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MX2019011023A - Diarilureas como moduladores alostéricos de cannabinoide cb1. - Google Patents

Diarilureas como moduladores alostéricos de cannabinoide cb1.

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Publication number
MX2019011023A
MX2019011023A MX2019011023A MX2019011023A MX2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A MX 2019011023 A MX2019011023 A MX 2019011023A
Authority
MX
Mexico
Prior art keywords
allosteric modulators
diarylureas
compounds
present
receptor
Prior art date
Application number
MX2019011023A
Other languages
English (en)
Inventor
Zhang Yanan
NGUYEN Thuy
German Nadezhda
Original Assignee
Rti Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rti Int filed Critical Rti Int
Publication of MX2019011023A publication Critical patent/MX2019011023A/es

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
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Abstract

La presente invención proporciona nuevos derivados de diarilurea (compuestos de la fórmula (I)) y sus usos. Los compuestos de la presente invención se demuestra que son moduladores alostéricos del receptor de CB1 y, por lo tanto, son útiles para el tratamiento de enfermedades y condiciones mediadas por CB1.
MX2019011023A 2017-05-12 2018-05-10 Diarilureas como moduladores alostéricos de cannabinoide cb1. MX2019011023A (es)

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PCT/US2018/031977 WO2018209030A1 (en) 2017-05-12 2018-05-10 Diarylureas as cb1 allosteric modulators

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CN114269719A (zh) * 2019-06-28 2022-04-01 Rti国际 作为cb1变构调节剂的脲衍生物

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US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
DE69830513T2 (de) 1997-12-22 2006-03-16 Bayer Pharmaceuticals Corp., West Haven HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
JP2003192659A (ja) 2001-12-26 2003-07-09 Bayer Ag フェニル尿素誘導体
JP2005513154A (ja) * 2001-12-26 2005-05-12 バイエル・ヘルスケア・アクチェンゲゼルシャフト 尿素誘導体
WO2003062206A2 (en) * 2002-01-23 2003-07-31 Arena Pharmaceuticals, Inc. Small molecule modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
JP2007516258A (ja) * 2003-12-12 2007-06-21 ワイス 心臓血管の疾患治療に有用なキノリン誘導体
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
US20090239841A1 (en) * 2004-10-27 2009-09-24 Hutchison Alan J Diaryl Ureas as CB1 Antagonists
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
US20110118234A1 (en) 2008-05-05 2011-05-19 Kaustav Biswas Urea Compounds as Gamma Secretase Modulators
KR101332830B1 (ko) * 2012-07-05 2013-11-27 한국화학연구원 페닐우레아 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 항암감작제
US9926275B2 (en) * 2013-08-22 2018-03-27 Northeastern University Allosteric modulators of the cannabinoid 1 receptor
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CN105884699B (zh) * 2016-05-11 2019-05-07 中国药科大学 4-取代苯胺喹唑啉类衍生物及其制备方法和用途

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AU2024205565A1 (en) 2024-08-22
US20200062699A1 (en) 2020-02-27
AU2022205221B2 (en) 2024-08-29
AU2018265148A1 (en) 2019-10-03
EP3621951A4 (en) 2021-01-27
CN110621656A (zh) 2019-12-27
US11084781B2 (en) 2021-08-10
CA3056305A1 (en) 2018-11-15
JP7455581B2 (ja) 2024-03-26
WO2018209030A1 (en) 2018-11-15
MX2023001906A (es) 2023-03-13
EP3621951A1 (en) 2020-03-18
JP2024088647A (ja) 2024-07-02
JP2020519566A (ja) 2020-07-02
AU2022205221A1 (en) 2022-08-04
US20210332007A1 (en) 2021-10-28

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