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MX2019003593A - Composiciones de vacuna neumococica multivalente que comprenden conjugados de polisacaridos y proteinas. - Google Patents

Composiciones de vacuna neumococica multivalente que comprenden conjugados de polisacaridos y proteinas.

Info

Publication number
MX2019003593A
MX2019003593A MX2019003593A MX2019003593A MX2019003593A MX 2019003593 A MX2019003593 A MX 2019003593A MX 2019003593 A MX2019003593 A MX 2019003593A MX 2019003593 A MX2019003593 A MX 2019003593A MX 2019003593 A MX2019003593 A MX 2019003593A
Authority
MX
Mexico
Prior art keywords
vaccine compositions
polysaccharide
pneumococcal vaccine
pneumococcal
protein conjugates
Prior art date
Application number
MX2019003593A
Other languages
English (en)
Inventor
Datla Mahima
Dev Mantena Narender
Venkat Matur Ramesh
Burki Rajendar
Sriraman Rajan
Chakka Deviprasanna
Naidu Sureddi Satyam
Rao Ganti Sreenivasa
Original Assignee
Biological E Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biological E Ltd filed Critical Biological E Ltd
Publication of MX2019003593A publication Critical patent/MX2019003593A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente descripción se relaciona a composiciones de vacuna neumocócica multivalentes que comprenden los serotipos de polisacáridos neumocócicos capsulares cada uno individualmente conjugado con proteínas portadoras. Cuando se conjuga, la combinación del serotipo de polisacárido neumocócico capsular y la proteína portadora es referida en la 5 presente como un conjugado de polisacárido y proteína. Las composiciones de vacunas neumocócicas pueden además comprender uno o más de los siguientes; un portador farmacéuticamente aceptable, un diluyente farmacéuticamente aceptable, una solución amortiguadora, un conservador, un estabilizador, un adyuvante, y/o un excipiente de liofilización. También se proporcionan los métodos de fabricación y administración de las 10 composiciones de vacunas neumocócicas descritas en la presente.
MX2019003593A 2016-09-30 2017-09-29 Composiciones de vacuna neumococica multivalente que comprenden conjugados de polisacaridos y proteinas. MX2019003593A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641033563 2016-09-30
PCT/US2017/054237 WO2018064444A1 (en) 2016-09-30 2017-09-29 Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates

Publications (1)

Publication Number Publication Date
MX2019003593A true MX2019003593A (es) 2019-06-10

Family

ID=60117775

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019003593A MX2019003593A (es) 2016-09-30 2017-09-29 Composiciones de vacuna neumococica multivalente que comprenden conjugados de polisacaridos y proteinas.

Country Status (20)

Country Link
US (1) US11547752B2 (es)
EP (1) EP3518965A1 (es)
JP (2) JP2019529497A (es)
KR (1) KR102608081B1 (es)
CN (1) CN109789198B (es)
AU (1) AU2017336806B2 (es)
BR (1) BR112019006278A2 (es)
CA (1) CA3037056A1 (es)
CL (1) CL2019000849A1 (es)
CO (1) CO2019002955A2 (es)
CU (1) CU24660B1 (es)
EA (1) EA201990838A1 (es)
IL (2) IL265623B2 (es)
MX (1) MX2019003593A (es)
NZ (1) NZ752348A (es)
PH (1) PH12019500672A1 (es)
SA (1) SA519401317B1 (es)
UA (1) UA126385C2 (es)
WO (1) WO2018064444A1 (es)
ZA (1) ZA201901170B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL255106B2 (en) 2015-05-04 2023-04-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses
JP7164200B2 (ja) * 2016-03-31 2022-11-01 ポゴナ, エルエルシー サッカライド-ポリペプチドコンジュゲートの組成物およびその使用の方法
MX2019007910A (es) 2016-12-30 2019-12-05 Sutrovax Inc Conjugados de polipeptido-antigeno con aminoacidos no naturales.
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
GB201711635D0 (en) * 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
AU2018400751B2 (en) 2017-12-06 2022-07-21 Merck Sharp & Dohme Llc Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
KR102486891B1 (ko) * 2018-02-05 2023-01-10 사노피 파스퇴르 인코포레이티드 다가 폐렴구균성 다당류-단백질 접합체 조성물
IL276229B2 (en) * 2018-02-05 2024-01-01 Sanofi Pasteur Inc A multivalent pneumococcal protein-polysaccharide conjugate preparation
KR20190121713A (ko) 2018-04-18 2019-10-28 에스케이바이오사이언스(주) 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체
WO2020010000A1 (en) * 2018-07-04 2020-01-09 Sutrovax, Inc. Improved methods for the preparation of immunogenic conjugates
EP3817775B1 (en) * 2018-07-04 2024-09-04 Vaxcyte, Inc. Improvements in immunogenic conjugates
JP7337145B2 (ja) * 2018-07-21 2023-09-01 バイオロジカル イー リミテッド 保存剤系を含むワクチン製剤
AU2019341723B2 (en) * 2018-09-23 2024-03-21 Biological E Limited Purified capsular polysaccharides of Streptococcus pneumoniae
EP3863667A4 (en) * 2018-10-12 2022-08-17 Biological E Limited POLYVALENT PNEUMOCOCCAL POLYSACCHARIDE PROTEIN CONJUGATE VACCINE
AU2019401535B2 (en) * 2018-12-19 2023-12-14 Merck Sharp & Dohme Llc Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
WO2020152706A1 (en) * 2019-01-21 2020-07-30 Biological E Limited Multivalent pneumococcal conjugate vaccine compositions
WO2020157772A1 (en) * 2019-01-28 2020-08-06 Biological E Limited Multivalent pneumococcal polysaccharide-protein conjugate vaccine compositions
CN109771640A (zh) * 2019-02-28 2019-05-21 北京智飞绿竹生物制药有限公司 多价肺炎球菌结合疫苗
EP3980055A4 (en) * 2019-06-05 2023-07-26 Merck Sharp & Dohme LLC IMMUNOGENIC PNEUMOCOCCUS POLYSACCHARID-PROTEIN CONJUGATE OF SEROTYPE 35B AND CONJUGATION METHODS FOR ITS PRODUCTION
AU2020289048A1 (en) * 2019-06-05 2021-12-09 Merck Sharp & Dohme Llc Methods of treating patients with an immunogenic composition that protects against
CN110302375A (zh) * 2019-06-27 2019-10-08 康希诺生物股份公司 一种糖缀合物及其用途
TW202116352A (zh) * 2019-07-18 2021-05-01 南韓商賽特瑞恩股份有限公司 包含多價肺炎球菌多醣-蛋白共軛物的免疫組成物、醫藥組成物及其用途
CN114728050A (zh) * 2019-07-31 2022-07-08 圣诺菲·帕斯图尔公司 多价肺炎球菌多糖-蛋白质缀合物组合物及其使用方法
CN110804097B (zh) * 2019-10-30 2021-02-26 云南沃森生物技术股份有限公司 一种同时制备两种单克隆抗体的方法
US20210220461A1 (en) * 2020-01-17 2021-07-22 Inventprise, Llc Multivalent Streptococcus Vaccines
US12053515B2 (en) 2020-08-10 2024-08-06 Inventprise, Inc. Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F
KR20220102871A (ko) * 2021-01-14 2022-07-21 (주)셀트리온 다가 폐렴구균 다당류-단백질 접합체를 포함하는 면역원성 조성물
EP4297776A1 (en) * 2021-02-26 2024-01-03 Biological E Limited Activated-quenched polysaccharide and improved methods for quantification of polysaccharide in a vaccine composition
US20240181028A1 (en) * 2022-11-22 2024-06-06 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027888B1 (en) 1979-09-21 1986-04-16 Hitachi, Ltd. Semiconductor switch
US5360897A (en) 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4902506A (en) 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US5854416A (en) 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
NZ249704A (en) 1992-02-11 1996-11-26 Jackson H M Found Military Med A two carrier immunogenic construct comprising a 70+ kd molecule conjugated to at least 1 t-dependent antigen, preparation, compositions containing the construct
DE69434079T2 (de) 1993-03-05 2005-02-24 Wyeth Holdings Corp. Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin
ATE254475T1 (de) 1993-09-22 2003-12-15 Jackson H M Found Military Med Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
NZ304715A (en) 1995-03-22 1999-07-29 Jackson H M Found Military Med Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten
US6299881B1 (en) 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
FR2763244B1 (fr) * 1997-05-14 2003-08-01 Pasteur Merieux Serums Vacc Composition vaccinale multivalente a porteur mixte
US8048432B2 (en) 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
EP2425856A1 (en) 2005-04-08 2012-03-07 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
LT2384765T (lt) * 2005-12-22 2017-01-10 Glaxosmithkline Biologicals S.A. Streptococcus pneumoniae vakcina
KR20130135399A (ko) 2006-03-17 2013-12-10 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 복합 다가 면역원성 콘쥬게이트의 제조 방법
US20070253985A1 (en) * 2006-04-26 2007-11-01 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
EA020817B1 (ru) 2007-06-26 2015-02-27 Глаксосмитклайн Байолоджикалс С.А. Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
US8003112B2 (en) * 2009-04-16 2011-08-23 Howard University Meningococcal and pneumococcal conjugate vaccine and method of using same
CN101590224A (zh) 2009-06-30 2009-12-02 广州精达医学科技有限公司 高效14价肺炎球菌结合疫苗
TW201136603A (en) 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
WO2011151841A1 (en) * 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
CN103623401A (zh) 2012-08-23 2014-03-12 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法
CN103656632B (zh) 2012-09-24 2016-01-13 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖组合物、其制备方法及应用
CN103656631B (zh) 2012-09-24 2015-08-19 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法
KR20140075201A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075196A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
CN104069488A (zh) 2013-03-29 2014-10-01 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法
WO2016079755A1 (en) 2014-11-20 2016-05-26 Biological E Limited Codon optimized polynucleotide for high level expression of crm197
CN107835821B (zh) 2015-04-28 2022-01-28 生物E有限公司 用于从微生物荚膜多糖分离蛋白质和其他杂质的方法
RS61440B1 (sr) * 2015-06-23 2021-03-31 Biological E Ltd Multivalentna pneumokokna konjugatna vakcina
EP3296741B1 (en) * 2016-09-14 2019-08-21 Serum Institute of India Private Limited Multiplex bead based assay for quantification of multiple types of carrier protein in a multivalent conjugate vaccine composition

Also Published As

Publication number Publication date
CL2019000849A1 (es) 2019-09-23
IL265623A (en) 2019-05-30
IL265623B2 (en) 2023-04-01
SA519401317B1 (ar) 2023-11-14
EA201990838A1 (ru) 2019-08-30
BR112019006278A2 (pt) 2019-07-02
AU2017336806A1 (en) 2019-05-02
IL297575B1 (en) 2023-08-01
CU24660B1 (es) 2023-05-11
WO2018064444A1 (en) 2018-04-05
UA126385C2 (uk) 2022-09-28
PH12019500672A1 (en) 2019-07-29
CU20190030A7 (es) 2019-11-04
JP2022105155A (ja) 2022-07-12
CA3037056A1 (en) 2018-04-05
ZA201901170B (en) 2024-08-28
IL265623B (en) 2022-12-01
US20190224295A1 (en) 2019-07-25
JP2019529497A (ja) 2019-10-17
CN109789198B (zh) 2024-08-16
KR102608081B1 (ko) 2023-11-29
AU2017336806B2 (en) 2024-06-27
NZ752348A (en) 2022-11-25
JP7403576B2 (ja) 2023-12-22
AU2017336806A8 (en) 2019-05-16
CO2019002955A2 (es) 2019-06-11
IL297575B2 (en) 2023-12-01
CN109789198A (zh) 2019-05-21
KR20190066032A (ko) 2019-06-12
IL297575A (en) 2022-12-01
US11547752B2 (en) 2023-01-10
EP3518965A1 (en) 2019-08-07

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