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MX340999B - Anticuerpos de peptido relacionado con el gen calcitonina. - Google Patents

Anticuerpos de peptido relacionado con el gen calcitonina.

Info

Publication number
MX340999B
MX340999B MX2012014480A MX2012014480A MX340999B MX 340999 B MX340999 B MX 340999B MX 2012014480 A MX2012014480 A MX 2012014480A MX 2012014480 A MX2012014480 A MX 2012014480A MX 340999 B MX340999 B MX 340999B
Authority
MX
Mexico
Prior art keywords
cgrp
antibodies
cgrp antibodies
antigen
binding fragment
Prior art date
Application number
MX2012014480A
Other languages
English (en)
Other versions
MX2012014480A (es
Inventor
Allan Barrett
James Darling Ryan
Jan Benschop Robert
Geoffrey Chambers Mark
Original Assignee
Eli Lilly And Company *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company * filed Critical Eli Lilly And Company *
Publication of MX2012014480A publication Critical patent/MX2012014480A/es
Publication of MX340999B publication Critical patent/MX340999B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57527—Calcitonin gene related peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un anticuerpo de péptido relacionado con gen de calcitonina (CGRP) diseñado humano o su fragmento de unión a antígeno. Además, la presente invención provee el uso de anticuerpos de péptido relacionado con gene de calcitonina (CGRP) diseñado humano o su fragmento de unión a antígeno para el tratamiento de dolor de osteoartritis.
MX2012014480A 2010-06-10 2011-06-07 Anticuerpos de peptido relacionado con el gen calcitonina. MX340999B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35332310P 2010-06-10 2010-06-10
PCT/US2011/039381 WO2011156324A1 (en) 2010-06-10 2011-06-07 Cgrp antibodies

Publications (2)

Publication Number Publication Date
MX2012014480A MX2012014480A (es) 2013-02-07
MX340999B true MX340999B (es) 2016-08-03

Family

ID=45096388

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005150A MX363209B (es) 2010-06-10 2011-06-07 Anticuerpos de peptido relacionado con el gen calcitonina.
MX2012014480A MX340999B (es) 2010-06-10 2011-06-07 Anticuerpos de peptido relacionado con el gen calcitonina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016005150A MX363209B (es) 2010-06-10 2011-06-07 Anticuerpos de peptido relacionado con el gen calcitonina.

Country Status (34)

Country Link
US (3) US9073991B2 (es)
EP (2) EP2579894B1 (es)
JP (2) JP6021806B2 (es)
KR (1) KR101489566B1 (es)
CN (2) CN104292332B (es)
AR (1) AR081434A1 (es)
AU (1) AU2011265050B2 (es)
BR (1) BR112012031501B1 (es)
CA (1) CA2802102C (es)
CY (2) CY1119789T1 (es)
DK (1) DK2579894T3 (es)
EA (1) EA022931B1 (es)
ES (2) ES2930321T3 (es)
HK (1) HK1203211A1 (es)
HR (1) HRP20171992T1 (es)
HU (2) HUE038135T2 (es)
IL (2) IL222885B (es)
JO (1) JO3330B1 (es)
LT (2) LT2579894T (es)
LU (1) LUC00112I2 (es)
ME (1) ME02862B (es)
MX (2) MX363209B (es)
NL (1) NL300979I2 (es)
NO (2) NO2579894T3 (es)
NZ (1) NZ603607A (es)
PL (1) PL2579894T3 (es)
PT (1) PT2579894T (es)
RS (1) RS56638B1 (es)
SG (1) SG185648A1 (es)
SI (1) SI2579894T1 (es)
TW (1) TWI423818B (es)
UA (1) UA109658C2 (es)
WO (1) WO2011156324A1 (es)
ZA (1) ZA201208996B (es)

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CN105483091A (zh) * 2015-12-29 2016-04-13 天津三箭生物技术股份有限公司 小鼠抗人Calcitonin单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
JP2019501152A (ja) * 2016-01-28 2019-01-17 イーライ リリー アンド カンパニー Ｃｇｒｐ抗体及びその使用
EP3411066A1 (en) 2016-02-01 2018-12-12 Eli Lilly and Company Parathyroid hormone anti-rankl antibody fusion compounds
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EP3515937A1 (en) * 2016-09-23 2019-07-31 Teva Pharmaceuticals International GmbH Treating refractory migraine
US20180111984A1 (en) 2016-09-23 2018-04-26 Teva Pharmaceuticals International Gmbh Treating cluster headache
MX2019010397A (es) 2017-03-02 2020-08-20 Beth Israel Deaconess Medical Ct Inc Seleccion de pacientes de cefalea que responden a anticuerpos dirigidos contra el peptido relacionado con el gen de la calcitonina.
TW201902926A (zh) * 2017-05-03 2019-01-16 美商美國禮來大藥廠 抗cgrp／抗il-23雙特異性抗體及其用途
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TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
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WO2019231800A1 (en) 2018-05-31 2019-12-05 Eli Lilly And Company Anti-cgrp antibodies for treating menstrual-related migraines
WO2020041468A1 (en) 2018-08-22 2020-02-27 Eli Lilly And Company Anti-cgrp antibodies for treatment-resistant patients
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JP7551744B2 (ja) 2019-10-15 2024-09-17 イーライ リリー アンド カンパニー 組換え操作された、リパーゼ／エステラーゼ欠損哺乳動物細胞株
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Also Published As

Publication number Publication date
NL300979I1 (nl) 2019-04-17
US20150259415A1 (en) 2015-09-17
EP3318272A1 (en) 2018-05-09
JO3330B1 (ar) 2019-03-13
US9505838B2 (en) 2016-11-29
CN104292332A (zh) 2015-01-21
JP2017014203A (ja) 2017-01-19
HK1203211A1 (en) 2015-10-23
EP2579894B1 (en) 2017-11-22
LT2579894T (lt) 2018-02-26
TWI423818B (zh) 2014-01-21
PL2579894T3 (pl) 2018-04-30
CA2802102A1 (en) 2011-12-15
JP6466883B2 (ja) 2019-02-06
IL222885B (en) 2019-09-26
NO2019017I1 (no) 2019-04-05
LUC00112I2 (es) 2019-12-27
NZ603607A (en) 2014-09-26
US9073991B2 (en) 2015-07-07
HUE038135T2 (hu) 2018-09-28
KR20130034024A (ko) 2013-04-04
US20110305711A1 (en) 2011-12-15
IL222885A0 (en) 2012-12-31
IL242409B (en) 2020-07-30
CY2019017I1 (el) 2020-05-29
ES2930321T3 (es) 2022-12-09
TW201210618A (en) 2012-03-16
RS56638B1 (sr) 2018-03-30
WO2011156324A1 (en) 2011-12-15
CA2802102C (en) 2016-07-26
US20170073403A1 (en) 2017-03-16
DK2579894T3 (en) 2018-01-15
UA109658C2 (xx) 2015-09-25
CY2019017I2 (el) 2020-05-29
LUC00112I1 (es) 2019-04-10
BR112012031501B1 (pt) 2020-02-11
CN102946905B (zh) 2014-10-15
ES2656000T3 (es) 2018-02-22
EP2579894A1 (en) 2013-04-17
EP3318272B1 (en) 2022-08-10
MX363209B (es) 2019-03-14
AU2011265050B2 (en) 2013-06-27
SG185648A1 (en) 2012-12-28
HRP20171992T1 (hr) 2018-02-09
AU2011265050A1 (en) 2012-11-08
CN102946905A (zh) 2013-02-27
KR101489566B1 (ko) 2015-02-03
EA201270769A1 (ru) 2013-04-30
JP6021806B2 (ja) 2016-11-09
SI2579894T1 (en) 2018-01-31
MX2012014480A (es) 2013-02-07
ME02862B (me) 2018-04-20
JP2013532143A (ja) 2013-08-15
CN104292332B (zh) 2019-11-01
NL300979I2 (nl) 2019-07-11
EP2579894A4 (en) 2013-12-04
LTPA2019011I1 (lt) 2019-05-10
LTC2579894I2 (lt) 2020-03-25
EA022931B1 (ru) 2016-03-31
AR081434A1 (es) 2012-08-29
PT2579894T (pt) 2018-02-06
BR112012031501A2 (pt) 2016-10-25
NO2579894T3 (es) 2018-04-21
HUS1900020I1 (hu) 2019-05-28
ZA201208996B (en) 2014-05-28
CY1119789T1 (el) 2018-06-27

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