es)
AT (1) ATE444065T1 (es)
AU (1) AU2002335015B8 (es)
BR (1) BR0213660A (es)
CA (1) CA2463469A1 (es)
CO (1) CO5570674A2 (es)
DE (1) DE60233884D1 (es)
ES (1) ES2334650T3 (es)
HR (1) HRP20040409A2 (es)
IL (1) IL161317A0 (es)
MX (1) MXPA04003516A (es)
NO (1) NO20042024L (es)
NZ (1) NZ532288A (es)
RU (2) RU2340600C2 (es)
WO (1) WO2003032981A1 (es)
ZA (1) ZA200402856B (es)

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US9931318B2 (en) 2003-04-08 2018-04-03 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
ATE444488T1 (de) * 2000-12-14 2009-10-15 Burnham Inst Non-apoptotische formen des zelltods und verfahren zur modulation
DE60233884D1 (de) 2001-10-16 2009-11-12 Memory Pharmaceutical Corp 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-derivate als pde-4-hemmer zur behandlung von neurologischen syndromen
US20030157053A1 (en) * 2002-02-19 2003-08-21 Sabina Sperandio Modulators of paraptosis and related methods
US7495016B2 (en) 2002-10-21 2009-02-24 Irm Llc Pyrrolidones with anti-HIV activity
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006523710A (ja) * 2003-04-16 2006-10-19 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ４インヒビター
JP2006525312A (ja) * 2003-04-28 2006-11-09 アブ サイエンス 脳虚血を治療するためのチロシンキナーゼ阻害剤の使用方法
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
JP2008517066A (ja) * 2004-10-20 2008-05-22 メモリー ファーマシューティカルス コーポレーション ホスホジエステラーゼ４阻害剤
ZA200803758B (en) 2005-11-15 2009-08-26 Otsuka Pharma Co Ltd Oxazole compound and pharmaceutical composition
CA2635262C (en) * 2005-12-30 2011-08-16 Merck & Co., Inc. 1, 3-oxazolidin-2-one derivatives useful as cetp inhibitors
SG10201407258RA (en) * 2006-05-19 2015-01-29 Dart Neuroscience Cayman Ltd Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
ES2320954B1 (es) * 2007-03-02 2010-03-16 Laboratorio Almirall S.A. Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
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