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MX2007007262A - Metabolitos de analogos de ciclosporina. - Google Patents

Metabolitos de analogos de ciclosporina.

Info

Publication number
MX2007007262A
MX2007007262A MX2007007262A MX2007007262A MX2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A
Authority
MX
Mexico
Prior art keywords
metabolites
isa247
methods
formation
synthetic methods
Prior art date
Application number
MX2007007262A
Other languages
English (en)
Inventor
Randall W Yatscoff
Robert T Foster
Seetharaman Jayaraman
Mark D Abel
Derrick G Freitag
Daniel J Trepanier
Shin Sugiyama
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Publication of MX2007007262A publication Critical patent/MX2007007262A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen los metabolitos aislados del analogo de ciclosporina ISA247, incluyendo los metodos in vitro para su preparacion. Los metabolitos comprenden una modificacion quimica de ISA247, en donde la modificacion es al menos una reaccion seleccionada del grupo que consiste de hidroxilacion, N-desmetilacion, formacion de diol, formacion de epoxido, y fosforilacion por ciclizacion intramolecular, sulfatacion, formacion de glucuronido y glucosilacion. Los metodos de preparacion incluyen los metodos semi-sinteticos, en donde los metabolitos de ISA247 son producidos a traves de los extractos microsomales de celulas hepaticas de animal, o de cultivos utilizando microorganismos, y metodos completamente sinteticos, tales como la modificacion quimica del compuesto progenitor o los metabolismos aislados utilizando metodos sinteticos organicos.
MX2007007262A 2004-12-17 2005-12-19 Metabolitos de analogos de ciclosporina. MX2007007262A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63739204P 2004-12-17 2004-12-17
PCT/CA2005/001926 WO2006063470A1 (en) 2004-12-17 2005-12-19 Metabolites of cyclosporin analogs

Publications (1)

Publication Number Publication Date
MX2007007262A true MX2007007262A (es) 2007-10-19

Family

ID=36587506

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007262A MX2007007262A (es) 2004-12-17 2005-12-19 Metabolitos de analogos de ciclosporina.

Country Status (14)

Country Link
US (1) US20060223743A1 (es)
EP (1) EP1828229A4 (es)
JP (1) JP2008524122A (es)
KR (1) KR20070100284A (es)
CN (1) CN101120012A (es)
AU (1) AU2005316095A1 (es)
BR (1) BRPI0517207A (es)
CA (1) CA2592343A1 (es)
IL (1) IL183908A0 (es)
MX (1) MX2007007262A (es)
TN (1) TNSN07225A1 (es)
TW (1) TW200635954A (es)
WO (1) WO2006063470A1 (es)
ZA (1) ZA200705475B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CA2656903A1 (en) * 2006-07-06 2008-01-10 Ares Trading S.A. An oral pharmaceutical composition of anilinopyrimidine, preparation and use thereof
US20100094560A1 (en) * 2006-08-15 2010-04-15 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
KR20110045032A (ko) * 2008-07-30 2011-05-03 이소테크니카 파마 인크. 비면역억제성 사이클로스포린 유사체 분자
AU2010256677A1 (en) * 2009-06-02 2012-01-12 Nikan Pharmaceuticals, Llc Antagonism of human formyl peptide receptor for treatment of disease
RU2630690C9 (ru) 2010-12-15 2017-12-28 КонтраВир Фармасьютикалз, Инк. МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
AR111963A1 (es) * 2017-05-26 2019-09-04 Univ California Método y moléculas
WO2019196953A1 (en) 2018-04-13 2019-10-17 National Institute Of Biological Sciences, Beijing Ntcp inhibitors
CN110174363A (zh) * 2019-01-09 2019-08-27 北京九强生物技术股份有限公司 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途
CN113388002A (zh) * 2021-06-10 2021-09-14 梯尔希（南京）药物研发有限公司 一种环孢菌素相关化合物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
US5834266A (en) * 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
US5716928A (en) * 1995-06-07 1998-02-10 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
BR9811716A (pt) * 1997-10-08 2000-07-18 Isotechnika Inc Análogos de ciclosporina deuterados e o seu emprego como agentes de modulação imunológica
US6784156B2 (en) * 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
CA2461740C (en) * 2001-10-19 2013-02-12 Isotechnika Inc. Synthesis of cyclosporin analogs
KR100992850B1 (ko) * 2001-10-19 2010-11-09 이소테크니카 인코포레이티드 시클로스포린 유사체 혼합물 및 면역조절제로서 이들의 용도
US20040110666A1 (en) * 2002-12-04 2004-06-10 Or Yat Sun Cyclosporins for the treatment of immune disorders
US7012065B2 (en) * 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
CA2518265A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US20040266669A1 (en) * 2003-06-20 2004-12-30 Wu Frank X. H. Cyclosporin derivatives for the treatment of immune disorders

Also Published As

Publication number Publication date
EP1828229A4 (en) 2010-06-30
WO2006063470B1 (en) 2006-08-03
US20060223743A1 (en) 2006-10-05
EP1828229A1 (en) 2007-09-05
IL183908A0 (en) 2007-10-31
ZA200705475B (en) 2008-07-30
KR20070100284A (ko) 2007-10-10
WO2006063470A1 (en) 2006-06-22
TNSN07225A1 (en) 2008-11-21
JP2008524122A (ja) 2008-07-10
CN101120012A (zh) 2008-02-06
AU2005316095A1 (en) 2006-06-22
CA2592343A1 (en) 2006-06-22
BRPI0517207A (pt) 2008-09-30
TW200635954A (en) 2006-10-16

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