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MX2015017535A - Tratamiento de resistencia a la insulina a traves de inhibidores del factor de transcripcion tsc22d4. - Google Patents

Tratamiento de resistencia a la insulina a traves de inhibidores del factor de transcripcion tsc22d4.

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Publication number
MX2015017535A
MX2015017535A MX2015017535A MX2015017535A MX2015017535A MX 2015017535 A MX2015017535 A MX 2015017535A MX 2015017535 A MX2015017535 A MX 2015017535A MX 2015017535 A MX2015017535 A MX 2015017535A MX 2015017535 A MX2015017535 A MX 2015017535A
Authority
MX
Mexico
Prior art keywords
treatment
tsc22d4
insulin resistance
inhibitors
transcription factor
Prior art date
Application number
MX2015017535A
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English (en)
Other versions
MX364003B (es
Inventor
BERRIEL DIAZ Mauricio
Herzig Stephan
Friedrich Kilian
Jones Allan
Original Assignee
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts filed Critical Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
Publication of MX2015017535A publication Critical patent/MX2015017535A/es
Publication of MX364003B publication Critical patent/MX364003B/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

Se refiere la presente invención a moduladores, en particular inhibidores, de la actividad o expresión de TSC22D4 y sus usos para la prevención, tratamiento y/o regulación de la resistencia a la insulina, síndrome metabólico y/o diabetes y/o para mejorar la sensibilidad a la insulina en mamíferos. La presente invención se refiere además a métodos de evaluación para identificar estos moduladores, el uso de moduladores como se identifica en el diagnóstico de estas enfermedades, así como kits, que comprenden los materiales para llevar a cabo los métodos de acuerdo con la presente invención.
MX2015017535A 2013-06-17 2014-06-17 Tratamiento de resistencia a la insulina a traves de inhibidores del factor de transcripcion tsc22d4. MX364003B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20130172362 EP2816356A1 (en) 2013-06-17 2013-06-17 Treatment of insulin resistance through inhibitors of transcription factor TSC22D4
PCT/EP2014/062713 WO2014202602A1 (en) 2013-06-17 2014-06-17 Treatment of insulin resistance through inhibitors of transcription factor tsc22d4

Publications (2)

Publication Number Publication Date
MX2015017535A true MX2015017535A (es) 2016-08-08
MX364003B MX364003B (es) 2019-04-10

Family

ID=48625934

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017535A MX364003B (es) 2013-06-17 2014-06-17 Tratamiento de resistencia a la insulina a traves de inhibidores del factor de transcripcion tsc22d4.

Country Status (10)

Country Link
US (1) US9879258B2 (es)
EP (2) EP2816356A1 (es)
JP (1) JP6479780B2 (es)
KR (1) KR102401450B1 (es)
CN (1) CN105247371B (es)
CA (1) CA2908889C (es)
DK (1) DK3011341T3 (es)
ES (1) ES2733555T3 (es)
MX (1) MX364003B (es)
WO (1) WO2014202602A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3072969A1 (en) 2015-03-23 2016-09-28 DKFZ Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance
CN107137701B (zh) * 2017-05-07 2020-07-14 山东兴瑞生物科技有限公司 一种提高dc疫苗抗肝癌效果的基因靶标、抑制剂和dc肿瘤疫苗
CN112956453B (zh) * 2021-04-07 2022-10-11 华北理工大学 一种黑腹果蝇胰岛素抵抗糖尿病模型的建立方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1703625A (zh) * 2002-08-06 2005-11-30 法赫马西亚及普强有限公司 果蝇g蛋白偶联受体,核酸和相关方法
CA2548285A1 (en) * 2003-12-11 2005-06-30 Beth Israel Deaconess Medical Center, Inc. Rbp4 in insulin sensitivity/resistance, diabetes, and obesity
WO2005073164A1 (en) * 2004-01-30 2005-08-11 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
WO2012061754A2 (en) * 2010-11-05 2012-05-10 The Broad Institute, Inc. Compounds and methods for treating autoimmune diseases
US20140227289A1 (en) * 2011-05-13 2014-08-14 Stephen Michael Cohen Compounds and methods for treating insulin resistance syndrome
CN102311952A (zh) * 2011-09-19 2012-01-11 中南大学 一种多癌风险易感性突变位点及其应用和制备的试剂盒
GB201120317D0 (en) * 2011-11-24 2012-01-04 Queen Mary & Westfield College Screening method

Also Published As

Publication number Publication date
CN105247371B (zh) 2019-01-11
EP2816356A1 (en) 2014-12-24
CN105247371A (zh) 2016-01-13
JP2016532098A (ja) 2016-10-13
KR102401450B1 (ko) 2022-05-24
ES2733555T3 (es) 2019-11-29
JP6479780B2 (ja) 2019-03-06
DK3011341T3 (da) 2019-07-22
CA2908889A1 (en) 2014-12-24
CA2908889C (en) 2022-07-26
WO2014202602A9 (en) 2015-12-23
US20160115475A1 (en) 2016-04-28
US9879258B2 (en) 2018-01-30
MX364003B (es) 2019-04-10
KR20160021106A (ko) 2016-02-24
EP3011341A1 (en) 2016-04-27
EP3011341B1 (en) 2019-04-10
WO2014202602A1 (en) 2014-12-24

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