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MX9800809A - Process for preparing solid dosage forms of very low-dose drugs. - Google Patents

Process for preparing solid dosage forms of very low-dose drugs.

Info

Publication number
MX9800809A
MX9800809A MX9800809A MX9800809A MX9800809A MX 9800809 A MX9800809 A MX 9800809A MX 9800809 A MX9800809 A MX 9800809A MX 9800809 A MX9800809 A MX 9800809A MX 9800809 A MX9800809 A MX 9800809A
Authority
MX
Mexico
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Application number
MX9800809A
Other languages
Spanish (es)
Other versions
MXPA98000809A (en
Inventor
James Albert Napper
Neil Mortimer
Karen Triona O'brien
Sultan James Manek
Rajinder Kumar
Michael Sidney George Clark
Julia Mary Loudon
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MXPA98000809A publication Critical patent/MXPA98000809A/en
Publication of MX9800809A publication Critical patent/MX9800809A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A drug formulation process which comprises admixing carrier particles with a solution of drug in water in a quantity of 1-3 percent by weight of solution to total mix and a method of treatment and/or prophylaxis of dementia, which method comprises administering to the patient [R-(Z)]-'alpha'-(methoxyimino)-'alpha'-(1-azabicyclo [2.2.2]oct-3-yl)acetonitrile monohydrochloride at a daily dose below 0.01 mg/kg and pharmaceutical compositions used therein.
MX9800809A 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs. MX9800809A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9515624.6 1995-07-29
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GB9606684.0 1996-03-29
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
PCT/EP1996/003326 WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Publications (2)

Publication Number Publication Date
MXPA98000809A MXPA98000809A (en) 1998-04-01
MX9800809A true MX9800809A (en) 1998-04-30

Family

ID=26307485

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800809A MX9800809A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs.

Country Status (25)

Country Link
EP (1) EP0841902A2 (en)
JP (1) JPH11510493A (en)
KR (1) KR19990035972A (en)
CN (1) CN1196677A (en)
AP (1) AP858A (en)
AR (1) AR004178A1 (en)
AU (1) AU716961B2 (en)
BG (1) BG102266A (en)
BR (1) BR9609804A (en)
CA (1) CA2228048A1 (en)
CZ (1) CZ24798A3 (en)
DZ (1) DZ2077A1 (en)
EA (2) EA199901055A1 (en)
HU (1) HUP9900521A3 (en)
IL (1) IL122897A0 (en)
MA (1) MA23953A1 (en)
MX (1) MX9800809A (en)
NO (1) NO980384L (en)
NZ (1) NZ315632A (en)
OA (1) OA10659A (en)
PL (1) PL325242A1 (en)
SK (1) SK11098A3 (en)
TR (1) TR199800156T1 (en)
UY (1) UY24297A1 (en)
WO (1) WO1997004750A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
CA2323177A1 (en) * 1998-03-11 1999-09-16 Susan Marie Milosovich Composition
FR2796840B1 (en) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION
DK1591121T3 (en) 2000-12-14 2009-10-05 Ortho Mcneil Janssen Pharm Process for the preparation of steroid hormone products containing a stabilizer in non-crystalline form
EP1734930A2 (en) * 2004-04-09 2006-12-27 Smithkline Beecham Corporation Low dose pharmaceutical products

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (en) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd Wet solid pharmaceutical preparation of very small amount of main drug
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
ATE269330T1 (en) * 1989-04-13 2004-07-15 Beecham Group Plc CHEMICAL COMPOUNDS
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
NO980384D0 (en) 1998-01-28
TR199800156T1 (en) 1998-04-21
SK11098A3 (en) 1998-07-08
JPH11510493A (en) 1999-09-14
CZ24798A3 (en) 1998-06-17
NO980384L (en) 1998-03-26
BG102266A (en) 1998-10-30
IL122897A0 (en) 1998-08-16
BR9609804A (en) 1999-07-06
OA10659A (en) 2002-09-18
EA199901055A1 (en) 2000-06-26
DZ2077A1 (en) 2002-07-22
MA23953A1 (en) 1997-04-01
PL325242A1 (en) 1998-07-06
EA000740B1 (en) 2000-02-28
CN1196677A (en) 1998-10-21
CA2228048A1 (en) 1997-02-13
AP9801170A0 (en) 1998-01-31
AP858A (en) 2000-07-12
AU6738496A (en) 1997-02-26
EA199800179A1 (en) 1998-10-29
WO1997004750A2 (en) 1997-02-13
UY24297A1 (en) 1997-01-23
HUP9900521A2 (en) 1999-06-28
HUP9900521A3 (en) 2001-04-28
NZ315632A (en) 1999-11-29
AR004178A1 (en) 1998-11-04
KR19990035972A (en) 1999-05-25
AU716961B2 (en) 2000-03-09
WO1997004750A3 (en) 1997-03-27
EP0841902A2 (en) 1998-05-20

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