MX2008014101A - Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinilamino, metodo para su produccion y su uso como medicamentos. - Google Patents
Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinilamino, metodo para su produccion y su uso como medicamentos.Info
- Publication number
- MX2008014101A MX2008014101A MX2008014101A MX2008014101A MX2008014101A MX 2008014101 A MX2008014101 A MX 2008014101A MX 2008014101 A MX2008014101 A MX 2008014101A MX 2008014101 A MX2008014101 A MX 2008014101A MX 2008014101 A MX2008014101 A MX 2008014101A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidinyl
- diphenyl
- carboxylic acids
- medicaments
- amino substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a ácidos carboxílicos sustituidos con 4,5- difenil-pirimidinil-oxi o -mercapto y a sus sales fisiológicamente toleradas; la invención se refiere también a compuestos de la fórmula (1) (ver fórmula I) donde R1, R2, R3, n, m, V, W, X e Y tienen los significados establecidos, y a sus sales fisiológicamente toleradas; dichos compuestos son adecuados para el tratamiento de la diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006021874A DE102006021874B4 (de) | 2006-05-11 | 2006-05-11 | 4,5-Diphenyl-pyrimidinyl-amino substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
PCT/EP2007/003804 WO2007131620A1 (de) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-amino substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008014101A true MX2008014101A (es) | 2008-11-14 |
Family
ID=38326940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008014101A MX2008014101A (es) | 2006-05-11 | 2007-04-30 | Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinilamino, metodo para su produccion y su uso como medicamentos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US7713988B2 (es) |
EP (1) | EP2024340B1 (es) |
JP (1) | JP5277159B2 (es) |
KR (1) | KR20090006845A (es) |
CN (1) | CN101421251B (es) |
AR (1) | AR060992A1 (es) |
AU (1) | AU2007250211B2 (es) |
BR (1) | BRPI0711393A2 (es) |
CA (1) | CA2651657A1 (es) |
DE (1) | DE102006021874B4 (es) |
HK (1) | HK1130800A1 (es) |
IL (1) | IL195177A0 (es) |
MX (1) | MX2008014101A (es) |
MY (1) | MY148096A (es) |
NO (1) | NO20085066L (es) |
TW (1) | TW200815366A (es) |
UY (1) | UY30339A1 (es) |
WO (1) | WO2007131620A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
CA2621949A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
AU2007293028B2 (en) | 2006-09-07 | 2012-05-31 | Amgen Inc. | Heterocyclic GPR40 modulators |
AU2007292816B2 (en) | 2006-09-07 | 2011-11-17 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP5591706B2 (ja) | 2007-10-10 | 2014-09-17 | アムジエン・インコーポレーテツド | 置換ビフェニルgpr40調節因子 |
EP2260017A1 (en) | 2008-03-06 | 2010-12-15 | Amgen, Inc | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
EP2358656B1 (en) | 2008-10-15 | 2014-01-01 | Amgen, Inc | Spirocyclic gpr40 modulators |
AU2009326108A1 (en) * | 2008-12-08 | 2010-06-17 | Euroscreen S.A. | Compounds, pharmaceutical composition and methods for use in treating metabolic disorders |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
KR101898610B1 (ko) | 2010-08-31 | 2018-09-14 | 서울대학교산학협력단 | PPARδ 활성물질의 태자 재프로그래밍 용도 |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2015119899A1 (en) | 2014-02-06 | 2015-08-13 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
AU2019222644B2 (en) | 2018-02-13 | 2021-04-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2499497A1 (en) * | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Substituted pyrimidines |
US20040259887A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
WO2005103022A1 (en) * | 2004-04-20 | 2005-11-03 | Transtech Pharma, Inc. | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2006
- 2006-05-11 DE DE102006021874A patent/DE102006021874B4/de not_active Expired - Fee Related
-
2007
- 2007-04-30 CN CN2007800133035A patent/CN101421251B/zh not_active Expired - Fee Related
- 2007-04-30 CA CA002651657A patent/CA2651657A1/en not_active Abandoned
- 2007-04-30 BR BRPI0711393-5A patent/BRPI0711393A2/pt not_active IP Right Cessation
- 2007-04-30 MX MX2008014101A patent/MX2008014101A/es not_active Application Discontinuation
- 2007-04-30 AU AU2007250211A patent/AU2007250211B2/en not_active Ceased
- 2007-04-30 KR KR1020087027548A patent/KR20090006845A/ko active IP Right Grant
- 2007-04-30 JP JP2009508191A patent/JP5277159B2/ja not_active Expired - Fee Related
- 2007-04-30 WO PCT/EP2007/003804 patent/WO2007131620A1/de active Application Filing
- 2007-04-30 EP EP07724731A patent/EP2024340B1/de not_active Not-in-force
- 2007-05-09 TW TW096116359A patent/TW200815366A/zh unknown
- 2007-05-09 AR ARP070102010A patent/AR060992A1/es not_active Application Discontinuation
- 2007-05-10 UY UY30339A patent/UY30339A1/es not_active Application Discontinuation
-
2008
- 2008-11-06 MY MYPI20084448A patent/MY148096A/en unknown
- 2008-11-09 IL IL195177A patent/IL195177A0/en unknown
- 2008-11-10 US US12/267,918 patent/US7713988B2/en not_active Expired - Fee Related
- 2008-12-04 NO NO20085066A patent/NO20085066L/no not_active Application Discontinuation
-
2009
- 2009-10-14 HK HK09109504.1A patent/HK1130800A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE102006021874A1 (de) | 2007-11-22 |
CN101421251B (zh) | 2011-10-19 |
AU2007250211A1 (en) | 2007-11-22 |
CA2651657A1 (en) | 2007-11-22 |
EP2024340A1 (de) | 2009-02-18 |
UY30339A1 (es) | 2008-01-02 |
JP2009536627A (ja) | 2009-10-15 |
WO2007131620A1 (de) | 2007-11-22 |
JP5277159B2 (ja) | 2013-08-28 |
US7713988B2 (en) | 2010-05-11 |
HK1130800A1 (es) | 2010-01-08 |
TW200815366A (en) | 2008-04-01 |
MY148096A (en) | 2013-02-28 |
NO20085066L (no) | 2009-02-06 |
CN101421251A (zh) | 2009-04-29 |
BRPI0711393A2 (pt) | 2011-11-01 |
IL195177A0 (en) | 2009-08-03 |
DE102006021874B4 (de) | 2008-03-27 |
EP2024340B1 (de) | 2012-07-18 |
AU2007250211B2 (en) | 2011-11-10 |
US20090149487A1 (en) | 2009-06-11 |
KR20090006845A (ko) | 2009-01-15 |
AR060992A1 (es) | 2008-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |