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MX2020006012A - Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas. - Google Patents

Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas.

Info

Publication number
MX2020006012A
MX2020006012A MX2020006012A MX2020006012A MX2020006012A MX 2020006012 A MX2020006012 A MX 2020006012A MX 2020006012 A MX2020006012 A MX 2020006012A MX 2020006012 A MX2020006012 A MX 2020006012A MX 2020006012 A MX2020006012 A MX 2020006012A
Authority
MX
Mexico
Prior art keywords
methods
hmgb1
high mobility
mobility group
group box
Prior art date
Application number
MX2020006012A
Other languages
English (en)
Inventor
Gregory Hinkle
Frederic Tremblay
James D Mcininch
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2020006012A publication Critical patent/MX2020006012A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/312—Phosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a agente de ARNi, por ejemplo, agente de ARN de doble hebra (ARNdh), que se dirige al gen de HMGB1. La invención también se refiere a métodos de uso de tales agentes de ARNi para inhibir la expresión de un gen de HMGB1 y a métodos de prevención y tratamiento de un trastorno asociado con HMGB1, por ejemplo, trastorno metabólico o enfermedad del hígado graso no alcohólico, por ejemplo, esteatohepatitis no alcohólica (NASH).
MX2020006012A 2017-12-18 2018-12-18 Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas. MX2020006012A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762599860P 2017-12-18 2017-12-18
PCT/US2018/066126 WO2019126097A1 (en) 2017-12-18 2018-12-18 High mobility group box-1 (hmgb1) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2020006012A true MX2020006012A (es) 2020-09-14

Family

ID=65024027

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006012A MX2020006012A (es) 2017-12-18 2018-12-18 Composiciones de arni de la caja 1 del grupo de alta movilidad (hmgb1) y métodos de uso de las mismas.

Country Status (13)

Country Link
US (1) US20200308588A1 (es)
EP (1) EP3728593A1 (es)
JP (1) JP2021508491A (es)
KR (1) KR20200110655A (es)
CN (1) CN111727252A (es)
AU (1) AU2018388484A1 (es)
BR (1) BR112020012088A2 (es)
CA (1) CA3086343A1 (es)
EA (1) EA202091520A1 (es)
IL (1) IL275249A (es)
MX (1) MX2020006012A (es)
WO (1) WO2019126097A1 (es)
ZA (1) ZA202003954B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200023427A (ko) 2017-06-29 2020-03-04 다이서나 파마수이티컬, 인크. Hmgb1 발현을 억제하기 위한 조성물 및 방법
JP2022517742A (ja) * 2018-12-28 2022-03-10 ディセルナ ファーマシューティカルズ インコーポレイテッド Ｈｍｇｂ１発現を阻害するための組成物及び方法
WO2021242180A1 (en) * 2020-04-22 2021-12-02 Chulalongkorn University A composition and a method of rejuvenating dna and preventing dna damage
WO2023053384A1 (ja) * 2021-09-30 2023-04-06 国立大学法人大阪大学 脂肪肝および非アルコール性脂肪肝炎の治療薬
CN117264954A (zh) * 2022-09-20 2023-12-22 北京福元医药股份有限公司 用于抑制hmgb1基因表达的双链核糖核酸及其修饰物、缀合物和用途

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