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MX2023011658A - Linajes hematopoyeticos derivados de celulas madre pluripotentes. - Google Patents

Linajes hematopoyeticos derivados de celulas madre pluripotentes.

Info

Publication number
MX2023011658A
MX2023011658A MX2023011658A MX2023011658A MX2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A MX 2023011658 A MX2023011658 A MX 2023011658A
Authority
MX
Mexico
Prior art keywords
cells
hematopoietic
lineages
pluripotent stem
provides
Prior art date
Application number
MX2023011658A
Other languages
English (en)
Inventor
Dhvanit Shah
Original Assignee
Garuda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Garuda Therapeutics Inc filed Critical Garuda Therapeutics Inc
Publication of MX2023011658A publication Critical patent/MX2023011658A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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  • Hematology (AREA)
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Abstract

La presente divulgación, en diversos aspectos y modalidades, proporciona métodos para generar células de linaje hematopoyético para la terapia con células hematopoyéticas. Los diversos linajes hematopoyéticos incluyen linfocitos T que incluyen células T progenitoras, células asesinas naturales, linfocitos B, neutrófilos, monocitos y/o macrófagos, glóbulos rojos, megacariocitos, y plaquetas. En varias modalidades, la invención proporciona procesos ex vivo eficientes para el desarrollo de linajes hematopoyéticos, que incluye, pero no se limita a, las células T progenitoras y linajes de células T, a partir de células madre pluripotentes inducidas (iPSC) humanas. Las células generadas de acuerdo con la divulgación en varias modalidades son funcionales y/o más se asemejan al linaje correspondiente aislado de sangre periférica o de órganos linfoides. La presente invención en algunos aspectos proporciona células aisladas y composiciones de células producidas por los métodos divulgados en la presente, así como métodos para la terapia celular adoptiva.
MX2023011658A 2021-03-31 2022-03-30 Linajes hematopoyeticos derivados de celulas madre pluripotentes. MX2023011658A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163168360P 2021-03-31 2021-03-31
PCT/US2022/022562 WO2022212514A1 (en) 2021-03-31 2022-03-30 Pluripotent stem cell-derived hematopoietic lineages

Publications (1)

Publication Number Publication Date
MX2023011658A true MX2023011658A (es) 2023-12-14

Family

ID=83459917

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023011658A MX2023011658A (es) 2021-03-31 2022-03-30 Linajes hematopoyeticos derivados de celulas madre pluripotentes.

Country Status (11)

Country Link
US (1) US20240180961A1 (es)
EP (1) EP4313082A1 (es)
JP (1) JP2024514091A (es)
KR (1) KR20240037179A (es)
CN (1) CN117597435A (es)
AU (1) AU2022252247A1 (es)
BR (1) BR112023019951A2 (es)
CA (1) CA3214216A1 (es)
IL (1) IL307219A (es)
MX (1) MX2023011658A (es)
WO (1) WO2022212514A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024077146A2 (en) * 2022-10-05 2024-04-11 Garuda Therapeutics, Inc. Erythroid lineages derived from pluripotent cells
CN116574672B (zh) * 2023-07-11 2023-10-20 北京北启生物医药有限公司 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016123100A1 (en) * 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
DK3368052T3 (da) * 2015-10-27 2022-03-14 Childrens Hospital Med Ct Anvendelse af mapk-hæmmere for at nedbringe tabet af hæmatopoietiske stamceller under ex vivo-dyrkning og -genmanipulation
KR20180066262A (ko) * 2015-11-04 2018-06-18 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
US11162073B2 (en) * 2015-12-03 2021-11-02 The Brigham And Women's Hospital, Inc. Methods for generating functional hematopoietic stem cells

Also Published As

Publication number Publication date
BR112023019951A2 (pt) 2023-11-14
KR20240037179A (ko) 2024-03-21
EP4313082A1 (en) 2024-02-07
AU2022252247A1 (en) 2023-10-26
US20240180961A1 (en) 2024-06-06
IL307219A (en) 2023-11-01
JP2024514091A (ja) 2024-03-28
CN117597435A (zh) 2024-02-23
CA3214216A1 (en) 2022-10-06
WO2022212514A1 (en) 2022-10-06

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