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Slichenmyer et al., 1993 - Google Patents

The current status of camptothecin analogues as antitumor agents

Slichenmyer et al., 1993

Document ID
1998048569609650879
Author
Slichenmyer W
Rowinsky E
Donehower R
Kaufmann S
Publication year
Publication venue
JNCI: Journal of the National Cancer Institute

External Links

Snippet

The nuclear enzyme topoisomerase I (topo I) has been recently recognized as the target for the anticancer drug camptothecin (CPT) and its derivatives. Two of the agents that target this enzyme—topotecan (TPT) and CPT-11—appear to be active against a broad range of …
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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