Nothing Special   »   [go: up one dir, main page]

Camli et al., 2024 - Google Patents

Two photon imaging probe with highly efficient autofluorescence collection at high scattering and deep imaging conditions

Camli et al., 2024

View HTML @Full View
Document ID
17252108638638876002
Author
Camli B
Andrus L
Roy A
Mishra B
Xu C
Georgakoudi I
Tkaczyk T
Ben-Yakar A
Publication year
Publication venue
Biomedical Optics Express

External Links

Snippet

In this paper, we present a 2-photon imaging probe system featuring a novel fluorescence collection method with improved and reliable efficiency. The system aims to miniaturize the potential of 2-photon imaging in the metabolic and morphological characterization of …
Continue reading at opg.optica.org (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059—Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultra-violet illumination; Fluorescence microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059—Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B6/00—Light guides
    • G02B6/02—Optical fibre with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements

Similar Documents

Publication Publication Date Title
Lukic et al. Endoscopic fiber probe for nonlinear spectroscopic imaging
Rouse et al. Design and demonstration of a miniature catheter for a confocal microendoscope
Huland et al. In vivo imaging of unstained tissues using long gradient index lens multiphoton endoscopic systems
Shin et al. Fiber-optic confocal microscope using a MEMS scanner and miniature objective lens
Cheng et al. Handheld multispectral fluorescence lifetime imaging system for in vivo applications
Shin et al. A fiber-optic fluorescence microscope using a consumer-grade digital camera for in vivo cellular imaging
Sung et al. Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo
Hoy et al. Optical design and imaging performance testing of a 9.6-mm diameter femtosecond laser microsurgery probe
US8705184B2 (en) Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods
Cicchi et al. Time-and spectral-resolved two-photon imaging of healthy bladder mucosa and carcinoma in situ
Pillai et al. Deep-tissue access with confocal fluorescence microendoscopy through hypodermic needles
Yin et al. Miniature in vivo MEMS-based line-scanned dual-axis confocal microscope for point-of-care pathology
Balu et al. Rapid mesoscale multiphoton microscopy of human skin
Kang et al. Endoscopic probe optics for spectrally encoded confocal microscopy
US20130324858A1 (en) Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods
Kyrish et al. Ultra-slim plastic endomicroscope objective for non-linear microscopy
Rivera et al. Use of a lensed fiber for a large-field-of-view, high-resolution, fiber-scanning microendoscope
Septier et al. Label-free highly multimodal nonlinear endoscope
JP2011508889A (en) Optical probe
Ouzounov et al. Dual modality endomicroscope with optical zoom capability
Kyrish et al. Achromatized endomicroscope objective for optical biopsy
Patil et al. A handheld laser scanning confocal reflectance imaging–confocal Raman microspectroscopy system
Huland et al. Multiphoton gradient index endoscopy for evaluation of diseased human prostatic tissue ex vivo
Mehravar et al. Label-free multi-photon imaging of dysplasia in Barrett’s esophagus
Peyrot et al. Development of a nonlinear fiber-optic spectrometer for human lung tissue exploration