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Frank et al., 1984 - Google Patents

Interaction of herpes simplex virus-induced DNA polymerase with 9-(1, 3-dihydroxy-2-propoxymethyl) guanine triphosphate.

Frank et al., 1984

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Document ID
2158181638008080318
Author
Frank K
Chiou J
Cheng Y
Publication year
Publication venue
Journal of Biological Chemistry

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Snippet

The triphosphate of 9-(1, 3-dihydroxy-2-propoxymethyl) guanine (DHPG) competitively inhibits incorporation of dGTP into DNA catalyzed by DNA polymerases specified by both type 1 and type 2 herpes simplex virus. K1 values were estimated to be 33 nM for type 1 and …
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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