NO176911C - Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling - Google Patents

Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling

Info

Publication number: NO176911C
Authority: NO; Norway
Prior art keywords: preparation; doxorubicin; diode; compounds; morpholinyl derivatives
Prior art date: 1989-12-19

Application number

NO940831A

Other languages

English (en)

Other versions

NO176911B (no

NO940831L (no

NO940831D0 (no

Inventor

Alberto Bargiotti

Maria Grandi

Antonino Suarato

Daniela Faiardi

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-19

Filing date

1994-03-09

Publication date

1995-06-21

1989-12-19 Priority claimed from GB898928654A external-priority patent/GB8928654D0/en

1990-04-03 Priority claimed from GB909007513A external-priority patent/GB9007513D0/en

1991-08-14 Publication of NO940831L publication Critical patent/NO940831L/no

1994-03-09 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1994-03-09 Priority to NO940831A priority Critical patent/NO176911C/no

1994-03-09 Publication of NO940831D0 publication Critical patent/NO940831D0/no

1995-03-13 Publication of NO176911B publication Critical patent/NO176911B/no

1995-06-21 Publication of NO176911C publication Critical patent/NO176911C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/313—Compounds having groups containing halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

NO940831A 1989-12-19 1994-03-09 Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling NO176911C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO940831A NO176911C (no)	1989-12-19	1994-03-09	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB898928654A GB8928654D0 (en)	1989-12-19	1989-12-19	Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en)	1990-04-03	1990-04-03	Morpholinyl derivatives of doxorubicin and process for their preparation
PCT/EP1990/002229 WO1991009046A1 (en)	1989-12-19	1990-12-18	Morpholinyl derivatives of doxorubicin and process for their preparation
NO913176A NO175533C (no)	1989-12-19	1991-08-14	Fremstilling av morfolinylderivater av doxorubicin
NO940831A NO176911C (no)	1989-12-19	1994-03-09	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling

Publications (4)

Publication Number	Publication Date
NO940831L NO940831L (no)	1991-08-14
NO940831D0 NO940831D0 (no)	1994-03-09
NO176911B NO176911B (no)	1995-03-13
NO176911C true NO176911C (no)	1995-06-21

Family

ID=26296395

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO913176A NO175533C (no)	1989-12-19	1991-08-14	Fremstilling av morfolinylderivater av doxorubicin
NO940831A NO176911C (no)	1989-12-19	1994-03-09	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO913176A NO175533C (no)	1989-12-19	1991-08-14	Fremstilling av morfolinylderivater av doxorubicin

Country Status (28)

Country	Link
EP (1)	EP0434960B1 (no)
JP (1)	JP3300342B2 (no)
KR (1)	KR0183033B1 (no)
CN (2)	CN1024922C (no)
AT (1)	ATE143023T1 (no)
AU (1)	AU636429B2 (no)
CA (1)	CA2046857C (no)
CZ (1)	CZ281949B6 (no)
DE (1)	DE69028610T2 (no)
DK (1)	DK0434960T3 (no)
ES (1)	ES2094136T3 (no)
FI (1)	FI97389C (no)
GR (1)	GR3021557T3 (no)
HR (1)	HRP921226B1 (no)
HU (2)	HU209433B (no)
IE (1)	IE81174B1 (no)
IL (3)	IL111527A (no)
MY (1)	MY119192A (no)
NO (2)	NO175533C (no)
NZ (1)	NZ243695A (no)
PT (1)	PT96226B (no)
RU (1)	RU2100366C1 (no)
SI (1)	SI9012379B (no)
SK (1)	SK621990A3 (no)
TW (1)	TW208019B (no)
UA (1)	UA27108A1 (no)
WO (1)	WO1991009046A1 (no)
YU (1)	YU48136B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843903A (en) *	1995-11-27	1998-12-01	The Administrators Of The Tulane Educational Fund	Targeted cytotoxic anthracycline analogs
WO2001049698A1 (en) *	1999-12-29	2001-07-12	Immunogen, Inc.	Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
EP2075014B9 (en)	2002-05-24	2012-02-01	Angiotech International Ag	Compositions and methods for coating medical implants
US20040146546A1 (en)	2002-09-26	2004-07-29	Angiotech Pharmaceuticals, Inc.	Perivascular wraps
WO2004060346A2 (en)	2002-12-30	2004-07-22	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
CA2519310A1 (en) *	2003-03-18	2004-09-30	Maria Adele Pacciarini	Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
EP2049530A2 (en) *	2006-07-12	2009-04-22	Nerviano Medical Sciences S.r.l.	Crystalline nemorubicin hydrochloride
CN101555264B (zh) *	2008-04-11	2014-09-03	天津和美生物技术有限公司	具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CN101353361B (zh) *	2008-08-08	2011-06-01	中国人民解放军第四军医大学	一种阿霉素前体药物的制备方法及其应用
RU2563638C2 (ru) *	2010-12-02	2015-09-20	НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.	Способ получения производных морфолинилантрациклина
CN105164138B (zh)	2013-04-29	2017-11-07	内尔维阿诺医学科学有限公司	新吗啉基蒽环类抗生素衍生物
US10201589B2 (en)	2013-12-11	2019-02-12	University Of Massachusetts	Compositions and methods for treating disease using Salmonella T3SS effector protein (SipA)
EP3215513B1 (en)	2014-11-05	2019-05-08	Nerviano Medical Sciences S.r.l.	Functionalized morpholinyl anthracycline derivatives
CN115043895A (zh) *	2022-07-15	2022-09-13	戊言医药科技（上海）有限公司	一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) *	2022-08-15	2024-02-22	Synaffix B.V.	Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2883443A (en) *	1956-07-13	1959-04-21	Ruetschi Karl	Lead-acid storage battery
US4423123A (en) *	1980-04-17	1983-12-27	Shin-Kobe Electric Machinery Co., Ltd.	Electric storage battery and a method of making the same
JPS57163393A (en) *	1981-03-27	1982-10-07	Microbial Chem Res Found	Novel anthracyclin derivative and its preparation
US4363857A (en) *	1981-10-16	1982-12-14	General Motors Corporation	Laminated metal-plastic battery grid
US4710564A (en) *	1985-01-18	1987-12-01	Microbial Chemistry Research Foundation	Anthracycline compounds
GB2172594B (en) *	1985-03-22	1988-06-08	Erba Farmitalia	New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) *	1986-02-14	1987-01-23	Dainippon Ink & Chem Inc	微多孔中空繊維の製造法
US4861836A (en) *	1986-12-23	1989-08-29	Daikin Industries Ltd.	Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

1990
- 1990-11-15 AT AT90121905T patent/ATE143023T1/de not_active IP Right Cessation
- 1990-11-15 ES ES90121905T patent/ES2094136T3/es not_active Expired - Lifetime
- 1990-11-15 DE DE69028610T patent/DE69028610T2/de not_active Expired - Fee Related
- 1990-11-15 DK DK90121905.5T patent/DK0434960T3/da active
- 1990-11-15 EP EP90121905A patent/EP0434960B1/en not_active Expired - Lifetime
- 1990-12-12 SK SK6219-90A patent/SK621990A3/sk unknown
- 1990-12-12 NZ NZ243695A patent/NZ243695A/xx unknown
- 1990-12-12 CZ CS906219A patent/CZ281949B6/cs not_active IP Right Cessation
- 1990-12-12 IL IL111527A patent/IL111527A/en not_active IP Right Cessation
- 1990-12-12 IL IL9664390A patent/IL96643A/en not_active IP Right Cessation
- 1990-12-14 TW TW079110518A patent/TW208019B/zh active
- 1990-12-17 SI SI9012379A patent/SI9012379B/sl not_active IP Right Cessation
- 1990-12-17 MY MYPI94001426A patent/MY119192A/en unknown
- 1990-12-17 IE IE454390A patent/IE81174B1/en not_active IP Right Cessation
- 1990-12-17 PT PT96226A patent/PT96226B/pt not_active IP Right Cessation
- 1990-12-17 YU YU237990A patent/YU48136B/sh unknown
- 1990-12-18 KR KR1019910700930A patent/KR0183033B1/ko not_active IP Right Cessation
- 1990-12-18 AU AU69194/91A patent/AU636429B2/en not_active Ceased
- 1990-12-18 WO PCT/EP1990/002229 patent/WO1991009046A1/en active IP Right Grant
- 1990-12-18 RU SU915001540A patent/RU2100366C1/ru not_active IP Right Cessation
- 1990-12-18 HU HU9200656A patent/HU209433B/hu unknown
- 1990-12-18 HU HU912994A patent/HU208148B/hu not_active IP Right Cessation
- 1990-12-18 CA CA002046857A patent/CA2046857C/en not_active Expired - Fee Related
- 1990-12-18 JP JP50124491A patent/JP3300342B2/ja not_active Expired - Fee Related
- 1990-12-18 UA UA5001540A patent/UA27108A1/uk unknown
- 1990-12-18 CN CN90110144A patent/CN1024922C/zh not_active Expired - Fee Related
1991
- 1991-08-14 NO NO913176A patent/NO175533C/no unknown
- 1991-08-16 FI FI913887A patent/FI97389C/fi active
1992
- 1992-11-11 HR HRP-2379/90A patent/HRP921226B1/xx not_active IP Right Cessation
1993
- 1993-03-05 CN CN93102413A patent/CN1039708C/zh not_active Expired - Fee Related
1994
- 1994-03-09 NO NO940831A patent/NO176911C/no unknown
- 1994-11-04 IL IL11152794A patent/IL111527A0/xx unknown
1996
- 1996-11-06 GR GR960402934T patent/GR3021557T3/el unknown

Also Published As

Publication number	Publication date
SI9012379A (en)	1997-12-31
ES2094136T3 (es)	1997-01-16
WO1991009046A1 (en)	1991-06-27
TW208019B (no)	1993-06-21
SK278994B6 (sk)	1998-05-06
HU209433B (en)	1994-06-28
NO176911B (no)	1995-03-13
CA2046857A1 (en)	1991-06-20
CA2046857C (en)	2001-06-12
JPH04503679A (ja)	1992-07-02
FI97389C (fi)	1996-12-10
PT96226B (pt)	1998-06-30
FI97389B (fi)	1996-08-30
CZ621990A3 (en)	1997-01-15
PT96226A (pt)	1991-09-30
YU48136B (sh)	1997-05-28
CN1053238A (zh)	1991-07-24
IE904543A1 (en)	1991-06-19
YU237990A (sh)	1993-05-28
NO913176L (no)	1991-08-14
AU6919491A (en)	1991-07-18
IE81174B1 (en)	2000-06-14
HRP921226A2 (en)	1995-12-31
DE69028610T2 (de)	1997-02-06
UA27108A1 (uk)	2000-02-28
IL96643A0 (en)	1991-09-16
EP0434960A1 (en)	1991-07-03
HU912994D0 (en)	1992-01-28
CN1024922C (zh)	1994-06-08
NO913176D0 (no)	1991-08-14
KR920701228A (ko)	1992-08-11
DK0434960T3 (da)	1996-10-14
ATE143023T1 (de)	1996-10-15
FI913887A0 (fi)	1991-08-16
HU9200656D0 (en)	1992-05-28
HRP921226B1 (en)	1998-10-31
IL96643A (en)	1995-01-24
MY119192A (en)	2005-04-30
NZ243695A (en)	1993-06-25
RU2100366C1 (ru)	1997-12-27
IL111527A (en)	1998-02-22
HUT59693A (en)	1992-06-29
NO175533C (no)	1994-10-26
NO940831L (no)	1991-08-14
NO940831D0 (no)	1994-03-09
CN1039708C (zh)	1998-09-09
IL111527A0 (en)	1995-01-24
JP3300342B2 (ja)	2002-07-08
GR3021557T3 (en)	1997-02-28
HU208148B (en)	1993-08-30
HUT60232A (en)	1992-08-28
SK621990A3 (en)	1998-05-06
CZ281949B6 (cs)	1997-04-16
NO175533B (no)	1994-07-18
EP0434960B1 (en)	1996-09-18
SI9012379B (sl)	2000-02-29
CN1079215A (zh)	1993-12-08
AU636429B2 (en)	1993-04-29
KR0183033B1 (ko)	1999-04-01
DE69028610D1 (de)	1996-10-24

Publication	Publication Date	Title
ATE142630T1 (de)	1996-09-15	Triazin-derivate und unkrautvertilgungsmittel daraus
NO940831L (no)	1991-08-14	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
AU9281198A (en)	1999-04-23	Benzofuran derivatives
ATE172463T1 (de)	1998-11-15	Pyrrolocarbazol
ES2068413T3 (es)	1995-04-16	Derivados de 4-fenilftalazina.
MX9101270A (es)	1992-07-08	Compuesto,preparacion y uso
ATE63921T1 (de)	1991-06-15	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
FI913699A0 (fi)	1991-08-02	Menetelmä farmaseuttisesti käyttökelpoisten 4'-epi-4'-aminoantrasykliinien valmistamiseksi sekä menetelmässä käytettävät välituotteet
ATE105565T1 (de)	1994-05-15	Pradimicinderivate.
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
EP0421668A3 (en)	1991-08-07	1,4-dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents