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MXPA04005886A - Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6. - Google Patents

Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.

Info

Publication number
MXPA04005886A
MXPA04005886A MXPA04005886A MXPA04005886A MXPA04005886A MX PA04005886 A MXPA04005886 A MX PA04005886A MX PA04005886 A MXPA04005886 A MX PA04005886A MX PA04005886 A MXPA04005886 A MX PA04005886A MX PA04005886 A MXPA04005886 A MX PA04005886A
Authority
MX
Mexico
Prior art keywords
hydroxytryptamine
ligands
azaindolylalkylamine
derivatives
azaindolylalkylamine derivatives
Prior art date
Application number
MXPA04005886A
Other languages
English (en)
Inventor
Charles Bernotas Ronald
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA04005886A publication Critical patent/MXPA04005886A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion proporciona un compuesto de la formula (I) y el uso del mismo para el tratamiento terapeutico de desordenes relacionados a o afectados por el receptor 5-HT6.(ver formula I).
MXPA04005886A 2001-12-20 2002-12-17 Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6. MXPA04005886A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34283801P 2001-12-20 2001-12-20
PCT/US2002/040220 WO2003053970A1 (en) 2001-12-20 2002-12-17 Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands

Publications (1)

Publication Number Publication Date
MXPA04005886A true MXPA04005886A (es) 2004-09-13

Family

ID=23343489

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005886A MXPA04005886A (es) 2001-12-20 2002-12-17 Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.

Country Status (22)

Country Link
US (3) US6800640B2 (es)
EP (1) EP1456206B1 (es)
JP (1) JP4339123B2 (es)
KR (1) KR20040077861A (es)
CN (1) CN1620455A (es)
AR (1) AR037907A1 (es)
AT (1) ATE396191T1 (es)
AU (1) AU2002360618B2 (es)
BR (1) BR0215151A (es)
CA (1) CA2470832C (es)
CO (1) CO5590960A2 (es)
DE (1) DE60226775D1 (es)
DK (1) DK1456206T3 (es)
ES (1) ES2305338T3 (es)
IL (1) IL162242A0 (es)
MX (1) MXPA04005886A (es)
NO (1) NO20043099L (es)
PL (1) PL370890A1 (es)
RU (1) RU2004122094A (es)
TW (1) TW200301251A (es)
WO (1) WO2003053970A1 (es)
ZA (1) ZA200405733B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2222828B1 (es) * 2003-07-30 2006-04-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
CN1902193B (zh) 2003-12-04 2011-07-13 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的喹喔啉
CA2569887A1 (en) 2004-06-09 2005-12-22 Glaxo Group Limited Pyrrolopyridine derivatives
ATE466013T1 (de) * 2004-09-03 2010-05-15 Yuhan Corp Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung
AU2005280740B2 (en) * 2004-09-03 2011-04-28 Yuhan Corporation Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof
KR101142363B1 (ko) 2005-06-27 2012-05-21 주식회사유한양행 피롤로피리딘 유도체를 포함하는 항암제 조성물
EP1947085A1 (en) * 2007-01-19 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted indole sulfonamide compounds, their preparation and use as medicaments
MX2009012623A (es) * 2007-05-21 2009-12-11 Sgx Pharmaceuticals Inc Moduladores de cinasa heterociclicos.
US20080318941A1 (en) * 2007-05-24 2008-12-25 Memory Pharmaceuticals Corporation 4' substituted compounds having 5-ht6 receptor affinity
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
EP2356116A1 (en) * 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
WO2011019634A2 (en) * 2009-08-10 2011-02-17 Taipei Medical University Aryl substituted sulfonamide compounds and their use as anticancer agents
EP2569315A1 (en) 2010-05-14 2013-03-20 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
EP2714688B1 (en) 2011-05-26 2016-02-24 Daiichi Sankyo Company, Limited Heterocyclic compounds as protein kinase inhibitors
CA2841361A1 (en) 2011-07-22 2013-01-31 Glaxosmithkline Llc Composition for the treatment of allergic diseases and inflammatory conditions
JP6196674B2 (ja) 2012-08-24 2017-09-13 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ ピラゾロピリミジン化合物
AU2013348217B2 (en) 2012-11-20 2016-10-06 Glaxosmithkline Llc Novel compounds
ES2625023T3 (es) 2012-11-20 2017-07-18 Glaxosmithkline Llc Compuestos novedosos
UA114645C2 (uk) 2012-11-20 2017-07-10 Ґлаксосмітклайн Ллк Піролопіримідини як індуктори інтерферону людини
CN102977094A (zh) * 2012-11-30 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 一种2-羟基-1,5-萘啶的合成方法
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
WO2016004882A1 (en) 2014-07-08 2016-01-14 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
RU2725886C1 (ru) 2017-03-30 2020-07-07 ЭксДабл-Ю ЛЭБОРЕТРИЗ ИНК. Бициклические гетероарильные производные и их получение и применение

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977131A (en) 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
US6100291A (en) * 1998-03-16 2000-08-08 Allelix Biopharmaceuticals Inc. Pyrrolidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
DE69937372T2 (de) * 1999-04-21 2008-06-26 Nps Allelix Corp., Mississauga Piperidin-indol derivate mit 5-ht6 affinität
CA2382247C (en) * 1999-08-12 2010-09-28 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
CN1309385C (zh) * 2001-12-20 2007-04-11 惠氏公司 作为5－羟色胺－6配体的吲哚基烷基胺衍生物
CA2590841A1 (en) * 2004-12-14 2006-06-22 Wyeth Use of a 5-ht6 agonist for the treatment and prevention of neurodegenerative disorders

Also Published As

Publication number Publication date
NO20043099L (no) 2004-08-17
DE60226775D1 (de) 2008-07-03
ZA200405733B (en) 2005-10-19
JP4339123B2 (ja) 2009-10-07
CN1620455A (zh) 2005-05-25
US20030171395A1 (en) 2003-09-11
US7297705B2 (en) 2007-11-20
CA2470832A1 (en) 2003-07-03
AR037907A1 (es) 2004-12-22
AU2002360618B2 (en) 2009-01-08
ATE396191T1 (de) 2008-06-15
EP1456206B1 (en) 2008-05-21
JP2005519046A (ja) 2005-06-30
US6800640B2 (en) 2004-10-05
CA2470832C (en) 2010-09-21
DK1456206T3 (da) 2008-09-08
KR20040077861A (ko) 2004-09-07
TW200301251A (en) 2003-07-01
PL370890A1 (en) 2005-05-30
AU2002360618A1 (en) 2003-07-09
IL162242A0 (en) 2005-11-20
CO5590960A2 (es) 2005-12-30
US20080114023A1 (en) 2008-05-15
RU2004122094A (ru) 2005-03-27
WO2003053970A1 (en) 2003-07-03
ES2305338T3 (es) 2008-11-01
BR0215151A (pt) 2004-10-19
US20050020598A1 (en) 2005-01-27
EP1456206A1 (en) 2004-09-15
US7585876B2 (en) 2009-09-08

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