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Avior et al., 2015 - Google Patents

Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes

Avior et al., 2015

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Document ID
2469127844909613816
Author
Avior Y
Levy G
Zimerman M
Kitsberg D
Schwartz R
Sadeh R
Moussaieff A
Cohen M
Itskovitz‐Eldor J
Nahmias Y
Publication year
Publication venue
Hepatology

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Snippet

The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility …
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