Nothing Special   »   [go: up one dir, main page]

MX2022009786A - Proceso para la sintesis de s-beflubutamid utilizando hidrogenacion asimetrica. - Google Patents

Proceso para la sintesis de s-beflubutamid utilizando hidrogenacion asimetrica.

Info

Publication number
MX2022009786A
MX2022009786A MX2022009786A MX2022009786A MX2022009786A MX 2022009786 A MX2022009786 A MX 2022009786A MX 2022009786 A MX2022009786 A MX 2022009786A MX 2022009786 A MX2022009786 A MX 2022009786A MX 2022009786 A MX2022009786 A MX 2022009786A
Authority
MX
Mexico
Prior art keywords
beflubutamid
synthesis
asymmetric hydrogenation
compound
prepared
Prior art date
Application number
MX2022009786A
Other languages
English (en)
Inventor
Kåre Søndergaard
Original Assignee
Cheminova As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheminova As filed Critical Cheminova As
Publication of MX2022009786A publication Critical patent/MX2022009786A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2442—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems
    • B01J31/2447—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring
    • B01J31/2452—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/49—Esterification or transesterification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se divulga un método para preparar el compuesto S-1 (ver Fórmula), a partir del compuesto S-5 (ver Fórmula); en donde el compuesto S-5 se prepara tratando el compuesto 2 con una amina terciaria y una fuente de hidrógeno en presencia de un complejo quiral (ver Fórmula).
MX2022009786A 2020-02-11 2021-02-10 Proceso para la sintesis de s-beflubutamid utilizando hidrogenacion asimetrica. MX2022009786A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062972779P 2020-02-11 2020-02-11
PCT/EP2021/053159 WO2021160649A1 (en) 2020-02-11 2021-02-10 Process for the synthesis of s-beflubutamid using asymmetric hydrogenation

Publications (1)

Publication Number Publication Date
MX2022009786A true MX2022009786A (es) 2022-09-09

Family

ID=74625951

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009786A MX2022009786A (es) 2020-02-11 2021-02-10 Proceso para la sintesis de s-beflubutamid utilizando hidrogenacion asimetrica.

Country Status (11)

Country Link
US (1) US20230099631A1 (es)
EP (1) EP4103543B1 (es)
JP (1) JP2023513184A (es)
KR (1) KR20220140556A (es)
CN (1) CN115151525A (es)
AU (1) AU2021219021A1 (es)
BR (1) BR112022015698A2 (es)
IL (1) IL295480B2 (es)
MX (1) MX2022009786A (es)
WO (1) WO2021160649A1 (es)
ZA (1) ZA202208861B (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0657684B2 (ja) * 1986-03-28 1994-08-03 宇部興産株式会社 Ｎ―ベンジル２―（４―フルオル―３―トリフルオルメチルフェノキシ）ブタン酸アミド及びそれを含有する除草剤
CN102766067A (zh) * 2012-08-10 2012-11-07 太仓市运通化工厂 一种氟丁酰草胺的合成方法

Also Published As

Publication number Publication date
CN115151525A (zh) 2022-10-04
EP4103543A1 (en) 2022-12-21
IL295480B1 (en) 2023-04-01
IL295480B2 (en) 2023-08-01
AU2021219021A1 (en) 2022-09-01
JP2023513184A (ja) 2023-03-30
ZA202208861B (en) 2024-01-31
US20230099631A1 (en) 2023-03-30
EP4103543B1 (en) 2023-12-06
WO2021160649A1 (en) 2021-08-19
BR112022015698A2 (pt) 2022-09-27
IL295480A (en) 2022-10-01
KR20220140556A (ko) 2022-10-18

Similar Documents

Publication Publication Date Title
MY142297A (en) Method for the production of formic acid
ATE231118T1 (de) Verfahren zur herstellung von isophorondiamin
ATE474823T1 (de) Verfahren zur herstellung von ethylen
MY174977A (en) Method for the production of hydrogen from ammonia borane
ATE535554T1 (de) Verfahren zur herstellung von sehr steifem polyproylen
EA201170556A1 (ru) Способ активации усиленного железного катализатора для суспензионных реакторов
ATE545626T1 (de) Verfahren zur herstellung eines amins
DE502004011239D1 (de) Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-katalyse
DE602004008183D1 (de) Verfahren zur Herstellung von L-Cystein unter Verwendung eines zur Gattung Escherichia gehörenden Bakteriums
SA520411417B1 (ar) مفاعل تحويل وإدارة الطريقة
MX2010002453A (es) Procedimiento para la preparacion de derivados de 2,2-difluoroetilamina mediante hidrogenacion de imina.
MX2022009786A (es) Proceso para la sintesis de s-beflubutamid utilizando hidrogenacion asimetrica.
ATE551318T1 (de) Verfahren zur herstellung von n,n-substituierten- 1,3-propandiaminen
MX2021005343A (es) Proceso para la preparacion de isoxazolinas opticamente enriquecidas.
CA2477085A1 (en) Method for the production of primary amines by hydrogenating nitriles
MY190173A (en) Process for producing alkanolamine
ATE520647T1 (de) Verfahren zur herstellung eines primären amins mit tertiärem alpha-c-atom durch umsetzung eines tertiären alkohols mit ammoniak
MX2023010436A (es) Nueva variante de citrato sintasa y procedimiento para producir l-valina utilizando la misma.
MX2023005954A (es) Procesos para preparar citrato de arimoclomol e intermediarios del mismo.
DE60141399D1 (de) Verfahren zur herstellung von äthanol unter verwendung eines rekombinanten coryneformen bakteriums
SG178864A1 (en) Method for producing a compound with a double bond
DE60103381D1 (de) Verfahren zur herstellung eines 1,3-diols
ATE545625T1 (de) Stereoselektives verfahren zur herstellung eines chiralen, fluorierten moleküls
MX2012001009A (es) Proceso para la preparacion de 1,4-butanodiamina por medio de precursores de 1,4-butanodiamina protegidos con n-acilo o n-guanidilo.
MY194470A (en) Method for preparing natural l-cysteine hydrochloride hydrate crystals by continuous chromatography